Celiac Disease and Gluten
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- čas přidán 6. 07. 2024
- Gluten-free foods are almost everywhere, and for a good reason - around 1% of the world population suffer from celiac disease and cannot eat gluten. What happens in the body when gluten is eaten, and why does it lead to symptoms like diarrhea, malnutrition, or even anemia? Watch this episode of Medicurio to find out!
EXTRA INFORMATION ABOUT CELIAC DISEASE
Are oats safe for celiac patients to eat?
Most people with celiac disease can tolerate avenins, the gluten protein found in oats. However, they should still be cautious because oats may be contaminated with gluten proteins from wheat/barley/rye, as these grains are often processed in the same factory. Discuss with a dietician or physician when deciding if oats should be included in a gluten-free diet.
What kinds of food contain gluten?
The Celiac Disease Foundation has a list here: bit.ly/1DtfMdL
Why are antibodies against gluten and tissue transglutaminase produced?
B cells have unique B cell receptors (BCR). Whatever the BCR can bind to, the antibodies this B cell produces will bind to. When a protein binds to a particular B cell’s BCR, it gets internalized, broken down into small peptides, and presented on MHC class II proteins on the surface. If an activated helper T cell can bind to the B cell’s MHC class II protein using their TCR, they can activate the B cell. The B cell then starts producing antibodies against the protein that was internalized.
For gluten peptides, the B cell internalizes these peptides and presents them to T cells, which will recognize them with their TCR since they were activated by dendritic cells earlier with the same peptide. The B cell then produces antibodies against the gluten peptides.
For tissue transglutaminase (tTG), since tTG needs to bind to gluten peptides to modify them, they often exist as one protein complex. B cells that have BCRs that can bind to tTG will internalize a complex with both tTG and gluten peptides. When they break that complex down into smaller peptides, the B cell will present both fragments of tTG and gluten peptides on their MHC class II protein. Activated helper T cells will recognize gluten peptides and activate this B cell, but this B cell will produce antibodies that are against tTG since its BCR could bind to tTG.
What are the rates of HLA-DQ2 or 8 in the world? What about for celiac disease?
Look up your country in this link for HLA-DQ2 or 8 rates: bit.ly/2rRhGVJ
The World Gastroenterology Organisation also has a list of celiac disease rates in different countries here (click the Epidemiology section): bit.ly/2p9Ne67
Notice how the countries with more people with HLA-DQ2 or 8 also have more people with celiac disease!
What tests are involved for diagnosing celiac disease?
The Celiac Disease Foundation has great explanations:
Blood test and Genetic Screening: bit.ly/2hqRIjN
Endoscopy: bit.ly/2E0djMN
What about wheat allergies and other gluten-induced diseases?
Celiac disease is a slow, autoimmune disorder that damages the intestines. Wheat allergies occur very quickly and can result in anaphylactic shock, but damage to tissue is limited. Imagine a peanut allergy, but with gluten instead. Gluten ataxia is when the autoimmune damage is to the brain instead of the intestine, resulting in loss of motor coordination. Finally, non-celiac gluten sensitivity is a blanket term that is diagnosed by elimination - if a person’s symptoms get better after going on a gluten-free diet but tests have been negative for the previous three conditions, then they are diagnosed with NCGS. Symptoms include both intestinal and non-intestinal (headaches, depression, fatigue) symptoms, but the mechanism is unknown.
Why do some celiac disease patients develop rashes?
Medically, this rash is called dermatitis herpetiformis, and is described as an intensely itchy blistering that can occur anywhere on the body. While the mechanisms are not well understood, scientists believe that the tissue transglutaminase antibodies that are produced in the intestine eventually enter the bloodstream and end up binding to tissue transglutaminase found in the skin (epithelium). Antibodies stimulate the immune system, resulting in inflammation that causes itchiness and a burning sensation, which subsides after going on a gluten-free diet.
What is refractory celiac disease?
