#05 - Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer
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- čas přidán 7. 09. 2024
- Original release date: 7/16/2018
In this episode, Dom D’Agostino, one of the smartest people on all things related to ketones, digs deep into the research and application of these molecules. We discuss ketone esters, diesters and monoesters, racemic ketones, medium-chain triglycerides (MCTs), C8 (caprylic acid) on the exogenous ketone (EK) side of things. We also cover a lot of Dom’s fascinating work with hyperbaric oxygen therapy (HBOT). Dom also discusses the strategy and tactics of the metabolic management of cancer, which includes, but is certainly not limited to, a ketogenic diet (KD). Cancer is covered throughout this episode, but if there’s one section to listen to, skip ahead to the 2-hour mark and listen to what Dom has to say about the Press-Pulse approach.
Show notes page: peterattiamd.c...
We discuss:
-Dom’s early medical training in hyperbaric chambers [7:00];
-Effect of ketones on cancer cells [20:00];
-Ketones and oxygen toxicity seizures [32:00];
-HBOT & its many applications [40:00];
-Ketones, MCTs, and exogenous ketones [59:15];
-How ketones affect blood glucose [1:20:00];
-Ketone esters, salts, enantiomers vs. racemic BOHB [1:38:00];
-Dom’s ketone tolerance test [1:56:00];
-The metabolic management of cancer using a Press-Pulse approach [1:59:45]; and
-More.
About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: peterattiamd.com/
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I thank the Lord for Peter Attia and Dom D’Agostino!
The first time it was difficult but after listening to a plethora of these talks by these guys, Rhonda Patrick, Tim Ferriss, Lew Cantley, Jed Fahey, It's starting to make sense and I started a biology course to help my future interest. Keep up this groundbreaking work and research guys as for sure between that collection of minds.......something goods gotta happen. Good Luck, Good Work & Goodnight. Thank you for your efforts.
I understood 1.5 % of this but am fascinated by hearing these geniuses talk
The ttttt
Dr Attia, muchas gracias por toda la informacion y el esfuerzo dedicado a diseminar inofrmacion tan util para los que no estamos en el mundo de la medician . Muy agradecidos . GOD bless 🤗👏
Wow! Great talk. I have recently started an Atkins/keto diet after a gtt showed 2 hr glucose of 141 and 4 hr glucose of 46; in addition to hyperlipidemia that occurred since the previous normal test 1 year prior. A few weeks after starting my diet I did the cardio IQ for IR and got total insulin of
1:24:13 Dom talking about his personal experience with exogenous keytones pushing down base line insulin levels.
Excellent, comes at the right time too, I've had two diagnoses of cancer in the past two months, one dead, (4th stage pancreatic) the other live (lymphoma) will arm me well to see the oncologist. Cheers
This deserves so many more views
The push/pulse discussion was incredible. Such a good question Peter. If someone I care about comes across one of these more complex cancers I will work hard to try and reach out to one of you guys.
The explanation Warburg effect by Dom was the geekiest thing I ever heard in my life :)
Can you do an updated interview with Dom? That'd be great! 🙂
Dr Attia I love your channel very informative and interesting .. please keep up the great work
24:15 normal, healthy neurons functioned and thrived In a low glucose environment as long as ketones were present, but the cancer cells would die
Amazing content! You guys hit every topic that I'm interested in. Thank you.
I’d love to see an updated interview!
Interruption after interruption after interruption
I hate that shit.
Yup, annoying.
Yeah, I’m trying to take notes and it’s impossible for him to stay on track, let alone make a semblance of coherent notes. (My loved one is suffering from stage 4 cancer, so trying to get as much info as possible to help)
Perfect podcast duo!
Thank you for sharing gold! I got a lot to study!
Peter, you never let him answer the question about metastatic breast cancer..............
While fasting your glucose can go down to as low as 30 on its own with no problems.
I fasted for 108 hours and my glucose went to 43 mg /dl and ketones level of Hi all on a strict regular keto /carnivore diet Omad ... I took my ketones on my other hand and still registered HI ... I stop my fast and drank some juice to bring my glucose up there was nothing on utube to say if ketones are high what you do to bring it down ... now I’m out of the extended fast my ketones level 5.8
Great exchange. Many thanks
The reason Dom lost weight (while diving) was indeed higher metabolic rate which was a consequence of forming brown fat - due to cold waters- which is very energy demanding and takes glucose out of the blood. Listen to Susanna Soeberg, she’s done several podcasts lately, one with Dr. Andrew Huberman.
It’s interesting to hear personal experience of someone confirming her results without knowing of her research 😁
Amazing information... thank you!
Great interview!
@1.07.14
Lol, thank God you said that! It makes me feel so much better about myself😂 This stuff is so complicated
Another brilliant episode. I just wish someone had brought up the issue of apoB on keto. I assume this was recorded before the day of Dayspring. As an LMHR, I am mourning the loss of my wonderful keto diet, which I quit after seeing my apoB numbers double. Now I’m hoping that exogenous ketones can come to my rescue.
I did a 108 fast had GKI of 1.0 my ketones measure from 6.9 to Hi and glucose down to 43 mg/dl I just eat naturally did not take anything I felt great no hunger pangs .. I stop because my glucose was 43 mg/dl and ketones HI I did not know if I was doing any damage to my body ..but it was great
Awesome podcast thanks guys! I've been reading and listening to everything I can find... Alot from u and Dom about exogenous ketones as I've been experimenting with them recently. I love them!
what is the best exogenous. ketone that one can buy .
Should a cancer patient eat a a low anti oxidant keto diet? What would that look like?
Look at the work of Thomas Seyfried, or at least his videos on youtube.
Dr. Attia, Have you experienced Hyperbaric oxygen therapy (HBOT)? With your personal health protocol, do use oxygen therapy? Thank you.
Can I use Liposomal vitamin C preferably the product by Livon instead of the IV vit C. Great pod cast
I have a question about antioxidant use: I understand what you’re saying about normal conditions, but if one were either a smoker, drinker, eating the SAD diet, wouldn’t they be experiencing much higher levels of oxidative stress already, my tent then antioxidant supplementation be a good idea?
Perhaps Peter does not plan to respond.
@@danielmccarthyy possibly. He’s busy in the extreme I imagine.
What are the best exhaustion is ketones
What if you are a super fat adapted cancer patient. Your body snaps up ketones like a Crackhead at a Crack party, I would think you have to do exogenous ketone supplements to keep up with the demand during exercise before the liver kicks in with glucose. Would a ketone crackhead have to do it differently?
My guess is peter was at john hopkins...and because of his ego investment he takes up issue with the info that Thomas purports. Bizarre
Ima eat all of this buffet