Influenza A Virus

ssRNA: influenza A virus offers a detailed illustration of the known replication strategy of inluenza A virus inside an infected cell. Influenza A is a negative single-stranded RNA virus and it belongs to the family Orthomyxoviridae. It has been in the past and still is today a major cause of disease and mortality. The disease influenza is a respiratory infection and thus, one of the most commonly spread diseases between humans and mammals. Particularly with the recent concerns regarding an avian flu pandemic, extensive research has been conducted on the protein synthesis and replication strategies of this virus.
Written and directed by Irene Petropoulou
Co-directed and edited by Andrew Tucker
Main scientific advisors: Dr. Christopher Clegg, Dr. Eric J. Snijder, Dr. Ernest Gould.
Chief Animator: John Bardakos
Narrated by Marianne Graffam

[@a.henderson22]

you are doing GOD's work bless you

[@BioBush]

What an amazing resource! Thank you for putting together this information with such good visuals. Keep up your good work!

[@NoName-un9fk]

Thank you for this detailed video, it was really helpful! I have one comment regarding the release of the new virus particles: neuraminidase is actually already actively cleaving sialic acids off of proteins in the Golgi apparatus. This way, all future plasma membrane proteins are preventively depleted of their sialic acids.
This is a safer strategy, because if the bond between HA and sialic acid containing receptors were that easily disrupted by NA, it would make attachment much harder. I guess we cannot exclude the possibility that NA occasionally does disrupt the interaction between HA and sialic acid (possibly also during attachment then), but this can be dealt with by the virus by expressing 4x as much HA as NA and binding to multiple receptors simultaneously.