Exploring FOLFIRI and checkpoint inhibitors in gastric adenocarcinoma

David Tougeron, MD, PhD, Poitiers University Hospital, Poitiers, France, discusses the findings from the PRODIGE 59-FFCD 1707-DURIGAST trial (NCT03959293), which evaluates the efficacy of combining FOLFIRI with tremelimumab (anti-CTLA-4) and durvalamab (anti-PD-1) as second-line treatment for gastric adenocarcinoma. The trial has demonstrated a favorable response rate among patients receiving this combination therapy. Beyond biomarkers such as PD-L1 expression and combined positive scores (CPS), researchers are exploring novel predictive and prognostic biomarkers such as tumor mutation burden (TMB). This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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