How to Prevent Almost ALL Disease - The Medlife Crisis Podcast #1
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- čas přidán 21. 07. 2024
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This is an in-depth interview with scientist, author and expert on longevity science, Dr Andrew Steele. We discuss what ageing even is, whether it should be regarded as a disease, how we differ from other animals, where the research is, what treatments look promising, health and economic policy, and what the future looks like.
Watch Andrew and I chat about all things wearable - what numbers you should care about, which you shouldn’t • The most important num...
Find more Andrew here:
/ drandrewsteele
Book: ageless.link
/ statto
/ andrewjsteele
If you do want to listen to this as a podcast, it is available here (I hope!) open.acast.com/public/streams...
How to prevent almost ALL disease shows.acast.com/medlifecrisis... via @acast
Sign up for my free newsletter: medlife.substack.com/
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I’ll add chapters as soon as I get home! Edit: many thanks to user Dihydrousoxide for making them, which I'm shamelessly stealing!
0:00 Intro
5:37 Why you got into the anti-ageing field?
7:15 Ageing as a cause of death
9:18 What is ageing?
13:32 Hallmarks of Ageing - Senescent Cells
17:25 How do we target senescent cells?
20:10 What are telomeres?
22:40 How do we stop telomeres shortening?
26:00 Evolution optimised for reproduction, not ageing well - BOFFFs
33:54 Autophagy - cellular recycling
42:00 Testing of rapamycin - Effective Dose
45:35 Why don't we have human data on rapamycin?
46:24 Metformin - TAME trial monetary issues
49:04 What is Metformin?
52:50 How does Metformin work as an anti-ageing drug?
54:03 What therapies excite you at the moment?
58:39 Thoughts on Calorie restriction
1:04:53 Rhesus Monkey Diet Trials
1:08:14 Potential Therapies - theoretical mechanistic science
1:12:46 Amyloid Studies
1:17:20 Should we stop ageing?
1:31:29 Where do you see the anti-ageing field being in 2050?
1:43:03 Outro
-----------------
More Medlife Crisis:
/ medcrisis
/ medlifecrisis
/ @medlife2
watchnebula.com/medlifecrisis
/ medcrisis
Thanks for having me round your garage, Dr Crisis! If we cure ageing, we can look forward to decades of extra healthy life to enjoy nearly-two-hour CZcams interviews.
I saw this video and thought: "Huh I know that turtle". It's the same as on your books cover! Great to see two of my favorite channels covering medical topics collaborate.
@@ninjam77 Ha, the tortoise is famous! You have great taste in CZcams channels :)
Great interesting information in this podcast😉 thanks for putting this out there guys.
As for a billion causing 50% of the co2, an Oxfam report put it at the wealthiest 10%, more recently I've heard it's mostly the 1%, which when I see their lifestyle is really easy to believe.
Dr. Crisis! That felt really funny for some reason. "Hi, I'm Dr. Crisis. Friends call me Medlife"
@@Siderite Please, Dr Crisis is my father! Call me Meddy
Rohin's Facial Foliage Deserves a channel of it's own
He is INCREDIBLY proper.
ABSOLUTELY!
The man could sell beard oil, if this whole highly skilled, high demand, essential for life medical career thing doesn't work out.
I think you will enjoy what I hope will be my next video...
@@MedlifeCrisis Don't talk to me if it isn't another issue of the Old England Journal of Medicine
Very informative and pleasurable interview. Thank you from a 76 year-old who lives a life of gratitude, pays attention to diet, exercise, (including taking the stairs from and to my 8th floor apartment), and who I let into my emotional space. I remain pain and meds-free, and feel this is the best time in my life so far.
Time-Stamp Breakdown of Facial Hair:
0:00 - Full Frontal Foliage
1:15 - Subtle Stubble
4:21 - Marvellous Moustache
these are the time stamps we really needed
It's like eternal sunshine of a spotless mind
Wasn't that Borat with the moustache?
I thought it wasn't real 😅
Not the hero we want; the hero we NEED.
Timestamps / Chapters
0:00 Intro
5:37 Why you got into the anti-ageing field?
7:15 Ageing as a cause of death
9:18 What is ageing?
13:32 Hallmarks of Ageing - Senescent Cells
17:25 How do we target senescent cells?
20:10 What are telomeres?
22:40 How do we stop telomeres shortening?
