LEV is inching closer! Rejuvenating mitochondria - Clinical Trials
Vložit
- čas přidán 4. 05. 2024
- There are several clinical trials and research initiatives in Japan focused on drugs and therapies aimed at rejuvenating mitochondria. One notable example is the approval of Imeglimin, a first-in-class mitochondria-targeted reagent for type 2 diabetes, by a French biopharmaceutical company, Poxel SA. This drug has been approved for marketing in Japan as of 2021 and has shown favorable safety and tolerability[2]. Imeglimin targets mitochondrial function, which is crucial for its therapeutic effects in diabetes management, indirectly contributing to mitochondrial health.
Additionally, Japan is involved in various other clinical trials and research projects that explore mitochondrial rejuvenation through different mechanisms and diseases. For instance, the clinical trial registry and research initiatives often include studies on mitochondrial diseases and therapies that could potentially rejuvenate mitochondrial function. However, specific ongoing trials directly targeting mitochondrial rejuvenation in Japan were not detailed in the provided search results.
For a comprehensive understanding of all current mitochondrial rejuvenation drug trials in Japan, one would typically refer to databases like ClinicalTrials.gov or research publications from relevant Japanese research institutions and pharmaceutical companies. These sources would provide detailed information on the scope, stage, and findings of such trials.
Citations:
[1] www.ncbi.nlm.nih.gov/pmc/arti...
[2] www.ncbi.nlm.nih.gov/pmc/arti...
[3] www.nature.com/articles/s4141...
[4] pubmed.ncbi.nlm.nih.gov/33473...
[5] classic.clinicaltrials.gov/Pr...
[6] pubmed.ncbi.nlm.nih.gov/30917...
[7] pubmed.ncbi.nlm.nih.gov/36320...
[8] www.astellas.com/en/stories/m...
[9] classic.clinicaltrials.gov/ct...
[10] classic.clinicaltrials.gov/Pr...
[11] pubmed.ncbi.nlm.nih.gov/30348...
[12] classic.clinicaltrials.gov/Pr...
[13] www.mitomoonshot.med.tohoku.a...
[14] pubmed.ncbi.nlm.nih.gov/26850...
[15] classic.clinicaltrials.gov/Pr...
[16] www.sciencedirect.com/science...
[17] classic.clinicaltrials.gov/ct...
[18] onlinelibrary.wiley.com/doi/f...
[19] classic.clinicaltrials.gov/ct...
[20] www.raddarj.org/en/registry/a... - Věda a technologie
I immediately think of tolkins elves, how few children they have, their longevity, and their patience and ability to spend time being artisans rather than rushing their lives.
Edit. Like some have said, and I totally agree, there also comes much grief amongst the elves
Yeah but broken hearts always end them.
It is actually one example I hand out these days - that humans turn into Tolkien's elves, also because those are very advanced (magic, but still).
@@JohnSmith762A11B As depression does humans - at the end one can say they end through some sort of unconscious suicide, loosing the will to live.
Bryan Johnson is the first true elf
@JohnSmith762A11B honestly that's one thing medicine can't really cure yet
If you've ever been divorced.....we all mourn the loss of those years wasted!!! Bring it on!! Please, please, please give me 25yrs back!
soon we're gonna have "trans age" people.
Heeehehehheeeeee just b gay instead
I'm ok with the heat death of the universe getting me. That's an acceptable amount of time to me 😂
And even that will be solved eventually.
I am NOT 😁
You say that now...
I've always had my doubts about the 'heat death' model - our models of cosmology are still radically changing every decade or so, and there are still big uncertainties about the nature of dark energy & dark matter; I don't think we can have a great deal of confidence in predictions about the far future of the universe given our current state of knowledge. In particular, it's not clear that the 2nd law of thermodynamics applies to the universe as a whole, since it's not clear that it makes sense to call the universe an 'isolated system'.
You’re right… plenty of time to figure out universe b by then
I am 41 about to be 42. Because of Brittle Bones Disease I could never walk in my life and always lived on crutches and wheelchair. I hope before I reach 50 I get this therapy not only to reverse my age but able to walk normal like the rest.
Because of my disability I couldn't marry a decent woman and woman I married to divorced me because she saw I kept breaking and she didn't want to take care of me.
