Hereditary Spherocytosis (HS)

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[@MedicosisPerfectionalis]

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[@Venus-kb7ws]

i wish i could make my professor at the uni watch your videos and learn how to teach medical students in a simple and clear way like you do! :')

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@markbishop4098]

@@MedicosisPerfectionalis can I ask a question? I have had spherocytosis (and known about it all of my life) I have no symptoms, but was diagnosed type1 diabetic 17 years ago (after an electric shock to my abdomen, killing my pancreas) but since then my hBa1c have been extremely low. Better than normal? I'm absolutely convinced this is down to my spherocytosis and not down to my diabetes control? But my diabetes consultant seems to know nothing about spherocytosis... I'm just after some clarification, as it's starting to worry me as I'm getting older..(i was diagnosed at birth, as my dad has spherocytosis and suffers alot from anemia, I am now 49 and not really had any other issues..) you input would be much appreciated... As you seem to know alot about this ailment. (P. S LOVED THE VIDEO!!)

[@angelprincess818]

@@markbishop4098 take folic acid supplements, iron and vitamin c. Also eat lots of vegetables and fruits daily.

[@sarahpurple6547]

Exactly ❤❤

[@maithilypatel104]

WOW! I have been following your videos for a while now, and just wanted to say a BIG THANK YOU! The way you explain from the basic, explaining every detail that there are no doubts left! I just get SO INVOLVED in the topic. You are amaaaazing! :D

[@MedicosisPerfectionalis]

Thank you so much 😊
I appreciate you

[@zaidansari-fi8yx]

I've hated hematology from 1st year and never would have guessed I'd be this good at it! Thanks for making it so light and amusing!

[@hkohlanyy]

the amount of details in your lectures is really what makes you stand out, keep going gentle doctor :)

[@MedicosisPerfectionalis]

Thank you 🙏

[@DR-gp1tl]

We've learned more from your video, than our doctors ever told us! Thanks a lot! You're also very entertaining and hilarious, keep up the good work :) kind regards from Austria

[@MedicosisPerfectionalis]

Thanks a million, dear!
Are you a student?

[@DR-gp1tl]

@@MedicosisPerfectionalis used to be in nursing school,but no :) my husband got diagnosed with HS, and the doctors here in Austria didn't even inform us about any of this

[@MedicosisPerfectionalis]

Oh! I am so sorry to hear that!
How is his health now?

[@DR-gp1tl]

@@MedicosisPerfectionalis thanks for asking, he's been very exhausted lately, but he's getting better. :)

[@DR-gp1tl]

His spleen is 12 cm bigger than normal, would you suggest having it taken out? He loves running and he's very active, but I think he's overly exhausting himself.

[@farisfirdaus4744]

Omg, you explain this better than the lecturers. Thank you so much!

[@MedicosisPerfectionalis]

My pleasure 😇

[@antthiratehwan5758]

Seriously you helped me alot. And your light humour makes watching your video repeatly, not boring. Thank you so much. Pls continue making more videos and helping my medicine degree life 😂

[@MedicosisPerfectionalis]

Absolutely...Thank you so much for your comment...I wish you the best of luck!

[@dababy4528]

I have hereditary spherocytosis, and this video helped better understand my condition, keep up the good work!

[@MedicosisPerfectionalis]

Thank you so much!
How is your health today?

[@crazydog1625]

I do to this video really helped me understand it better

[@maddiedacshund4785]

same

[@abedalee6985]

so

[@emmanuelpapi]

Same here man

[@iamgopz]

2:02 Hematopoietic stem cell lineages
2:26 Normocytic anemia classification
3:03 Mechanisms of Hemolysis
3:21 Extravascular Hemolysis
3:33 RBC membrane structure
5:13 Hereditary spherocytosis
10:56 Pathophysiology of Hereditary spherocytosis
13:09 Diagnosis
17:27 Treatment

[@drhuraa27]

Thanks

[@tahiransari3917]

MasahAllah bro your lecture erased many cconfusion about anemia

[@MedicosisPerfectionalis]

Thanks 🙏

[@1995nicat]

Dear Dr. and friend, thank you so much for your videos, may God always be with you.

