Pharmacology of Anticancer Drugs (Complete Overview) [ENGLISH] | Dr. Shikha Parmar

Pharmacology of Anticancer Drugs (Complete Overview) [ENGLISH] by Dr. Shikha Parmar
Excessive, abnormal and uncontrolled growth of body cell is called cancer. Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues. Many cancers form solid tumours, which are masses of tissue. Cancers of the blood, such as leukaemias, generally do not form solid tumours. Cancerous tumours are malignant, which means they can spread into, or invade nearby tissues. In addition, as these tumours grow, some cancer cells can break off and travel to distant places in the body through the blood or the lymph system and form new tumours far from the original tumour.
Unlike malignant tumours, benign tumours do not spread into, or invade nearby tissues. Benign tumours can sometimes be quite large, however, when removed, they usually don’t grow back, whereas malignant tumours sometimes do. Unlike most benign tumours elsewhere in the body, benign brain tumours can be life-threatening.
Metastatic cancer has the same name and the same type of cancer cells as the original, or primary, cancer. For example, breast cancer that spreads to and forms a metastatic tumour in the lung is metastatic breast cancer, not lung cancer.
Symptoms of cancer may be following found in patients with different cancers: fatigue, weight loss, pain, skin changes, change in bowel or bladder function, unusual bleeding, persistent cough or voice change, fever, lumps, or tissue masses.
In cell biology, actinomycin D is shown to have the ability to inhibit transcription. Actinomycin D does this by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase. Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with the synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.
This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ovarian cancer. It is given by injection into a vein.
Description Source: Wikipedia

[@user-vd4ef6mr2e]

Doc brilliant👌🏿

[@naluwembahilda5273]

Thanks so much

[@mahrukhan4330]

Amazing lecture

[@DrShikhaParmarClasses]

Thanks for watching and liking the video

[@MuhammedSuhail-ct2in]

AMAZING LECTURE MAM

[@DrShikhaParmarClasses]

Thank you for watching and liking the video 🙂

[@tejasvinisr8526]

Mam plz do vedio on cardiovascular drugs

[@nikitanayak6482]

Thank you Mam

[@DrShikhaParmarClasses]

Thank you for liking the video 🙂

[@ambanandappaksrtc864]

Mam Please upload the pathogenesis of Cancer

[@heharshrajkamal8268]

Need notes

[@praveshacharya30]

Are lectures sufficient for MBBS, mam?

[@DrShikhaParmarClasses]

Yes, content is sufficient, it covers all the classes of Anticancer Drugs. You can also go through individual classes of Anticancer Drugs. All videos are available on the channel.

[@praveshacharya30]

@@DrShikhaParmarClasses thank you mam. A much demanding lecture indeed!