I hope you can be healed in the near future mate, looks promising
that sounds so hard. Hoping that you will be able to walk soon with these therapies.
Heartbreaking. It's cruel that we have people living with diseases like that. Really hope you can make it to LEV and start your real life.
Would that work? I mean, even if the gene is fixed - would you need some sort of bone strenghening (via nanobots or implants) would is there a self healing factor that could be activated?
@@ThomasTomiczek Idk maybe my bones can be replaced by some aluminum or steel metal?
Anything that makes me walk. All my life I saw everyone around me walking and with sad heart just sighed. I wanted to dress like a gentleman and walk before I die.
Japan has been Fast tracking a lot of clinical trials for quite some time now and it usually goes nowhere. Just look at all those hair cures and cloning clinical trials. most are based on small animal clinical trials that have a failure rate as high as 99.99%.
Possibly a version of Super A.G.I can make the difference. As I believe theirs 9 to 13 Hallmarks of aging.
1. Genomic instability
2. Telomere attrition
3. Epigenetic alterations
4. Loss of proteostasis
5. Deregulated nutrient-sensing
(6. Mitochondrial dysfunction, is only one of many Hallmarks of aging)
7. Cellular senescence
8. Stem-cell exhaustion
9. Altered intercellular communication
Yep...we are not even close to the beginning of living forever even if that is possible (which I dont believe it is).
Imeglimin is already available in Japan ! Commercialization just started. I just bought some poxel shares after seeing this video :)
This is why Im fascinated by Michael Levins bioelectrics and electroceutical work. What he's doing is more like high-level subroutine calls rather than writing peices of code. Electroceutical in combination with drugs can orchestrate so many things simultaneously. For example, Levin has demonstrated starting and stopping cancer, controlling morphology, etc, all by controlling the bioelectric field. No genetic engineering or special proteins, just altering the bioelectrics only.
@@mjr7991to live forever we also need fatal accident prevention but I have reason to believe if we last another 10 or 20 years longevity escape velocity will begin. We need something to give us the amount of time needed to get the following antaging intervention.
You get your mitochondria from your mother. She got it from her mother. There must be a way to reset them.
This is a very interesting way of thinking about it - makes the concept seem not just plausible, but probable.
How does this follow? I'm not getting it.
@@popothebright Ageing has a lot of hallmarks. Your body creates new cells all the time, but they deteriorate as they divide and we age. Some magic is happening when a child is conceived. Even though the cells starting the embryo come from aged individuals, the child starts from zero. A lot of the anti-ageing effort is about understanding this process.
@@mrleenudlerI’ve never thought of this before
I just bought some poxel shares after seeing this video :)
9:15 the irony of Dave telling us we're going to live for Centuries whilst simultaneously nearly slipping and drowning in a river!
😂😂😂😂😂
Yeah, I thought the same "we are going to live forev..." /*brokes neck/*
I had the same thought. Maximum universal irony: Having a fatal accident while disclosing a pivotal longevity breakthrough. The universe does have a sense of humor. Good thing he wasn’t driving a Segway.
@@paultoensing3126 🤣🤣🤣
@@alespider9905Redd Foxx had a skit, who is smoking cigarettes like mad and he said he wanted to keep smoking for the rest of his life and he had a friend who quit smoking and he told red fox that he was going to live 10 years longer than him and then read said well he was walking across the street one day about 2 weeks after he quit smoking he got run over and killed by a tobacco truck.
Reminiscent of the Segue inventor guy who Segued off a cliff.
I wouldn’t want to live forever. But I wouldn’t mind living 200 or 300 years and seeing all the things that humanity is going to accomplish. If not, then as a male in his mid 30s currently suffering from an undiagnosed neurological illness, I would want to at least live a normal lifespan where I feel healthy all the way up to when I die. What makes aging a disease isn’t that it kills you at the end, it’s that it makes you feel sick long before it kills you. Take it from me, y’all don’t know what pain and suffering is until your health is no longer intact. It’s indescribable.
The problem is - once you live 200 or 300 years, will you want it to end? Serious here - you speak from the perspective of a current human. You do not know what you want then. You also do not know what the world will look like. Imagine 1822 - to now. The change will be way more.
