CRISPR Talk with Jennifer Doudna |
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- čas přidán 24. 07. 2024
- Jennifer Doudna, co-inventor of CRISPR Genome Editing joined us for BIS2020 Volume II to answer our questions on the future of health care. Jennifer is one of the world’s most sought-after scientists. Within genomics, we believe the convergence of next generation DNA sequencing, CRISPR gene-editing, and artificial intelligence will transform health care completely. While many don’t believe we are on the threshold of curing disease, we do.
ARK believes that the turbulence caused by the COVID-19 pandemic is giving innovation an opportunity to break through the traditional world order. Unlike their entrenched and bureaucratic competitors, those offering faster, cheaper, more effective, and creative products and services should gain significant market share and help people and businesses to overcome this crisis.
We believe that genomics and fintech are two areas primed to gain traction but currently represent some of the most misunderstood parts of the market.
For that reason, on June 24th ARK hosted BIS2020 Volume II, a live Q&A video conference that brought together a group of experts from our research ecosystem to help answer questions on innovation, fintech, genomics, and the market outlook.
Download ARK's Big Ideas: ark-invest.com/big-ideas-2020/
Learn more about ARK Invest and investing in disruptive innovation: ark-invest.com
For full disclosure, please visit our Terms of Use Page: ark-invest.com/terms-of-use
I love the way Cathie puts her work out there for all of us to see, and then personally takes the time to thank her analysts. I am sold on Ark. Cathie Wood is a rock star.
Same! Never been more optimistic about investing money.
More than that. She’s a superstar. She’s like THE star in finance for me
Like Jagger, or maybe Ron Wood ... yeah, I'm seeing that.
I only simp for Cathie
Another amazing interview. Cathie is a treasure in the world of finance. I absolutely love her mindset. Thank you so much for all you do. My kids' UTMAs are heavily invested in ARKK, as their vision is the future we all want for our children.
Smart!!
ARK is the future of investing!
Brave..future is exciting but expensive.
Hope you remained brave during the dips. The market is about to reward people who didn't sell and bought more of ARK ETFs
All of Cathie’s predictions age very well. Watching in Dec 2020 and ARKG is looking unstoppable!
Just became aware of the ARK Genomics EFT today, and bought some shares. It should be a safer investment than buying individual genetic company stocks. I’m very excited for the future of this science.
@@DanyCervantes heard about it today and bought immediately? Tricky business ;p not that I don't trust ARK invest ofcourse ;)
@@tomknop8675 ETFs don’t go bankrupt like individual companies can. It’s a basket of investments on that particular field. There’s less risk, and anyone can fund exciting innovation.
Consider this story: t.co/NWE4jt1Qv0?amp=1 to understand the importance of the funding of these.
Just heard about it today, refers to me being aware of all these innovative technologies, but not necessarily wanting to risk my investments on a failing company. It’s hard to pick the winners. So an ETF is brilliant. Also, there aren’t many of these particular ETFs on offer either. I wasn’t aware that ARK even had ETFs, though I had seen their CEO talk several times, and followed their podcast; FYI.
The stock market isn’t very innovative. I can trade Bitcoin 24hrs a day, 7 days a week, all year round. Yet, still in 2021, I have to wait for the stock market to open, and hope that they are not on vacation. So it’s refreshing to see these exist.
@@DanyCervantes good to hear there is some more consideration compared to impulse buying. Very promising stuff indeed, just watched human nature on Netflix yesterday. Recommended!
Cheers
@@tomknop8675 I will take a look at that.
Unbelievable. Dr. Doudna started working on Cas9 about 15 years ago as she says here (I like the Puerto Rico story and how she smiles when talking about it) and fast forward 15 years, Crispr Therapuetics already has reported "curative treatments" for patients. What an amazing thing for Dr. Doudna and society to witness.
13:24 damn... I am just speechless. All I can say is thank you.
Two incredible women
Both women don't need CRISPR to look healthy and they're both older than your Mom, son.
that's SO sexist. I'd like to hear what a Geneticist "identifies as" in California where humans have 8 to 52 'genders' in the legal system
🤔😂
I watched this video to learn from Cathie about investing and ended up hearing this incredible scientist mention the possibility of her invention being able to remove Huntington's Disease from entire families. Thank you for your work, and giving my family hope.
