Water content by Karl Fischer Titration

Water content determination by Karl Fischer titration is described. The usage of Sodium Tartrate Dihydrate (DST) or purified water for standardisation is discussed. Water determination calculations are explained in a simpler way to remember easily. The routine test procedure should include all these intricate points for accurate determination of water content - Ramalinga Prasad Kuppa.

[@gkravindran]

Good teaching I everseen

[@naveenreddy8704]

You are all rounder sir...
Your every video useful to us..
Thank you sir.. 🙏🙏🙏

[@pharmaworldk1473]

Thanks. If you have any specific questions, you may indicate. I'll try to make video.

[@mallimacha2099]

Super...sir...age plays crucial role here

[@osmanali9629]

No detailed video like this on CZcams .......very well explained sir ....need more explanations from you

[@pharmaworldk1473]

Thanks for your compliments. You may indicate on specific requirement so that more such short videos could be made for your benefit

[@osmanali9629]

Sir can you please make a video on UV spectrometry operation,principle.

[@pharmaworldk1473]

@@osmanali9629 There is one video on UV. You may check my links. Alternatively, please send your whatsapp number so that I can share it to you.

[@osmanali9629]

Sir can you please share a link of your Facebook account or Instagram account so that I can text you personally.

[@pharmaworldk1473]

Go to Ramalinga Prasad Kuppa for Facebook

[@gayathribabu1214]

Superb teaching sir thank you so much

[@maheshamk1728]

Very good teaching

[@anushka297]

nice presentation :)

[@toluayo9769]

Fantastic and very well explained. Well done sir

[@pharmaworldk1473]

Glad you liked it!

[@shubhangidwivedi5749]

Wonderful explanation 👍

[@pharmaworldk1473]

Thank you

[@PSR444]

Excellent explanation sir.. If possible try to make video with KF apparatus, it may leads to understand much better

[@NiniUppuluri]

You got many likes here congrats

[@pharmaworldk1473]

Thank you

[@solankirupal7829]

Sir please prepare a video on GC and hplc

[@rajibahsan6524]

Sir, I am using Mettler Toledo V10S. Sometimes my Karl Fischer reagent conc. decreased to below 4.5, hence this value not stored in system. Also there is no option to input titer value manually. Now, am I getting wrong results for samples?

[@pharmaworldk1473]

Dear Rajib, you have to modify the program to include the K F factor below 4 5 also. Your system administrator can do this. Generally, there will not be any provision to enter manually in fully automated KF titraters. If the system is not operated as per instructions of the instrument, it is likely to give you erratic results.

[@raghuvaran7883]

Spr

[@ebersonleoraj6728]

In a kfr bottle for 5mg water consumes 1ml reagent, then factor is 5. But how to give 5 to 6, kfr solution strength decrease slowly so factor also below 5. Can you explain

[@pharmaworldk1473]

@@ebersonleoraj6728 Even if the factor is below 5 mg/ml, it can be used to estimate water content. 5 to 6 factor is only a guiding reference. USP allows to use KF with lower than 5 factor. Is it clear now?

[@pharmaworldk1473]

@@ebersonleoraj6728 You can give the factor below 5 also.

[@telukulakesava29]

difference between water content &loss on driying

[@pharmaworldk1473]

LOD is total volatile content including any solvents. Water content by KF will give exclusively on water content.

[@ojjaarundhathi7971]

What is the acceptance criteria limit sir

[@pharmaworldk1473]

Generally, factor will be between 5.0 mg per ml to 6.0 mg per ml. You can also have up to 2 mg per ml KF factor for very low water content samples. Please refer USP for more details.

[@ojjaarundhathi7971]

Tq sir

[@ojjaarundhathi7971]

Sir what is acceptance criteria limit for kf standardization RSD..?

[@pharmaworldk1473]

@@ojjaarundhathi7971 It is NMT1.0% or NMT 2.0%, depending upon the capability of the instrument on reproducibility.

[@ojjaarundhathi7971]

@@pharmaworldk1473 tq so much sir

[@pandiribalakrishna1254]

Telugu lo cheppandi sir plz

[@pharmaworldk1473]

Do you want me to make the same video in Telugu?