Don’t know how that’s a problem. If I live to 200-300 and want to keep living well hey, it was a great 200-300 years.
I don't think I want to live forever, either. I do want to remain healthy and mentally fit until such time as decide that I'm bored enough to stop, though.
@@ThomasTomiczek I don’t think that’s a problem though. Then you just keep going.
I think if humans have a choice on when to pass on, we'll know when it's time. If at 300 yrs old you still feel the same way you do now, then that's probably the sign. If you change your mind by that time, well good, the tech by then will give you all the time you'd want.
Your videos give a lot more reasons to live. Thank you for this portion of enthusiasm
David, your videos always give me so much hope. My mother never much cared about her own health, she's 70 yo. But sinse I told her about all this discoveries I found out with you, she has started to change, she's so much more conscious about her health... I told her what you said in this video: hang in there for more 10 years!
It's funny I was having this conversation recently because of your channel and these topics.
One of the things that the person I was speaking with had strongly believed was that he thought at some point he would just want to die, if not for anything else then just being on this world for too long. Similar to your grandparents being OK with death during seemingly casual conversation.
I responded by telling him it’s because they’ve spent maybe half or more of their lives continuously having a lower quality of life and sometimes becoming completely dependent. Of course they wouldn’t want to live after that? I said have you ever met physically and mentally healthy young people who’ve just casually wanted to die? Probably not and if he did it was rare.
I really appreciate this video...keep up the post labor grind :)
I am just about 58 and spent most of the last 30 years getting high, getting drunk, skateboarding, snowboarding and riding bikes of all kinds. Never spent the time to build anything palpable in life, never bought a house, built a family or a stable career. Yes I would love to stay as healthy as I have being, be it 30, 40 or even 50. I would love to keep riding bikes and snowboarding, plus have the time to find a good companion, build some wealth and maybe go back to school to keep learning about things. Maybe even get focused at the gym and get super ripped. So yes, sign me up for a few more 100 years or so. As far as forever, let's think about that when it comes, hahah.
I like these walking through the woods videos. Heady days we're living through...filled with wondrous possibilities and hellish horrors. Really hope our species chooses the wondrous🤞
David been anxiously waiting for new vid! You are the best
I went back to school for my doctorate in my mid 30s in part because I felt that there’s a decent shot of getting an extra ten years on my total lifespan, thus offsetting the fact that I didn’t start my doctorate 10 years earlier. The point I’m making is that increased lifespan can cause people to rethink undertaking things that they previously thought it was too late for.
Seems like the stress of getting your doctorate would reduce your lifespan
Dude I appreciate your covering this topic a lot, ur doing great work man love ya ❤
I love this channel and David's sense of humour. Thank you for all the videos!!
Damn..what a gift to give this drug to one’s mother or father.
Yup true...
Funniest but = When he speaks of living for eternity and then nearly falls in the river!
Yeah, that was great. "Somethin' will get ya". heh. Looking back on my life and thinking about all those times I could have died or been killed (at least 9 times) when a second or two made all the difference.... Cats have nothing on me.
I wanna do things i want to do, hobbies, travel, learn new skills, experience new things, maybe see space or other worlds and finish certain tasks. I dont think i would wanna live forever. But 3-5 hundred years possibly.
We could travel by walking there. That would be quite eco friendly.
I will assure you, when these 500 years are over, you will definetly NOT say " ok now i will die." Noone just gives up a decent life.
Who would want to give up being 27 forever?
20k years max probably then long sleep for a few million and reawaken
@@macrumpton perfect age for me would be me being 20-23 again
Thank you for such comprehensive notes. I wish all CZcamsrs did this.
Also, David Sinclair said his therapy was dirt cheap and that you could make it with common household products.
which therapy was that?
The new camera looks amazing!
i love your videos! ❤️💯
"Indefinite lifespan" was how I said it in my novel in 2009 😊
David is one of the few people to leave Plato’s cave
The air and view from outside are just not comparable 🌸
We're in the plato cave watching him touch grass on our phone screens
@@SalamAnuar the grass is also in plato's cave but it might be closer to the entrance.