Refractory celiac disease describes the condition in which even after going on a gluten-free diet for over a year, the intestine does not recover and symptoms persist. It is not well understood what causes this phenomenon. If this is the case, immunosuppressants such as steroids should be used to suppress the immune system. However, most causes of “refractory” celiac disease are actually due to the patient still eating gluten without realizing it. This is why it is so important for people to know what contains gluten and what does not.
So I watched this video and as a result, went to the Doctor's to get diagnosed. I had most of the symptoms, but I have always been told it was something different (dermatitis was allergies, occasional blood in my stool and flatulence was IBS, diet deficiencies was because I was vegan, mood swings was depression; along with basically all the others.) It always fluctuated though. Sometimes I'd wake up at 7am and work all day and feel great, while other times I'd wake up after sleeping for 12 hours feeling tired with aching joints, and not wanting to leave my bed all day. Well whad'ya know. Undiagnosed f*ing Celiac Disease. Thank you so so so much for putting this out there. I hope this channel explodes in popularity. You deserve every bit of it.
Wow. Your comment really means a lot to me - to realize that my videos are actually making a real difference in someone's life has been the whole point of making them all along. I'm glad you finally know what's going on with your body. Take care!
@Eromasin wait whaat? now iam scared cause me too
@Cookie Monster sounds like she had a confirmed diagnosis after
Ask your doctor to investigate about ATIs (amylase/trypsin-inhibitors), that are present in wheat grains. Not only gluten can be a trigger to cause these symptoms.
My girlfriend has Celiac disease and this video has been not only informative, but also very comforting. It's nice to know that someone spent their time putting together a video to spread information on this disease, as it was awful for her before we finally figured out the cause. Keep up the amazing work :)
Hi Eric. Can you watch my video about Celiac and tell me what you think.
It's on CZcams.
Search my name dusty jann
and it'll be there. Thank you so much!
Very informative, I’m also going to use this opportunity to recommend Dr IGUDIA on CZcams who cured my coeliac disease with his natural herbs medication
My friend has Coeliac Disease Wheat Sensitivity, after consulting an online Biotheraphy treatment, he is able to consume gluten in recommended quantity on daily basis....
I have Celiacs and you honestly were more informative than most of my doctor visits haha
Exactly right. Doctors could easily point us in the direction of resources like this.
That's so sad to hear you are still suffering from this same disease. Am feeling for you right now, I know of a doctor who can help you get rid of this. He also help me from this same disease, He can also help cure yours permanently
Yup, recently diagnosed
I also have celiac
@@gracehaward5330 smh the only treatment is following a gluten free diet for life
I've been really busy the past few months preparing for medical school applications and interviews, so sorry that I haven't posted in a while. Thank you everyone for continuing to support my channel!
References:
Kupfer, S.S., & Jabri, B. (2012). Celiac Disease Pathophysiology. Gastrointestinal Endoscopy Clinics of North America, 22(4). www.ncbi.nlm.nih.gov/pmc/articles/PMC3872820/
Caja, S., Mäki, M., Kaukinen, K., & Lindfors, K. (2011). Antibodies in celiac disease: implications beyond diagnostics. Cellular and Molecular Immunology, 8(2), 103-109. www.ncbi.nlm.nih.gov/pmc/articles/PMC4003135/
Tjon, J. M.-L., van Bergen, J., & Koning, F. (2010). Celiac disease: how complicated can it get? Immunogenetics, 62(10), 641-651. www.ncbi.nlm.nih.gov/pmc/articles/PMC2944025/
Alaedini A, Green PH. (2008). Autoantibodies in celiac disease. Autoimmunity, 41(1):19-26. www.ncbi.nlm.nih.gov/pubmed/18176861
Skovbjerg H, Koch C, Anthonsen D, Sjöström H. (2004). Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim Biophys Acta, 1690(3):220-30. www.ncbi.nlm.nih.gov/pubmed/15511629
Oberhuber G. (2000). Histopathology of celiac disease. Biomedical Pharmacotherapy, 54(7):368-72. www.ncbi.nlm.nih.gov/pubmed/10989975
This is a great channel because it does not dumb down the information in an attempt to appeal to a bigger audience.
