How do Thiazide Diuretics Work? Understanding Bendroflumethiazide and Indapamide

The video contains a simple and visual explanation of how bendroflumethiazide and indapamide, both thiazide diuretics, work to encourage the kidneys to excrete more water and sodium. We cover some basics about how the nephron works and look in detail at the action of thiazide diuretics on the thiazide sensitive sodium chloride co transporter molecule in the distal tubule of the nephron. We also talk about the indications, some practical tips on using thiazide diuretics, adverse effects and contraindications.
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[@carolinamonteiro1179]

A little bit incomplete. It would be very useful to mention the importance of reabsorption of Ca2+ in hypercalciuria promoted by thiazides. Thank you, still!

[@drcharutapradeep]

Short and simple but very helpful. Thank you!

[@ZeroToFinals]

Glad to help Charuta

[@jamesbrook81]

Thank you! I've been struggling with upcoming exam and seeing this simple and easy explanation through this video helps a lot. There's too much information to be absorb, but seeing simple animation and with your soothing voice ease me up lol.

[@ZeroToFinals]

lol thanks! glad to help. good luck in your exam

[@maritavanzweel6338]

Thank you, this is a clear, easy to understand !

[@tammyhittner1088]

Thank you! Best video I've seen to explain the theory! Very helpful :)

[@ZeroToFinals]

Great to hear!

[@kimmy6110]

Why am I just now discovering your channel!! Oh my goodness! Studying Pharmacology is going to be so much more easier to understand! Thank you for taking the time to make these videos! You’re AWESOME!😎

[@ZeroToFinals]

You're welcome. Can't wait to have more time to make more!

[@stanleychigozie2551]

Please 🙏 , make videos of the individual systems that drugs in pharmacology act on . Your explanation is top notch . The animation is second to none. Thank you so much for simplifying this.

[@ismaelsedky1246]

You are a Genius, Perfect video, very clear and helpful thankss

[@aminzairi51]

have watched, listened and read every single of your video, podcats and notes. very useful resource for revision as i'm cramming for my finals. tq so so much

[@ZeroToFinals]

every single one? wow. good luck in your finals!

[@shadowsidesoamplified]

Best one ive seen. Simple and quick

[@ZeroToFinals]

Thanks!

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[@jeremiahbaker6396]

your videos are always great sir. thank you

[@laurafinnell8167]

so helpful. thank you

[@immadisarojini2775]

Liked so much

[@MarkyDelaCruz]

Crystal clear..thanks much!

[@chantelletrenoweth6083]

Thank you - wonderful explanation!

[@ZeroToFinals]

Thanks Chantelle

[@gocha1892]

Thank you so much! It really made more sense.

[@ZeroToFinals]

Glad to help!

[@amritveerkaur3113]

Itz really helpful for me ..easily understood moa thanku alot 👍😍

[@nuwabiinealex9328]

Great en nice explanation

[@shortyyzac1433]

I am From India your Explanation is very well

[@drnamankhatri]

Awesome video.

[@manasideshpande8170]

This is really helpful😊

[@user-jz2nx6xt3t]

Very very useful. Thank you

[@arkoopots3129]

Thank u buddu, it was very very very useful and easy to understand 🤩🥰😘😘😘😘

[@meenabhoo3568]

very informative , thank you

[@CourtneyX]

Clear explanation thanks

[@gonulg1851]

Excellent. Thank you. 👍👍

[@annmaryjose7811]

Thankuu sir.. Very good explanation

[@lstrawaya6403]

Thank you so much 😊😍😍😍😍🥳🥳🥳🧁🧁

[@Quicklase]

Hi Would you have an explanation video or thoughts on using both thiazide and sglt2 meds?

[@aga5897]

Superb, as always.
Is there a any 'roadmap' of where to start and finish, or is it a case where you just need to learn it all ?

[@hotchocolatebrownie4397]

Very helpful. Tysm sir.👍

[@christopherjames7368]

Awesome thank you

[@alfoalem-1621]

Thank you!

[@rijuuk8969]

well explained..thank you

[@ZeroToFinals]

Thanks Riju. Glad it helped

[@nasirusulaiman7001]

Nice lecture

[@prateeksharma291]

Thanks A lot buddy🤙🏻

[@raviprajapati3774]

Very helpful

[@user-lu6ce4yc9g]

Do you have to supplement potasium with indapimade

[@magy2973]

thanks alot ♥

[@ZeroToFinals]

You're welcome!

[@juveriasjf]

Thank you so much.. 💙

[@ZeroToFinals]

Glad to help!

[@simranranjan6792]

Thanks sir 👍

[@ektashukla3515]

Best 👍💯

[@dr.radhikaupadhyay7906]

Superb 👍

[@ZeroToFinals]

Thank you!

[@a.s.kamakshishriya5487]

Why hypokalemia is seen in thiazide diuretics?

[@drchinyendujokoronkwo2458]

Great

[@irannamalali1326]

Please upload the video of potassium sparing diuretics

[@user-gw5ji3xd2n]

Why isn't pharmacology notes there on website?

[@madhaviravi359]

Nice 1

[@iMaGiNaTiOnWpAsSiOn]

I’m trying to understand the difference in mechanism of action between loops and thiazides. It seems like they do the exact same thing by not allowing Na/Cl to go back into the bloodstream. The only difference I’m seeing is that they’re operating at different points in this kidneys. I’m so confused 😭

[@avtawf]

4:13 Why would the increase loss of water cause a higher serum glucose level in the body?

[@aliyakhan7240]

Doubt : how K+ is also excreted along with Na+
Plz Xplain : under thiazide actuon increased amount of sodium is presented to distal nephron, more of it xchanges with potassium. As a result potassium xcretion increased in parallel to naturetic response
In reference to: KD Tripathi 3 rd edition page 213last para

[@jesussalvadorgonzalezlopez3678]

Why loop diuretics dont cause hyponatremia if the also inhibit Na reabsortion in ascending loop?

[@ZeroToFinals]

mostly because water follows sodium. hyponatraemia occurs due to a greater proportion of water to sodium, but when sodium is excreted, water follows so the proportion stays the same. having said that loop diuretics can cause hyponatraemia.

[@simakahamed9445]

How k+ loss in thiazide diuretic use

[@govindshriyareddy6673]

How are thiazides useful in diabetes insipidus patients?

[@Tom-eq5bz]

hello Tom!

[@julielarge6120]

I was on Indapamide. I had to come off it.

[@silverstarlight9395]

Why hypercalcaemia and hypokalemia?

[@assmaaalawad4014]

100%👍

[@Thopa8004]

👍

[@immadisarojini2775]

Caution ⚠️. Postural hypotension in. Older frail comorbities

[@dharmendrakumarrana7557]

That’s good

[@Sk87_13]

Well explained... Thank you

[@ZeroToFinals]

No problem, glad you liked it

[@ankitshukla4653]

Very helpful