Having your children live at home until they are 352,689 years old
I'm 68 years of age never been legally married and never had any kids the woman I lived with had a hysterectomy when she was 29 and she didn't want kids anyway. If we have near indefinite lifespan well then most of us don't need to have any kids.
All the money I saved by never getting married and divorced and paying child support will more than pay for the therapy.
Amazing news! Hopefully the trials go well and they help a lot of people manage their chronic diseases, even if it takes a few years before we see progress. But this gives me a lot of hope by 2030 that maybe I'll be able to try some rejuvenating treatment of some sort.
Damn I like these future bio/medicine vids/talks. They are really a preview of all the cool things that will come soon
Great video and loved the nature walk vibes
What a nice way to explain all the content really helpful
"Except for any Vampires out there in the audience~"
**silently backs into bushes like Homer Simpson**
When do you think this will be available though?
Without significant FDA and government reform, medical tourism is definitely the way.
Ever since David's nature videos I get the vibe of Luke Smith wandering through the woods talking to us dear viewers, all over again :)
Hey man I’ve just started to watch your videos, lemme tell you’ve been answering most of the questions that have been bothering me thanks for making these videos.also any advice for a 20 year old to be financially prepared for AGI?I’m currently a finances analyst.
Where do you look for most of your information and research?
Indeed it gives immense optimism tysm
Thanks, that definitely provides hope for the future! Does anyone know what the name of the drug/company is?
Such an interesting perspective
Having children has been the greatest joy of my life! If I could afford it I’d have dozens🤩🤔😍
Well you definitely should be excluded from the longevity treatment then
@@rgonzalo511 lmao
I think most people will continue to have children. Children bring too much personal fulfillment for it to just go away. Kids aren’t like 8 tracks.
It is also possible to inject new mitochondria into your body. A study came out this year that found that that transplanted mitochondria migrate into cells on their own and they preferentially migrate into cells with damaged mitochondria.
Ooooh, that's exciting! You got a source for that?
@@mrleenudler I read about it on a longevity website called Lifespan
Yea source please and I’ll google it too.
@@croneyr Mitochondria Injection Alleviates Parkinson’s in Mice on the website Lifespan, by Arkadi Mazin
@@mrleenudler in the message i sent to the other commenter
What study are we talking about? Is there a link to check the details?
Just imagine the amount of responsibility you have to take over your choices when there is no naturally occurring escape from the consequences.
Definitely a lot of questions
I follow this sort of thing, and mito /aging is pretty general, perhaps you could mention the details of this prospective Japanese study - I’m really interested to know what substance is within the study..
Re: "The heat death of the universe will get you" -- by all means, if you haven't already, check out Isaac Asimov's 1956 short story "The Last Question". The text is available on-line, and there are a number of audio versions on CZcams. It's a classic, and was recognized by Asimov himself as perhaps his most memorable story.
Is this Japonese science based on the Yamanaka transcription factors ? I read some research like 4-5 years ago, showing full "regression-rejuvination" at the cellular level, but timing of treatment was the major limiting factor.
Do you think longevity medication should be open-source? (If that is even possible.)
At the end of a recent video David welcomed feedback on whether the video is better. I wonder if there are some details there in the description or comments 🤔
I mean, if it's published it's open source. The means of production is not open source tho. It takes capital to make
Unrelated comment, what camera/mic system are you using in this vid?
NO COPYING
I'm 53. I'd take ten years of life and be ecstatic. 43 is a universe of difference, even if you are active like I am. But 33 or 23? I think I might faint.🎉
Hi, I'm in my late 30s but been dealing with autoimmune diseases since my early 20s, so would be awesome to get younger too lol
btw, is your icon Yakumo Ran? (⋈◍＞◡＜◍) sorry for random question.
@phen-themoogle7651 I believe it is Yakumo Ran. I never played the games, but when I was researching the background for my D&D character, I modeled some of her traits and history. 😁
@@weredragon1447im 25 i never thought 50's would be physically exhausting i thought it happens in 70's or something
@@Kingkhan-qk2vk 🤣🤣🤣🤣
Not to knock the Japanese experiment on mitochondrial rejuvenation, but isn't David Sinclair already working on rejuvinating whole cells/tissues in vivo?
