Carbon Dioxide Transport
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- čas přidán 6. 09. 2024
- Brief introduction to carbon dioxide transport in the blood. Bicarbonate buffer system perspective.
Topics Discussed:
Bicarbonate buffer
Carbon Dioxide transport
Oxygen Transport
Chloride shift
carbonic anhydrase
red blood cell
co2
h2o
hemoglobin
*Brought to you by Anatomy On Demand
/ @anatomyondemand
far better than any of my teachers have ever explained it thanks
I saw a comment asking about where the CO2 in the blood comes from and where it goes, so I thought I'd comment in case anyone else watching wants to know. CO2 is a waste product of glucose metabolism in cells and it accumulates in the tissues. When oxygen carried by hemoglobin (in red blood cells in plasma of blood) passes thru the body, it gets ejected at places where the CO2 is accumulated. But the CO2 accumulation itself doesn't trigger the release of oxygen. The CO2 actually enters the blood plasma and from there it enters red blood cells where its broken down into carbonic acid and then further into protons (H+) and bicarbonate. The increase in this proton (H+) concentration is what triggers the hemoglobin to release the oxygen that it's holding, into the tissue. After delivering the oxygen to the tissues, the red blood cell takes up the CO2 and the blood flow continues to the heart from where it will enter the lungs to be exhaled.
literally the BEST explanation of what happens in the blood buffer system both chemically, mechanism, and biologically. Thank you!!!!
One of the best lectures I've seen on the subject.
First semester nursing school student here. great video :)
In the uk we have to do this at 16/17, it’s so difficult! Good luck with nursing school :)
I stumbled upon your explanation and it was by far the most concise yet informative and detailed.
So well explained that even I as a non-native speaker could get it. Thank you!
SO helpful! I was having trouble understanding this in lecture and from the textbook, but the way you explained it made it easy to grasp. Thanks!
While many videos explain the conversion of carbon dioxide in the red blood cell, this is the first I found that explains how the conversion is reversed in the alveoli. Thank you.
this was great! all of the other videos on this subject that I found on youtube can't match yours. this is the complete cycle from the tissue to the lungs, and no one else has talked about the whole cycle. thanks!
AndreaaaNS please do watch my video on transport of carbon dioxide czcams.com/video/Sc-g6Ogg-RI/video.html
9 years later and it's still being used
Thnku very much. The thumbnail itself suffice to know the mechanism. Thnks🙌🙌🙌love from india
Still can't believe you gave us so much information with only 1 picture, great work!
Thank you so much! For some reason it wasn’t clicking until I watched your video.
Thanks for the CZcams videos! You talk about science the way people talk about movie twists. You’re so excited and passionate! It helps me see just how incredible our body is, all the things that have to happen in order for us to function!
I had this diagram in my CIE endorsed textbook and it wasn't that easy to understand and thought wasn't making any sense. After I watched your video it made it easy for me to understand the concept.
I have a feeling this topic is going to be the essay question on my final because my teacher talked a lot about this today. He made no sense at all. You explained this so well, thank you.
Great explanation thx really helped
Thank you so much, very clear explaination. I now understand the chloride shift and carbon dioxide transport! Better explaination than my teacher
Thank you very much, it made carbon dioxide transport easier to understand.
Such a phenomenal explanation, the diagram was perfect and you simplified it all very easily. Thanks!
it's 2 am and i have a bio exam tomorrow and i love you greg
H+ ion plus Haemoglobin gives Haemoglobinic acid.
What beautiful way to explain this process, thank you so much!!
Thank you! This will help me with my final, you explained it easier than the book and my teacher combined.
What i dont Understand: Chlorid is Negative and hco3 as well so why do i have to Change?
I don't think he mentioned this in the video but NaCl is present in the plasma as this reaction takes place. So HCO3 is forced out of the RBC into the plasma and attaches to Na (from the NaCl compound) resulting in NaHCO3. The Cl (from the NaCl compound) then enters the RBC to maintain electric neutrality. Thats why this process is called the chloride shift because Cl is shifting back and forth from the plasma to the RBC.
Hope that helps! :)
Electric balance would have been the same if HCO3 stayed in the RBC and Cl in NaCl. Why exchange?
Thanks for this video. I want to study Respiratory Therapy and this will help me a lot.
Thank you! Very simple yet informative
This is very helpful. Thank you so much!
Your explanation of this process is great!
Thank you!!!
Why is deoxygenated Hb a better H+ buffer/proton acceptor than oxygenated Hb?
After we get the C02 from the working tissue cell, and its pulled into the RBC, where do we get the h2o from to turn it into carbonic acid? - do we just 'suck' it in from the high concentration of h2o in the blood plasma ?
Thanks for the video ! the rest made more sense then my text book !
Since the blood is a watery (aqueous) solution the water is always present and available for use in chemical reactions.
Thank you! thank you!
Really great explanation, far better than any other I have seen.
Clean, simple and makes sense.
Appreciate it very much!
EXCELLENT VIDEO!
Thank you for the easy explanation, mademy med physiology exam a lot easier
Thank you so much. You’re such a blessing
Can you comment on the difference between the hemoglobin buffer system vs the carbonic acid-bicarbonate buffer system?
Awesome video! This helped so much more than my teacher did in lecture!!
Lmao. Been so many years after the med school and never knew since when I actually had this idea in my mind that acidosis is due to the lactic acid.. thanks. Well spent 8 minutes 😬
thankyou so much for this! i finally understood it after trying to get it for so long!! thank youu
a very good and helpful video 100 percent. thank you so much
very good explanation! Please make more videos with pictures. You helped me a lot during studying! ❤️
Very spectacular Video, I really understand the entire mechanism, thanks a lot
Great job bro , jst awesome explaination man 🤩🤩
Great video! thank you so much!!
incredible explanation !!!