[@MedicosisPerfectionalis]

You too, dear :)
Thanks 🙏

[@sajedakanaan4662]

Thank you soooo much, my exam is on Monday and your videos were really helpful. I like your inspirational words at the last of the video.

[@MedicosisPerfectionalis]

Thanks a ton! Please consider sharing my videos with others! Good luck 🍀 with your exam!

[@banankhalid4072]

i really don't understand why ur channel is not popular! this was the 1st lecture i watched and i IMMEDIATELY subscribed !! GREAT WORK thumbs upppppppppppppppp

[@MedicosisPerfectionalis]

My channel is not popular because life is not fair 😂😂...Just kidding...Thanks a lot for your kind words!

[@nightlilly2918]

@@MedicosisPerfectionaliscongrats on 1.05 million 🎉🎉🎉

[@lordniloc101]

I have hereditary spherocytosis, and I lost my spleen and gall bladder to it. Definitely gonna show this to people

[@DJANM_G4MING]

I have it to

[@abedalee6985]

wats your age and hows now after it spleen removed ? tell me

[@abedalee6985]

share plz experience

[@abedalee6985]

@@DJANM_G4MING so how

[@louiscraik7235]

I have it but I’ve only had my gall bladder removed when I was 15 and I’m now 18

[@khalidk4069]

Well, as far as I know
Spherocytosis
Sickle cell disease
Hemoglobin C
These are the 3 cases when you can see an elevated MCHC. Usually its more than 37.

[@saadetnisakara2860]

You said the herediter spherocytosis is only anemia with high MCHC in the video. As far as ı know MCHC is also increases in Autoimmune Hemolytic Anemia and Sickle Cell Disease.Thank you for your instructive videos.

[@fatimamohamed7224]

u save me ,thank you my hematology class be come fun because of your talented explanation .

[@MedicosisPerfectionalis]

Thank you so much 😊

[@drmaham8439]

I m in final year now and looking forward to ur playlist of surgery and medicine 😍😍😍😍 u are awesome bro

[@MedicosisPerfectionalis]

Thanks 🙏

[@paigedesiree6181]

Finally a video I can refer people to when they ask me about my blood condition! 2 years ago I had my spleen and gall bladder removed. I’m the lucky one out of my siblings. They both had their spleens removed, but I got both my spleen and my gall bladder removed because I was the only one with gall stones. Thank you so much for this video it’ll really help me explain my condition to other people!

[@MedicosisPerfectionalis]

Thank you so much for your kind words.
Keep fighting the good fight.
Say Hi to your siblings!
Love ❤️

[@lordniloc101]

Bro Me too! I don't have a spleen or gall bladder because of this! We are family!

[@paigedesiree6181]

Colin Looby😂 I’ve never met a single person outside of my family that has this condition!

[@lordniloc101]

Me neither! I have struggled with jaundice and high hemoglobin all my life, and two years ago I collapsed and had my surgeries. Really scary stuff, but cool stories for my friends either way. I wonder what my life would be like without this condition, but I think God has a plan for us even if we don't see it ya know

[@paigedesiree6181]

Colin Looby Most definitely! In 6th grade I passed out in phy-Ed class and that’s when they figured out I needed surgery. I’ve also had countless teachers ask my why I’m so yellow my whole life as I struggle with jaundice too. Life would be easier I guess without Spherocytosis but I like being a little different. God definitely has a plan!

[@L.YAGAMI]

You are a GENIUS! Thanks from 🇮🇹

[@MedicosisPerfectionalis]

😍

[@shifa4290]

This is an amazing video! Pls continue or make more videos like this!!

[@MedicosisPerfectionalis]

Thanks for your encouragement 😃

[@anupambrahma4406]

Ohh.. so nice !! I am a path resident and preparing for final exam.. came across the video in a casual surfing.. You are love .. 😍😍

[@MedicosisPerfectionalis]

Thank you so much 😊

[@warrcoww6717]

I have Spherocytosis and didn’t know most of this, thanks guy.

[@MedicosisPerfectionalis]

You’re welcome!
How is your health now?

[@emmanuelpapi]

Bro I can tell, you lookin yellow af

[@carp3tstain]

"You can blame his parents!" haha

[@MedicosisPerfectionalis]

LOL!

