Non-Alcoholic Fatty Liver Disease and its Link to Chronic Illnesses, Unraveling the Hidden Epidemic.
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- čas přidán 12. 06. 2023
- Professor Robert Lustig, a professor of Pediatric Endocrinology, is giving a presentation on non-alcoholic fatty liver disease (NAFLD) and its connection to chronic diseases like type 2 diabetes. NAFLD affects a significant portion of the population without their knowledge. Dr. Lustig emphasizes the importance of understanding the cause and pathogenesis of this disease, as it has become prevalent even in children who don't consume alcohol. He challenges the notion that obesity alone is the primary cause of metabolic diseases, presenting data showing that lean individuals also suffer from these conditions. He explains that the measurement of fat on the scale does not accurately determine a person's health status. Dr. Lustig highlights the significance of insulin resistance as a key factor in determining the development of diabetes and other chronic diseases. He discusses the different fat depots in the body, namely subcutaneous fat and visceral fat, and how their distribution and metabolic activity affect health outcomes. Dr. Lustig considers sugar (glucose-fructose) as a hazardous substance that can alter one metabolic pathway and help develop fatty liver.
we encourage everyone to also watch other CZcams videos of Dr. Lustig on Emery Pharma channel:
• The Subcellular Proces...
• Professor Lustig’s Hat...
• Non-Alcoholic Fatty Li...
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kewords:
Emery Pharma Speaker Series
Professor Lustig
Pediatric Endocrinology
Sugar: The Bitter Truth
metabolica
Non-alcoholic fatty liver disease
Silent killer
Pathogenesis
Type 2 diabetes
Lean diabetes
Normal weight
Risk factor
Metabolic disease
Metabolically healthy obese
Metabolically healthy
Obesity pandemic
Chronic disease
BMI
Growth hormone receptor mutation
The Little Women of Loha
Larone dwarfism
Insulin resistance
Lipodystrophy
Adipose tissue
Visceral fat
Subcutaneous fat
Metabolic Health
Waist circumference
Acute stress
Norepinephrine
Beta-3 adrenergic receptor
Lipolysis
Triglyceride - Věda a technologie
Dr. Lustig is a treasure!
He should have an audience of thousands not just the few!!!
Please forward this to as many people as you can. His message will save lives
Here we go.
This is the point of youtube.
@@Emerypharma p
We agree!!
He guested in many YT shows and school seminars of all kinds already, and written many books.
I have not met a single professor in my whole life, who is a Knowledgeable Orator like Dr.Lustig.
This should be on all tv channels 24/7.
Now when I see the cupcakes and fake juice boxes come out at my grandchildren’s soccer games, I physically twitch. Exercise and poison.
I have no medical background whatsoever, and forget about remembering basic chemistry. This lecture was gold, for someone like me who has NAFLD. First time that I found out what it means... Trying to lose weight like everybody else. But after this video, I have to make major shifts in how I eat... amazing and enlightening even to the regular person. Brilliant! Thank you!!
So it’s what we are eating etc?
#Carnivore Diet #Dr. Ovadia #Dr.Berry
@@mrwhiskers1471 What happens to your car engine when you pour sugar in the gas tank? It ruins the engine. Same in humans. Our engine is the metabolism, the liver and all mechanisms they drive.
Just about carbs and eat mostly red meat with a lot of fat.
Isn’t it odd that most of us learned out we had fatty liver when being treated for some other disease? They don’t even use the words “ fatty liver” on your lab tests. I had to google each term to find out what each was and what it meant. I also got ZERO information on what that meant for my health.
My boss didn't find out he had diabetes until he had surgery for something else. I know a guy who only found out he had diabetes when, as he put it, "I woke up one morning and couldn't see". At least in the US, preventative medicine and screening are only available to the wealthy. The US is not like a first-world country where you get a check up each year and can see the doctor without it costing you a ton of money.
Guess what else they won't tell you even if you do find out you have fatty liver. That is that it turns into Cancer. Keep learning and don't think it is something you have time with!
The sad part is that fatty liver will turn to cirrhosis as did mine . Not from alcohol! I went from fatty liver and 16 yrs later I now was told that I have cirrhosis back last June . I'm compensated stage one, with now a much higher risk of liver cancer. I have perhaps 12 to 15 yrs. I'm type two diabetes. When I was told about fatty liver, I weighed 172 lbs . A little heavy but not to the extreme! So anyone with fatty liver be warned that it may very likely turn your liver to cirrhosis.
Im sorry to hear that, Im also have fatty liver stage 3, Im very sad now is like i dont have much time. But is that true that we have a chance to live 10 years more?? My doctor didnt said anything just suggent to me to diet. Sorry for my bad english@@user-zl3xs1cf8x
Keeping us in ignorance is a plan and not by good people but the 2 percent corrupt trying to keep control of this world through tyranny
Always a brilliant lecture by Dr. Lustig. I have highest respect for the depth and breadth of his knowledge. If actively applied, he would save our medical system and restore health to millions. The burden of chronic care for lifestyle illness is undeniable.
Consumption of oxidized industrial seed oils is a huge problem too.
Seed oils like canola oil are perfectly healthy. Lustig is a notorious misinformer.
Oh really...🤔
Both omega 6 linoleic acid and omega 3 fatty acids oxidize rapidly. (It's why they bleach flour), because it goes rancid within 5 days of splitting the seeds to oxygen, (oxidation).
