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Amazing! maybe only some dendritic cells do cross presentation due to the higher chance of lysis. So it’s like a captain of a ship performing a highly dangerous maneuver. then after successful completion of maneuver(presenting antigen on MHC I), the dendritic cell “earns it’s stripes” and gets the license to present, like you mentioned in the video. Such a cool video. Thank you.
Thank you so much! I am just wondering if there is any chance to have a copy of your power point presentation, sir? I hope you could also consider it. Your channel deserve millions of subscriber, swear!
At 6:58 you said CD8+ helper T cells , CD8+ cells aren't helper T cells they are cytotoxic T cells , in the slide you showed correct but pronounced it incorrectly.
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I have a doubt, u said due to some actions there is breakdown of antigen that causes MHC 1 receptor to come out and cause cross presentation, but at last u said it is the IL-2 cells that cause the dendritic cell to start cross presentation. Which one is correctcorrect?
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Why not dendritic cells could directly load processed viral antigens to class I mhc for cd8 activation .Why follow this complex class II and then to present to classI? Kindly explain
Two reasons: Peripheral tissue is generally exposed to viral antigens but cannot activate naïve T-cells found in lymph nodes because infected tissue is generally stuck in place without access to the draining lymph node. Since pathogens infect the body most commonly through permeable tissue which is often immobile (for example, epithelial cells in the lungs), the infected tissue can't present the viral antigen to naïve T cells that are in the lymph nodes. The second reason is that infected dendritic cells are often unable to present MHC-1 peptides due to viral immunoevasin activity which is preventing migration and MHC-1 presentation. The solution our immune system came up with is cross-presentation which is an exception to the general rule where MHC-1 ONLY detects cytoplasmic antigens. A cross-presenting dendritic cell will then phagocytose extracellular parts of dying/infected cells which contain the viral antigen and then pass this onto the MHC-1 presentation pathway and thus activate CD8 T-cells. Hope this helps, and feel free to correct anything.
I wonder if cross presentation is used to present cancer protein to the naive cd8 T cell waiting in the lymph nodes. A cancerous cell shows cancerous protein on mhc1. Somehow it needs to be presented to a naive cd8 T cell for the first time so that it can clone itself and come to the rescue.
You are right my friend. I strongly suggest you read this article for better understanding www.sciencedirect.com/science/article/pii/S0923753419541461#:~:text=Cross%2Dpresentation%20of%20tumor%20antigens,used%20in%20this%20same%20way.
Whenever I think I am done with immunology something new always come more I learn more doubt's I get which makes me more confuse. Sometimes times I think I should stop trying to understand it and just mug up all. what do you think sir?
This is easily the most detailed yet easy to understand video on Antigen Cross Presentation on CZcams.
Great work!
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This is one of the best explanation for cross presentation. Crisp short and really helpful
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thank you! Basic Immunology Abbas didn't cover this topic as crystal clear as yours
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Thank you so much for your explanation! It helped me understand the topic well.
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Amazing! maybe only some dendritic cells do cross presentation due to the higher chance of lysis. So it’s like a captain of a ship performing a highly dangerous maneuver. then after successful completion of maneuver(presenting antigen on MHC I), the dendritic cell “earns it’s stripes” and gets the license to present, like you mentioned in the video. Such a cool video. Thank you.
Thanks a lot my friend
You helped me clear my confusion, thank you so much!!
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Great clarification on cross-presentation !
Shaqayeq Rudd please share among your friends and help me to reach big audience
Great clarification, thank you so much!!
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This video actually clarified some of my concerns, thank you!!
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Thank you so much! I am just wondering if there is any chance to have a copy of your power point presentation, sir? I hope you could also consider it. Your channel deserve millions of subscriber, swear!
At 6:58 you said CD8+ helper T cells , CD8+ cells aren't helper T cells they are cytotoxic T cells , in the slide you showed correct but pronounced it incorrectly.
thanks for pointing that out...it was a slip of the tongue...i would be more careful.. Butt i hope the overall video was useful
thanks ! this video help me a lot
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Thank you Arpan! I’ll show my classmates
That sounds great....lots of love from India
Great presentation.
Thank you
please share with your friends
Nice one and thank you for the knowledge😊
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so good! thank you so much!
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Thank you, it's quite understandable and helpful, but it would be better if the references were avaliable for further reading. :)
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All the info is taken from kuby immunology 7th ed
I have a doubt, u said due to some actions there is breakdown of antigen that causes MHC 1 receptor to come out and cause cross presentation, but at last u said it is the IL-2 cells that cause the dendritic cell to start cross presentation.
Which one is correctcorrect?
Thank you.
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Great explanation
pritam Maitra please share my channel link with your friends and help me to reach big audience
@@animatedbiologywitharpan sure👍
good video
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Why not dendritic cells could directly load processed viral antigens to class I mhc for cd8 activation .Why follow this complex class II and then to present to classI? Kindly explain
I think it's because cd8 can only bind to MHC I and not MHC II
Two reasons: Peripheral tissue is generally exposed to viral antigens but cannot activate naïve T-cells found in lymph nodes because infected tissue is generally stuck in place without access to the draining lymph node. Since pathogens infect the body most commonly through permeable tissue which is often immobile (for example, epithelial cells in the lungs), the infected tissue can't present the viral antigen to naïve T cells that are in the lymph nodes. The second reason is that infected dendritic cells are often unable to present MHC-1 peptides due to viral immunoevasin activity which is preventing migration and MHC-1 presentation. The solution our immune system came up with is cross-presentation which is an exception to the general rule where MHC-1 ONLY detects cytoplasmic antigens. A cross-presenting dendritic cell will then phagocytose extracellular parts of dying/infected cells which contain the viral antigen and then pass this onto the MHC-1 presentation pathway and thus activate CD8 T-cells. Hope this helps, and feel free to correct anything.
I wonder if cross presentation is used to present cancer protein to the naive cd8 T cell waiting in the lymph nodes. A cancerous cell shows cancerous protein on mhc1. Somehow it needs to be presented to a naive cd8 T cell for the first time so that it can clone itself and come to the rescue.
You are right my friend. I strongly suggest you read this article for better understanding www.sciencedirect.com/science/article/pii/S0923753419541461#:~:text=Cross%2Dpresentation%20of%20tumor%20antigens,used%20in%20this%20same%20way.
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@@animatedbiologywitharpan Thanks arpan! That article hits the nail on thead.
Why not dendritic cell is killed by cytotoxic t cell when cross presentation is done by it? Pls answer.
That risk is always there
@@animatedbiologywitharpan thank u so much sir! I liked the way of explanation very much.👍
Whenever I think I am done with immunology something new always come more I learn more doubt's I get which makes me more confuse. Sometimes times I think I should stop trying to understand it and just mug up all. what do you think sir?
Don’t mug up...,, every field biology is evolving and changing .... no need to mug up... just enjoy
What is the purpose of presenting antigens to a cytotoxic T cell?
czcams.com/video/eOO8jEFsodo/video.html watch this video it would be clear
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From where did you study this topic?
Kuby immunology 7th edition
This guy said CD8+ Th cells lmfaooo