[@ammry3333]

of course he isn't making fun of the patient he just wants you to remember

[@MedicosisPerfectionalis]

Exactly 👌

[@mariaGreenDay4ever]

I peed my pants 🤪🤣🤣🤣🤣

[@rida3209]

İ love the way u talk its intersting and ur explanation is amazing i learn so quickly from it thnk u

[@MedicosisPerfectionalis]

My pleasure 😇

[@tebibamina9563]

I just love how you simply explain 😍😍😍you are a GENIUS🤩Thank you so much

[@MedicosisPerfectionalis]

I appreciate you so much!

[@Eri-br9wv]

Im glad i saw this. Im only 19 and ive had this since i was a baby and recently had to have my gallbladder removed and my spleen is next, im so scared but knowing more about this condition is making me feel a bit better. It almost completely ruined my highschool life, after everything happened i couldnt go to school for awhile and risked all my hardwork to graduate on time and my goa also suffered at the end, it wasnt pretty but im determined to try and get into a good medical school to help people like myself if i can. Ik its alot to dream but what can i say im determined.

[@dorisvc4240]

I don't think I have the correct words to thank you enough for this video but .... THANK YOU SO MUCH!

[@MedicosisPerfectionalis]

You are always welcome...Thanks for watching!

[@Zyanide_]

I was diagnosed with moderate HS at age 7 and well I learn more here than doctors told me

[@MedicosisPerfectionalis]

Thank you!
How is your health now?

[@christianledesma9017]

This video explained everything so well and furthered my knowledge about my own body since I have this and had all the treatments stated however I’m still not sure why penicillin is controversial ? But I had the splenectomy and cholecystectomy when I was 13 due to having an abundance of gallstones which causes pains and maybe visits to the er but I’ve been better since just gotta eat clean though

[@xPlasticRosesx]

I was diagnosed with this at 14. My grandmother and great-grandfather had it. My grandmother had the splenectomy at the age of 20. She regretted it and it was her dying wish for me not to go through with the surgery that the doctors were suggesting. She died of liver cancer. As far as I know, great-grandpa died of old age and never did anything to treat the disease.
I'm 37 now, still have my spleen and my gallbladder, I would say that aside from sometimes being slightly anemic I'm in good health.
The last time I got all my bloodwork done one of the doctors that diagnosed me took a look and said it looked normal. Is this something that can just be outgrown?

[@sunevnu911]

Thank you so much! Your teaching skills are amazing ❤️

[@bhargavikn4320]

Wonderful videos! My heartfelt thanks! God bless!

[@MedicosisPerfectionalis]

You too, dear...Thanks!

[@justiniancruz6314]

You saved my ass from reading a lot of lecture materials for my theory exam. Subscribed!!!!!!

[@MedicosisPerfectionalis]

Welcome to the tribe, sir 😃

[@doctorofmedicine1113]

ist time i have shard someone's video to my friends ..
U will get more subscribers soon ...
Thasnkyuu

[@MedicosisPerfectionalis]

Thanks for sharing! I appreciate it :)

[@user-xz2ct5dt6o]

Thank you very much Dr.. greetings from Libya 😊

[@MedicosisPerfectionalis]

You are welcome, brother!

[@rafaelpeixoto7635]

Nice video, mate. Thank you for sharing this, it helped me a lot in some physiology classes

[@MedicosisPerfectionalis]

Awesome 👏
I am honored

[@MedicosisPerfectionalis]

Can you please help me by sharing my videos with your friends?

[@rafaelpeixoto7635]

@@MedicosisPerfectionalis I dit it already xD

[@MedicosisPerfectionalis]

Thanks a ton

[@abrahiemdash7676]

Bro you are amazing
Thanks for the great video i missed the class about this topic but I understand it now lol

[@aytakchichak7456]

thank you.. your videos are light in the darkness...🌺🌺

[@paulmontron4020]

I first didn t wanted to go through the hole 19:46 but it is so well explained that i did ! Awesome job ! :)
Thank you.

[@MedicosisPerfectionalis]

Thanks, brother...I’m so happy to hear that!

