Andres Lozano: Parkinson's, depression and the switch that might turn them off
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- čas přidán 17. 04. 2013
- Deep brain stimulation is becoming very precise. This technique allows surgeons to place electrodes in almost any area of the brain, and turn them up or down -- like a radio dial or thermostat -- to correct dysfunction. A dramatic look at emerging techniques, in which a woman with Parkinson's instantly stops shaking and brain areas eroded by Alzheimer's are brought back to life. (Filmed at TEDxCaltech.)
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My father has parkinson's and he had this implant a couple years ago I can tell you it is life changing. I cant even start to describe how wonderfull works, it is unimaginable. My father couldn't stop moving because of the dicease after the surgery he was a regular guy just standing there, reading the newspaper or playing with his grandaughters. I am in tears right now, but tears of joy because I got my Dad back. Please share this video, this is the answer of many people prayers.
Thank you very much for this great video.I am currently a participant in the Broaden Study for Depression.I`m at my eighth month and doing better.Deep Brain Stimulation has done for me what no drug or electroconvulsive therapy could do.Thanks also to Dr. Lozano and Dr. Mayberg for their great work in the field of Neurobiology.Also I would like to thank St. Jude Medical for making this clinical trial possible to help so many people who are truly suffering.In my own small way I`m glad I could help
The next step will be non-invasive methods of achieving the same results, which there is good evidence that we can do via focussed electrical or ultrasonic stimulation, and then of course regenerating brain tissue or permanently rerouting brain circuitry to remove the need for continual stimulation altogether.
Fantastic. Truly fantastic.
Amazing!!
i really hope that this treatment will be available everywhere..
I was lucky enough to be allowed to witness this operation and the improvement it provided on the patient. It wasn't as abvious as the 2 patients shown here but there was definitly an improvment.
Nowadays I am learning the effect of electricity on the Action Potential of the Neurons, as well as glycolisis(sugar) providing energy to the ATP pumps of the Neurons.
The understanding of how the brain works brings hope of curing diseases like depression, epilepsy and others.
Isso é maravilhoso! Graças a Deus existe pessoas comprometidas com a vida e o bem estar dos demais.
Thank you. I do appreciate the clarification.
These are HUGE problems and yet, they're being quickly treated all of a sudden. I have nothing but respect and awe.
I feel for you, Citygal. I hope you find some answers. Relief will be sweet when you get it. So nice that you've been clean for so long.
This is very interesting I hope that they have more talks about this in further detail.
excellent neurosurgeon around the world and his department is the best too. All the success for them.
This is AMAZING...exciting progress...over simplified or not...it certainly beats supporting the pharmaceutical business...launching countless 'news drugs' prior to fully understanding the long term effects - using people as guinea pigs - causing more harm than good. Thank you Dr Andrea Lozano for this powerful insight into this fine work.
With all of the negative things happening in the world, this is truly uplifting to see.
I cried watching this and applauded from home.
My Wife had this procedure done twice, a year apart. The First went well .The second surgery was done by a different Dr. and turned out to be a nightmare. The 2nd probe struck and cut a small artery which caused a stroke. She needed immediate surgery to remove the probe and the pressure the blood was causing. She nearly died. The first probe was able to remain which still is functional. It has been a year now, She has some brain damage due to the stroke but she is getting better each day.
she could have the surgery again by a better doctor and potentially fix that
Great explanation, prayers for the parents who can't afford such surgery/procedure for their children facing those problems.
how much is dbs in your counry?
what happens with the woman with parkinsons and the boy with distonia is just amazing... I can't even wrap my mind around the fact that is about to be available to everyone with these horrible conditions! simply amazing!
This is all good, but to be correct this is the answer of many people working their asses off in labs and surgeries, including the speaker.
Wonderful talk indeed.
This is amazing. I'm wondering if you're also working on making three procedure less invasive? The electrodes look huge.
I don't appreciate people belittling research that could be my only chance for relief from decades of suffering, and has already been used to reduce the suffering of others.