In fact the manufacturers are well aware of this and some add vitamin E as a preservative to seed oils.
Krill & salmon oil has astaxanthan a natural antioxidant that preserves the oil. It's what gives it tge reddish pink color.
Take a look at the data on diabetes and heart disease for Japan before during and after the western diet was introduced there.
Also the first heart attacks started coming around 20 years after crisco first started being used as a cooking oil as opposed to an industrial lubricant. Petroleum replaced seed oils in industry and tge seed oils aggressively tried replacing lard to salvage their plummeting market share.
It's a concern because Americans consume around a 30:1 omega 6-3 ratio these days.
Traditionally it's a 1:1 ratio.
In mouse models anything over A 5:1 ratio CAUSeD cancer in the mice.
So something is going on here.
HFHC diet is shortening lifespans.
@@donwinston Wrong, Lusting is right on the money IMO.
@@boomerang6130 Almost everything he says about sugar is completely bogus. No evidence for it what so ever. Zillions of evidence against what he says. He is a quack. He tries to appeal to morons not to other scientists.
@user-kc7mu4jp4p Natural doesn’t mean anything.
I cured my NAFLD with NASH and fibrosis by simply removing carbohydrates from my diet. My liver is now normal.
Well done! 🙌🏼
@@ShazWag - Dat man, he tol me dis Earth is flat and then I believe him yah.
Mama mia!
Could you tell me what is NASH IVE GOT FATTY Liver hardly touch alcohol never drink coke or Pepsi and am now pre diabetic
@@loreto761Non Alcoholic Sterohepatitis . As NAFLD progresses, this is the next and more damaging stage which can lead to full blown Cirrhosis.
@@loreto761get rid of machine made "processed" foods & sweeteners/ starchy carbs... Cook each meal yourself. Danger list: sauces like mayo ketchup + barbeque, beverages like fruit juices, lemonade, even so-called "sugar-free" energy drinks or sports drinks too! Cereal, pasta, bread, crackers & chips, bagels, muffins, rolls, basically a lot of the crap in the pantry made from wheat.
*Solution*: EXERCISE & STRENGTH TRAIN . eat a normal 1-plate portion of a wide variety of fresh garden produce, WATER, meat, beans, nuts, and a little fruit only in season & local. 1-3 meals a day, never go back to snacking between
Glad to see Dr Lustig doing more interviews! What big food corp has done to society is criminal!
Not to mention Big Pharma……
What our govt allowed big food to do is criminal. The sugar industry should very held liable for American healthcare
I’m still wanting to sue whoever came out with that damn food pyramid!😡
The government is to blame. Government is supposed to protect the inalienable rights of the people that it works for. They haven't been doing that for at least 70 years.
@@janebadon3988
The SDAdventist sect - in control of dietary associations - is pushing for its acceptance behind the scenes; beginning with Kellogg's... Listen to Gary&Belinda Fettke explain this.
Non fatty liver disease ( is a silent killer like hypertension. Liver fat is adriver of diabetes even in normal weight people.
Fatty liver disease is a precursor of type 2 diabetes.
It was the liver fat that dictates insulin resistance .
Where the liver fat came from ? From nonsystemic fatty acids came from de novo lipogenesis ( DNL)
Systemic fatty acids came from diet and lipolysis of peripheral adipose tissues.
3 hits to the liver that leads fatty liver disease.
1. DNL ( de novo lipogenesis) because of mitochondrial dysfunction.
Ex. Reyes Syndrome - aspirin causes mitochondrial dysfunction
because of changes in hepatic lipids and TGD.
Causes a defect in ACAD-L enzyme.
Sugar is a mitochondrial toxin. Glucose is non- toxic, because it is converted into glycogen in the liver., and glycogen is safe.
But Fructose overwhelms the mitochondria to be ale to to metabolize it to ATP, and carbon dioxide. It then throw off excess as citrate which then become malonyl-CoA, into free fatty acids , then into VLDL, and exporting it out of the liver. But some will precipitate as fatty/lipid droplets in the liver causing fatty liver , insulin resistance, pancreas has to produce more insulin, which makes you fat , and you keep eating because insulin block.
.Fructose reduces liver mitochondrial function, while glucose stimulates it.
Fructose inhibits 3 enzymes in the liver : AMP Kinase, ACAD-L, CTP1A , decreases beta oxidation of fatty acids /lipids.
Glucose stimulates 2 enzymes that increase beta oxidation.
Sugar is a mitochondrial toxin.
Fructose makes liver to store more fat.
Sugar is toxic unrelated to calories.
Metabolic improvement results after fructose restriction without calorie change, without weight loss. Liver fat production reduced, visceral fat and liver fat reduced, increased insulin sensitivity. .
2. ROS formation and inflammation. Fructose produces more ROS , and faster than glucose.
Need anti-oxidants to counteract ROS. Fructose is a cellular toxin in vulnerable cells without anti-oxidants.
.
Fructose causes , leaky gut and liver inflammation.
3. Malnutrition and defective packaging and transport. Fat has to exit liver as VLDL.
Sucrose necessary to provide the substrate for steatosis.
Methionine ( methionine provide the methyl group for glutathione) deficiency reduces glutathione .
Choline is necessary for hepatic lipid export because phosphatidyl choline which is needed for ApoB100 for VLDL to exit liver. .
