Thalassemia Major | Iron Chelation Therapy | Pediatrics

[@NeerajPatidar-cg8nw]

Why deferiprone is given tds and desferal od mam any specific reason?

[@learningpediatrics5347]

Deferasirox's plasma half-life is 8 to 16 hours, once-daily dosing permits circulating drug for 24 hours
While Deferiprone is having short half life of 2-3 hours so Requires at least 3-times-per-day dosing

[@learningpediatrics5347]

Desferal is having very short half life of minutes only so requires constant subcutaneous infusion.

[@NeerajPatidar-cg8nw]

Thankyou 😊😊

[@drliaqatalishah]

Yersinia infection due to iron excretion??

[@learningpediatrics5347]

Iron overload and desferrioxamine use both are predisposing factors for yersinia infection

[@drliaqatalishah]

@Learning Pediatrics thanks.other iron chelator as well