Thanks for our continued learning and the breaking down of silos! Vision becomes so much clearer. Opening doors and minds ~
Thank you so much Cathie Wood, and thank you so much Jennifer Doudna!!! What an amazing episode. So lucky to have access to this.
And the Nobel Prize goes Drs. Doudna and Charpentier.
What a pleasure to hear a top scientist discussing her work in layman's terms. And, of course, her thoughts about how her work can affect the rest of us. Thanks for this & keep it coming!
SMH!!! CRISPR mechanism and name was originally discovered back in the 90s by a particularly humble microbiologist, Francisco Mojica, Professor at the University of Alicante.
@@fitnesspoint2006 This does not demote the work of Jennifer Doudna whatsoever but thank you for the correction!
@@mathewwright4129 who said anything about demoting her work...you used the word demote
These are the worst of times, these are the best of times. The isolation of the pandemic has me listening to some of the smartest people in the world. These women are at the top of my list. Overall, what a wonderful time we live in! Just wish I was a bit younger. Hmmmmmm
Cathie Woods ahead of the curve again. Profs Doudna and Charpentier wins Nobel Prize for this work 10/07/2020! Go Bears!
Thank you for arranging the interview with Jennifer Doudna. It was one of the most interesting interviews. I am wondering if Crisper can develop food supply and rid of hunger from the world. Mike from California
this is what it needed to be done a long way ago, Invest into the future, the new technologies the things that most people don't understand , CRISPR will become so common in the future that for new generations it will be as normal as a flu shot. Thanks Ark
Yes I agree. Ark, and the companies they invest in, are so forward thinking that most people can't comprehend their ideas.
Absolutely fascinating! Thank you for bringing this information to us. How would a lay person get involved in providing help to these kinds of efforts (citizen involvement)? Unfortunately I don’t live near Berkeley but this whole effort sounds worthy of every effort that can be provided.
And a big thank you to ARK for these shows and what they do.
Such a great interview. I feel so hopeful for new opportunities in healthcare and investments. Thank you 🙏
I need to use serendipitous more when I speak
A serendipitous statement, how fortuitous.
The etymology of the word "serendipity" is very fascinating.
Same here. I've been working on using "verisimilitude" regularly, as well.
@@3hooks781 Thanks. A new word for me, looked it up and stored it for future use to say "very similarness" in a sophisticated/nerdy way
Best to foul your foreign friend. Never heard this word till then. :P
Dr. Doudna and her French colleague won the 2020 Nobel Prize in Chemistry. She graduated from the same high school I did, fantastic.
What Dr. Doudna says during minute 7:00 is very interesting. It really pays to listen to one's gut. Logic and examining evidence are paramount. But it's not the only way we know things.
Officially, you're one of my favorite CZcamsrs out here!
This should be the most watched video in the world, true scientific discovery!
My plays: ILMN, CRISP, INVITAE - thanky for the research Ark
I'm up between 20-40+% on them... Highly believe in them
No PACB in there ??
@@amdistant5547 No, Illuminat is owning the market of sequencing Machinery, basically 90% Market Share or so. Have TMO next to illumona, pacific is a speculative Play (funny that they even got Investments from illumina)
@@thammymiller8167 They may be owning the market but I've heard ark are pulling out of their investments . So what's going on ?
@@amdistant5547 because they had a Bad quarter. I don't care about one quarter. Look, ark must make short Term gains as Well. They don't wanna hold to a Position to year end that is going down. You should not only look what ark is doing...
Both of you really need to go on Joe Rogan, he has a large fan base and he has had tons of scientist on his show including Elon, about 2 or 3 times. Would be amazing to hear you two discussing with him. Pleeeeeeease reach out!
True he did have Peter Schiff would be interesting to see more people from the finance world on Joe.
10000000%
Not on CZcams. And he would likely interrupt too much due to his ego.
It would be awfully hard to beat this interview.