Need methionine to make glutathione , if deficient will lead to fatty liver
Sugar exposure/diet with Methionine-Choline deficiency causes fatty liver disease, because sugar as substrate for ROS formation, need Methionine to make Glutathione anti-oxidant, and Choline is needed to make the fat exit the liver..
So the " 3-hit hypothesis of fatty liver or NAFLD are:
1. Mitochondrial dysfunction and DNL
2. ROS generation and inflammation
3. Malnutrition and defective packaging and transport.
Sugar causes diabetes , heart disease, fatty liver disease , tooth decay .
Sugar is correlated to cancer , dementia.
Fructose in diet cause the Liver to get fat first/Fatty liver , causing insulin resistance, then pancreas has to produce more insulin,
Foodstuffs and metabolic syndrome : Trans fats; branched chain amino acids, ethanol, Fructose
All cause fatty liver disease.
Liver is the only site for energy metabolism
Liver is not insulin regulated
No glycogen popoff ( fat , mitochondria is overwhelmed.
What to do:
1. No sugar( reduce the substrate) ,
2. high fiber ( to reduce sugar To liver) ,
3. Choline ( improve transport) .
4. Exercise to increase clearance.
Anti-oxidants are vitamin E and glutathione. Need methionine to make glutathione, Need choline to make fat exit liver.
folate deficiency will also cause a fatty liver
Thank you, Tpry, for your succinct summary 😊
Awesome
Hi Fibre in what food content, vegetables and some fruits. Berries have a lower sugar index apparently. I am lost as I am currently in a flair up of a sick biliary system. Does fasting for 24 -48 hours help .
Thank you so much for this written explanation. Would this also explain fatty pancreas, kidney, heart and other organs of the body?
I have listened to this lecture 3 or 4 times. One of the best I have ever heard (at least since his precursor lecture on the “hateful 8”). A tour de force of intellectual analysis and explanation of one of the most serious and intractable public health problems of our age. I would be intrigued to learn about the role that toxins play in mitochondrial overwhelm, ROS, and dyslipidemia.
M😊
Look up 4-HNE oxidative stress papers on mitochondria
So helpful, thank you! ❤
I was told by doctors for 3 decades to “not worry” about my fatty liver! They said to eat less fat. Now my liver disease has progressed. Thanks to videos and kind doctors who help the public via CZcams, I am reversing it.
We are not surprised. Many doctors are not knowledgeable with respect to metabolic syndrome and conversion of fructose to fat.
Just found out I have fatty liver. I was actually having an. Ultrasound on something else when the lady doing the ultrasound says you have fatty liver and gall stones. I had no idea. Im trying to learn all I can to try and fix it. I read recently that a new study claims Splenda or sucralose is also a cause of fatty Liver. I was drinking it daily in sugar free Gatorade. They also say it messes up your gut biome and I have leaky gut! Also aspertame will soon be labeled that it causes or may cause cancer! This is frietening why were these ever allowed in food if they are killing us?
Because they want you sick and reliant on them for everything, even dead outright. They want you to buy their junk food, see their controlled Pharma doctors and buy their expensive meds.
If you are trying to learn all you can, be sure to tap "air pollution fatty liver" in a search engine.
It isn't just the crap we put in our food that makes us sick, the crap we put in the air makes us sick too.
@@robinhood4640totally agree with you. But, what about "Round Up" in our foods? Electro magnetic frequencies? Stress!!!!
@@charliesamantha4660 I think round up falls into the category of "crap we put into our food".
EMF are an interesting subject because i think they are affecting us via the same mechanism. They modify the air we breathe.
Stress, in my opinion is a scapegoat, it allows us to explain everything that happens in the body that we cannot find an adequate explanation for. I think the reason millions of people can be very often stressed, and not have any physiological problems, is because stress itself isn't the problem. Stress affects the body in a way that increases the negative effects of the air we breathe. Basically, psychological stress alone will not cause the physiological problems that are associated with stress. The oxidative stress caused by the air we breathe, can cause physiological problems without psychological stress, but psychological stress will make it worse.
The problem is the oxidative stress (physiological) not the stress (psychological).
@@robinhood4640 hi. Hope you’re doing well. I say a pain management doctor. Increased stressed increases cortisol levels, increase insulin levels, increases glucose levels, plays with your adrenal glands “Addison’s disease”=too low cortisol level, “Cushings’ disease” = too high cortisol level. It’s unbelievable what havoc stress can chemically harm your body.
I carry an unconditional love for Robert and I wanted to share that as he shares with us
I thought I was the only one
@@freedomanyprice9560 🫂
I like your name
great presentation, this came in handy for the upcoming exam ❤
brilliant webinar and presentation. I wish Prof. Dr. lustig would offer this presentation as a MOOC. I would sign up immediately to enhance my knowledge on nutrition science and get certified for it. thanks you, Dr. Lustig for sharing your insights across the world. miss Reimara
Please also watch: czcams.com/video/DdDiarWB_h0/video.html
czcams.com/video/oIWRmOIR_CM/video.html
czcams.com/video/g07Ph84U86M/video.html
Deeply studied author ; very nice and useful for millions ! Author may eligible for Noble prize about his discovery and linking so many things !
we strongly agree!
You are a grossly misinformed. Almost everything Lustig says about diabetes is horse shit.There is no such thing as "lean" type 2 diabetes.