26:00 Evolution optimised for reproduction, not ageing well - BOFFFs
33:54 Autophagy - cellular recycling
42:00 Testing of rapamycin - Effective Dose
45:35 Why don't we have human data on rapamycin?
46:24 Metformin - TAME trial monetary issues
49:04 What is Metformin?
52:50 How does Metformin work as an anti-ageing drug?
54:03 What therapies excite you at the moment?
58:39 Thoughts on Calorie restriction
1:04:53 Rhesus Monkey Diet Trials
1:08:14 Potential Therapies - theoretical mechanistic science
1:12:46 Amyloid Studies
1:17:20 Should we stop ageing?
1:31:29 Where do you see the anti-ageing field being in 2050?
1:43:03 Outro
Not all heroes wear white coats
Thanks for that public service!
Thank you! I was travelling yesterday so couldn’t do it myself but I’m just going to use yours, much appreciated! 🙏🙏
There comes a time when gravity takes your butt and your triceps…overnight seemingly…around 50….when this starts to happen your not thinking of living another 150 years. There is a turning point in the psyche as well.
Ok
1a@€22
Was driving. Now listening while parked against a tree.
One of the best roundabout ways of describing a crash I've ever seen!
Did you crash?!
Is the tree okay?
is the CAR ok ??? 🤣🤣🤣🤣
Is the guy in your trunk okay?
The Nietzche mustache is making my day
There's nothing Nieizsche couldn't teach 'ya 'bout the raising of the wrist. Socrates, himself, was permanently pissed.
@@gordslater John Stewart Mill, of his own free will, on half a pint of shandy was particularly ill.
@@blindleader42 Plato, they say, could stick it away, half a crate of whisky every day
Nahhh, he looks more an Old Timey Bare Knuckle Boxer... 😂
Kids who watched Phineas and Ferb know exactly what an aglet was.
Growing up I had a high opinion on all sorts of medical interventions. While studying chemistry and biochemistry, I got more and more disillusionised to what medicine is really capable of. Learning how finely tuned our bodies homeostasis works and following the medical news where common practices and medications are retracted on a regular basis because they don´t work after all, you really get more pessimistic. Rohin has a very realistic view on that, which I like.
I think it's possible to go too far the other way and assume that no medications are effective or that exercise cures everything. When you have a body that misbehaves like mine, medications are needed to stay alive. I tend to have low blood pressure and I struggle with POTS. If I stand up too quickly, I faint. Obviously this isn't good. I take medication to boost my blood volume and raise my blood pressure so I don't faint.
It's easy for doctors to default to diet and exercise as cure alls when they're absolutely not. The body tends to homeostasis, but sometimes our bodies just don't work in the way they need to.
@@katfoster845 You’re not wrong in a certain sense, but I think the complexity of the situation is so beyond us because of how much tampering humans have done to their environments and their own bodies. I personally am diagnosed with a chronic illness, chron’s disease specifically, and for most of the time I’ve basically been told that my life is over, I will be on medication for the rest of my life and there’s nothing I can do about. Here’s a pamphlet on why vegetables and nuts are good for you. They gave me meds and I had a surgery to remove some intestine that was beyond repair, but after the fact I never got healthier. I wasn’t dying anymore, but the entire time they couldn’t tell me anything about the disease, why it happens, where it comes from etc. And I was so pissed throat they thought they could just give me some meds that seem to work without actually telling me why it works and why I should use it. I stopped listening to everything anyone would tell me and exclusively listed to what my body told me. Eventually I found a diet and exercise routine over the course of 10 years that was able to help me come back from this hell that I was told I had to live in. My point being that not all is set in stone, and while medication can be useful, I think it is used too much as a crutch to solve problems.
@@Maakyo Multiple things can be true at the same time. It is totally possible that 1) you were not recommended enough diet and exercise and 2) Kat here was recommended too much diet and exercise.
@@katfoster845 I think one of the biggest problems is that in many cases we legitimately cannot figure out what can and can't be dealt with using medication or lifestyle modifications, because we can't untangle the underlying disease process(es).
Possibly the purest example of this problem that I can think of is the two types of diabetes. Type 1 diabetes is _only_ treatable with insulin, no amount of non-medical interventions will help. Type 2 diabetes is partially caused by this aging process, partially caused by this diet and exercise stuff, and giving insulin to these people would be completely missing the point. These both present clinically as diabetes, as a struggle to maintain blood sugar, and yet one is absolutely reliant on medical science and the other really needs to be treated with something that isn't a medicine at all.
