Multiple Myeloma - signs and symptoms, pathophysiology, treatment
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- čas přidán 25. 07. 2015
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My father was diagnosed with MM 2.5 years ago and doctors said its already in an advanced stage. We did treatments to slower the progression but he grew weaker and weaker. He had extreme water retention and fluid tapping had to be done every 2 weeks with continuous doses of albumin. His pottasium levels showed sudden spikes and was admitted in the hospital a lot of times. Lately he was not responding to treatments. Unfortunately he passed away in his sleep a few days ago. He was the only person in my family who used to support me all the time. I miss him so much.
God be with you. Am so sorry
May God give you strength 🫂
MAY ALLAH GIVE HIM HIGH RANKS IN JANNAN...
What a sad story 😔 I'm so sorry for your loss
may god give u strength
Great explanation of the pathophysiology. It's a shame most medical school professors never reach anywhere near this level of clarity or integration in their lectures.
you can say that again
yeah i was wondering if we were taught this way, i would have been a little smarter in shorter period of time
Which university do you study?
True🤐
Casey Liveringhouse Yes you are right....they should watch such vedios and change there pattrn of teaching
The easiest way to remember symptoms: CRAB (hyperCalcemia, Renal failure, Anaemia, Bone lesions) :)
B also stands for Back pain :)
He's ryt...it's bone lesion but there's always back pain
Reply me hypercalcemia how much
I honestly could not study for hematology without all these youtubers resuming and clarifying the info. My professor sadly has the information so jumbled up and goes back and forth so often I can't make sense of what is going on. This video however is so well explained! I owe you for helping me understand this class!
i swear its the same....the big issue nowadays is that even teachers know the infos most of them doesnt know how to deliver them especialy when it comes to mecanisms of certain diseases which is crucial btw....they just dont put their mind and soul into it sadely
Armando Hasudungan deserves a Nobel Peace Prize.
hahahahah
if he can cure this disease in a natural way ;-)
and Chemo is a bad option imo :-(
Yes he does
Thanks
Totally!
Thisss video helped me so much Armando
Thank u
You have explained the entire concept in the best possible way.It was crisp, clear and simple .I am thankful to you for this .
Lost a friend to this earlier this week. He was only in his 50s. There was no cure and chemo didn't help but prolong his suffering.😪
Thanks Armando for your skilled pictorial explanations of this very complex condition. I have a friend who has been diagnosed with MM and he quite understandably struggles to fully grasp its various possible symptoms. Your artistic talent helps tremendously.
The best channel and dare I say..learning tool for us medical students that I have ever seen!
Thankyou for this Armando, so much easier to understand with your pictures and explanation rather than reading a text book!
This video is way beyond me and I'm only a retired house painter. Very precise artwork and the Doctor's ability to explain this is awesome... I will look for a few more.
6 years on this is still the best video, thanks
Love your videos!! Thank you! I'm going through PA school rn and it's kicking my butt! These videos really help put everything together in a full picture kind of way.
Thank from France! As a student nurse in the last year (third year) Your video help me alot to understand the multiple myeloma
Genetic tests could actually reveal some mutations like: t(4;14) t(14;16), del (17p), del (13). Thanks for the great work ! Also, it would be great if you could provide the final picture access for download :))
Remember CRABI - hyperCalcaemia, renal failure, anaemia, bone lesions, infection
Everything seems so simple with you ! Thank you so much ! :)
paraprotein -> increased plasma protein -> rbcs stick together -> rouleaux formation on blood smear.
Waldenstrom and MM both cause:
infection(monoclonal expansion -> dec Ab diversity -> infection)
DM
connective tissue disorders(increase light chain -> AL amyloidosis)
Dan Roper dermatitis
Dan Rope
I always come back to this video whenever this topic comes up in whilst I'm studying, such a great video! Thank you!
Super detailed and great explanation! Thank you!
Great job! Love your videos. They make learning so easy. Keep it up😊❤🙌🏻
i'm a medical student i'm studying with tears mt bestfreind's mum has died last year by multip myeloma i just can't imagen her feeling when she was taking this cours hope one day we can beat cancer
My grandpa died this night bc of it
my father passed away 2016 b/c of this as well
Thank you so much for this explanation, I am currently having tests done for multiple myeloma and this is the most thorough explanation of what it is. 👍
How did the outcome of your test come out?
@@ew6778 guess you got your answer...
Great content as always!! hope you realise how much life you are saving among pharma students here in france lol
Excellent video! Thank you so much.
Great overview. The patophysiology part really tied things together :)
this explanation is so good that it makes me wanna cry
Me too hahah
I struggled so hard to get my head round some of these concepts this video is excellent!
Thank you so so much for this tutorial. This helped me alot recently for an assigntment I had to do. Thanks again. You're awesome
Great video and a wonderful explanation!!