*quality*
I've an MD degree and study to resurface old med info and want to tell from my perspective you have an excellent info filter and I enjoy your videos and wish you had resources to make thousands of them right away so they would be available to study from. otherwise, thanks for your efforts as able. -dave
How long does it take for the villi to get back to normal as long as I stay on a gluten free diet?
I so glad being a coeliac that someone spent the time to put this together thank you so much
Dude that video was so good. So much detailed information and so easy to understand and well presented. Great Job, I hope you get more attention. You deserve it!
hey dude thank you for a very informative video i really appreciate it. I hope you had as much fun making it as i had watching it.
love you
The explanation and animation are just brilliant! Thank you for making such a great and in-depth material!
Great video! I'm very happy to see you're still making them.
I'm only a few videos into your channel my friend and have always been highly intrigued with medicine and physiology just for the sake of knowing, already it's so apparent how much effort and how palatable you make your videos are. You are rekindling my interest for the human body and allowing me to be aware of its ever complex functions so I'm so much prepared. Stay well and i really hope you continue making videos
The best video break down ever. Everyone else I’ve watched were so confusing! Thank you!
This is amazing 🙌🏼 it’s so hard to explain the mechanisms of celiacs to people even if they are biology majors in my classes. You’re a real one for this
Great video! Glad to see you're uploading again!
Very simple, informative and helpful! Thank you!
I just found out about your channel and I love it! You are very underrated...
Great quality and super informative
I was diagnosed when I was 4 and I’m now doing a science project for school and this vid is very helpful
Can you pls tell me your height and weight and any other things that you’ve been through
Thank you very much for the great explanation! I've discovered your channel just today. Hope to see new videos soon.
Thank you so much for doing this! As someone who deals with celiac and another condition called "Cyclical vomiting syndrome" or "CVS". this will help so much in explaining to others why my stomach and me don't always get along! Just wondering if anyone here has heard of or is dealing with CVS as it's quite rare.
Thank you. This was the only video i could understand the disease. It was also very detailed.
Thanks you so much. A perfect balance of informative and clearly explained.
Celiac disease develops a hereditary and autoimmune that usually affects the small intestine that occurs in genetically predetermined people. When people with this problem consume a protein called gluten (found in wheat, barley and rye), it helps to protect the small intestine in their body. So this attack and damage the small intestine as well as the villi (small finger like projections along the wall of the small intestine). When the villi is damaged, the absorption of nutrition within the human body stops. There are various symptoms of celiac disease and they include diarrhea, nutritional deficiency (anemia, nutritional deficiency), loss of appetite, abnormal growth in children, late puberty, pregnancy complications, some Dermatitis, small and under-active spleen, liver failing to function properly and abdominal enlargement. Mouth ulcers, gastrointestinal problems, diabetes mellitus type 1 and thyroiditis are also associated with celiac disease, which can occur when the problem is not treated properly.
This is awesome! Great video!
Quality content, thanks!
Nice to see you again !
I always love learning about biology keep the videos up
most useful Thankyou very much
I have celiac and this video informed me so much more than what the gastrointestinal doctor ever could! It sucks but this really helped to understand so I can help get myself on the right track sooner. It's kinda hard to try to make something better when you dont know what the hell it is! Lol
Get the amazing liver and gallbladder flush by Andreas moritz
Can you tell me your symptoms and your illness story
How wonderful you are ?
Thanks alot 💙
Quality vid! Earned yourself a sub!
You better start growing like a madman because i cant take such long breaks.
Your height
It would be a great help if you also share the source of information here.
Excellent info
Came here from Tier Zoo, subbing for the knowledge. Cheers!
I was diagnosed with Celiac Disease in 2009
I hate having this.
Very clear 👍🏻👍🏻
More informative
Please do more videos
Thank u
Thank you for this informative and “easily digestible” video. I am going to post to our local gluten free FB page.
Nice.
Can you talk about GERD in one of your videos and its known treatments?