Now - what if we didn't know that the difference between type 1 and type 2 diabetes existed at all? Then we would be flailing around trying to give insulin to people who have no reason to be on a highly perishable injectable for the rest of their lives... and/or we could lose people to totally preventable consequences of type 1 diabetes because we would be too scared of having people dependent on a highly perishable injectable for the rest of their lives.
All this is to say, it can be absolutely true that you cannot possibly be helped by anything short of vasopressins and Makyo needed to get away from medical science entirely, _at the same time._
I think about this a lot because I am somehow in both camps simultaneously. Specifically, I take several medications for my treatment-resistant depression (due to C-PTSD). I am absolutely reliant on a significant amount of tablets and pills... and one of them is a probiotic supplement.
Let me repeat this: I take _probiotics_ for my _depression._
There's probably some gut-brain stuff going on there, but part of the most difficult symptoms for me is a lack of energy, and apparently improving my digestion helps with that part??
...At the same time, if I am out of even _one_ of my actual prescribed psychiatric medications, I collapse entirely. So I can't stop relying on modern medicine either.
Human bodies make no sense and this whole thing is a mess.
@@orngjce223 I’m aware multiple possibilities exist. I’d be dead without medical intervention. My point is more that none of our collective knowledge is 100% true and that our contemporary standards for medicine and health are highly flawed and need reconsideration. They talked to me about my illness like they knew anything about it, but really there solution to my problems was a shot in the dark with a medication for which it’s primary purpose was not even related to the illness they were trying to heal inside me. I might not even have an illness I might just be ruined from America’s garbage health standards. It pissed me off and I want to be a force for good change in this regard.
Fascinating! An entertaining and informative overview of how anti-ageing keeps turning into "oops, it's cancer again!"
Damn that cancer, it gets everywhere
Damn rebellious bastards.
Cancer cells are immortal, so it isn't that surprising.
Inflammatory comment. Ha!
@@BlueBeeThemeMusic Late to spot this but this is a good pun
It's always exciting to see a video from Rohin
Let alone a video about a topic that's saturated with medbros and pedlers of sudoscientific nonsense
_Let alone_ a video that's the length of an extendened documentary
All the best things rolled into one
That was a very very interesting watch/listen. I'm vaguely familiar with Andrew's stuff and hearing more from him is always good (I should really subscribe)
The next 30 years look to be full of very interesting things in terms of medical science from the studies being done just now, to ones that could be done in the near future
I like to think that I'll get to live to at least 120 years old but I'm very clued into how short one's natural life can be considering I live in Glasgow (a very depressing shout-out but it's one that's present in the minds of everyone I know haha)
Very exciting and interesting
Rohin should do more podcasts (if he can get the time)!
*pseudo not sudo
@@konbini2004 sudo science is where you force your computer to do your science for you (and thanks @Sandwich247, looking forward to hearing you’ve become a 120-year-old Glaswegian! PS you subscribed right)
Pseudo longevity science is much more palatable than the FAKE statin science from Merck. Why do I hate Merck? My mom was prescribed Vioxx and had a bad stroke. Fake data from Merck killing and maiming again and again. Who is selling snake oil? Rohin.
In 2014, as a mature-aged student, I got my degree in Molecular Biology and Biomedical Science - largely due to people like Aubrey de Grey, who was only briefly mentioned at the end of the video. For a long time these ideas were seen as "fringe science" or not as scientific at all, so I think it might have been nice to pay some respects to those who fearlessly pioneered the whole concept of increasing life-span and health-span via biotechnology and serious research into both ageing mechanisms and potential interventions based on what we learn about those mechanisms. It's only been in the last few decades - literally as I grew from a teenager to an adult (now 43) that those pioneers forced the scientific community to take this field seriously. It's a major achievement by Nir Barzilai to have convinced the FDA to allow an interventional study that treats ageing itself, as they previously refused to classify ageing as a target pathology. Hopefully people interested in this stuff, who can now see serious discussions and papers on it in virtually any health-related sphere, realise the paradigm shift they are looking at and will undoubtedly benefit from.
Yes indeed.
the algorithm has been hiding this from me since its release, i think youtube hates podcasts now. great work as always! you never fail to cover interesting topics and bring up insightful questions, leaving me to rethink my career choice in chemistry. fascinating stuff.