It must be nice not to know what it's like to suffer from a chronic debilitating illness.
That's really amazing...
What do I need to qualify for the depression switch?
That is just fantastic.
great man God bless you....
You're completely correct. It's a matter of definition, and that definition is incomplete (i.e. 'abnormal' would require some ranges to be defined for it to be complete).
I'll clarify my position, since I got myself into this: given that my personality is entirely a product of the chemistry in my brain, I am very skeptical about attempting to alter that by sticking chemicals and electrodes in it. I used to be entirely against it, but now I'm just not sure.
Oh, and you avatar is incredible.
I totally need THIS
This is insane, I look forward to how this research will progress
The INTRO.... is AMAAAAAZING!!!!!!!!
maravilloso, espero poder hacer este procedimiento a mi bello Benjamin
Incredible!
What is the current status today of DBS for treatment refractory patients with chronic OCD?
Amazing how some people among us can be so special and push our race forward while the rest of us fight for more money, oil, better car ....
What can you do for Ataxia for a patient living near Emory?
GREAT INFORMATION AND VIDEO THANKS. Have PARKINSON starts of trimmers. WOW, this is great. PLEASE HELP.
Troy Hagen B12 plant based diet, no dairy products because of the B - protein that acts like BMAA in seafood causing ALS.
Vegan diet with B12, DHA and D3 supplements, because of new research on the vagus nerve and gut flora.
How does one get on the list for the implantation of the electrodes to get help with the early onset of Alzheimer?
these are true heroes and nothing less
time to master our destiny
.
Spot on
A modern day hero, Agree?
Hero? Hardly heroic, but notable probably. After all he's just doing his job at no great risk to himself. The courageous patient undergoing experimental treatment is heroic.
Totally!
No, he is definitely no a "modern day hero" but rather reckless medical experimenter. He shows what by chance succeeded (he himself states "why not TRY this") but opens up huge area of abuse and terrible human suffering in the process, from all failed attempts and experiments. No proper disclosure. There are horrific side effects of implants that are talked away and misreported and faked out of prestigious research papers. Horrendous abuse of desperation, selling false hopes, by greedy big pharma and device maker industry lacking regulatory oversight.
@@nehopsa You're an idiot.
It's true. I've gone to the ER for psychiatric reasons and have had nurses and doctors there say some stupid and hurtful things to me. This has even kept me from seeking their help in times of crisis because I don't want to deal with them.
where/how can I find the complete video of that lady?
Awesome!!! I wonder if this type of implant could help my sister who has Cerebral Palsy that affects her posture and movement.
May 2018. A lot has happened since 2013. Radio waves are being used to treat essential tremor. The treatment is non-invasive. No chance of infection.
this was 6 years ago- hope there's been progress
It has.. but not the point that it’s being practiced daily
@@heshau Hurry up clever people! :)
Wondeful. I hope many will be helped by this. Mental illness is horrendous and has not seen the revolution in treatment that other bodily illnesses have. Maybe now it will.
Very exciting stuff, never knew you could insert something that big anywhere into your brain o.o
Society has bastardized the term "depression" you are reffering to sadness, which is an emotion that people do recover from with love and support. Clinical depression is a medical condition that does exactly what he says it does, it inhibits a person's motivation and positive moods, and, most importantly, requires far more than a hug to overcome. He's helping people to live normal, happy lives.
He's not turning off our love for one another, just helping us move on before chronic grief sets in.
This should have been at the big TEDTalks conference.
You'll get out of depression eventually man :)
I am coming back to life after a year at the bottom of the pit so I know it's possible.
Keep on hopin' !
This is one of the most exciting technologies we have seen.
With great power comes great responsibility.
I'm concerned with some thoughts about this. Would you think that directly controlling pathological behavior, such as depression, would ultimately leave the patient better off. Well, of course, but are we equipping ourselves with the right tools to fight our neuroses and fits? Shall we take on an attitude where everything can be measured and determined? What are the consequences?
