Neuromuscular Blocking Agents | Skeletal Muscle Relaxant Types and Mechanism of Action (HINDI)

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Neuromuscular blocking agents are among the most commonly used drugs during general anaesthesia. They compete with acetylcholine and interfere with the transmission of nerve impulses resulting in skeletal muscle relaxation. Based on their mechanism of action, neuromuscular blocking agents are classified as either depolarizing or nondepolarizing. Succinylcholine is a short-acting depolarizing agent. Commonly used nondepolarizing agents are curare (long-acting), pancuronium (long-acting), atracurium (intermediate-acting), and vecuronium (intermediate-acting). Neuromuscular blocking agents are used clinically to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery.
Classification- Non-depolarizing blocking agents: These agents constitute the majority of the clinically relevant neuromuscular blockers.
Depolarizing blocking agents: These agents act by depolarizing the sarcolemma of the skeletal muscle fibre. This persistent depolarization makes the muscle fibre resistant to further stimulation by ACh.
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Acetycholine already showing calming effect and if we use non-depolarizing(competitive) Antagonist then it will reverse or give excitatory effect.
Kindly clear my doubt sir.

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Sir what about pharmacological actions of NM blocking agents

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Sir , Maine Drug acting on ANS wala Sara Video Dekha hai Systematically. But Sir Mujhe Neuromuscular Blocking Agent ke Badd kya Dekhna Chahiye Drug acting on CNS .too kya Neuromuscular blocking agent Acche se Clear hoga?

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Res sir ,U have uploaded the video on neuro muscular bloking agents but may missed below topic ..,...... plz upload a video on CENTRALLY ACTING MUSCLE RELAXANTS .

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Sir Acetylcholine Ko Nicotinic Receptor Pe Inhibit karne ke liye ke Koin Sa Drug Use karenge?Should we use Kocal Anaesthetic?

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Sir in comparative type it will compite with Ach and inhibite binding of Ach so we will use anticolinergic drug (atropin) or another nicotinic blocker as a muscle relaxant or not ? If no than why not use..

[@solutionpharmacy]

This is a good question. As i have explained in video that NMB act on Nicotinic type of receptors. (Actually NMB are classification of anticholinergic drugs) and atopin binds on muscarinic receptors.
Anticholinergics are divided into three categories in accordance with their specific targets in the central and peripheral nervous system: antimuscarinic agents, ganglionic blockers, and neuromuscular blockers

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Sir,if question in semester exam is classify centrally acting muscle relaxants,than in ans we will write only defination ,classification and machanisam of action it is sufficient or write about diffrent example like d-tybercronin, vecuronium ,rocuronium or succinylchoine etc..

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MANISH KUMAR Answer of any queation depends on marks. If that is 10 marks ques. Then definition, classification with examples, MOA with diagram (Dig is must) and explainatikn of any 1 will be enough. Please dont forget to explain any answer with diagram or flow chart.

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Sir while major surgery if doctor will be giving msucle relaxant and also genral anaesthesia ( though it'll be in small quantity) but there is chance of drug drug interaction isn't it sir??

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No. Drug-Drug interaction does not depends on its category mainly its based on profile of individual deugs

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Sir mujhe ek doubt h sir. Sir KD Tripathi m Mechaniam of action m ek Non-Depolarization blocker(competitive) and agla Depolarizing Blocker k bare m bta rkha h aur apne Depolarizing Agonist k bare m btaya h.
Even iske classification m bhi Depolarizing blockers hi de rkha h book m.
So, sir kindly solve my problem.

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