Schizophrenia Treatment Revolution? Introducing Xanomeline: Potential and Latest Updates

Tired of hearing the same old meds for schizophrenia? Buckle up, because a game-changer might be on the horizon. This video looks into xanomeline, a drug with the potential to transform schizophrenia treatment. Unlike traditional antipsychotics, xanomeline works through the acetylcholine system, offering hope for those who haven't found relief with existing options. From delusions and hallucinations to negative symptoms and cognitive deficits, xanomeline shows promise in addressing the full spectrum of schizophrenia. But hold your horses! Xanomeline is still in the final stages of clinical trials, but the results are looking promising.
References:
1. Paul SM, Yohn SE, Popiolek M, Miller AC, Felder CC. Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia. Am J Psychiatry. 2022;179(9):611-627.
2. Shekhar A, Potter WZ, Lightfoot J, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165(8):1033-1039.
3. Singh A. Xanomeline and Trospium: A Potential Fixed Drug Combination (FDC) for Schizophrenia-A Brief Review of Current Data. Innov Clin Neurosci. 2022;19(10-12):43-47.
4. Breier A, Brannan SK, Paul SM, Miller AC. Evidence of trospium's ability to mitigate cholinergic adverse events related to xanomeline: phase 1 study results. Psychopharmacology (Berl). 2023;240(5):1191-1198. doi:10.1007/s00213-023-06362-2
5. Brannan SK, Sawchak S, Miller AC, Lieberman JA, Paul SM, Breier A. Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia. N Engl J Med. 2021;384(8):717-726. doi:10.1056/NEJMoa2017015
Disclaimer: This CZcams video is not intended to provide diagnosis, treatment, or medical advice. The content provided in this video is for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options. Information on this video should not be considered as a substitute for advice from a healthcare professional. The statements made about specific products are not to diagnose, treat, cure, or prevent disease.
#schizophrenia #xanomeline #mentalhealth #newtreatment #antipsychotics #medicaladvancements #medicalbreakthroughs #pharmacology

[@saradoun]

شكرا ، مبادرة جيدة 🌺

[@andreimarian7140]

How about erectile dysfunction?

[@jeanpaultongeren125]

KarXT

[@Roberto11231]

They say it is not good for negative symptoms. And it is not known if it is good for preventing weight gain, there is still a lack of evidence.

[@constantinhaller4391]

Really? Its suppost to be good all around!!! No weight gain or metabolic changes

[@Roberto11231]

@@constantinhaller4391 I think the score on the negative symptoms scale was 1.8, similar to olanzapine. There is no clear evidence that it is good for negative symptoms.

[@constantinhaller4391]

@@Roberto11231i see. Ulotaront Hits hard in neg symtoms But not Sure it will Hit the market

[@jeanpaultongeren125]

yeah I just read in oyou're other comment Ulotaront failed.

[@Roberto11231]

@@constantinhaller4391 The difference with placebo was not significant in the score of the negative symptoms subscale.

[@alinalemanska2029]

God did not tell us to take brain altering drugs when we have problems.
We were told to pray, fast and seek healing from Him and stay clear of things that would polute our minds !