[@lamyaal-mansi2122]

Great job, thanx
Shall we give the patient iron?
Or post spleenectomy, when the source of destruction removed..
And many thanx for ur effort

[@candymay8116]

I have this but the splean remove of the age I was five and they took the gallbladder also it never helped my H.S would you think a bone marrow transplant would help or not help the Dr think it will but now I have Help and in ordering to take the bone marrow we have to stop the Hep C first but I with all my problams and no splean or gallbladder and the yellow joundious they said it to dangerous for me to take the hep.c treatment but they are new drugs out for the hep c treatment I am hummillic anima but my problam now it my iron leaves are high and I'm in stage 4 chrysos of the liver and they said the iro over load was becauses of it it's call hematomacrosis

[@ammarn3738]

Why MCHC increased ?
Is it due to mild dehydration ?

[@rubymusqan3792]

thanks a lot!! my whole study plan includes your videos. i have watched more than 20 videos from the hematology playlist just today. btw why is the MCHC increased in Hereditary spherocytosis?

[@MedicosisPerfectionalis]

Wow 🤩
Thank you so much, Ruby!
I really appreciate it!
MCHC is high in HS because the cell is more condensed.

[@bollywoodshorts8482]

Same question what about the MCH??

[@carmensanchez-th6lh]

God bless your little heart !!!!

[@MedicosisPerfectionalis]

Thanks 😊

[@siadulislamsoikot8084]

Superb bro🖤
Love from Bangladesh

[@SCC1606]

Hi!! I just want to say that your lectures are awesome!!!
Is there any Hodgkin and not Hodgkin lymphoma coming soon? pleeeeease?!! Please! I'm begging!

[@MedicosisPerfectionalis]

Thanks for your comment...Yea, they are coming soon 😃

[@chllovespizza]

hi may i know why the CB is being converted back into UCB in the gallbladder? is this part of the normal physiology as from what i know CB will travel down the biliary tree and be excreted out into urine and feces... pls correct me if im wrong:)

[@JANOELCIRUJANO]

Saludos desde Chile, eres mi ídolo

[@abdennourbourtal4685]

Aren't we gonna get iron overload if we give iron ?

[@ifrahakbar2878]

I WANT A MEDICINE AND SURGERY PLAYLIST PLEASEE SAVE MEEEEEEEEE

[@mawaddashaban477]

You are amazing !
The end 😂

[@MedicosisPerfectionalis]

😂😂 Thanks!

[@bkryyousf2954]

Thanks from sudan
🤗🤗😍😍🤗🤗

[@MohammadAli-fn2nj]

Thank you very much Sir, btw you sound like the kid from 'breakin bad'

[@emperor1368]

Actually watching your Videos Is much beneficial than Going through Those Bulky Books 🤣
Thanks sir !! No words Can Describe you your knowledge and Of course your wonderful videos ✔️❣️

[@Chisnamosas]

you are amazing explaining things

[@MedicosisPerfectionalis]

Thank you 😊

[@akshaybn97]

Love from India❤️..Thank youuu

[@MedicosisPerfectionalis]

My pleasure 😇

[@andreilica1454]

Hey i hope u will answer, first sorry for my English… my daughter has this problem, the spleen is smaller than last year , she is 6 and she always run , is verry active , I’m concerned because she’s hipeeactiv probably normal for a kid at she’s age … my question is : how bad can be for her condition beeing so active ?
Thx!

[@brandyj.8321]

I’ll never think of RBC again without thinking of a vagina 🤣😂🤣 excellent video from 5 generations of hereditary spherocytosis.

[@MedicosisPerfectionalis]

Thanks a ton!

[@QassamAlaa]

thank you so much but i have question . you mentioned that C.B is converted into U.B in the gall bladder ? does this happen in all cases of extra vascular hemolysis or only in spherocytosis cases ?

[@MedicosisPerfectionalis]

You mean unconjugated bilirubin to conjugated bilirubin.
Yes, it happens with all of extravascular hemolyses.

[@QassamAlaa]

@@MedicosisPerfectionalis Yes /thanks . but whats the purpose to give folate and iron for DNA synthesis if in all cases the cells produced will be spherocytes and will be destructed by the spleen ? does this mean that the patient have normal cells together with the spherocyte ? or you mean in autosomal dominant only ?