I love watching Dr. Lustig's treasure trove of valuable videos. The longer his videos, the more I want to watch them because I learn so much about Metabolic diseases, Insulin Resistance, insulin, sugar/fructose and how toxic they are and finally about the importance of our Mitochondrial health and its dysfunction. I read both of Dr. Lustig's books, METABOLICAL and FAT CHANCE, cover to cover, and I feel like I am fresh out of medical school with all that medical knowledge. Thank you, Dr. Lustic, you are saving lives with your videos and books.
Every time I see a kid with a juice box I want to scream. May as well be vodka.
- Vodka is goot, yah in wit da natural tea ant da fresh squeeze lemon yah!!!!
Fool@@JamminClemmons
Wow! This was a great presentation. Very informative. I have a PhD in organic chemistry so I can manage the chemistry, but I will go back and re-watch to get more information. Thanks for sharing this.
Whooop whooop!!! Love Dr Lustig is the best!
SO many ads with these guys. But yes, Dr. Lustig is a treasure!
Ads a PAIN! But don’t want to pay utube a dime.
Dr Lustig is a genius and so do clear in his data and speech.thank you Dr
Love me some Lustig incentive, thank you Dr!
This guy is amazing , the explanation is on point amazing ❤
Keep the amazing videos coming! :)
Dr. Lustig is the GOAT!!! ❤❤❤
One study found that consuming 255 grams of fructose per day did lead to an increase in liver fat and reduced insulin sensitivity. It also showed the same result if you consumed 255 grams of straight glucose as well, suggesting it may not be just the fructose that is the issue.
Thank you doctor for an excellent
Lecture presentation 👏🏻👏🏻👏🏻👌🏻🙏🏻
Great up to date research important for more people to know about. It's an absurd world where we have poverty induced obesity
I can’t believe how well detailed this is it’s amazing I got more from you then my VA doctor I’ll limit my sugars and try intermittent fasting to see if I get better results
Type 2 Diabetes is a manifestation of fatty liver disease.
Type 2 diabetes occurs in obese , lean or normal weight adults, alcoholics, and children . Although obesity is a risk factor for diabetes, but obesity is not the cause of diabetes.
Metabolic health ( no liver fat, no diabetes) is not necessaily related to body weight.
Lean normal weight can also be sick with diabetes and fatty liver.
Intra-abdominal fat ( but not subcutaneous fat - under the skin only) correlates to fatty liver and diabetes and chronic disease.
Insulin resistance ( and high fasting Insulin) and Trigycerides ( not the LDL per se) are
At 16:25 " the standard model of insulin resistance"
Fat makes cytokines, ( TN-alpha, IL-6 ), which circulates and enter liver and causes liver to become insulin resistant, this increases hepatic glucose output , increases blood glucose which causes pancreas to produce more Insulin, which causes hyperinsulinemia, which causes more fat formation ., so on in a cycle. This is not true, .
As weight increases, insulin sensitivity reduces, but there are exceptions.
It is the insulin sensitivity vs insulin resistance that determines the the fate of a person, in terms of diabetes , heart disease, morbidity and mortality.
3 fat depots in the body:
1.Subcutaneous fat does not matter. You have to gain 22 lbs or 10 kilos of subcut fat before you get sick.
2. Visceral/ belly fat - is very metabolically active.
Is responsive to ( acute stress) adrenergic stimulation of epinephrine, causing lipolysis in fat cells releasing fatty acids , go to liver where it is turned into ketones. ( burn fat). Neurapeptide-Y is the break for the adrenergic stimulation by epinephrine , and leads lipid storage , therefore reverses the effect of adrenergic effect of acute stress.
Chronic stress releases cortisol which increases visceral fat formation, appetite and lipogenesis .
Only, have to gain 5-6 lbs of visceral fat before getting sick , because visceral fat drains into the liver, more cytokines effects.
3. Liver fat ( at 25:35) - cause is alcohol , in the past. But now, it is caused by sugar , even in children . But the liver effects of alcohol and sugar are the same.
Fatty liver disease is everywhere and occurs in obese and normal weight people.
If have fatty liver disease is 3.5 times more likely to develop type 2 diabetes in your lifetime, because fatty liver causes liver to develop insulin resistance and pancreas beta cells burn out.
Where does the fat came from?
It was the liver fat that dictated insulin resistance/.
Liver fat came from non- Systemic fatty acids. Systemic fatty acids come from diet and lipolysis from peripheral tissues
Non- systemic fatty acids came from de novo lipogenesis by the liver.
1. De novo lipogenesis because of mitochondrial dysfunction . Example is in Reye Syndrome( acute fatty infiltration) . Cause is aspirin. Don't give aspirin to children. Aspirin causes mitochondrial dysfunction. Aspirin causes changes in hepatic lipids and triglycerides , causing mitochondria not to work.
Aspirin causes a defect in ACAD-L enzyme.
2. Sugar is a mitochondrial toxin . When glucose enters the liver almost all is converted to glycogen.
Glycogen is safe.
But Fructose , overwhelms the mitochondria capability to metabolize it into ATP , throw off excess as citrate , to malonylCOa
, then forms free fatty acids and packaged as VLDL ( with apoB100). This is how the liver turns excess sugar into fat and export it out. . But some get precipitated as fatty lipid droplets, to get fatty liver, then get insulin resistance, then pancreas has to make more insulin and you get fat, and the insulin is block and you keep eating.