@@chessdad182 You obviously don't know Joe Rogan.
great interview Cathy. My biggest question is how soon CRISPER technology can be monetized to scale for the masses to benefit from the science. Much of the science, so far, is not available to most of us who could benefit from it and most doctors are clueless when you try to invoke "genomic" preventative medicine conversations. It's just not integrated enough yet into our medical systems. I love the idea of being assessed for genetic disease but I can't get pass 1st base with my PCM (i.e., a referral so my insurance might pay for the assessment) to have an assessment done. I think the baby boomers aren't going to benefit from this technology but future generations hopefully will.
My life changed 7 years ago when I started to feel unwell. I went from being incredibly active to minimally active. 5 years later I had a diagnosis of a Glycogen Storage Disease (the inability to store and breakdown glycogen properly), which is caused by a lack of an enzyme, thanks to my genes. I hope one day I could receive this treatment as I am dying to be back in the gym.
Are there any other technologies that have been discovered for gene editing?
Damn it really is incredible that this info is available for so many. Cheers
Aboriginal people say they would dream their worlds into existence. This woman is dreaming her future discoveries into existence.
Thank you for the very interesting interview here. Amazing.
Two of the most intelligent women on the planet. Thank you, great interview.
Where would one find these clinical trials for the purpose of possibly taking an opportunity to join one?
Thank you Cathie! Excellent interview.
You both have thousands likes, tnx a lot for this interview
Why is there always a beeping phone sound in Ark's videos? It would be nice to get rid of that, thanks!
email notifications
At this point it's actually a hilarious meme they should run with it
Cathie, you are now one of my heroes. Your the fifth to be precise just behind Jordan Peterson and Elon Musk. God bless you and keep working happily and hard.
You do realize that DNA research has proven evolution to be a fact. That means the Adam and Eve story is false...you can take it from here.
Ok Jordan
Great interview, very interesting and informative. Thank you for this.
Are you working on the Dystrophin gene for conditions like Duchenne Muscular Dystrophy?
Cathie, these are very good questions!
I agree
What companies have been founded by Jennifer Doudna?
Its clear companies like this crsp etc....is where the trillion dollar valuation need to go. Anything that has the potential to extend life should always have more value then a phone or social media app or a retailer that sells everything online....this is a no brainer. If demographics aren't going to grow then life extension is the only growth game in town long-term
Agreed. Adam knows best.
longer life does not equal a happy or more full filling life. No good deed goes unpunished and the road to chaos is paved with good intensions.
Fascinate and scary at the same time. I need to start reading her book.
Marvelous discussion! Thank you.
V insightful . Thank you
Great content, thanks for sharing!
what are the best youtube channels and podcasts about CRISPR and this company?
Joe Kim just gotta do research on CRISPR; there's a symbol on stocks called CRISPR, but I'm not sure if it has to do with Doudna, but it does have to do with her partner, Emmanuelle Charpentier. Ill be on a look out for those 5 companies she said she founded.
you can tell Cathy is excited...so cool
I was drawn to this video because I am a fan of Cathie Wood's. Great interview! I am a cancer survivor, however, and wonder if there is a place to volunteer to give a DNA sample, etc.? Anyone know about this?
Congratulations on the nobel prize and thanks for your research, Prof. Doudna!
Just WOW!!! This was amazing!
ARKG is my biggest holding. Followed by: ARKK, ARKF, ARKG. Bullish.
How do you have them divvied up if you don't mind me asking.
i bought ark etf's since jan 3, 2018.
arkq: lowest $32.03. today $77.00. up 296.91%
arkg: lowest $27.91. today $96.97. up 366.65%
arkw: lowest $49.08. today $148.61. up 546.13%
Congratulations on your Nobel Prize
Wow! She just won the Nobel Prize for coinventing CRISPR. Much respect for taking the human race forward!
This feels like Tesla stock in May 2019.
