Controlling crystals for more reliable drugs | Headline Science
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- čas přidán 7. 09. 2024
- Sometimes, compounds crystallize in unexpected ways. This is a problem for drug manufacturers, who need to create consistent products. Scientists are working to understand why substances take on different crystal forms, called polymorphs, under different conditions. Recently, they’ve shown that impurities can affect the relative stability of those forms.
Read the paper: doi.org/10.102...
(Corresponding author: Fredrik L. Nordstrom, Ph.D.)
Video credits:
Written by Anne Hylden
Produced by Anne Hylden, Kerri Jansen and Andrew Sobey
Edited by Vangie Koonce
Narrated by Anne Hylden
Executive produced by Matthew Radcliff
Research videos from Mitchell Paolello and Seyed Sepehr Mohajerani
Scientific consultant: Gerard Capellades, Ph.D.
Additional video: Darren Weaver
Hand models: Anne Hylden, Kerri Jansen and Allison Tau
Music: “Handwriting” by Frank Jonsson from Epidemic Sound
Sound effects from Soundsnap
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#crystals #science #chemistry #pharma
A very appropriate video to pop up on my feed. I've been swimming in polymorphs recently and its doing my head in.
Crystal growth is black magic. I swear, moving a crucible 2cm to the left: different crystal. Recipe works with alumina crucible for me, but lab down the hall can only get it to work with platinum crucibles, using the same batch of chemicals.
It’s probably down to very slight differences in humidity, ambient airflow, solvent quality, reagent quality, or any one/combination of hundreds of variables
This was the inspiration for the Kurt Vonnegut book, Cat's Cradle and the fictional substance ice9
They get approval for one polymorph.
Is that for patent reasons or does the drug work differently in a different shape?
Mostly for patent reasons, but also the polymorphic form can affect properties like solubility.
If you look up "disappearing polymorphs," you'll find examples where drug makers had to change their formulations when they kept getting the wrong crystal form.
This is true. LOL. In the world of methamphetamine, you could tell when it was of lesser quality by the crystalline structure sometimes.
Oh, interesting!
huh i wonder where you found out about this very interesting bit of info
Personally I love these crystals and I love all crystals #rockhounding #bryanchannell7715