" fructose reduces liver mitochondrial function, while glucose stimulates it. "
Fructose inhibits 3 enzymes in the liver : AMP kinase , the fuel gaugeon the liver cell
ACAD-L.
CTP1A generates carnosine - enzyme necessary for beta oxidation
excess vitamin B6 can be hazardous to your health. see Emery Pharma's petition with the FDA: emerypharma.com/news/fda-citizen-petition-on-vitamin-b6-press-coverage/
Is the insulin resistance caused by the fat or by the cytokines?
@@allanchino35 Fat leads to localized hypoxia. The body reacts by accumulation of leukocytes. These cause inflammation. This impairs insulin receptor signalling.
Another way to look at it: when e.g. your liver gets too fat then your body protects itself by reducing insulin sensitivity through inflammation because high insulin sensitivity would mean the cells would store even more trigylcerides.
Yes he should be speaking all over the world with this subject. Our high refine carb diet is the cause. It is not the fat in our diet.
Super keen to understand the mechanism of serum ferretin, stored tissue ferretin with NAFLD and at what level it becomes a problem. Maybe a lecture on that would be great.
Is that something to do with ferroptosis?
@@JeanMcCormack hemachromatosis. It's the biggest genetic unknown issue in Caucasian populations. Possibly responsible for 20 % of NAFLD as a secondary condition to fructose NAFLD.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
czcams.com/video/t7PIURKDTes/video.html
I about lost my life a few weeks ago. I'm still recovering. It seems my liver failure was triggered by Tamiflu, yet I think that was the toxin that broke the camel's back, but this makes sense as a situation that may have set up that situation, along with Alpha-1 antitrypsin deficiency. I eat mostly natural foods, so it was quite a shock and surprise. I'm going to try stopping the fruit, as this makes sense.
Excellent lecture. Thank you. You are saving lives.
Creating a video that breaks down a healthy diet based on this would be a huge help for the general population.
I try to tell people about restricting sugars from a grandchild's diet, and they simply don't understand, and try to ignore it. This makes it difficult to take kids places.
Also check out Rob Lustig Latest video on this channel:
Robert Lustig, MD: Vitamin D, overdose or under-dose, Ketogenic Diets & Personal Responsibility
czcams.com/video/YDShRaMVZBA/video.html
Respected sir
thanks ..The best and very useful scientific infometion.
Many thanks
So sugar bad, ethanol also bad. Thank you Dr Lustig, most enlightening. I'd cut out most carbohydrates including sucrose and fructose some time ago but now I learn bottled solace is also best avoided.
Think of it this way - the woozy feeling alcohol gives you is because it’s a mild poison. ☠️
It also creates poor judgment. 🤪
People often know they have a problem but don’t do anything to correct it. I given up talking to people about nutrition.
As an RN for 20 years I am looking outside medicine to continue being healthy as I age. Medicine is designed to prolong your life with disease so you can be a pharma customer as long as possible! Understanding how our bodies work is the key to actual healthcare.
Going WFPB (the vast majority of the time, not always) for the last 9.5 years had changed my life/health. And I'm sure longevity if natural causes are my demise. Sugar and oils and animal products avoidance changed me the very first week. Felt better-less inflammation, more nutrition. Enjoy your new life.
Very much of data out there is horribly corrupt. You have to dig for the truth, food and pharma make SURE of that.
Increasing health span through prevention is the key to a good life
Great lecture.
But still stuck on how to linearly get from [de novo] liver lipogenesis to insulin resistance.
Can anyone recapitulate? Please.
Thanks for this.
Fantastic talk.
I truly admire Dr. Lustig and really appreciate all his research in this topic. Just one suggestion that if he himself can drop his belly fat, it would be even more persuasive.
Fascinating lecture. Thank you. Reyes Syndrome has a connection to ASA use in the face of a virus was mentioned in this lecture. My mind couldn’t help leaping to the thought that we may be seeing a new adult version of Reyes Syndrome in individuals taking 5-ASA in the face of a virus like COVID. It might lead to the unexpected dx of fatty liver and type 2 diabetes with no risk factors except being human. (No familial hx, a ketosis diet low in sugars and fructose ). Is it possible that 5-ASA might be catalyst for fatty liver formation in the face of a virus? Has anyone ever considered this? There were questions arising about the development of type 2 diabetes after COVID and those ideas being poo poo’d as mere coincidence at the timing of dx. Could there be an actual link with taking 5-ASA? Would love to hear of someone researching this. Thanks again for the lecture which is a much broader topic but can’t help but toss this out there to the pharmaceutical and scientific community to investigate.
Very troubling to hear that the GLP-1 analogs (Ozempic, et al) cause as much muscle loss as fat loss and increased risk of pancreatitis now that off-label use for weight loss is very common.
People cannot accept that there is no magic pill.
My own fellow medical professionals tease me about me Keto lifestyle.
But I’ve maintained a 55 pound weight loss for four and a half years. More importantly, I’ve gone from daily 100 mgs Losartan (blood pressure pill) to NONE ! I have more energy than many of my coworkers who are half my age! I’ll be 66 in a few weeks, weigh 118 pounds, and feel great.
Keto 💪🥩🍤🥓🥒🥑
I've heard many are developing ozempic face which makes you look older after fast weight loss.
Also causes Gastroparesis with severe chronic constipation. Terrible drug... Won't be surprised if there's litigation against it soon.
