Why do people get cancer, how it spreads, and how to prevent it? | Sendurai Mani | TEDxProvidence
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- čas přidán 31. 08. 2023
- After heart disease, cancer remains the second most common cause of death in the US. Only around 5% of cancers are hereditary, and the remaining 95% are sporadic, contributed by environmental factors and lifestyle. Among these cancers, carcinomas account for over 80%, which develop in epithelial cells. Epithelial cells are attached to one another; therefore, when cancer starts in these cells, they are also attached to one another, confined to the local environment, and develop a benign tumor. At some point, when cancer progresses, the cancer cells activate a latent embryonic program known as epithelial-mesenchymal transition, gain stem cell properties, and start to behave like cells in an embryo. These cancer cells with stem cell properties are resistant to most therapies. They move around the body and develop metastasis. Advancements in sequencing, imaging, and precision oncology allow us to characterize these detrimental cells spatially and temporally at a single-cell level to find a cure for cancer. Sendurai A. Mani is a tenured Professor in the Department of Pathology and Laboratory Medicine and Dean’s Endowed Chair for Translational Oncology. He is also the Associate Director for Translational Oncology at Legorreta Cancer Center and Director of the Cancer Stem Cell Center at Brown University. After completing his Ph.D. at the Indian Institute of Science, Bangalore, India, Dr. Mani joined the Weinberg laboratory at the Whitehead Institute/MIT as a postdoctoral fellow. Dr. Mani and his colleagues at MIT demonstrated that the activation of latent embryonic epithelial-mesenchymal transition (EMT) promotes metastasis. In addition, Dr. Mani was the first to show that the activation of EMT provides stem cell properties to cancer cells. This highly cited finding provided insights into the presence of plasticity within the tumor and how cancer cells survive in the circulation and develop metastasis similar to the tissue of origin at the distant site. Dr. Mani received several prestigious awards, including the V-Scholar and American Cancer Society Research Scholar awards and Dean's Endowed Chair for Translational Oncology at Brown University. He is an elected member of the scientific research honor society Sigma Xi and an elected fellow of the American Association for the Advancement of Sciences (AAAS). This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
One of the longest cancer survivors in the UK, delivers a triple award-winning book of inspiration. Me and My Shadow - memoirs of a cancer survivor, described as one of the most inspirational books of 2023.
Love the anecdotel storytelling here, one of the best TEDx Talk I've heard of late !
Research is lucky to have you, I read about you in an article recently too
Value led leadership at its finest in this wonderful talk
I know two people successfully on immunotherapy for melanoma. Both were given six months and both are fine and one is over three years on, the other about two years one. Absolutely brilliant for them and their families but it was very expensive.
Both must have been in early stages, and both would have been fine without establishment immunotherapy or chemo. Find better doctors.
Your explanation of the difference between DNA and genes 5:10 is amazing.
Mr you give hope to a generation
I love how you described the body as a community! This was such a powerful talk, my friend!
Thank you, Tara!
Yes, that's all you got out of it. Community. Rest was palaver.
One of the most clear, articulate, positive, powerful speakers i have seen
Thank you!
Some incredible information in this one, I don't know how you remembered it all!
Happy to note the positive developments in Cancer Research.
Important topic and work you, God bless you all in Providence
Looked at your website too Mani, inspirational work you do!
You are in the list of favorites
Beautifully delivered, such stage presence Dr Rai.
Your weekend shares are honestly my favorite. I look forward to them
The Values Compass- I love this , thank you fort sharing, enlightened !
Please make treatme t for chronic diseases cheaper. Our right to live shouldnt depend on how much money one has. 😢
Many of us are here for the same reason so therefore, i recommend that you look at the work of Dr Thomas Seyfried and how his Boston university clinic is tackling cancer using a metabolic approach. While cancer continues to be treated as a genetic disease, we will never get on top of it. It also goes without saying that standard of care (chemotherapy and radiation) is going to do us in anyway.
Dr Thomas is the best at cancer he changed my life for the better.
