You, with Hank and JOhn Green, and lots of others are step by step are the factors that are changing the world. Spending time spreading high quality knowledge. Thank you
@@paulmayer9790 Thats beyond ignorant ahaha. You have no clue how hard the material is in medical school. This is something they would spend 5 minutes on in a lecture and the rest is up to you to learn. You would be blessed to have a doctor who goes above and beyond to learn the material!
You helped me through a few courses in my undergrad studies; and now you are helping me through veterinary school as well! Easily my favorite and the best CZcams instructor!
Truly a fantastic lecture, clear, concise and well planned. Thank you very much for posting this!! Something that was made rather confusing has now been cleared up so easily by your one video! :)
Hi, I think you may have made a mistake with referencing heparin. The disaccharide is supposed to be heparan sulfate (composed of uronic acid and glucosamine). I only wanted to let you know because my professor made a point that it was not the same as heparin which is used in IVs for hospital patients as an anticoagulant. Other than that, this video was really helpful - thanks!
Heparin is a GAG composed of disaccharides as well (namely iduronic acid and glucosamine) and one of its function is to prevent the coagulation to spread. Heparan sulfate is a GAG composed of glucuronic acid and 2x sulfated glucosamid. It`s a component of basal membranes and cell membrane structures. I don`t think he has made any mistake. The structure and function of heparin is written correctly, according to what i know.
08:46 You mentioned that the negative charges on the disaccharide repeats of chondroitin 6 sulfate & keratan sulfate within the aggrecan molecules are responsible for the non covalent interaction between water & aggrecan ! Well , water is not a positively charged molecule to form IONIC BONDS to the negatively charged aggrecan molecules . But it'd rather form HYDROGEN BONDS with water molecules through the hydroxyl groups present in the polysaccharide chain of the aggrecan !
That may be possibility..but non covalent bond is also possible because Oxygen is electronegative atom and for this reason there are partial positive charge on the two hydrogen attached to that oxygen. So these two hydrogen can form ionic interaction with negative charged sulfate ion. Don't you think this is right?
@@sudiptajana1854 Negatively charged sulphate groups would rather form ionic bonds with other positively charged molecules ! Sulphate groups are hydrogen donors in their own right ; while hydrogen bonds are by far the most common kind of bonds between water & other molecules !
@@WhyNot-si4pj sulfate group are hydrogen donor?I don't think so..they don't have any hydrogen attached to them..and still if you think it's H bond acceptor..then I would say F,O,N are.. Secondly, water loves to form hydrogen bond but it makes ionic bond as well (like the NaCl solution..)
I was taught that the reason that the glycosaminoglycans attract water is because they attract positive ions and that it's the osmotic pressure attracts the water.
You, with Hank and JOhn Green, and lots of others are step by step are the factors that are changing the world. Spending time spreading high quality knowledge. Thank you
His voice and way of speaking made me 100% engaged and focused.
yeee hi from syria
i think youre the reason im going to pass medical school lol
ur an idiot t maz u should study what your teacher says dumbass
stfu, you're here for this video too, dickbrain.
LUUUUL
dang professors do'n't teach in medical school too!!
@@paulmayer9790 Thats beyond ignorant ahaha. You have no clue how hard the material is in medical school. This is something they would spend 5 minutes on in a lecture and the rest is up to you to learn. You would be blessed to have a doctor who goes above and beyond to learn the material!
You helped me through a few courses in my undergrad studies; and now you are helping me through veterinary school as well! Easily my favorite and the best CZcams instructor!
I love how I type stuff in your channel's search bar and I always get the exact stuff I need :D
Truly a fantastic lecture, clear, concise and well planned. Thank you very much for posting this!! Something that was made rather confusing has now been cleared up so easily by your one video! :)
Your whole series of lectures are made very simple, clear and interesting. Thanks very much!
hello i 'm a french guy and it is the clearest lecture i ever seen, that was great !
Very informative! I'm most likely gonna forget what I just watched but you're amazing dude :)
there is nothing to say...you are amazing,I always study university subjects with your lectures,thank you so much🌹🌹
I could learn anything he says only because he really knows how to engange you into the subject. I can't be any more thanful with him
YOU ARE AN ANGEL SIR THANK YOU! I'm cramming for biochem and you are a total lifesaver
Making hard part turning easy.I have benefited greatly from your vedio. thanks a lot!
dude. I gotta tell you. Your lectures are gold mine. I can't thank you enough.
Thank you so much. I am able to understand this topic even more. You explained it really well. Good job!
Very helpful discussion.
Watching it on 23/06/2021
Tomorrow is my biochemistry xm😌
Fascinating! The human body is an incredible design.
WTFFF I FEEL LIKE I SHOULD BE PAYING YOU for actually understanding my lesson, absolutely perfect, I love u, u high quality precise boy❤
This is a very wonderful work 👏 🙌 😀
Thank you for explaining ..is to easy...شكرا جزيلاً
Thanks so much! Usually I love my text book but with this I had no idea what it was saying, now I do. Thank you again.
This is very good information. I had heard of proteoglycans but now I understand so much more about their structure and function.
In one word "spectacular" lecture.