He is absolutely correct! I have a BMI off 22 and have a lot of liver fat. I’m a definite TOFI.
Thank you Dr Lustig. I am TOFI - 1.67 m tall 50kg, very healthy diet exercise 5 hrs per week, high LDL but very low Tri. AC1 near max bound. Ultrasound shows finely layer of fat on liver!
When large quantities of fructose reach the liver, the liver uses excess fructose to create fat, a process called lipogenesis. Eventually, people who consume too much fructose can develop nonalcoholic fatty liver disease, a condition in which too much fat is stored in the liver cells.
Such a brilliant guy. I would love to see him
Watch his other videos:
czcams.com/video/DdDiarWB_h0/video.html
czcams.com/video/oIWRmOIR_CM/video.html
czcams.com/video/g07Ph84U86M/video.html
Thanks for your channel
Thank you!!
Thank you guys for bringing dr Lustig's 🙏 indepth, medical knowledge dense lectures🙏 to wider audience... This unique sharing of real knowledge is revived spirit of true scientist who is researching for indepth true knowledge of the processes and is paid to tell lies paid by industry.
TY Dr. Lustig! If all this is true, then what about Bi,g P,h,arma products? For example, Sta,tins; side effect is Dm and mitochondrial dysfunction. They are heavily pushed for elevated cholesterol, which is easy to do since guideline numbers have been lowered over the years. (Memory loss is also a by product.) Body/brain needs cholesterol. What about antidepressants and mitochondrial damage? Antibiotics, which are also linked to NAFLD? And, last but not least, what about the accumulative effect of being on multiple medications? All these meds get filtered through the liver. Just wondering.🤷♀️
Perhaps another lecture?
This man is a super human!
What else has changed, Robert? Many great points from you about insulin, fructose etc. what about electromagnetic waves, that is, light?
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
czcams.com/video/t7PIURKDTes/video.html
High fructose corn syrup isn't just in Pepsi and Coca-Cola, it's in almost everything in the American diet. It's in bacon and hot dogs and "healthy" fruit juices and in Sunny-D and in hamburger buns and you-name it. So you can't just cut out soda pop, you have to look at everything. And you can't just be like someone I know who's bordering on morbidly obese and eats a ton of fruit because "My doctor told me to, it's healthy".
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
czcams.com/video/t7PIURKDTes/video.html
Prescription for NAFLD:
High IGF-1 & high insulin level (both raised by fructose from refined carbs & animal prorein), BCAA's (leusine, isoleusine, valine, abundant in animal protein), transfats (naturally occuring in dairy fat and meats) and alcohol.
No wonder WFPBD lowers HOMA-IR and inflammation more effectively than DASH.
Superb.
The heart disease risk goes up with a waist size that is greater than 35 inches for women or greater than 40 inches for men.
What waist circumference is a stroke risk?
Male*: more than 94 cm (37 inches) is increased risk; more than 102 cm (40 inches) is substantially increased risk. Female*: more than 80 cm (31.5 inches) is increased risk; more than 88 cm (35 inches) is substantially increased risk.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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Dr. Lustig. My 4 year old female, of average weight, has developed obstructive sleep apnea. I thinks it's related to a tick bite, we are located SW Missouri and live on land that boarders the national forest. A ketogenic diet seems to significantly help reduce inflammation.
Oh sorry to hear that. I don’t know much but at 76 I’m doing ✅. This early illness makes me wonder about Mitochondria development. I’d look that up, I use methaline Blue just cause I read it helps recovery from old age but have no idea 🤷🏼♂️ about the Tick bite on a youngster but it sure calls for research. ❤
Sleep apnea is a chronic B1 deficiency according to Dr Joel Wallach ND DVM, EONutrition and my own experience. It’s cheep to see if it works for your family.
@@randyjarvis9802Vitamin B1 is not some kind of sleep apnea miracle.
@@Dude8718 my wife is a FNP with her own practice. I do research for her. Dr Eric Berg with 11 million followers says it is a, (not always, but often) root cause. It’s 30 dollars to find out by trying it. Over 90% of her patients labs come back very B1 deficient. Have you ran labs to rule it out?
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Just received a type 2 diabetes diagnosis. I'm sure that it has nothing to do with high fructose corn syrup or a parasitical infection and is completely incurable. Because I'm an idiot and don't have a functional mind, but rely on my programming.
Oh wait.. That's not me. That's my physician.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
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Thank you
I love this man!
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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Excellent ❤
Thanks 😊
Shouldn"t it to be put on the slide at 19.15 - "normal/obesity" as before was "sensitivity/resistance"?
I’m def a Lustig disciple.
Dr. Lustig is wrong with regard to red meat.
Both heme-iron and TMAO are only problem if your insulin is high. Heme-iron because high insulin affects the absorbtion of it (similarly to what insulin does to natrium [re]absorbtion).
Also, high TMAO is a direct result of insulin resistance/hyperinsulinaemia, it has nothing to do with choline availability.
So: If you eat sugar and are hyperinsulinaemic, adding red meat is bad.
If you don't eat sugar and are insulin sensitive, red meat is the perfect food for us humans.