Bravo. Clear and organized. Refreshing change.
Thank you so much for this video from a grateful med student!
I can't explain how much helpful for me this video....keep it up sir...never stop please...
Thank you for the help sir, people in South Africa are benefiting from your videos.
Do you have mm
Very clear and well explained ❤️
Thank you Sir for giving us a crastal crystal clear concept 💗💗
Your explanation is on the point sir. Thanks for the beautiful video. 🙏
Sir you are a great help
May God give you more respect,honour and success
Regards
Thank you. This was well done.
I am a healer and i have a patient suffering from mm..this video helped me a lot to treat my patient.. thank you so much
My patient is improving and responding for the treatment 🙏
@@kamalarao5146what treatment are you using?
@@kamalarao5146so glad to hear that. God bless you both. My mom jist had a biopsy some, as her doctos are suspecting she may have MM. I am scared & worried.
Great video! it is much easier for me to understand than digging patho books.
this is brilliant. thank you very much!
Nicely explained,great job
This is just wow.. I really enjoyed the video.. Thanks a lot.. do more
Great video!!! Super helpful! Thanks so much!
Thanks for coming through today
speechless sir....thank you so much...
Beautiful illustrations!
I did my seminar well today with this video 😍😍it was very useful 😎😎😎TK u so much 😊😊u r awesome
Arjun Athwik can u please suggest how to control multiple myeloma back pain early??
fantastic explanation! thank you!
Extraordinary explanation ❤
can you do more videos on rheumatology topics like SLE, Scleroderma, Osteoporosis, Vasculitis, Anklosing Spondylitis etc..I would be happy to buy them :) thanks for your hard work!
psoriatic arthritis and Sjogren’s as well please.
You are a star! Great Introduction.
Thanks so much for this. I had MRIs of my lumbar & thoracic spine earlier this week, found lesions at L-1 & T-4. This really helped me understand what multiple myeloma is and the tests that have been ordered.
Was it multiple myeloma or something else? They found three lesions and fractures in my father's spine and we are waiting for what will be the diagnose :/
@@mmustapicsthow is your father doing? They suspect my mom may have this and just did a biopsy. Waiting for results is the hardest part.
@@drs2994 He is doing great. Basic therapy made him go from 20% to 2% malignant cells. He is going soon for autolog cell transplant and one month in sterile room. Aftet recovery, I hope he will be great. He was diagnosed pretty soon and is overall healthy so he has that going for him :)
I hope for a similiar story for you mother if she gets diagnosed with it.
Great job!!!
It's amazing material !! thanks so much
Brilliant,, keep up the good work🙂
Armando my time saver 😍😍😍 thanks a million
Thank you! Provided a lot of information
absolutely wonderful explanation! Thank you!
Thank you very much your information it’s so good keep doing this videos.
Great job and informative
That went terrifyingly in-depth, great work, I learned a lot, and now know exactly where to research for further studies. Thanks.
Immensely helpful. Thanks!
i fall loving in your beautiful teaching methodology and i give bless from the cure of my heart ❤️ lub you sir g❤️❤️❤️❤️
Thank you so much Sir !
Drawings and explaination is so satisfying
Undoubtedly great tutorial.
One of the best lecture ❤️
Good Job! Great Video!
Very good explaination. Thank you so much
Thank you so much... explained very well 👍
Thank you for the wonderful explanation
you made it so easy. thank you!
My dad is undergoing blood and imaging tests and biopsies to determine whether the plasmacytoma tumor in his t11 vertebrae is local or if it is multiple myeloma. Your presentation helped me understand the physiological processes going on so I could explain it better to him.
Invaluable service you provided me and my family…thank you.
How is your father?
My mom is currently in this situation right now and this video helped me very much
@Melissaxorenee my mom is also possibly in this situation. They suspect she may have this and they just did a biopsy to test for this. I pray she doesn't have it, I'm so scared and feel like the world is closing in on me. I hear people can live with this for years. May I ask, how is your mom doing? I wish you peace & comfort in this nightmare. You are not alone.
@@drs2994hi how are you, my mum has this but it's not multiple it's in a stable level rn and hasn't caused any damage, but the doctors said they will monitor her in case it becomes active. how are you coping?? we're in this together ❤️ wish you the best
@newshot_ your message means more to me then you know. Because it makes you feel alone. My only siblings g passed away when I was 25, so I've been my mom's caretaker for 17 years, since jer stroke not losing after losing my sister. But she is a high functioning stroke survivor, at least in my eyes compared to how other stroke survivors are left after a stroke. We are still waiting for biopsy results to see if she has MM so it is the longest wait of my life. I hope your mom continues to do well 🙏
Perfect! Thank you!
armando you the best... thank you for the vid.
Excellent video. I fully understand what Myeloma is. Thank you for sharing your knowledge on this horrible disease.