Today the genomic sector went on a 5-25% discount too! These ARK Invest stock coupons work wonders
LOL
Man, I just went through the ARKG holdings two hours ago and starting to do my due diligence on some of the companies. I might have to pick this one up tomorrow... Might even be worth selling some of my Tesla to pay for it :)
@@dezac90 saame I just started doing research today! My port is doing great with Tesla and I'm looking now to diversify to some genomic stock since Tesla is quite expensive already 😂 i like how undervalued this stock/ genomic sector is. And i think that's where the opportunity lies!
@@dezac90 Big fan of Tesla and ARKG! Personally, I won't be selling my Tesla, but did pick up CRISPR and PACB after my two week long 'attempt' to research and understand genome editing (still learning).
Amazing podcast, I wish the mic was better though
2 powerhouses here, great interview
Bloomburg reported that Cathy Wood just finished the best year ever in the history of professional money management. Buffet, Munger, etc, have never done better. Yeah it takes many years to get a Buffet rep., but her predictions were years earlier. 2018 $4000 dollar Tesla, everybody laughed at her. Telsa at $800 equals her 4000 in 2018.
Can someone please explain to me how geneediting works in practic. I Mean, we have some genes but we have millons of dna strands. How do You Edit All those?
I think it's a scam. Snake oil.
Through artificial intelligence and machine learning you can achieve this. Before it was computers and servers calculating these kind of things.
18:22
catherine is a great student of gene editing and great fund manager. my best stay safe
감동감동.
I think...those two women are already doing clinical trials on themselves...they look so young!
hahahaha right!?
If so im selling my stock, aint helping.
:)) hahaha
Great interview. Very informative.
This is one of the most valuable videos on CZcams. Holy ... 🔥
What are the implications of CRISPR advancing from monogentic diseases to multigentic diseases? I wonder if CRISPR can be use to upregulate or downregulate certain molecular processes, such as over expression of certain genes/proteins to help with metabolism for weight loss and neurotransmitters for depression.
Implications are they can cure many more diseases. Crispr Therapeutics are already doing multiple edits in a cells, see their CAR-T data. Yes.. control the genes you can also control the regulation of the genes, all you need to know are the proper promoter sequences to manipulate for a start. Not a big deal.
@@crisprtalk6963 thanks for the input! Would you suspect a shift in how the current pharmaceutical industry is operating? If diseases can be cured without medications, I figured the companies that make cancer drugs would go out of business if CRISPR were to be the new and up coming method of treatment, especially if cost is drastically reduced
This was just amazing.
Love you Cathie!!
@@quickclipsgaming1888 It's great to hear from two most revolutionary women in their fields - finance and genomics. Amazing!
Some single-gene disorders:
Congenital Deafness (nonsyndromic)
Tay-Sachs
Familial hypercholesterolemia
Sickle cell anemia
Duchenne muscular dystrophy
Cystic Fibrosis
Hemochromatosis
Huntington disease
Familial hereditary cancers as well (BRCA 1/2, etc)
I love that the stock is FINALLY falling hopefully it continues Im going to start scaling in CRSPR on this 20% pullback
As someone doing a PhD in biomedicine who is surrounded by colleagues using CRISPR for some of their projects I have to say that I agree with the potential for it to be used someday to treat the monogenic diseases, but I would think for more multifaceted diseases such as type 2 diabetes or obesity or external causes such as viruses that it is unlikely to be the preferred option for treatment of said diseases.
The reason being that with monogenic diseases the cause is clear and the application of CRISPR will likely get approved by institutions like the FDA for treatment of them. For diseases like type 2 diabetes (T2D) however genetics only contributes 10-15% in the development of the disease based on Genome wide association studies and its unclear whether if you target every single gene associated with the disease if that could actually reverse the damage that has already been done to the pancreatic islets or reverse insulin resistance in the liver, muscles and fat. The only other application of CRISPR in that case would be as prevention, however it would be as of right now impossible to determine which genes to target and in which tissues and who should get this prevention that I doubt CRISPR would be the preferred option for any of these more complex diseases over a very dedicated treatment application.
Perhaps though with ever more advancing research CRISPR can be used in combination with other treatment modalities to make it more geared towards specific multifaceted diseases like obesity or diabetes, but as is right now that is likely a long ways a way.