That's why ketogenic and carnivore diets work (both eliminate the sugar and insulin spikes) but the standard american diet does not.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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1:04 I'm close to tears this man is so right but please do not say sugar as it is fructose and not glucose. When will he get the Nobel Prize? Please give him the Nobel Prize
My understanding is that Japan actually has a very high rate of "lean diabetes" and I forecast a ton of problems with diabetes and overweight also in Asia because of the huge amount and variety of ultra processed foods and sugary, starchy, snacks - check your local Asian market and you'll see what I mean. Not many are eating the true traditional diet.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
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This study is excellent based on children..how about adoults..i've got insuline resistance along with monopuse..i think it must be connection there too..i have never eaten processed food or soda...
Dr Joel Wallach ND DVM says insulin resistance is related to a Chromium/ Vanadium and B6 deficiency. It may also be related to iron overload as per the Root Cause Protocol.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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Geez, 10 people. Perhaps you could have held this talk in an auditorium and invited the community?
Dr tell us what to eat
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
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ZDr Robert Lustig is my gardening Angel of Health Healing Knowledge 💖
And have shared his wonderful awakening podcasts with Nate Hagens 😇
Also what about foods like chicken breast, qunioa and eggs? What oils should i use? If I shouldn't then let me know. What about nuts?
Everything is good… in moderation. As for what kind of oil, we do not have any recommendation. Avoid butter and other solid fats. Saturated fatty acids (butter) have been implicated in cardiovascular disease
Try to imagine how many doctors there are in United States who tell their male patients in the '50s and '60s to lose 50 lb and start exercising. I think there's about seven or eight of them. The rest of them have given up.
Because it doesn't work. The eat less exercise more, and eat less fat has been preached since the 70's a and was just as corrupt as todays food industry. Ancel Keys was evil.
Mine cares only about LDL and wanted me on statins. I lost 35LBS (at 60) by cutting out processed foods & added sugars. LDL and TG still above pharma-dictated levels, but I feel better than ever and I refuse to go on 'meds'. I read Dr Lustig's Metabolical and the book explained much of what was presented here.
SO many patients only see obesity as an aesthetic problem and so don’t care that they are overweight. When I explain that their heart and lungs are overworked because they weigh two or three (or more!) times what they should weigh, they are flabbergasted.
I’m reading one of your books 📚 now and just stopped to watch this video again.
Thank you for watching!
Be sure to also watch this: Robert Lustig, MD "Hateful-Grateful 8" a conversation with Ron Najafi, CEO - Emery Pharma
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Which one? They’re all great
@@RATM77777 “Metabolically” but my old brain 🧠 is on over load from it. It is a good workout for the brain.
I have insulin-like growth factor-1 deficiency which is one of the causes of my fatty liver. I am 5’8” & 128 lbs If I was fat, it would be so much easier to heal because endocrine issues are much more difficult
One problem with the red meat is bad -part. There’s data showing that tye mentioned problems dont apply to people who reduce carb intake - the meat absorbs better without carbs, and due to less carbs and fiber, it doesnt sit in the colon as long inorder to produce TMO.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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This was an absolutely fascinating presentation 👏🏼and I'm not even a scientist or doctor 🤣. Right then, no more alcohol for me, and I'm eating as much whole and unprocessed foods as possible, and eating lots of whole foods. The only thing that confused me was why this was being resented to a pharma company, whose top priority is profiting from drugs 💊🤔 🤷🏻♀
We are interested in developing drugs that saves lives! Eating Bad food will need medicine. Let’s start with food. Also look up the history of Emery Pharma and it’s contribution to drug safety. Kindly check out some of our news around January 2, 2020 regarding Zantac.
Good drugs save lives, bad drugs shortens lives!
Pharmaceutical companies have all sorts of perverse incentives that cause the institution's aggregate actions to be negative, but individuals within the company aren't necessarily morally bankrupt themselves and still do good. Someone certainly thought Dr. Lustig would be good to have so they did, even if the invisible hand of the bottom line would like to reach out and quash it.
@@Emerypharmayou are interested in making huge profits at the cost of public health.
Great choice, Swag. Be sure to strength train and do lots of walking and higher level cardio as well to reap the longevity and anti-inflammatory benefits of exercising your muscles
How is it compatible that hepatocytes are insulin independent but have the receptors to insulin?
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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Liver cell death by fructose exposure can be prevented by :
a) Vitamin B1 and B6, vitamin C;
b) P450 inhibitors
c) hydroxyl radical and carbon scavengers.
d) metal chelators
excess vitamin B6 can be hazardous to your health. see Emery Pharma's petition with the FDA: emerypharma.com/news/fda-citizen-petition-on-vitamin-b6-press-coverage/
Never did he actually talk about fructose from fruit. I would like to know what a diet without high fructose corn syrup or other forms of processed fructose, but with Fruit providing the fructose. It has the antioxidant boost, but still fructose. What are good studies for this?
Dr.Ekberg holistic "doctor" youtube
Fructose coming with fruit is not a bad thing. Because it come with a lot of fiber. However, drinking too much fruit juice is recipe for diabetes.
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
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Serious question. If fructose is so bad should I not be eating fruit and eat white rice and potatoes instead after working out?
Or can I eat fruits as long as it's not together with fatty meal
fruit has a lot of good fiber. so eating it is better than not eating it. if you have high blood sugar then, you may want to be careful with your fruit intake. consult your doctor.
Rice is poison whats that is that white stuff arsenic potatoes are pure carbs, fruit, do not eat our body doesn’t need any poison, eat what is an offering from the animal kingdom cattle have all the organs like what we have, eat a steak a day with a good level of fat, drink plenty of pure water with the minerals, suggested by common sense
Children get type 2 diabetes
I'm really shocked
I thought it only applied to adults.