[@ana7909]

Thank you so much!

[@manalmubarak6055]

Amazing!!! thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@bollywoodshorts8482]

Nice vedio But what about MCH plz clear this confusion?

[@ammry3333]

Can we keep stimulating the patient bone marrow and give him folate and iron for the rest of his life?
Because I don't think splenectomy is a good choice

[@sidra_]

hi sir, do you have any videos on may hegglin anomaly, pelger huet anomaly, chediak, etc? it would be super helpful 😊

[@MedicosisPerfectionalis]

Unfortunately not! 😞

[@Doctor____Z]

Lot of thanks 🎉🎉🎉🎉🎉

[@MedicosisPerfectionalis]

My pleasure 😇

[@meryemlahbara2834]

You are born to teach … ❤❤

[@MedicosisPerfectionalis]

Thank you!

[@ParvinRecipes]

Just a question from an egyptian fellow, isn’t hemolysis equals iron accumulation in the body? So isn’t it logical to decrease iron whether through diet or drugs?

[@MedicosisPerfectionalis]

Decrease what “iron”?
Serum iron, transferrin, or ferritin?

[@ParvinRecipes]

Not the lab ones, the external sources ( like high iron meals, supplement )
Isn’t hereditary spherocytosis cause RBCs to rapture? Which means iron released into the body ( serum or liver as a storage or whatever ) so isn’t it logical to decrease iron intake in meals or supplement?

[@ParvinRecipes]

In another word, what’s the nutritional plan should these kind of patients receive?
A low iron diet?

[@MedicosisPerfectionalis]

No, because there serum iron level is usually low, because the bone marrow has used all the iron to make new RBCs...Remember, that it's working like crazy, also other organs are working like crazy (extrameduallary hematopoiesis) consuming all the iron.

[@sabitjan494]

Thank you so so much.you helped me alot.

[@MedicosisPerfectionalis]

Thank YOU for watching! Good luck!

[@sabitjan494]

thanks !)

[@kawinewmai]

Ty

[@MedicosisPerfectionalis]

My pleasure!

[@nutella1317]

yes you the best keep going i like you lecture I'm from somail

[@MedicosisPerfectionalis]

Thank you so much 😊

[@nutella1317]

really thanks too you

[@kii9579]

شكرا❤❤❤❤❤❤

[@MedicosisPerfectionalis]

🙏🙏

[@ibtesamawad746]

Amazing! ✨💙

[@MedicosisPerfectionalis]

Thanks 🙏

[@tirthankarroychoudhury5795]

Just explain why MCHC gets increased

[@jiminslostjams250]

I am doing a project for this where did you get the information from

[@MedicosisPerfectionalis]

Harrison’s, Cecil and Davidson’s

[@manager-nim2623]

Armys everywhere amirite

[@kerthushanmugam980]

How much perecent if HS run in family??shall we prevent this ??Are All children getting Hs from their parents?

[@Rena-ol7dn]

My mum had 4 of us and 2 of us kids had HS.
My sister had 2 kids and 1 has Hs all us with spleens taken out and are all very healthy.
I had one child he's fine, maybe if I had another they'd have HS

[@Jeene269]

The way you said I know is terrible I feel it🥲 anyway nice explanation 👏

[@catto2797]

Nice explanation

[@MedicosisPerfectionalis]

Thank you so much 😊

[@arfanmushtaq3594]

Actually my sister in law got hereditary spherocytosis ,now my wife is pregnant ,now could u plz enlighten me how to prevent my new born baby from hereditary shperocytosis

[@MedicosisPerfectionalis]

You can’t prevent it! It’s genetic...You can ask your doctor to order genetic studies on the fetus/ your pregnant wife to diagnose Hereditary spherocytosis...Talk to your doctor...I wish you the best!

[@chaditabaja1316]

god bless you bro you are amazing

[@MedicosisPerfectionalis]

Thank you so much! God bless you too!

[@21beastfromtheeast]

I have this and have both my spleen and Gallbladder removed at age 2 👍🏼

[@MedicosisPerfectionalis]

I am so sorry to hear that.
How is your health now?