David Sinclair is a career scam artist. I have one word that says it all about that fraud: Resveratrol.
Lot's of controversy around Sinclair. Hard to know what's real and what's hype. Both resveratrol and NMN results has issues. Notwithstanding his effort to monopolize NMN.
I'm skeptical about Sinclair's motives. I hate saying this, but I think his focus is on profit. I would love to be 100% wrong....and I hope I am!
Great vid!! Love these walks but prefer the wider angle with the background in focus. Getting a bit travel sick with the closeup.
GPT-4 on some risks: "While rejuvenating mitochondria in aging cells holds promise for potential therapeutic interventions against age-related diseases, including cancer, it's essential to consider potential risks and unintended consequences. One concern is the possibility of enhancing the survival of damaged or mutated cells, including those with cancerous potential, by improving their mitochondrial function. This could theoretically increase the risk of cancer development or progression.
Moreover, mitochondria are involved in cellular processes related to apoptosis (programmed cell death), which is crucial for eliminating damaged or abnormal cells, including cancer cells. Altering mitochondrial function could potentially interfere with these processes, leading to dysregulation of cell death mechanisms and promoting tumor growth."
I can't find this specific treatment, help anyone?
I'm skeptical. Very, comically optimistic, about so, so much.
I like the walks in the woods, gives peter Zeihan vibes
So sorry to hear about your bone disease. As he said, stay alive another 10 years. Stay alive longer if possible just in case its late.
If you follow the current recommendations on nutrition, health and lifestyle then an individual may live an additional 12 years with good health span, so this type of research seems plausible to achieve for most of us.
Im 38 as well, it's amazing how aging catches up with you.. my poor knees 😬
As of the latest information available, Japan has made significant progress in mitochondrial rejuvenation research, but widespread human trials specifically for anti-aging or mitochondrial rejuvenation therapies have not yet commenced. Research is still primarily in the preclinical or early clinical stages, focusing on understanding mitochondrial dynamics, improving delivery methods, and ensuring safety.
However, some related clinical trials, particularly those targeting mitochondrial diseases, may be ongoing. These studies focus on techniques like mitochondrial donation or replacement therapies, which are closer to application in humans for specific medical conditions rather than broad anti-aging purposes.
The transition to human trials for broader anti-aging applications will depend on the outcomes of current experimental studies, regulatory approval processes, and ethical considerations, especially given the complexity of mitochondrial manipulation.
If I could turn back the time from 60 years old to 30 years old, strangely enough I would look forward to continuing that same job that I say I hate so much. I'm guessing that although I hate my job, I really like my co-workers and look forward to the socialization and the purposes the job brings.
Imagine 200 years mortgage...
Interesting youtube though it was highly spectative and optimistic in my opinion. 10 years seems like a very short time span considering the glacial pace that medical research normally progresses. But we will see.
What might that mean for someone being 30, 40, 50 … at the time of LEV, or perhaps when this mitrochondria drug is released (at 20 rejuvenation therapies might not be relevant yet, and after that more for cosmetic reasons for a time, after 50 mostly for health/ longevity reasons) . Like all 30 year olds look and feel 20 again, all 40 year olds like 30 and so on? Might it be that the impact is larger for old peoples, like for an 80 year old person it an equivalent of 20-30 years while for a 30 or 40 year old it’s more only 10 or so. Eventually we might all end up with more or less zero self inflicted accumulated molecular and cellular damage (what aging is) and all be 20-25 again more or less for ever, but how will the initial rejuvenation tipping point will look like for someone at this initial point, also depending on his current age at the time. Functionally as well as in terms of optics
Great news! Rejuvenating mitochondria is a considerable step forward on the path to a longer, healthier life. Let's hope these clinical trials succeed and get approved worldwide soon.
Many biological treatments can be replicated very cheaply. It's the research, testing and FDA approvals that are freaking expensive. The actual production, especially on a small scale, can be dirt cheap. As long as the method is published.
Overpopulation is not really a problem, we can always limit birth rates with severe fines. One mistake David makes is assuming birth rates will be so close to death rates naturally that the population will plateau. The odds of that are basically zero. Most likely, birth rates will outpace death rates by orders of magnitude. Which means the population will grow exponentially if left unchecked.
