036-Dr Kara Fitzgerald: Can lifestyle reverse epigenetic age?

Reversing DNA methylation can result in restoration of vision loss in old mice (Lu 2020). Can human epigenetic methylation clocks be reversed using relatively straightforward lifestyle changes?
Dr Kara Fitzgerald is the first-ever recipient of the 2018 Emerging Leadership Award from the Personalized Lifestyle Medicine Institute in recognition of her work on DNA methylation. She is on the faculty at the Institute for Functional Medicine (IFM) and is an IFM Certified Practitioner.
She received her doctorate in naturopathic medicine from the National College of Naturopathic Medicine in Portland, Oregon.
Dr. Fitzgerald runs a Functional Medicine Clinic Immersion program for professionals, hosts a very popular podcast New Frontiers in Functional Medicine, and maintains an active blog on her website. Her new book 'Younger You' on how she was able to reverse aging with lifestyle is coming out in Jan 2022.
Please join Dr Kara Fitzgerald for this masterclass in human epigenetic DNA methylation manipulation.
Take away points:
-Increased DNA methylation age is associated with no significant net methylation change.
-~25% of methylation clock sites are related to glucocorticoid response elements underscoring the relationship of stress and aging.
-Supplemental methylation helpers (folate, b12, choline, etc) have a narrow effective range- with too little or too much having negative consequences.
-Lifestyle changes can reverse DNA methylation age in humans.
00:00 Kara's vision for reversing global epidemic of chronic disease
03:10 Appeal of naturopathic medicine as a systems model similar to functional medicine
06:04 Value of -omics; epigenomics, metabolomics, and microbiomics
07:39 DNA methylation process and epigenetic age
11:39 No net change in methylation with aging, just rearrangement of sites
12:25 Dose response of dietary methyl donors
15:18 Horvath methylation clock used in paper
19:23 Components of the lifestyle intervention
25:32 Effect on triglycerides
28:34 Options for vegans instead of liver as a methyl donor
32:05 Ongoing program and forthcoming book
35:05 Personal lifestyle choices
37:02 10 cups of vegetables a day, 12 hour fast per day
38:03 Exercise, relaxation, and sleep choices
www.drkarafitzgerald.com/
Lu, Yuancheng, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, et al. “Reprogramming to Recover Youthful Epigenetic Information and Restore Vision.” Nature 588, no. 7836 (December 3, 2020): 124-29. doi.org/10.1038/s41586-020-29....
Fitzgerald, Kara N., Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, et al. “Potential Reversal of Epigenetic Age Using a Diet and Lifestyle Intervention: A Pilot Randomized Clinical Trial.” Aging 13, no. 7 (April 15, 2021): 9419-32. doi.org/10.18632/aging.202913.
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