[@abdhulnizar8409]

😲 how r u now

[@rayayalmaz9403]

Ayyyy my questions does not finish, no hope for me... Why the conjugated bilirubin will be high? The conjugation won't overload the unconjugated bilirubin so, it still being high. Is conjugated bilirubin is due to stucked gallstones?

[@MedicosisPerfectionalis]

The conjugated will be slightly elevated, because the liver is working hard trying to conjugate the excessive unconjugated billirubin!

[@rayayalmaz9403]

@@MedicosisPerfectionalis what can i say!!! Thanks a billion, my stupid teachers nevers taught me that, they always say that conjugated bilirubin shouldn't be in blood stream and today i discover a receptor called MPR 3... Allah blesses you, in chaa allah you will be a big icon in medecine like Ibn sina and Rhazi.

[@marwaali1106]

THANKYOU SO MUCH!

[@MedicosisPerfectionalis]

My pleasure 😇

[@abhikhalder7351]

FYI : MCHC also increases in Autoimmune Hemolytic Anaemia.

[@b_p5558]

I have this. I just searched up the disease because I wanted to see if much people knew about it.

[@MedicosisPerfectionalis]

Thank you so much for watching!
How is your health now?

[@b_p5558]

Medicosis Perfectionalis it’s good, I have no spleen but I’m better than ever

[@amalRay23]

Is it normocytic normohromic anemia?

[@MedicosisPerfectionalis]

What does “it” refer to?

[@miguelquiroz4635]

Niceeee video mate

[@MedicosisPerfectionalis]

Thanks 🙏

[@samirnacer9206]

Legit where you made the correction between homo and hetero..... was the question I just got wrong on nbme.... Simpson homer “doeee!”

[@MedicosisPerfectionalis]

😮

[@tamaradimes4438]

thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@MennaKamel]

You’re amazing

[@MedicosisPerfectionalis]

Thanks 🙏

[@spiritninja5757]

I actually have hereditary spherocytosis

[@nisreennajim7433]

Excellent

[@MedicosisPerfectionalis]

Thanks 🙏

[@nejlabn1796]

Hi thanks for the video
I just have a question is this RBC functional or not 😳

[@MedicosisPerfectionalis]

It depends on what you mean by “functional”.

[@nejlabn1796]

@@MedicosisPerfectionalis can transport oxygen?

[@MedicosisPerfectionalis]

Yes, but there’s a high risk of hemolysis.

[@brucezarnick4345]

AFTER SPLENECTOMY DOES THE PERSON STILL EXPERIENCE LOW OXYGEN , FATIGUE, AND OTHER SYMPTOMS AND WHAT ARE THE LONG TERM EFFECTS OF HS AFTER SPLENECTOMY

[@MedicosisPerfectionalis]

It’s possible.
Please talk to your doctor

[@crazydog1625]

One long term effect would be immune system issues meaning theirs a possibility you’ll get sick more often than others will.

[@Rena-ol7dn]

No, I'm absolutely fine. I've never had a day off work in over 10yrs.

[@abedalee6985]

I had HS since 20 years with

[@MedicosisPerfectionalis]

I am sorry 😐

[@manman-eu2zz]

I have this and I am currently fighting with a problem right now form it

[@MedicosisPerfectionalis]

I am so sorry to hear that.
Don’t give up, please!

[@manman-eu2zz]

Medicosis Perfectionalis my body has stopped production of blood, so I got 4 units of blood and I don’t know what now

[@MedicosisPerfectionalis]

Why did your body stop producing blood?

[@manman-eu2zz]

Medicosis Perfectionalis i caught a virus and it messed up my body I just came back from the doctor she said my numbers are going down

[@darryljaymartin7356]

Can i ask for pdf of this topic?

[@MedicosisPerfectionalis]

Here: www.medicosisperfectionalis.com/products/p/video-notes/hematology/

[@InesDjem_]

I just love you lol thanks

[@MedicosisPerfectionalis]

❤️❤️

[@andreeadinca4268]

Watching the video for the 3rd time at 1,75x, still great explanation 😂

[@MedicosisPerfectionalis]

Thank you 🙏