+hiroshidude yes this is philosophical and wish washy to some, but i'm curious of the consequences. I mean, a good amount of people today hold a nihilistic view of the world. Moral question of what man considers as important and meaningful? Are these forces in our lives, or mere physiological functions that can be shaped without? Maybe, just like many things, it's a mixture of both.
Any anomaly to the normal function of the brain is considered a disease. But yes, I must agree with you because there have been in many cases, I too myself have experience some kind of a low point, that love and affection from friends and family does help in the rehabilitation process.
Where can you get this procedure done in Scotland
Depression is a lot worse than a "bad emotion", and you'll only know when you had a depression yourself or have lived with somebody who has. I hope you won't have to experience neither of them.
Any tips?
I don't know any details of this other than the video I'm watching. To relief pain and horrible symptoms is looks great. My problem: Do we want humanity on switches. Do we want to turn on and off happiness and sadness, bravery or cowardice, good behaviour or bad behaviour. Could we have a president of USA who could be switched on to love or hate. I don't want humanity on switches but it's good for rare situations. But not for the direction of humanity itself. The boy who twists himself it made him walk again and that's good, but we need to know more of what it did, like change his thought pattern etc.
You decide what you want Mate. We all have a choice, apparently!
Is DBS being used to treat tinnitus already?
At least 8600 people are lucky to find that they are amazingly lucky to be able to understand this work and to one day maybe able to benefit from it.
What about GAD or OCD? come on any info on anxiety disorders?
Yes! I have OCD and they will operate on me soon.
Can you use this same technique on a patient with Huntington's Disease?
Angels and Demons in the brain. As an entertainer I find this science fascinating in that the good doctor here parallels theories of cognitive projection within one's own brain, thoughts and feelings, creative visualization, guided imagery to effect the movement of our own brain chemistry thus our moods of course through the arts. When we lose our ability to regulate on our own he and his colleagues offer hope where we would be otherwise helpless and that is great. Thank you Ted Talks.
Synaptic transmission mediated via chemical exchange upgraded to electrode/electric mediation is incredible to think about.
Right now I process the world at the speed of chemical reactions between neurons in my brain. This can be seen as a type of neural chemical wifi connection. With electrodes using electricity to stimulate my neurons, you can make the parallel of fiber/or high bandwidth neuronal connection.
These exponential times are getting really exciting.
It used to be said that neurologist knew everything thing, but could do nothing, while surgeons do everything but know nothing. Internists do everything and know everything. But, now it is finally a day where neurologists know things and can do things! wow! This is great.
Thanks for the thought, but for the moment it's an incurable illness that I've had for decades. It's not likely to get better anytime soon.
this is good to explain DBS to the layman.. otherwise it would be very hard to present it in 15 minutes
so what kind of current, voltage and frequencies are we talking about ... is this destructive in the long term?
Was thinking the exact same thing.
Wow I want this treatment : O
Beautiful
Is the treatment available to wider public in the case of Parkinson's disease? My father suffers from Parkinson's and I wonder if it can help him.
Dr Andres Lozano tenho minha vó que apresentou A doença de Alzheimer poderia se possivel agendar uma consulta com vc ?
Bоost уour brain рowеeеer in 14 daуs? twitter.com/a988ac3a8671a5b89/status/804578733948444672 Аndrеs Lozаno Рarkinson s deрression and thе switсh that might turn thеm оff
There are difference between grief and depression. Yes, like any other psychological disorders the boundary is vague and the pharmaceutical companies are overbearing. However, if the depression makes a person dysfunctional we have a problem. We need to fix that problem - with electricity, drugs, or therapies - in order to prevent suicides and social isolation, and to promote general well-being. It is in our nature to find a cure, and you have to realize that it is a genuine motivation
This is the first I'm hearing of this.
I personally have never been more happy to feel like a robot.
Yes, but how effective could it be for bi-polar and schizophrenics?