Hopefully a cure will come soon. I was diagnosed a yr ago. Sucks at 60.
@@charleswest6372may I ask? How are you doing? My mom is suspected of having this and we are awaiting biopsy results. Waiting is the worst part. I hope you are doing well I hear people.can live years even decades with this. My mother-in-law's hair dressed has had and been living with it over 15 years.
Good job.👍 please upload more haematology and histopathology related vdios..
Useful video . Thank you
Next level explanation
Vielen dank! Ausgezeichnet!! Es hat mir viel geholfen, liebe gruesse aus Deutschland!!
Wonderful presentation that even non-medical patients can understand. Too bad every M.D. who diagnoses a patient with MGUS or MM doesn't use this site for education!
Very informative, thank you.
Can you explain why there is so much deep bone pain?
What are some other symptoms of MGUS ,SMM, and MM to look for in the patient?
katherine hunter due to formation of lytic lesions there will be of more bone pain which is the most common symptom of MM
awesome drawing n explanation
Thank you DOC!
You are a savior man
Thank you very much
Please keep on doing the good work, you are helping way too many people this way. Can you tell me if and how this disease would affect plaquets and/or coagulation, by increasing the risk of trombosis?
Victor Perrotta the increase amount of immunoglobin ( IGg. IGm) lead to hyperviscity syndrome that lead to thrombosis and couglation
Great video!
God bless you... Helped me like anything !
Thankyou so very much for this brilliant explanation of my condition, I was diagnosed with MM in early 2016 and my prognosis wasn't all that promising and as a Nurse, I needed to stop work immediately and begin 18 months of Chemotherapy which left me with several side effects, the worst being Peripheral Neuropathy in both feet and my lower legs, hands and my entire skin has a strange numbness sensation to it.
Im a 53 year old male, so I was only 51 when diagnosed.
It was only by sheer accident that I was diagnosed, for no reason, or so I thought, I kept breaking ribs ? Plus I had no energy what so ever so my GP sent me for CT Scan which showed the several broken ribs and said they will heal over time, then he sent me for a General FBC etc blood test, unrelated, he wanted it when I turned 50 to have base line bloods.
It was the Pathologist that detected the Paraprotiens etc and then I was seen by a Hematologist to begin treatment plus support from the Leukaemia Foundation and MM Support Nurses but none of them explained the MM like you did in that video, I think it should be seen by every MM patient and I intend on showing it to Anne from the Leukaemia Foundation and the MM Nurses because its factual but more importantly it puts the disease into its sequence, I got explanations that jumoed all over the place making it almost impossible to get a handle on the sequence of events.
So again,
Thankyou so very much.
Yours. Danny.
How are you holding up now
@@laffyzon3 Currently responding well to the second round, relapsed, treatment with only Lenolidomide.
Thanks for asking, cheers.
Danny Nichols wish you more success im just looking for answers towards treatment and how to move forward any tips or suggestions would really help and i really hope you beat this man !
@@laffyzon3
Im in Australia, so the treatment protocol is basically the same for each MM patient, except, when I was treated (chemo) in 2016, the next step was to have Stem Cell Therapy, which I refused, its dangerous and makes you extremely unwell and I was already unwell, I just didn't need that as well. I wasn't dying from treamtent. Mr Dr was angry because I didnt follow protocol but its my body etc so he put me on Thalidomide which caused the Peripheral Neuropathy but kept the MM at bay to the point I had no treatment for 18 months. Then it returned and once the FLC or Free Light Chain blood tests came back greater than 15, I was put on Lenalidomide, which is like the smarter relative to Thalidomide.
I live with lots of constant pain from the bone cysts, lots of fractures in my ribs, hip, knee and rib pain.
So its not nice but I dont look at the bigger picture which is that MM is a terminal diagnosis because no one knows when they'll die. I was living like a patient for the first year but since then I live like everyone else, I even brought another pupppy last year. Hahahahaha
I have no idea how long the Lenalidomide will keep the MM at bay but my treating Haematologist has said that there is other drugs plus newer drugs coming along all the time, so I just take it one day at a time.
Can I ask if you have MM or is it a relative ?
You don't need to tell me, I'll respect your privacy, Im an open book, I dont mind who knows. Hahahaha
Cheers.
Danny Nichols no thats the thing nobody in my family has this but then again i did have a younger cousin who died from cancer but not multiple myeloma plus im only 25 i dont know how this happened to me
Excellent
Thank you very much sir ❤💯🙌
You are a genius, and I wish I could draw like you
Though I am no longer in med school, please continue to make great audio-visual presentations.
I look forward to your in depth discussion about Mast Cell Activation Disorder.
Got to take this test tomorrow.
Thank you Armando ,great
Sir this video is excellent
Amazing video man thnx
Great video!!!!!