Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, LOX,Prostaglandin, LTNs

Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, Prostaglandin,Leukotrienes - Physiology, Pharmacology, Biochemistry
Arachidonic Acid (Ara. A) is one of the major inflammatory mediators in your body...It's liberated from the plasma membrane phospholipid by the phospholipase A2 enzyme. By cyclooxygenase (COX), arachidonic acid can be converted into prostaglandins (e.g. thromboxane A2, prostacyclin "Prostaglandin I2 or PGI2", PGE2, PGF2-alpha, and others.
By 5-lipooxygenase enzyme (LOX), the arachidonic acid can be converted into leukotrienes (e.g. LTB4, LTC4, LTD4, LTE4) which act as chemotactic agent "to recruit neutrophils for inflammation" and bronchoconstrictors "bad for asthma patients.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
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[@joshdudeguy2830]

Me *comes to video knowing absolutely NOTHING about the arichidonic acid pathway*
MP *makes 18 minute video full of freaking magic*
Me *leaves at end of video feeling like a subject matter expert*
I know this is a 4 year old video but still. You do incredibly important work here, man! Thank you!

[@MedicosisPerfectionalis]

Thank you!

[@moonprincess1992]

My professor didn't even attempt to teach this, just gave us a chart to memorize. So thank you for explaining everything so well!!

[@MedicosisPerfectionalis]

You’re very welcome 😊
Good luck 🍀
Let me know if you have any questions!

[@yes7855]

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yeah my doctors too .. never told me diz (in my campus there's no proffesor, just doctors until doctorate degree)

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I am rewriting an article on "arachidonic acid, inflammation and mental health" and needed to know the whole mechanism. This video gave me a head start to decode the overly densed wiki article on arachidonic acid and saved my mental health. :D

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15:21 to 16:10 was the best explanation of the pharmacology behind Aspirin , since it's invention !

[@MedicosisPerfectionalis]

Thanks, dear!

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Thank you so much, you got me laughing while watching this and learn :)

[@MedicosisPerfectionalis]

Always laugh 😆 😂

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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This truly made my night! Who knows learning the AA pathway (that I've been dying to defy since medschool) can be fun?! 7 years later and this made sense

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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This was explained 10x better than it was at my university. Thank you so much!

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

My pleasure 😇
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[@dge.]

Came across your video while studying for Pharmacology. I am so glad I did! Not only did you make it so simple, but I was laughing throughout the video, too!
Ps I'm surprised at how low the view count for this is. Honestly this is better than Khan Academy. It uses a white background and u managed to inject bouts of humor (which I think is so hard to do for topics like these) I hope you continue on making videos, my good sir! You have made a medical student's week 😊 I wish all of my lecturers were like you.... SUBBED!

[@MedicosisPerfectionalis]

Thanks a ton!
I am honored...You’re such a kind person.
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Love the sense of humor with the teachings!

[@MedicosisPerfectionalis]

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This really is the most beautiful thorough explanation! Thank You!

[@MedicosisPerfectionalis]

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I never understood this in my second prof ..And the fear of this topic stayed with me for too long.Thankyou for such simple easy explanations

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I don't generelly make comments, but this lecture was AMAZING. Very clear and engaging explanation, congrats and THANK YOU!

[@MedicosisPerfectionalis]

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Thanks for making this easier to understand!

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genius doc!! amazing teaching skills, thankyou.

[@MedicosisPerfectionalis]

My pleasure 😇

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Thanks for the video. It went more in depth than my dental pharmacology textbook and helps me picture this action.

[@MedicosisPerfectionalis]

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Absolutely loved the video!!! It was wonderful and not confusing at all. I am currently in Pharmacology and everything makes since now!!

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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The explanation is crazy yet understandable

[@MedicosisPerfectionalis]

From the arachidonic acid pathway, can you mention some side effects of Acetyl-Salicylic Acid (ASA)?

[@ricardobaroni1714]

Bleeding, peptic ulcer (decreases production of mucus)

[@MedicosisPerfectionalis]

Good...and why does it decrease production of mucus?

[@ricardobaroni1714]

@@MedicosisPerfectionalis Because ASA inhibits the COX pathway, consequentely inhibits the production of prostaglandins, wich are responsable for the production of mucus. Sorry for my english, I am still learning haha

[@MedicosisPerfectionalis]

You’re excellent 👍

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the best professor I've ever seen, good job !

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Thank you so much! Many greetings from Germany!

[@MedicosisPerfectionalis]

My pleasure 😇

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When a young guy beats our professors
Great respect for you bro🌺

[@MedicosisPerfectionalis]

Thank you ☺️

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This textbook chapter traumatised me. Thanks for undoing the damage :)

[@MedicosisPerfectionalis]

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Thank you 😊

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what an explanation, PERFECT MAN! thank you so much and God bless!

[@MedicosisPerfectionalis]

My pleasure 😇
God bless you too!

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Thanks bro, bless you too!

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[@MedicosisPerfectionalis]

Sure!

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[@MedicosisPerfectionalis]

My pleasure 😇

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جزاك الله خير...أنت تحفة!!

[@MedicosisPerfectionalis]

Thank you 😊

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Indeed the best explanation! Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇

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I am starting to lern with love&fun our medical lectures than i just find this masterpiece..thank god and may the god bless you 🫀

[@MedicosisPerfectionalis]

God bless you too!

[@shyamagrawal36]

First time ever I could understand the exact mechanism by this video.. Thanks

[@MedicosisPerfectionalis]

My pleasure!

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I respect you effort Sir
Nice explanation ❤❤

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Thank you! Thoroughly enjoyed learning.🙌🏾

[@MedicosisPerfectionalis]

My pleasure 😇

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Loved this, very helpful. Thank you!

[@MedicosisPerfectionalis]

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every single time I cry with happiness... Medicosis you are a gift from God

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You speak my language MP! Acronyms and association helps better memory retention. Thank you

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Thanks

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This is the BEST video I have seen on this topic. Thank you kind sir.

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[@MedicosisPerfectionalis]

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4:35
5:40
7:20 platelets as H2O pump
13:48 aspirin

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Thank you ☺️

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Thank you ❤

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Thank you so much sir 😍
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Thank you so much

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THANK YOU FOR THIS!

[@MedicosisPerfectionalis]

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[@zadrachkertjubahib6867]

@@MedicosisPerfectionalis By the way, I'm an incoming first year med student and I was advised by the higher med students to study signal transduction pathways in advance. Thankfully, I encountered your video and the AA pathway now made a lot of sense to me. Gosh, how I wish med books were fun to read similar to the way you explained the concepts in this video. Cheers!

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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