The benefits however are crazy. Almost nobody wants to die tomorrow, just because their age reached some number X. As long as you're healthy, you should be able to live indefinitely.
And yes, it's just biological immortality. If your brain is destroyed in a horrible accident, there's no coming back from that. Other organs we will be able to rebuild.
I remember seeing a death calculator that estimated your odds of death from various causes. I think car accidents kill half the people at around 40 thousand years, assuming modern car crash rates. But that can be fixed with AI driving. Heck, I wouldn't mind living 40K years. Much better than the current 75-80 expectancy.
"Overpopulation is not really a problem, we can always limit birth rates with severe fines." - you are aware that we just hit peak and population levels are supposed to fall - FAST. South Korea faces a 75% population DROP in the next cycle as their birth rates are 0.48 children per woman. The fix is already in - and we likely expand a lot soon, space wise and then insanity.
It would be great if AGI could end the livelihoods of bureaucrats and speed up the testing and approval of novel treatments. If all AGI does is propose loads and loads of new drugs and therapies with the same old regulatory snail's pace we are not gonna see much useful progress; simply an endless backlog akin to a 700-mile long line at the DMV.
@@JohnSmith762A11B Supposedly it already does. Sounds stupid, but there is a TON of statistical analysis and document preparation involved - clinical trials are not what actually determines the outcome, but the analysis of them - and AI is supposedly ALREADY being used in that. There was something about a major medical manufacturer having 750 internal GPT instances for - in many cases - exactly this.
The idea of getting rid of many of the beaurocrats and replacing it with automatic fast processes - a dream. Sadly, lot of career idiots there.
"limit birth rates with severe fines" - that's a horrible idea. China tried something like that, and they got tens of millions of brutally murdered babies. And I'm not talking about abortion, but killing actual born babies. They also got an aging population that is crippling their economy.
Banning something that most people really want is a recipe for disaster in general. Like the Prohibition or the War on Drugs.
And it's completely unnecessary, birth rates naturally plummet with rising living standards. It's because on a farm children are cheap labor, in a city they are very expensive pets. People are not animals, we understand consequences and able to plan. And it's a vicious cycle. If we choose to have less children, we start to care more about quality, we spend more resources on them, which raises the "barrier to entry" for the next one. In a few generations we end up with less than one child per family. And then we don't even date anymore, there's a fast growing loneliness epidemic.
Anyone has links to resources regarding the trial he is talking about?
In the description
So If this actually Happens (Immortal biological Body), the question is If our brains can keep up. Any neurologist who may chime in about whether rejuvenated mitochondria would also positively affect the brain? I could also imagine there being hidden Interactions Not yet discovered.
if I could just live to 200 yrs old id be grateful
even if its 100$ a month anyone making minimum wage would still buy it
we can Buy this Poxel Biotech on french market
Can you share how to order it? I am an MD myself.
David, all you have to do is stay alive for the next 10 years, then you are golden. My new anthem, Bee Gees. STAYIN ALIVE STAYIN ALIVE HA HA HA HA STAAAAYYYYYYIINNNNGGGG AAAALLLIIIIVVVVEEÈ
As a molecular biologist and computer scientist, I'm not too optimistic about pharmaceutical therapies. The biology of a single cell is multitudes more complex than anything humans have ever built, and for any pharmaceutical there's already a counter pathway in our biochemistry. I've been following the longevity science for a decade, and most of the therapies are designed to attract VC funding. Few clinical studies have ever confirmed the findings of in house trials. While it is true that all cells can rejuvenate, and technically the first cell never died, the flip side of unhinging those mechanisms is cancer.
Gene therapies, on the other hand, look far more promising to cure genetic diseases. Because we are working from 2 known states.
Do you think advanced AI coupled with advanced imaging could produce a novel ways of dealing with cellular aging? I guess what I'm asking is, do you see a way of cutting edge bio-research getting de-coupled from the human element? we're slow, prone to errors and easily distracted (among other things) so :)
@@theWACKIIRAQI There's simply not enough data to apply machine learning to solve the problem of cellular aging.
You can apply ML to sub-problems like protein folding or drug discovery. The AI we have today is not intelligent, it can't work from a few data points. And getting good data is the hard part.