Hyped for some well evidenced, grounded conversation about longevity! I'd like to make it to the triple digits, and I'd like to hang out with my parents for a good portion of that time as well. Immortality would be nice, but another decade where I can spend quality time with family would be nice too :)
If that’s how you feel, you must still be relatively young, and you never had any horrible experiences in your life.
Getting old may seem like a good thing, but only if people stop breeding at the incredible rate they do today.
@@kellydalstok8900 uhhh...? Aren't birth rates in free fall worldwide? Also, people can work through trauma and still find happiness?
@@jessip8654Correct. And it has repeatedly been shown that increased quality of life (food, water, shelter safety, education, access to medical help) reduces birthrates greatly. So as more of the world experiences those listed things, the more the birthrate will even out.
Very interesting to me, as the caregiver for my 97 yo mother. Bedbound and in hospice due to dementia, but very strong physically with better skin and vitals than most 50 yo. Her nurse said she did not know what would be the cause of death. Mom is forgetting how to swallow and therefore harder to feed, so that will probably be the cause , in my opinion.
Omg, that's rough.
Yes, there are people whose body outlasts the mind and those where the mind outlasts the body - both are tragic.
@BIGFOOOOOT You're right that cognitive health is just as critical as physical health. The field also dedicates a lot of research on the brain and maintaining cognitive healthspan.
You can get her a feeding tube or iv nutrition but i think most people want to pass naturally at that point
UP UP UP !!
Describing an opossum as "a sort of cat-sized rat," is temarkably accurate 😂. Thanks for another fascinating and enlightening video!
I've had a Nebula subscription for over a year but I still watch 90% of the creators' videos on CZcams because there's no comment functionality on Nebula.
Same 🎉
This is the kind of discussion that could possibly inspire someone, somewhere to make a breakthrough to improve our lives by orders of magnitude. Please continue creating videos like this. This was riveting.
Podcasts are more frequently of this quality, i only discovered them recently, i thought they'd be like radio
Focusing on the ageing process instead of what ageing risks causing reminds me of the saying "An ounce of prevention is worth a pound of cure"
Fascinating conversation. Even when you got to a subject that I happen to know a lot about professionally (Alzheimer's), you covered it incredibly well and in an unbiased, balanced way. A treat to listen to.
I know nothing about any of this so this is very reassuring to hear! For me it is quite rare that I find people talking in a knowledgable way about my field (computer science, AI) on the popular media
Turmeric powder taken with powder and pumping iron, while eating 'clean' prevents Alzteimers. Of course most professionals in the field refuse to acknowledge this simple truth because they themselves refuse to lead from the front and pump iron. If you're searching for a cure, then you just found it. Thanks
@@sucimI want time with any AI, to request it seek out and delete all numbers related to evil people. Think it might improve Earth.
as a teenager who recently got diagnosed with mitochondrial dna disease caused by spontaneous mutations (kearns sayre syndrome) this talk is very intresting. thanks for the video.
Did you take Covid Vax?
@@sheriwilliams8942 my symptoms started before the pandemic. so no, its not related to the vaccine.
Oh my freaking god, FINALLY you do the thing you so obviously should and make a podcast. THANK you.
Mustache is FABULOUS. If I were to select my family doctor based on a photo of the doctor, a person with this kind of mustache would get me as a client 100% of the time
How so?
Just like my maiden aunt, the testicle specialist.
You have NO idea what's living in that jungle.
A lot of us are used to 3-4 hours podcasts, so feel free to go at whatever length that feels necessary to cover all the most interesting aspects of a given topic!
Are "we"?
I must have missed the poll.
Absolutely fascinating. I would love more episodes like this one. I loved that you challenged him with difficult questions - made for a much more compelling interview!
I've been waiting for one of my favourite youtubers to get nebula, glad to be able to support you!
Portraits of the two greatest doctors of all time in the background.
👏👏👏👏👏👏
Talk about starting on a strong foot! This has been one of the best interviews/discussions I have seen ever. Looking forward to more Medlife Crisis Podcast
HOW do you not have over a million subscribers yet!? You’re so funny and so informative and fight against misinformation! The perfect trifecta!
Life expectancy is dropping in the US at least, partly due to the horrible healthcare "system" and the ever widening chasm of the wealth gap. People don't get paid enough to afford the terrible health insurance and even if you do have it, the quality is complete crap if you're not rich.
The bad diet isn't helping, either. More and more processed foods.
When you are broke, processed food is the least expensive and most available...and heaven help you if you've no way to cook or safely store uneaten food.