Your video is great! I just found out i have celiac and there were alot of things i didnt know about the disease before that video. Hope your video will reach other people too (:
That's so sad to hear you are still suffering from this same disease. Am feeling for you right now, I know of a doctor who can help you get rid of this. He also help me from this same disease, He can also help cure yours permanently
Thank u!
Great and informative video, so glad tierzoo gave a shoutout to your channel
Wow, great video and explanation.
I feel I am not Celiac, but I have some issues with consumption of containing Gluten products.
I have all simptoms, and seasonal allergy.
Recently (2020) I have been diagnosed with CRSwNP polyps in nose.
Got surgery and it came back in 12 months time.
@Medicurio do you think celiac disease is related to acne?
Wow bravo❤pls make more medical videos
How long did this video take to be done? Ir must have gone you a hard work tho. Keep up the good job!! Love your videos.
This took me about 40 hours from researching the topic to editing the video. Glad you enjoyed it!
Medicurio I really did! Good content, quality information and easy to understand. Greetings from Brazil.
so good
I have celiac disease and DH (dermatitis herpetiformis, rash with blisters). I was on a very strict Gluten free diet but kept getting sick. Well, please be aware that just staying away from gluten isn't the only answer. Gluten is a LECTIN. You have to stay away from lectins.
One I went on a lectin free diet, I no longer suffer from the horrible itchy rash, migraines and intestinal problems. Also, joint pain and muscle aches improved as well.
Dr. Steven Gundry has a great lectin free diet....look up his Yes and No list. Please do it, it will improve your life.
As a celiac I’m coming to realise, being gluten free really isn’t enough. Then you cut out all lectins 😢 and it’s going to be one pretty tough diet. Not much left variety wise, it’s hard enough eating out being celiac. I have all those symptoms you listed, I’m willing to try it. Thank you, I will tune into Dr Gundry. 😉
Hey you're back :D
...Don't go away again please :(
If i understand correctly, changing environment may trigger celiac disease. I met some immigrants, they started the celiac disease symptoms since they moved to Canada. Are organic food helpful?
More vids
Can it cause your blood sugar to rise?
Really love the video and found it really informative. Only flaw i have is with the endoscope at 12:39 . Wouldn't you insert it through the nose normally instead of the mouth?
Nasal endoscopies do exist - but they are mainly for taking images of sinuses and nasal passages (care.american-rhinologic.org/nasal_endoscopy). To image the digestive system, the main passage is through the mouth. Here's a good video showing how it works: czcams.com/video/OmsNjUOvbSs/video.htmlm7s
Yay new video!
Where did you adapt this information from? I am writing an essay on Coeliac Disease and would like to use some of this information.
Kupfer, S.S., & Jabri, B. (2012). Celiac Disease Pathophysiology.
Gastrointestinal Endoscopy Clinics of North America, 22(4). www.ncbi.nlm.nih.gov/pmc/articles/PMC3872820/
Caja, S., Mäki, M., Kaukinen, K., & Lindfors, K. (2011). Antibodies
in celiac disease: implications beyond diagnostics. Cellular and
Molecular Immunology, 8(2), 103-109. www.ncbi.nlm.nih.gov/pmc/articles/PMC4003135/
Tjon, J. M.-L., van Bergen, J., & Koning, F. (2010). Celiac disease:
how complicated can it get? Immunogenetics, 62(10), 641-651. www.ncbi.nlm.nih.gov/pmc/articles/PMC2944025/
Alaedini A, Green PH. (2008). Autoantibodies in celiac disease. Autoimmunity, 41(1):19-26. www.ncbi.nlm.nih.gov/pubmed/18176861
Skovbjerg H, Koch C, Anthonsen D, Sjöström H. (2004). Deamidation and
cross-linking of gliadin peptides by transglutaminases and the relation
to celiac disease. Biochim Biophys Acta, 1690(3):220-30. www.ncbi.nlm.nih.gov/pubmed/15511629
Oberhuber G. (2000). Histopathology of celiac disease. Biomedical Pharmacotherapy, 54(7):368-72. www.ncbi.nlm.nih.gov/pubmed/10989975
It took me 5 years of complaining about symptoms before my genius Dr sent me to someone who finally got the diagnosis underway. I had the scope first and the easy bloodwork as a backup
Can you tell me your symptoms pls
Celiac is not diagnosed when i tested from laboratory. But i can not drink and eat properly. There is lot of stomach pain and pain is relieved when i eat something, then motion start. The pain is worse between meals and night. When i eat rice i feel relaxed but lot of rice leads to asthma at night. Plz help
Please make more videos....n tat too more frequently....😊
Sir i have celiac disease and suffering from lack of sleep is this normal?pls reply🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🏻
I'm T2 diabetes and celiac, very hard to treat both, food i need for t2 i cant have due to celiac and vise versa, cant just go to any dietitian, have to see a dietitian who specializes in both T2 and C .