@@panicraptor2837 exactly. so ( bear with me ) if we could create an AI that could learn from first principle like us humans do and given that electronic systems think at the speed of light, non stop. Then a curious, self-taught AI could in theory arrive at a new theory of cellular aging by noon and devise, say, a complete therapy to mitigate its effects by dinner time, no?
@@theWACKIIRAQI Contrary to physics, biology is an experimental science. There is not much to reason about from first principles, it all comes down to meticulous and careful experimentation, and multi year clinical trials to follow up. Emergence is why our models of the world will always be incomplete, and given the complexity of biology even small errors have massive consequences.
We are in an exponential growth curve on aging. I think we will start seeing a doubling soon.
maybe they referred to telomere? or maybe there is something I miss
Im going to put it out there. Alot of these do called extreme advanced, will not require AGI, just an ability to think, and problem solve with our getting tired, and creatively putting it all together. We are literally leaning over the edge of a cliff with everything we wanted at the bottom, and were only holding ourselves up with a pinky finger, that is getting tired. The age of A.I is the equivalent of every single person on earth having Einstein in there pockets, the potential from that alone, is insane. Were talking about the age of custom tech, were you can design a bot in mid journey, 3d print the parts, and install your desired LLM. This is we are right now.
This is true and interesting, and I agree we can do so much already with simple integration, but even there things are moving so fast right now I think most of us in the tech space feel ourselves unsure about what value we can really add that won't be obsolete in weeks or months. I really wish the geopolitical situation would calm down because we are indeed near to the precipice of an entirely new world.
LEV in 2030 still sounds like total sci-fi to me and I very much doubt it, but I wish you were right Dave. If your prediction is correct, I will send you some good wine. :D
Well, anyway, it's a very interesting topic and I hope you will make videos about it from time to time. :)
11:22 That is an absolutely undesirable dystopian future.
You're right; personal choice will play a big role. While some will opt for rejuvenation treatments, others may choose to accept ageing and eventual death. Regarding children, some will still want kids, but many may forgo that path with greatly extended lifespans. It will be fascinating to see how societal norms evolve.
What were the results of mitochondrial rejuvenation in animals?
I could be wrong, but isn't the mitochondria about energy efficiency, and true longevity about telomeres?
Telomeres is one aspect among many of longevity. We either have to find a master control knob, or create a load of different rejuvenation interventions.
No. Those are essentially 2 axies you must both fix - supposedly mitochondria and some other low level hanges can rejuvenate the body, but then you still run into the telomere problem that makes cell incapable of replicating at some - WAY LONGER - point. Point is - that is also fixed and, again, I think that is a 150 year problem, not a 90ish, i.e. it hits later. By then... given how we play ow in labs with DNA,.... it likely is no problem in 20 years.
@ThomasTomiczek Telomeres aren't fixed, to my knowledge. DNA can either repair or replicate, and it's the replicate mode that is prone to telomere shortening. The repair mode is better at maintaining telomere length. It's been a while since I've read this stuff, but that's how I remember it! :)
This is why they say you must keep your body in flux: cold/hot, fast/famine, etc. DNA copies in repair mode.
@@JuanMacrame We have the tools to do DNA manipulation - and as I said, in 10 years or so it is EXTREMELY Unlikely we have not solved that. Given the the Tolemeres are a longer term problem - we do still have time, as I indicated.
Can you make a video on the new and delicious crops (vegetables/fruits) that will be created.
You should engage your community with questions. What projects would you undertake knowing you would live to complete them? What would you do differently knowing you will live to see the outcomes? Things like that. What would feel different in centuries of life? As a many century year old person returning seeing that tree you planted as a kid, is now a old giant, and a forest has come up of what used to be a field, how would you regard that?
We'd sure take better care of our planet.
Love Altered Carbon First Season !!
kinda wondering, what does a starving person on mitochondrial rejuvenation therapy look like?
This is incredibly interesting, especially in the context of space exploration, and for many reasons. We could consider that not only would we survive long journeys but also live long enough to colonise and pass on our knowledge to future generations. Mars suddenly seems like a realistic proposition
Mars has always been a realistic option. It's ~6 months to get there. You don't need biological immortality for that...
