Fighting Antibiotic Resistance with Phage Therapy
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- čas přidán 18. 10. 2023
- Phages have been battling bacteria since the dawn of time. Evolutionary biologist Paul Turner explains how phages could be harnessed to fight the rising threat of antibiotic resistance, and it’s not what you think!
For Educators: Access free teaching resources at sciencecommunicationlab.org/s...
~ About the Film: How to Kill a Superbug ~
Phages, the natural viral adversaries of #bacteria, have been locked in an ancient battle since the dawn of time. This relentless evolutionary struggle has taken on renewed significance in the face of antibiotic-resistant bacteria, commonly known as #superbugs. The widespread overuse and misuse of antibiotics have made antibiotic-resistant bacteria a grave global health threat.
Evolutionary biologist Paul Turner’s groundbreaking research centers on using #phagetherapy to tackle the modern challenge of antimicrobial resistance. Phage therapy works by treating bacteria, like Pseudomonas aeruginosa, with #phages. These #viruses infect the bacteria, killing most of them off, until they evolve in a way that makes them susceptible to conventional antibiotics. It’s biological trickery at its best!
This approach holds immense promise in the ongoing battle against antibiotic resistance. It not only targets specific superbugs but also addresses the risk of perpetuating further #drugresistance, a concern associated with conventional antibiotics. By utilizing phage therapy, Paul's work offers a glimpse into a future where we can outsmart and ultimately overcome the resilient superbugs that threaten public health.
#antimicrobialresistance #antibioticresistance #phage #PaulTurner #virus #microbe #microbes #microbiology
~About the Science Communication Lab~
We are a non-profit organization of scientists and filmmakers collaborating on documentaries in order to build a more scientifically-engaged society. Find out more at sciencecommunicationlab.org/
~ Credits and Resources ~
Directed by Ruth Lichtman & Sharon Shattuck
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© 2023 Science Communication Lab™. All rights reserved. - Věda a technologie
Teaching resources for educators are now available! Check them out here: sciencecommunicationlab.org/science-videos/phage-therapy/
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I am suffering from osteomyelitis caused by Pseudomonas bacteria. It's in my calcaneus. Waiting for another surgery while on Cipro who is not working. It is bad. Really bad. I don't have diabetes but I did have radiation therapy a long time ago. I feel that phage is the only option for me but how to get it?
I remember when Bacteriophage study was just coming of age in the mid 70s in grad school! Prof talked about their potential. Great that they are now being studied for their anti bacteria properties.
Thank you all for joining us for our World Premiere today! If you enjoyed this film, make sure to join us for the premiere of our next film in the series about Electric Microbes on November 2nd at 1pm ET | 10am PT: czcams.com/video/cXARtgRHFsM/video.html
Related Resources:
- Chan, B., Sistrom, M., Wertz, J. et al. Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Sci Rep 6, 26717 (2016). doi: 10.1038/srep26717 (Link: www.nature.com/articles/srep26717)
- Kortright KE, Chan BK, Koff JL, Turner PE. Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria. Cell Host Microbe. 2019 Feb 13;25(2):219-232. doi: 10.1016/j.chom.2019.01.014. (Link: doi.org/10.1016/j.chom.2019.01.014)
Love that this is a sponsored video that pops up with searching “mycoplasma pneumonia” haha. I anticipate that this video is about to become very popular.
It’s going to be a rough winter.
So much information except the info we need . How in the hell can I get my hands on phages. My girlfriend is dying. At the rate the bacteria is growing in her she doesn't stand a chance if I don't know where to get the phages we need.
Can't wait to see this video!!! T___T
We can't wait for you to see it!
Very interesting. Two questions:
1.Do these phages naturally use the pumps as a entry receptors.
2. Is there a chance that the bacteria mutate such that the pump remains active but no longer works as a phage receptor?
Thanks very much in advance.
Or what if phages mutate and gain the ability to infect mammalian cells?
This is extremely unlikely or impossible because the respective host cells differ in many ways.
@@bioquimica_animal There is already virus very adapted to infecting human cells ^^ Phage are too specialized into specific species of bacterias.
@@hans-petermuller4771 Just like how bat studies for coronaviruses was 'unlikely or impossible' to spread to humans because it used receptors humans don't have. Or 3 days ago a research lab in Guanzhou has had 3 workers die suddenly due to an infectious cancer which should not be possible as cancers are not infectious.
Please upload more often 😅
Two more films are coming in the series! Next one on Electric Microbes will premiere November 2nd. Click "Notify Me" button on this video to get an alert to join us when the time comes: czcams.com/video/cXARtgRHFsM/video.html
What are the side effects of using phages in humans?
Side effects are eliminating one specific species of bacteria from a persons body.
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Super bug fighter ginseng from tablets not from roots as you were
Does this kill the super bug
Gc-MAF ????
why do ya call em phages instead of viruses?
It's short for "bacteriophage" (or "bacteria-eater"), the kinds of viruses that specifically infect bacteria
It is a bit silly because that means we're just calling them "eaters," but oh well-etymology often falls between the cracks of language!
@@davidbahry9092 i mean every virus eats bacteria by definition. seems like just a fancier word which implies tryna be fancy for no good reason. aw well
@@SteveHazel every virus attacks cells, but not every virus attacks bacteria! E.g. the smallpox virus only attacked human cells; different kinds of influenza viruses attack different mammal and/or bird cells; etc.
This is MEGA funny to pretend this is innovative when Georgia has been doing this since the 1920ies lol.
What are you talking about?
@@rodrigomelendez1545 phage therapy was actually invented before antibiotics! It fell out of use in the Western world when antibiotics were discovered, but former USSR countries kept the tradition alive, especially at the Eliava Institute in Tbilisi, Georgia
Fun fact: America's first Nobel Prize in Literature was for a 1925 novel about a doctor who independently discovers phage therapy ("Arrowsmith")
@@rodrigomelendez1545 Go on Wikipedia
@@rodrigomelendez1545 i understand what he means and a few google search said this phages are being used in Soviet Union countries ie Russia and the Eastern Bloc because the west denies them antibiotics for political reasons so they use viruses these to kill bacteria in the body to cure illness and on the special occasions they are being used there
@@rodrigomelendez1545The Soviet Union and its states used to use phage therapy as a common way to treat illness until mass production antibiotics was available to them,for Georgia,though they also use antibiotics,but phage therapy is still a common method of treatment,you can even find phage paste for open wounds there
Attack it from multiple vectors