Excellent,your video just keep getting better & better All my favorites
Fantastic,your video just keep getting better & better All my favorites
You are amazing. So inspiring
Thank you Sir for sharing wonderful information. If we see the causes of cancer and try to get rid of those factors with help from inside family or outside help. And very important point is to be happy and be respectful towards everyone. Always use good words, all the time our cells are getting the signal of love and hate from us. If love is more, for others too then no cancer. This is what I could understand. Harmony in our cells and bacteria will promote healthy body.
Thank you, Mani, for making complex ideas in simple terms for everyone to understand.
Thank you!
Super talk.....sendurai mani ... by Prasad Madurai
Thank you, Prasad!
Appreciate💕 both you and your Shares Thank you
Outstanding talk, Mani. Thank you.
Thank you, John!
Absolutely amazing many thanks for you work and superb presentation
Thank you, @popotv9385!
Although the title of your video say "how to prevent it" you did not say how to prevent cancer. What is the point of giving us an overload of medical information, when we cannot even manage to see a doctor these days. What can we as patients do with that information? We need consciencious doctors who seriously care about their patients health.
He told u numb nuts - get early diagnosis to cure it
Jeez it’ll be done way to go before they invent brain cell corrections
Dr. Jason Fung wrote The Cancer Code.
For everyone interested in all the un-answered questions left by this speaker.
he said don't stress, take time to enjoy life. don't smoke, don't drink alcohol, don't eat junk food, stay away from pollution, be respectful of your microbiome. he told what to do and what not to do but you didn't listen.
He said how to prevent cancer around the 10 minute mark were you even listening
Sounds like you are looking for a pill ?
Oh My God! Your video is really Enormous Graceful Frame
Shade, gradient, idea, colour fantastic m8
Excellent talk Mandeep
Omg wow! That's incredible💓 I appreciate your Videos
He says more treatment coming in the future but so many still die today. We need cancer prevention strategies. Cause once it’s in your body, it’s a game over
Prevention helps but eventually it'll get us so we need a treatment option too. A better one.
@@jonfreeman9682 agreed but not sure when that will be coming our way 😔
Cancer is a metabolic disease, it’s not genetic. Otto Warburg won the Nobel Prize for this discovery in 1931.
That's not true, I'm a survivor..Stage one.. Surgery/ Radiation.. 99 percent survival I am cancer free bc of early diagnosis..
Stop saying that to people.
@@lorrie5881Don't be so sure and never let your guard down. Who told you ,you are cancer FREE. Once you are Stage 1 and dr. Says it's cleared, that's for NOW only .....wait for few year, eat all those junk food and sugarry stuff and you will have Stage 4 diagnosis. It's just matter of time. I have seen so many including myself .
Awesome talk, Mani.
Thank you, John!
GREAT STORY TELLING
awesome I think Im crying Its that engaging
Thank you for inspiring me to better ❤️😍😍
This looks incredible!!! ❤
Thanks so much for sharing!
your Snapshots really awesome, i like it, looking forward for you next Snapshots, keep it up!
My MOAS cancer surgery last year March 2023 left me crippled on my right leg. I hope every day is my last day on earth and have stopped going to my oncologist for follow-up as of this month and not having any more scans or blood work. I am a U. of TN. Certified Master Gardener who can no longer work my lovely garden and I had to resign my job after 21-years in merchandising due to this and I was not ready to retire and resign. This is supposed to be a recurring cancer and I cannot wait until it returns because I have been a coward to end my own life, which would create issues for my family and friends to be left after suicide. Dr's need to listen to their patients in a different way and just getting cancer out of the body. That is not always best for each patient. Now my oncology surgeon says to live life and go travel and do and see things....a little difficult to do with a full leg brace, major muscle atrophy and on a walker for the rest of my life. You saved my life to do nothing but sit in my house all day with my arms folded. Thanks for absolutely NOTHING! This talk did nothing but make me more angry. Stop trying to eradicate cancer just for the sake of making it go away. There is more to life than just this...there is what is left & destroyed after you send the patient home alone!