10 yrs Wow. I like you ! if I can stop aging at 60 yrs, I'll be happy. Still fit in my 50th. Hopefully, infinty life will come true...
whats are the chances for these trials to be successful
Yea, I think maybe in 10 years time we might start to see some benefits. LEV isn't around any corner.
Ageing doesn't just happen to cells - there's the extracellular matrix (the scaffolding, if you will) that will also need rejuvenation. Very little progress has been made on that.
When do you think will we be able to reverse aging? I mean not only longevity escape velocity (that might be close) which is about lifespan, but in the sense of really reverse the damage in our biological to the point that it is visually as well as functionally negligible. So people essentially can turn back to their early twenties
Now in my late 50s, I don't much care to live in this state of visual decrepitude indefinitely, even if perfectly healthy. What you realize over time is when your youth goes you lose the ability to inspire love in others you are attracted to, and life gets lonely and depressing if you have not been lucky enough to have already found and kept a satisfying lifelong partner. So yes, unless I can be visibly young and attractive again, this longevity stuff is just adding years to a kind of miserable prison term. A little side rant: I hate the judgement aimed at men or women in say their forties with partners in their twenties. Or all the Leonardo DiCaprio hate. No one's taste in relationships ages along with their bodies. No one in their seventies finds sagging blotchy skin, missing teeth, muscle atrophy, saggy bellies, stretchmarks, thinning gray hair, or aching backs attractive in others. No, they still find twenty-somethings sexy. Just like they did when they were a twenty-something themselves. Sorry, that's simple evolutionary biology. And people lie about this to themselves and others all the time.
Those two are one and the same, more or less.
@@mrleenudler likely as an outcome but not a necessity for LEV. You could also just add one year per year by keeping old people alive for longer without rejuvenating them. At least for a time LEV could be achieved and maintained by that. But I think the goal should be true rejuvenation. With the expressed goal to reduce the amount of damage in the body to or below that of a 20 year old, so where it is functionally as well as visually negligible.
@@JohnSmith762A11B Fully agreed
@@ct5471 Gaining a year of life for every year lived is the same as stopping aging. I can't conceive of a treatment that can stop ageing without reversing it as well. That'd be like balancing on a knife's edge, neither growing older nor younger.
imagine the subscription fee
Altered Carbon was dope!
There is already an American biotech company, called Mitrix, that is heading into human clinical trials to treat diseases of aging by doing mitochondrial transplantation. Mitochondria transplantation is not new. Its been used to treat diseases of mitochondria. What is new is to address aging square on using this as a regenerative therapy.
I'm doubling down on the grind, one because my goals are unusually open-ended, two AGI is still a black wall to me, also I and others will opt for a all-or-nothing maximization due to heightened competition and extended youth enables more risk-taking behavior (early adopters of emerging technologies), It's gonna be an interesting productivity prioritizers vs Take it easy camp.
I hope we will live it. I studied a second time pretty late and finished with 37. I did not make my PhD because I felt too old and I wanted to make money. If I could live e.g. 1000 years, it would be nothing! You could study whatever you want!
If a person lived for 1000 years, and met a new person everyday, they would still not get to meet 1% of the global population.
People that think they will be bored if they lived up to, or more, than a 1000 years, just have limited imagination.
My pragmatic side says the oligarch class will come up a way hide this or suppress it.
That seems pessimistic, not pragmatic. "Pragmatic" would be looking at all the forces acting to affect the outcome, not just one particular force.
Don't underestimate the power of pharmaceutical companies - with all their investors, lawyers, lobbyists, and pocket politicians. They have billions of dollars AND well-crafted political influence machines.
@@glenw3814 I don't know. I'd argue that the way its worked for the last 2000 years seems to be pattern where the elite exploit and take all they can. If you apply that historical notion.... it feels more pragmatic to have the expectation that the elite will act as they have over recorded history.
I've been following life extension since the 1970s and there was no treatment or intervention that would be considered a standout. I thought it may turn out to be NAD+ but instead the standout is rapamycin, a senolytic. I read about 3 or so trials either going now or plans to begin later in the year. Maybe the mitochondrial substance will overtake rapamycin. I just hope something is proven safe and effective asap