Perfect lecture; both equally enjoyable and insightful. Very much appreciated sir, thank you
This guy and Ninja Nerd are the best dudes on CZcams
wow! i have never understood like this before, i just love the way u explain your things, thanks for the time
Hi, I think you may have made a mistake with referencing heparin. The disaccharide is supposed to be heparan sulfate (composed of uronic acid and glucosamine). I only wanted to let you know because my professor made a point that it was not the same as heparin which is used in IVs for hospital patients as an anticoagulant. Other than that, this video was really helpful - thanks!
Georgia Molnor you are right, but it's the best natural form of anticoagulant in the body
Lol this is where I got confused
Heparin is a GAG composed of disaccharides as well (namely iduronic acid and glucosamine) and one of its function is to prevent the coagulation to spread.
Heparan sulfate is a GAG composed of glucuronic acid and 2x sulfated glucosamid. It`s a component of basal membranes and cell membrane structures.
I don`t think he has made any mistake. The structure and function of heparin is written correctly, according to what i know.
sodium will be likely and mostly attracted first, then the sodium in turn attracts water/// accrding to robbins. tnx Very nice lecture bod.
thank you veryyyy much always watching your videos
Excellent lecture. it was great. Thank you a lot...
Wonderful explanation and drawings. They are super helpful
You are so precise at this.
thank you for explaining it so clearly.
Thank you! This is a really good explanation
Thank you for breaking this for me to understand well. It's well will your soul bro ❤️
Love you regards from Pakistan
Thank you so much! This is really helpful for my intromed class.
This is a great lecture, v well explained!!
very nice lecture!!! clear and concise..well done.
Absolutely great
Lol AK is out here making sure I get through PA School
For sure! :)
it was really an informative video . thank you so much
Awesome video, extremely helpful for college cell biology!
Thaks for wonderful lecture
you explain it really good , wow
Great delivery of the topics! thanks man
great explanation, might just help me pass engineering
U LOOK LIKE LEONARDO DE CAPRIO...AND ALSO SOUND LIKE HIM..THANX AGAIN
Thank you AK 🇮🇳🇮🇳🇮🇳
08:46 You mentioned that the negative charges on the disaccharide repeats of chondroitin 6 sulfate & keratan sulfate within the aggrecan molecules are responsible for the non covalent interaction between water & aggrecan ! Well , water is not a positively charged molecule to form IONIC BONDS to the negatively charged aggrecan molecules . But it'd rather form HYDROGEN BONDS with water molecules through the hydroxyl groups present in the polysaccharide chain of the aggrecan !
That may be possibility..but non covalent bond is also possible because Oxygen is electronegative atom and for this reason there are partial positive charge on the two hydrogen attached to that oxygen. So these two hydrogen can form ionic interaction with negative charged sulfate ion. Don't you think this is right?
@@sudiptajana1854 Negatively charged sulphate groups would rather form ionic bonds with other positively charged molecules ! Sulphate groups are hydrogen donors in their own right ; while hydrogen bonds are by far the most common kind of bonds between water & other molecules !
@@WhyNot-si4pj sulfate group are hydrogen donor?I don't think so..they don't have any hydrogen attached to them..and still if you think it's H bond acceptor..then I would say F,O,N are..
Secondly, water loves to form hydrogen bond but it makes ionic bond as well (like the NaCl solution..)
Informative and clear , thank you
I really enjoyed your presentation buddy
This video was very clear! Can u pls add some more videos on detailed extracellular matrix.
thank you for share you knowledge !!!! you are the best
thank you for clear explanation
Splendid!!!!!!
Amazing lecture , Thanks a lot
Amazing explanation, thansk!!
What is best for stem cell that need consumption in cell culture?...!
Amazing sir, as always... Great help. Thankuuu
I'm so thankful :( really I don't know what to say but u make it clear for me. THANKS A LOT.
This was totally awesome!! Thanks a lot sir!!
You are a rock!
Thank you sir.
I have heparan sulfate deficiency - what would this cause symptom-wise? I am constantly fatigued. Headaches. Dry eyes
Thank you 💕
Thank you Sir!.....this really helped.
Wow !!! So good
i think i'm in love ♥
Thanks Dr
Thanks A lot
excellent. .....thank you so much
Love from Pakistan ❤️❤️❤️❤️❤️❤️❤️❤️
Thank you I. Studying for nbde1
God bless ya
Thank you sir
Thank you SO MUCH!
u are the best
I was taught that the reason that the glycosaminoglycans attract water is because they attract positive ions and that it's the osmotic pressure attracts the water.
Sir please make a video on ELASTIN
Great video
Great great great video
Chemistry sounds so much better in english than in german :D
I miss yr videos 😭♥️♥️♥️
Lovely ❤️
Thanks my dear .yes i watched this video that talk about cell membrane itis very helpful for me but i ask about more delials about cholesterol .
Ward Alyasmeeb Go to my website, watch the lecture on "Glycolipids and Cholesterol" in the biochemistry section.
AK LECTURES thanks ,so much my great teacher .God bless you
thank you so much ,
thank you!!!!
thank you so much
Thank u so much sir 🙏🙏 ♥️
what are the types of proteoglycan? plzz reply
I love you, man!
really great information but the pacing back and forth is giving me anxiety lol
let me leave a comment here today so after 6 years someone can remind me that i finally am a dr😭
Do you mean Heparin or heparan
You're amazing !!!
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