so clear and great illustrations help tremendously such dry subtopics! thank you for this. how to test for these antibodies, and for parietal cells - do you have one addressing that specifically? thx :D
vitamin b12 is used in the DNA replication of baby blood cells (progenitors). A lack of B12 causes faulty manufacturing of cells, the odd shape of these cells normally gets them killed by the immune system. this leads to a reduced blood cell count meaning there are less cells to transport oxygen.
This is from impaired DNA synthesis that inhibits nuclear division. Cytoplasmic maturation, mainly dependent on RNA and protein synthesis, is less affected; this leads to an asynchronous maturation between the nucleus and cytoplasm of erythroblasts, hence the large size of the megaloblasts. The process affects hematopoiesis and rapidly dividing tissues like gastrointestinal cells. Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med. Clin. North Am. 2017 Mar;101(2):297-317. [PubMed]
😂woou how many things I loyrn hear about my blood I fell so wik sleep taiert my brain dose not faxiont I can remember things before years some doctors give me ingexio vitamin B12 and I feel stronger now I don't have doctor too Kerry's any more I can find out what to do thank you for the information you gave to me
what did i just watch? ur simply a hero
Man ,you answered all my questions just in 5 minutes! Can’t thank u enough ✨God bless you
So glad!
Very important and often not clearly understood by many Doctors
This my 2nd video on this channel and it is still amazing really clear explanation but still rich in knowledge.Keep it up!!
Great illustration! Thank you so much you helped me a lot.
Simple vedio with soothing voice and helpful too
This is beautiful. Makes you fall in love with medicine all over again
Beautifully done
amazing video !!!! made me understand ^^ thank you so muchhhh
I don't know what to say .. tank you very much💙💙💙
so clear and great illustrations help tremendously such dry subtopics! thank you for this. how to test for these antibodies, and for parietal cells - do you have one addressing that specifically? thx :D
Thank you so mch for those mindmap presentation :)
The best 👍
Thank you
Super thank You.. God bless u
Good thank you
Thank you so much you deserve more subscribers
Thank you Aaun - Best of luck with all your studies
@@physiopathopharmaco4190 thank you very much 🙏💕
nice video
#amrikrashtra
Great 👏❤️
Megaloblastic anemia result of inhibition of DNA synthesis during RBC
Cool
thanku... waiting for more vids on tougher topics :)
Sounds great. What topic are you hoping for?
CNS endocrine may be.. leukemias etc.
and anything else... ur vids r too butifullu explained :)
Thank you. We are planning for more on leukemia. Thanks for the feedback.
Wow thats the first time I have heard of oral B12 having a positive affect on levels in people with PA, Is there any studies on this?
how does eating lack of b12 such as dairy products relates to the lack of intrinsic factors which leads to anaemia ????
vitamin b12 is used in the DNA replication of baby blood cells (progenitors). A lack of B12 causes faulty manufacturing of cells, the odd shape of these cells normally gets them killed by the immune system. this leads to a reduced blood cell count meaning there are less cells to transport oxygen.
Good video....is the narrator by any chance The Mandalorian😍
Thank you that is the highest compliment I’ve ever received
❤tq sir
Why would erythorcytes be larger if DNA synthesis is decreased? Wouldn't less DNA mean less mRNA and then less protein and so smaller erythrocytes?
This is from impaired DNA synthesis that inhibits nuclear division. Cytoplasmic maturation, mainly dependent on RNA and protein synthesis, is less affected; this leads to an asynchronous maturation between the nucleus and cytoplasm of erythroblasts, hence the large size of the megaloblasts. The process affects hematopoiesis and rapidly dividing tissues like gastrointestinal cells.
Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med. Clin. North Am. 2017 Mar;101(2):297-317. [PubMed]
Legend
Thanks 🙏
💗
😂woou how many things I loyrn hear about my blood I fell so wik sleep taiert my brain dose not faxiont I can remember things before years some doctors give me ingexio vitamin B12 and I feel stronger now I don't have doctor too Kerry's any more I can find out what to do thank you for the information you gave to me
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I have this anaemia 😅
This anemia is curable plz reply
***FOLATE You are doing a disservice to those with MTHFR. Shame on you for propagating the synthetic version as real.
This video says nothing about synthetic folate just folate in general. This video even mentions several foods that are high in folate