Great video. Thank you!
this is the best way ive heard it explained! thank you
that was ultra clear and helpful, many thanks
Super helpful! Thanks so much!
Excelent video, can you point out some references abou the rates, duration and energy costs of these processes?
+Jonathan Ron My favorite reference for human physiology is "Textbook of Medical Physiology" by Guyton & Hall. Also, CVphysiology.com is a great online resource.
Specifically what rates and durations are you interested in?
Thanks,
I'm trying to estimate a general limit time for apnea. so I'm interested in the reaction rates ( how long) and the rate of increase of CO2 levels in the blood and lungs
CVphysiology is indeed a gem. You've provided a well-paced and lucid video as well. Good job.
This video made it seem so simple thank you for the help! Great explanation!
Great👍👍👍👍
Excellent job explaining this! Thanks
Thank you so much very good explained and love your structure.👏🏻👏🏻👏🏻👏🏻
such a good explanation!
amazing explanation!
Started breathing properly after this video
well !! but i have a doubt - what happens if bicarbonate is accumulated in RBC???????????????? is it burst??????
Thanks a lot , you've saved me 🙏
Can you please clarify where CO2 is produced before being exhaled? At 6:28 you said it's produced in the aveoli...I thought it was produced in the RBC? Thank you.
Great question! The answer to your question depends which perspective you are viewing this process from. From a cell biology perspective, Carbon dioxide is originally produced by active cells throughout the body via the Citric Acid Cycle (AKA TCA cycle, Krebs cycle). This is probably the most accurate answer to your question "where CO2 is produced".
In the video at 6:28 I was describing it from the perspective of your lungs; more of a respiratory physiology perspective. From this perspective CO2 is constantly "produced" by the alveoli of the lungs and you breathing needs to expel the CO2 produced and also adjust to changes in that CO2 production. Technically the CO2 to transferred from the RBC to the alveolus. If you substitute the word transfer for produced in the video I think it will make more sense to you.
Thanks for watching!
Please let know if you have any other questions!
10\10
thnx for the additional informations❤
Perfect explanation. Really helpful.
Life saving video!! Thank you sir!!
Just wonderful. Thank you
Thank you so much for this!
When you create carbonic acid you are lowering the pH of blood but when the H+ is absorbed by hemoglobin and bicarbonate is kicked out to the plasma does that increase the pH of the blood? I think this is where im stuck when trying to understand respiratory alkalosis or acidosis
I'll try and help you out... I only know of respiratory acidosis but it's the same concept. Carbon dioxide reacts with water in the blood plasma. This forms carbonic acid (h2co3). Then an enzyme called carbonic anhydrase causes the carbonic acid to dissociate into hydrogen ions(H+) and hydrogen carbonate ions(HCO3-). What causes the pH to decrease, is the H+ ions combining with haemoglobin. They compete win oxygen and because they have a higher affinity for haemoglobin than oxygen, they reduce oxygen transport. Which is why you have difficulty breathing, drowsiness etc is this what you were trying to understand?
Amazing! Thank you so much, it finally makes sense
Very nicely done! Thanks!
so when is carbaminohemoglobin formed?
Carbaminohemoglobin is formed when ever CO2 binds to hemoglobin. Carbaminohemoglobin is simply the fancy name for hemoglobin when CO2 is bound to it.
thank you :)
So carbonic anhydrase has 2 roles? It catalyses the breakdown of h2co3 and also formation of it?
yes
spectacular explanation. Thank you
Great video!
That was fantastic!!!!!!!!!
This video basically saved my life 😅😅 ty tysm♥️♥️
Man that was sick!
this was insanely helpful!! thank you sir
sorry to be ask so this is mean that hemoglobin is not specificly bind the co2 but it actually made it to bind H+? so what does bind the HCO3 in RBC ?
Whats the point of the Co2 dissociation? why cant co2 just be transported by the red blood cells and diffused into the alveoli without the whole bicarbonate dissociation?
WuTang118 you cant 70% of our body is water when co2 enters rbc it combines with water to form acidic solution we have to convert acidic into to base because acidic solution can damage our body to bicarbonate plays an important rule
Good question
Good response
hence why bicarbonate is a buffer right?
Hb does not have nearly the same affinity for CO2 as Hb has for O2. The Hb affinity for O2 is based on the Fe 2+ to Fe 3+ conversion. CO2 is too stable of compound to be attracted to Fe. O2 is way more reactive.
So what stimulates the CO2 to leave the red blood cells?
very good
Great explanation. Thank You
Well put! It was a little unclear for me before this.
Thank you for this lecture man!
This was very helpful, thank you.
thank you very nice, appreciated
thanks this was awesome
Or
CO2 released by cell combine with H20 dihydrogen monoxide in the red blood cell and become a carbonic acid CH2O2 ones carbonic acid reaches the alveoli or air sac which is specifically found in the lungs chemical process is reverse then the process countinue.
Be more succinct stay chilled out.
No intensity no harshness
Thank you! Great video! Totally understand this now! :)
Why, chloride shift is essential?
Great video! Thank you
Btw where is the pict you got? Reference plis
this is fire flames thank you.
This was so helpful
so so so helpful. thank you!
Is carbonic acid diffusion from the lymphatic system into the blood effective or does it happen at a fast rate? I saw somewhere where they said this happened very slowly.
Thanks
Thhhank you
really helpful..thanks sir