Fruits contain fructose as well as many vitamins , minarals & fibre. Should we avoid the consumption of fruits? What is the openion of Dr. Lustig?
Fruits in moderation is good. Fruits have a lot of fiber. Fruit juice does not have fiber and contains lots of sucrose and fructose. Sucrose is a combination of a glucose and fructose. So it is advisable to avoid juices all together.
The fiber in fruit bound to sugars prevents the immediate absorption of fructose. The fructose then makes it farther into your gut where it and the fiber feed your gut bacteria and help create a beneficial gut barrier. Juicing or blending separates the sugar from the fiber.
Thanks for your guidance
The old rules before the never proven lipid hypothesis was 2 servings a day. No more.
A large apple was two servings. A banana was 2 servings. A half cup of berries was a serving. A tomato was also considered a fruit and a good source of vitamin C for the carb sensitive.
If you can eat an apple on a empty stomach and you are more hungry after you are carb sensitive. If you get the hunger shakes you are extremely carb sensitive.
He says ok. Just dont sit and eat two pounds of sweet grapes. Keep in mind sweet ripe GMO fruit available 24 7 365 is a recent thing.
Fasting can do a great deal to reverse fatty liver quickly!
Great hypothesis but why with all our medical science we can't solve the diabetic puzzle that's currently plaguing the world. Gout for example the current medical hypothesis is all wrong...was named "the rich man's disease" and what that tells us is the cure is diet moderation.
I like to see Dr. Lustig do a hypothesis on sugars and intake percentages fructose vs glucose
gout also starts in the liver. If your liver is healthy your kidneys will be healthy and you won't get gout.
There are obese people who are healthy because they are able to increase the number of fat cells so none of them are engorged with fat (still insulin sensitive and not releasing FFA and inflammatory cytokines). They may not have fatty liver either.
As fructose is the bad guy do i need to cut out fruits like apples and bananas?
So is eating starch safe as Dr. McDugal claims?
Starch converts to Glucose. If you do this every day and you do not exercise you will end of with metabolic syndrome and diabetes
I thought that would be your response. I agree. Thank you.
@@Emerypharma
If dairy is protective, and dairy has more saturated fat than monounsaturated and than polyunsaturated fat...saturated fat probably is protective!
We think good diet, in moderation + exercise is the answer
It is necessary!
It might be better if you got your hearing tested, he said "Dairy saturated fat which is odd chain fatty acids which with a specific phospholipid signature on the end of that fatty acid which has actually been shown to be protective against heart disease..." (1:16:58) & it increases water solubility which is different to other saturated fats. Personally, I avoid dairy foods as well but people are allowed to make their own choices about consuming them, I would have thought that the combination of milk & sugar in many dairy foods would make them something to avoid most of the time.
@@cantablocal6768good culture Dairy, is excellent, nothing harmful in it, probiotic, grass feed cows milk, no additive of any kind.
Look it up Good Culture is the brand name.
Regarding fruits and Vegtables
What vegtables and fruits should we avoid when we have NAFLD
fruits like tomato, blueberries, mangos and more
Vegtables like sweet potato and others
Please let me know!
Very sweet fruits are rich in fructose. I would avoid them. Or consume them in moderation. Sugar spike is bad! Stores in liver and forms fatty liver
Eating fruits is only safe if you are vegan. Because animal protein will make insulin resistance.
This makes a lot of sense again I’m 25 years old I have nonalcoholic fatty liver disease I work overnights and I am not carful with what I pick to eat I’m 215 pounds I eat a lot of fast food and garbage and I think I’m understanding that it’s the sugar and the poison that I am consuming and I need to drink coffee and drink more water and increase fiber intake to clear out my system from the poison and intermittent fasting ish.. is this correct
Go ketosis
I’m 25 years old and I have nonalcoholic fatty liver disease
I’m about 215 pounds I think it’s due to my bad diet being on overnight shift
Did u taking treatment,
So what could I eat and drink then?
Just posted this: Check out the latest Robert Lustig interview at Emery Pharma:
Robert Lustig, MD on Fatty Liver, Sugar, Metabolic Syndrome, Sarcopenia, Ozempic, Wagovy & Mounjaro
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Avoid sugar!
Carnivore ketosis lifestyle
Straight is the way and narrow is the gate to Health and "Few" there are who find it much less do the work. Health is work, discipline, self control and de-programming ones self from the TV programming and other programming as well. Those who are looking for better Health will find it and do the work to get Better Health....
Well said!
Sir, which kind of fat is stored in your belly?
All good fat ! 😊
Do you mean “visceral”. That’s not healthy. But eating fat doesn’t make your liver fatty - sugars create a fatty liver and overall obesity.
My cousin had liver disease for the last 5 years. His SGOT and SGPT level was high. Took medicines from everywhere but no relief was found. Then he took Ayurvedic medicine from Planet Ayurveda. Now he is feeling good. Thanks
It is well documented 5% weight loss leads to reduced liver fat, 7% reduces liver inflammation and 10% reduces liver fibrosis
How is weight loss then not important?
Professor Robert Lustig makes sense but looks a little fat especally around the waste. Is he eating in the right way and exercising?
his fat is good fat. he is not suffering from fatty liver disease.