Gained 150 lbs that way....
@@RICDirector That's pretty sad when one is broke. I've been in that situation a few times. In Europe you can still eat on a pretty tight budget (maybe less than 3 Dollars per day), but you will definitely lose weight, so if you are a labourer it might not be enough energy.
Thank you for putting this in podcast form, I found it truly fascinating. I would say the only thing missing from the podcast was your fantastic moustache or any indicator that you were sporting one. Thankfully I came here to comment about how much I enjoyed the podcast, so I didn't miss out!
I think I'm going to leave this playing at half speed while I go do something else for a few hours, just so you get some algorithmic love from youtube for the most excellent content.
Absolutely amazing - you roped me in to a topic I didn't think would interest me. Love the philosophical excursions.
1:16:25 I literally, most genuinely burst out laughing. I love this interview - you talk about specific studies, the questions invite deep elaborate responses and you're funny... which coincidentally is what I look for in a partner.
Lol.
The rizzler
please keep both long videos and their podcasts ; you’re doing a great job ❤❤❤
best video to date, we need more of this aging and age related disease videos so thank you so much
This is an incredible video. So engaging! How we see life is going to VASTLY change once death is not a certainty. Everything changes immediately, I'm very excited and I hope I get to see it.
It's amazing that I could understand you both so clearly.. especially your guest.. he spoke very rapidly quite rapidly but his diction was so perfect that I didn't even try and never missed the word..
Yay, you've just made my Thursday just that little bit more interesting with this upload. Love your videos and your dry sense of humour.
This is more entertaining and cheerful and less dogmatic than I thought a video about anti-aging would be. I tend to avoid anti-aging videos because of my experience with them.
The mustachioed wink at 16:59 really made my day :D
"Not doing something is a choice in itself." Best quote from @DrandrewSteele in this video. Another reason that doctors should start treating the individual patient and not just following "standard protocols." After almost three years with Long-Covid, I am constantly weighing interventions to reduce symptoms or "cure" the disease. It is amazing when I ask doctors for advice on "low-risk" interventions and they say "There are no RCTs for that treatment and your medical issue. Just wait (suffer) for 5, 10, 20 years for a proper treatment protocol." Luckily, there are some doctors willing to look at the early data or medical reasoning and help patients do controlled, low-risk, n=1 experiments. I have done many n=1 experiments so far that has led to large improvements!
BTW. Have you done a video on Peter Attia and his stance on nicotine patches?
Prof Roger Sheult.
@@Sarandib22 I am not fully recovered yet either, but the path seems clear. If you only need a bump to get back to work I suggest looking into doing Yoga Nidra and brain training. There are lots of free videos out there and different books that can help... let me know if you want recommendations. There are also lots of recovery stories... Look at the ones from "Kyle" on CZcams. He gives a good simple rundown of how brain training helped him...and he is not selling anything 🙂
@@Sarandib22 So many people out there need help with that it almost makes _me_ sick. @physicsgirl is one currently bedridden and I wish I knew what might, or who could help them.
@@Sarandib22 I am still at 75 or 80%. At this stage it becomes harder to rest and pace....since pushing a little lets you have an almost "normal" life.
At this stage we still need to run at 80% energy use most days so we can recover well during sleep. The temptation to push and run at 105% keeps us stuck... in my opinion. Each person has different journeys.
Thanks! Excellent discussion!
I will definitely check out Nebula! The demonetization is just too random!
That was a fascinating listen, I'm really liking Dr. Steele's optimism.
That podcast download link is a blessing. Medical podcast videos for life!
This is what I needed, your voice is pretty nice to listen to, and giving me 2hrs of content to watch is great.
Can we have more of these expert interviews? This was very informative!
Took me four days to watch all of it. Was too intrigued to forget about it in the mean time. Great video!
I watched this on Nebula, I will watch again here. Such an interesting conversation. My husband says he wants to live 150 years, I need to show him this, and probably make him exercise more to get his heart rate down (as per Andrew's video).
Exercise and some vegetables! Do they mention it in the video? Every single type of movement counts
- get off the bus a stop early
- vacuum
- don't bulk buy milk so you have to walk to the local shop to get it
- stairs (always try to live somewhere that has stairs if possible )
- think of things like say, someone who has an upstairs and downstairs bathroom, always using the upstairs one if you mostly live downstairs. Things like that where the habit is the version with a bit of movement so you don't even notice it.