I don't have celiac disease as far as I know, but I did one of those genetic testing kits which showed I am more likely to develop the disease. What a cruel fate. I love beer and bread :(
But you’re really lucky that you find out even before being ill
But what leaded you to do genetic test that’s awesome I don’t think that we have such these tests in our country
if a T cell tries to bind to a dandril peptide but fails, does that mean its food ? because each bacteria has its own peptide ?
so how can a T cell have a peptide that fits with something it Does not know ???
I'm your biggest fan.
CAC Curcumin capsule is prepared from the herb turmeric. The herb turmeric (Curcuma longa) contains the active compound curcumin that shows antioxidant, anti-inflammatory, analgesic, & immuno-modulator properties. These properties deal with the pain in abdomen, loss of appetite, indigestion, & improve overall digestion. It helps in building up the immunity of the small intestine to deal with the coeliac condition.
So do a lot more. But they are Asymptomatic
Can you translet urdu plzzz
I have celiac and it sucks I have headaches all the time
My daughter has celiac and she has headaches all the time as well but I had no idea they were related to celiac
Thanks
I am only 10 and I figured out I have celiac disease when I was nine
...I better stop eating bread...
How many days it will take to complete heal...??
This will vary from person to person. After adopting a gluten-free diet, for 70% of people, symptoms will begin to improve by 2 weeks. A normal anti-tTG level is achieved by 3-6 months. Improvement in intestinal villi atrophy may be seen at 4-6 months, although complete mucosal recovery may take a few years. Regular follow up with your doctor and dietician are extremely important during this time.
References:
Ciclitira, PJ. Management of celiac disease in adults. In: UpToDate, Post, TW (Ed), UpToDate, Waltham, MA, 2020.
Rubio-Tapia A, Rahim MW, See JA, Lahr BD, Wu TT, Murray JA. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am J Gastroenterol. 2010;105(6):1412‐1420.
Thank you so much for ur reply....☺☺👍👍
That's so sad to hear you are still suffering from this same disease. Am feeling for you right now, I know of a doctor who can help you get rid of this. He also help me from this same disease, He can also help cure yours permanently
dead line
4:27
I got gluten
And oh boy am I in terrible pain
Ok, so I found you through Tierzoo.
*Why aren't you bigger?!*
How the hell do humans know this is what happens?
The Tier Zoo sent me.
TierZoo brought me here.
I have been gluten free since 2nd grade and just recently I have been eating things like Oreos and bread. I hope I die
Another terrible disorder :/
Absolutely.
Yes, it is. It annoys me some folk think of it as a snowflake syndrome, or a fad diet. It IS a serious disease.
Thankyou veey much for explanation
I've an MD degree and study to resurface old med info and want to tell from my perspective you have an excellent info filter and I enjoy your videos and wish you had resources to make thousands of them right away so they would be available to study from. otherwise, thanks for your efforts as able. -dave
I've an MD degree and study to resurface old med info and want to tell from my perspective you have an excellent info filter and I enjoy your videos and wish you had resources to make thousands of them right away so they would be available to study from. otherwise, thanks for your efforts as able. -dave