The promise of CRISPR seems very nice to me but I struggle with seeing it used beyond research projects and treatment of monogenic diseases for a long time still simply due to the glacial pace at which healthcare moves. I think the genomic revolution that Cathie often speaks about might be on the horizon but might still be quite far away simply because certain institutions place much stricter guidelines for approval on biomedical technology than on for example electric vehicles. An automaker can bring out a new model every year if they so wish with limited restrictions as long as its safe , whereas with a treatment that usually takes much longer to get it approved through all 3 clinical stages and unless its to treat something on the scale of covid-19 wont get done within a year .
Excellent points. This is why advances will probably be made in places like China, which place a higher value on creating future industries than safety. The US has the research institutions which are very hard to match, but the regulation issues you mention will slow innovation to a crawl.
i've ordered the tri motor cybertuck fsd & may order the S dual fsd motor too NO one does what ELON DOES..I got lots or TSLA & SOLAR TOO
@ArkInvest, Maybe this is a question for one of your analysts, but I am just curious about one thing. If you were to take out some blood from a person with sickle cell disease and use CRISPR to gene edit that disease out, like Jennifer says is done, Once the blood is back in the body how does the edited genes cure propagate to the rest of the blood in the body?
Rene-Lee Sylvain, I think we won’t take out blood, but instead, just inject ourselves with CRISPR. Or take a CRISPR pill. CRISPR will then be able to edit every gene it’s programmed to target using sgRNA.
They scoop out the bad stuff from an HIV cell, inject the edited genes, then it spreads and drops off the edited genes to the cells.
Congratulation on your novel prize!!!
THIS WAS SO INTERESTING!!!!!!!!!!!!!!!!!!
Godspeed to this technology. Very personally hoping that solid type tumors such as Glioblastoma can go from likely what will kill you if you have it, to something that can at least be managed like a chronic disease.
Can this be done with Duchenne muscular dystrophy two of my sons have died already my other son is 16 now he is outlived his other brother who had Duchenne muscular dystrophy by two years please reply to us if you could I am in the Berkeley area I am willing to do anything to save his life please contact me
Can CRISPR cure Lou Gehrig's disease? My mom has Lou Gehrig's disease...
Please answer me back....
Possibly
@@edwardoropeza7333 😂
truly amazing... wow.. Nexus blade runner kind of stuff...
Thank you Cathie and Jennifer! :)
Who is here after nobel prize is awarded
Cathie has beaten even Myoshi-san & Warren Buffet in investing in 5 major fields. Women and the world need role models like Cathy. Hats off in educating people like me. Irrelevant whether she is a rockstar.. more relevant that she discovers hidden gems
Will this include all viruses because cold sores get on my nerves.
Jennifer come back and give the Vikings a pep talk after the COVID-19 period. Those kids are going to need some inspiration.
5:39 " The work I did is the work I know. The work I'm currently doing, well, it's the work I don't know yet. That's why I can't tell you. Because I don't know what I'm doing. It is the discovery that makes it worthwhile in living. "
- Phillip Glass
Right now on 18jan 2021 crsp is already at $210
Congratulations on the 2020 Nobel Prize!
Incredible x 1000000000000000 to the 10th + wow!
That's just one more zero.
Interesting discussion
I sense a vibe here...
Good info/interview
How do Big Pharm feel about this company ?? Billion $$ question
ARK should interview Feng Zhang as well
Brilliant!
Cathy giving credits to her people says a lot about her...
Then she goes on to win the Nobel prize
Aloha! Just bought a condo on the Big Island a couple hours from Hilo!
If you don't mind me asking how much did you pay? That is my dream. I recently spent two months on the big island and loved it.
Deborah Ritchie Rt now you can find a fantastic Big Island condo from 100 to 500K easy.
Been going to Big Island since I was 14. LOVE IT.
I did not understood how as a inventor going to make money on CRISPR
Intelligent women are so awesome :)
Would this technology work for Leiden Factor V? My blood over- clots.
Omg GATTACA movie but irl
Wonder when CRISPR will be used to cure cancer?
only monogenic gene mutation diseases
2:20 That you have, wonderful and amazing human.