Obviously officially "exercise" is important too 😅
If I didn't have exams I would be listening to this. sounds intersting. especially the politcal side of such problems.
good luck on your exams!
As a 21 year old prospective doctor I love your content so much. I fall in love with so many topics but medicine has been such a special love just because of how immense of a future I see for it.
I know maths isn’t a big subject on your channel but I would love to see some content on the flaws of peoples capacity for diagnosis. I hope to see some sort of system that allows physicians themselves to input clinical signs and symptoms in and receive a chart of some sort going over the probability of possible illnesses and ways to cross off the more lethal prognoses. Complex probabilities are just a process that computers are way more adept at than humans.
I think a big inpediment to this is just sheer data. A few years back my partner came down with a mysterious chronic illness, and I spent evening after evening trying to find datasets of all the diseases and symptoms and their relative rates of occurrence, but I could not find datasets that had this data.
But for this to change I think the whole medical information pipeline has to be rebuilt from the ground up. Where GP's comprehensibly record all appearantly symptoms and ask after less obvious ones. Then as diagnoses roll in over time a true dataset can be built up than can be used to make a predictive model like you want.
Maybe with improved natural language processing a lot of this could be extracted from current medical records, doctors notes, etc, but just the medical confidentiality aspect of it would make this very hard.
In the end it took almost two years for my partner to get diagnosed with chronic fatigue syndrome, but this was more down to the stubborn headedness of the GP than anything else.
@@markkalsbeek5883most GPs are pretty much useless when it comes to chronic conditions especially mental health
Thanks for taking valuable time out of your career for this channel. It's very useful to me and many others.
Great talk with Dr. Steele. Would be awesome if you could make this a regular series with frequent updates from the age experts including Dr. Sinclair.
Really enjoying this conversation so far, great job
Wow this was really enjoyable, the articulation at the Should We Stop Ageing Part 1:17:20 was really good
I would’ve liked this video 10+ times if it was possible
old guy who did stick around to hear you congratulate each other - I agree - it was a good job ! ... the dialogue between you works THX
This discussion makes me really hopeful but also a quick look at the current landscape of which communities have access to medicine makes this really worrying. The topic of the massive resource consumption inequality was brought up and if an anti ageing drug is developed it would surely be a really valuable product which might not be available to everyone further increasing the inequality.
What a great interview. Well explained, interesting and funny. Love it
This is an awesome format, would love to see more of these!
Well, you finally got the podcast going! Watched it on Nebula already but came here for the podcast link!
Could you give us an RSS feed as well?
I opened this video and put my phone in the pocket, listening it as a podcast. I am happy I looked at the picture close to the end of the video, because in the other case I would have missed that gorgeous moustache
This is very comforting, my life goal is trying and lerning everything the world has to offer but l've always dreaded the thought of not having enough time
Thanks for providing this as a proper podcast with an RSS Feed, which allowed me to comfortably listen to this while on a run, which helped with not getting to bad a conscience when listening.
great to sit and listen to the two of you geek out. thank you
Thank you to you both, great interview!
Great timestamps! 👍
Fabulous interview!
the podcast form is amazing 😊
it is a fascinating interview
thanks :)
This was incredible! Moar!
excited for the podcast! amazing episode
Rapamycin definitely isn't pence per dose. I've recently started taking it for aging and it costs in the pharmacy 3,6 euro per 1 mg tablet (because aging is not a recognized indication health insurance doesn't cover part of the cost).
To manufacture it is pence per dose he said i think. So generic versions will be very cheap. Some drugs are genuinely expensive to produce and their price does not have the potential to ever drop below that (even if the government or insurance is the one paying that price, i.e. tax and premiums)
@@therabbithat All sources seem to suggest that rapamycin's high price is due to the very low yield of its biosynthesis by Streptomyces hygroscopicus.
the mind, the soul, idea, ignorance, arrogance, dream, stray, patience, fear, life, worker, success, graduation, power, festival, deception, i struggle with myself, use reason so you can live for yourself
It did take me three sessions of watching but I made it to the end.
Thanks Garden-Chairs your service is appreciated :)
That was excellent. Really informative and entertaining. Thank you.
This was great. Excited for more.