Wow that's a lot. I'm in TN also; I wish comfort for you and am praying right now you can have that. Lots to be angry about. Similar issues with saving the life after severe stroke or head trauma, they go home to extreme hardship on themselves and their families. I do hope you can find joy in your last days and ask God to let you know Him before you go.
Cancer thrives and grows with carbohydrates. There have been two Nobel Prizes won regarding the discovery of the bodily function called autophagy. When cancer is starved of glucose (carbohydrates in the blood), it finds nutrition in damaged cells. Including cancer cells. In 1931, Otto Warburg was awarded the Nobel Prize in Physiology and Medicine. He observed that tumors displayed a metabolic shift toward glycolysis (consumption of glucose). In 2016, Yoshinori Ohsumi won a Nobel Prize in the field of Physiology for his discoveries of the mechanics for autophagy. So this is real science. My sister in law got rid of her cancer by going on a carnivore diet. That’s meat, eggs and cheese. Heavy cream doesn’t have any carbohydrates either. She learned this from a video by Ken Berry MD. For a sweetener, use erythritol. It tastes like sugar and passes out in the urine. I wish I had known this when my dad came down with cancer. I understand your longing for heaven. We lost our son several years ago, and we miss him terribly.
@@estherstone4860I'm so sorry..Did your son have cancer??It sucks as I've had cancer..I went keto very low carb and no sugar etc ...take care .
Don't give up please try turmeric pills and apricot kernel they are very good
Jesus loves you
Fantastic talk! Congrats!
Thank you!
I just want to name this Videos.."stunning"
So empowering, thank you
what is empowering for us though? He didnt talk about what WE can do besides sending them more money and volunteering for clinical trials. We don't have power here.
Deserves more views More people need to know
Thank you!
Wow one of my favorite
One of Thee Best!
No words, only emotions
💯Exceptionally amazing Videos
Breathtaking
Thanks lovely Videos!!
This is Fascinating
Thank you!
One Of The Best Talks in Recent Times 🔥🔥
Thank you, @Manishceo!
@@user-pp9ri4zc4t
Sir is it you in the lecture. Nice to see it. Thank you ❤
I learned a lot! Thank you
This is Powerful, concise and highly informative video Thank You
Thank you, @photoediter5850
absolutely stunning video Wow
Woow thanks for Sharing 🙏
Thank you for sharing.
Such Amazing
Silence is golden indeed !!!!!!!!!!!!!!!!!!
Why you say silence? I want to know
Such Wonderful
Superb!
It's fascinating not just cool!
Wow👌 Awesome!✌💪☝👏👏👏👏 Very different
Such notification,many playfulness,so wonderful
I LOVE THIS
Pleasant video
Some people can give up smoking and drinking but how environment something which is the most difficult.
Now people in the Himalayan region are having cancer diagnosis frequently
Oh wow! That's Fabulous💋 I love your Video
Prevention was never discussed…. Second part available Mr.Mani ???
It’s was discussed. These are just a few: smoking, eating junk food, microbes…
I would add: Eating a proper human diet (keto/carnivore), avoid alcohol, manage stress, and get some sun and fresh air.
Alcohol stress lifestyle
Loved it
Thank you!
This one is awsm❤❤
I love your posts so much
Super🎯amazing mate
Suggest a debate with Pr. Seyfried.
Superb❤️
❤🌹 God bless you 🙏🙏
Very Wonderful ❤️
great ! thanks !
So excited For This Supercool Videos
for all people of peace and love
Very elegant💎💎💎
This one is awsm😘😘
My role model ❤
Great stuff Wish The more success to you
Thank you!
@@user-pp9ri4zc4tawesome explanation, Mani!
Amazing 🔥🔥🔥
Marvelous⏺
Amazing🔥
An Awesome Example of the Beauty that 🌈Nature Creates Just stylish🔝🔝
fabulous😍😍😍
your so Sweet😍 Thank you so much
Very attractive❇
Well explained, Mani
👍
Thank you, Saravanan!
Please 🙏 also do something for hepatitus B positive patients 🙏
you are so Special thank you for this Videos
exceptional😍💞
You are a Star👏
Energetic
Top Notch 🌷