Yep, but it will not completely alleviate their symptoms. I want something which will completely alleviate their symptoms. What could we do to turn on and off specific brain areas as well as regulate neurotransmitter activity?
But what happens to the part of brain that we replace by the implant?
How different are those brain implants compared to drugs for those with bi-polar or schizophrenics?
Who could possibly dislike this?
Absolutely brilliant. We need more people like these who solve these big issues rather than to suggest that it's natural or worse "God's choice" and we should do nothing about it.
People interested in this talk should also look into magnetic stimulation of the brain and the practice known as "Neurotherapy." This is where electrodes are placed outside the brain (like an eeg) and magnetic coils are set to a certain frequency to encourage more natural brain wave function.
Also, this talk reminds me of a book titled "Amped" by Daniel H. Wilson, dealing with the ethics of possible future "brain doping" by using these methods.
It might be as you say, but we can't really control what people do that causes these type of disorders, whether it's from the food they consumed or the victim's job risk or some other one-time accidents.
Sometimes we need to run first before we can walk.
The video seems to be cut :)
Yeah, man.
I really came for that switch on depression, thinking it is a motivational switch, but it is a medical precise yew switch.
This video was in 2013. I wonder what the progress is now?
My mom has Parkinson disease. How many on Parkinson disease have tried on? For surgery is the age is important? How much does it cost?
+Oya Şanlı i would suggest asking people at you local hospital about this. you can also browse the web. read the wikipedia article and depending on how much effort (and pain) you are willing to put in, read some scientific papers. I will copy&paste what I posted to some other person:
try google scholar. it will provide you with cutting edge research papers for any search term:
scholar.google.at/scholar?hl=en&q=dbs+schizophrenia&btnG=&as_sdt=1%2C5&as_sdtp=
if you encounter papers behind a pay wall, this site can help you access the site anyways: sci-hub.io/
another option would be to ask your question on biology.stackexchange.com/ where your answer might be answered by students and reasearchers from the field
Georg Plaz Thanks. She has a good doctor at local hospital. I have being in IT over thirty years, yes I am searching on the web. Thanks for the links.
As I see for this sickness every patient is unique. Everyone following own path. Depending on what the patient is doing that path changes, and doctors are helping for that. I just wanted to hear other stories to be aware of it.
I think you make valid points. I agree, this like all technology holds both promise and danger and perhaps requires a higher degree of ethics and morality than society has shown historically, and yet I believe we are on the cusp of a new Renaissance, and new Age of Enlightenment and treating diseases effectively is humane if not a moral imperative.
How could anyone put a thumbs down on this?
At 9:11, Mr. Lozano identifies the "sadness center" of the brain. Is this the amygdala or limbic system? Or is there a specific name for it that I'm not aware of??
Phenomenal
I think you should follow up on the kid. From what I know I worried about rejection and fatigue (reduction of the effectiveness of stimulation/surpressoin) in long term more than the potential harm.
If you are perfectly normal then you should stay away from any artificial stimulation (drugs, sticking a needle into your brain, etc...)
only drastic situation requires drastic measures, and I think people really get ahead of themselves of trying to broadly apply one science method to all fields.
he mentioned that they could target empathic parts of the brain too... maybe you should look into it?
As someone with difficult to treat dysthymia, I am absolutely overjoyed that in the future no one will have to suffer as I do. I can't wait for the human race to finally uncover more secrets of how our brains function.
After 9 years i hope you are doing well i have dysthmia hoping new treatment will come out
I saw this on Monday Mornings, Dr Park ftw
i still hav a crt tv :[
Much improved intro
Where can I get this surgery?
This is AMAZING!!!! That crowd sucked though
Re Alzheimer's: isn't it so that the brain shrinks and eventually dies off? I once saw a comparison between a 'healthy' (i.e. normal) brain and a brain affected by Alzheimer's disease. The 'Alzheimer's brain' was about half the size of the other. The brain cells had died off. So I don't really understand how they can make brain tissue work when it has been damaged like that. Can anyone explain this to me?