Any plans to release audio only versions on apple podcast? Either way, always enjoy your long form, in-depth content. Cheers
I've submitted the stuff they ask for, just waiting to see if it goes through. Bit of a learning experience all this is!
loved this new format , more please !!!!😍😍😍
This was SO interesting! I didn't know about metformin, what an interesting result for a widely prescribed drug. This whole field is fascinating
A thoroughly captivating & informative conversation, thanks Rohin
This was very uplifting. Thank you!
what an interesting garage talk!
looking forward to hear more of these
I love the Phineas and Ferb reference with the aglets
Fantastic, thought provoking and incisive! Thank you chaps for sharing!
I'll live, try to be healthy, and eventually grow old and die. That's just how it goes. Keep moving until I die, and try to enjoy the good things in life.
Damn Doc you are really pushing the 8 minute mark huh? Lol love your videos.
Just found a new addition, need more podcasts from you
Great first podcast episode! More healthy lifespan is like more money: it gives you options and has virtually no downside as long as you enjoy it responsibly!
Wow, this was absolutely fascinating, I could easily have listened to this conversation for another 2 hours (assuming I live that long!)
I’d never thought about aging as anything other than an unfortunate inconvenience of life. Lots to consider in this video. Thanks to Drs. Andrew and of course Rohin for the discussion. Thought provoking even if that mo was very distracting as I waited for it to launch its own channel.
You’re very welcome, thanks for watching! Very happy to hear it offered a new perspective, that’s exactly what I’m trying to do. :)
And I too am looking forward to subbing to MoustachelifeCrisis…
Thank you for making this a podcast
considering the theory surrounding calorie restriction leading to better outcomes, it could explain why we've seen a correlation with eat a lot of vegetables. A low calorie, largely indigestible (in the case of things like leaves) food that still fills you up, meaning its essentially just a method of fooling your hunger system into letting you eat less without making you feel bad, instead of some magical property of their nutrients
00:02:28: You are the first person who I have heard talking about longevity research that I won't immediately dismiss out of hand. (Obviously I am as yet unaware of your friend. who you will be talking to in this video/podcast.)
I'm gonna go do other stuff now, but I will listen to or watch this soon.
I stuck around and you're very welcome!
I missed this was medlife crisis cause the thumbnail looked like a generic science channel, when i love medlife videos and always click immediately.
Anyone else who's listened to the end will realise how brilliant this is!! The guy in the middle didn't say much though.
Amazing information thank you!
I like this guy, like I really resonate with him. I feel we have a lot in common and want to pursue the same dreams. Also, I too have misplaced my pelvis and head, I wonder if science will ever solve that
On caloric restriction, I remember reading a short section on it in my pathology book around 2012, that (paraphrasing): “although it might increase lifespan somewhat, why would you deny yourself one of life’s greatest pleasures, only to be able to deny yourself these pleasures some more” or something to that effect, which I thought was very interesting perspective:)
Not everyone likes to eat tasty stuff, sensory stimulation isn't the only way to be happy and enjoy living. It's like saying "although it could make you healthy why deny yourself cocaine only so you can deny yourself some more"
What if i like fishing, or exercising or laughing or helping people?
@@secretname2670 Fishing, exercising and helping people increase metabolic demand and caloric requirements that will make you eat more and thus increase oxidative stress.
You can’t get energy from cocaine so it’s not a good analogy.
@@TheSteinbitt i have mentioned cocaine as a way to stimulate your senses to point out that not everyone does it the same way as you do (i hope).
Also oxidation is not directly linked to aging, it's an effect of digestion and nutrition dispersal throught the body which is harmless to young people with healthy cells , little to no CRD and working epigenome.
Time will tell if we'll reach that point of being healthy in this century, of what i'm skeptical just because we are moving blindly around vitamin B3 and it's sub-particles to suppliment what goes missing with aging, but not actually fixing the reason of aging.
Time will tell
@@TheSteinbitt It's an analogy because it insinuates that "You shouldn't quit X because it makes you feel good." "Why should I quit cocaine? I would be denied of life's greatest pleasure."
@@EpicMiniMeatwad Perhaps because cocaine isn’t essential for life😂
Fascinating conversation and great overview of the topic - thanks to you both!
Dear Andrew, could you please post a reference for the weight loss studies cited, which found a TRE approach to weight loss in obese participants led to more muscle loss and few other health benefits when compared to other ways of losing weight? This troubled me as it seems to contradict all the research into TRE that found it increases muscle mass and has considerable other health nbenefits. Thanks, Dani
Watched it in 10 parts 😁 great talk!
Fascinating thanks. I'd love to sign up for a human trial for any of the drugs mentioned apart from the placebo ;)
this was incredibly informative and interesting