I am seriously crying right now because your videos have just helped me explain what I couldn't comprehend from rewatching my lectures the past 2 days. I was so stuck in this topic. Thank you so much for taking the time to create these videos!!
I LOVE YOU! I was starting to panic because I had trouble understanding this concept through my psychology professor’s explanation. But you cleared all my doubts up! ❤️❤️❤️❤️
This series is the best. Why are there only 8K likes in the past 9 years? I agree with the comment below, each 2 minute episode is worth about 1 hr of lecture.
this was so simple and short and straight to the point! as a minor who knows nothing about neuroscience whatsoever, this was super easy to understand! tysm for this video!
HOW IS IT THAT IT'S 2022 AND THIS HAS SO FEW VIEWS/SUBSCRIBERS? Action potentials are so difficult to wrap your brain around no matter when you start learning them and this is one of the videos that helps make it less scary!
Lowkey I feel like the 2 minute cap was a convenience thing (i.e. I'm not trying to watch a 10 minute video on APs), but I think you accomplish the same thing with 3 minutes. And that's a 50% increase in your current screen time fam. Consider it.
0:37 I wonder if hyperpolerization is part of the reason people experience "brain/head zaps" from sudden SSRI discontinuation and amphetamine/phenethylamine WD. ? P.s. How accurately can we measure membrane potential? Like can we do it in semi real time with an EEG or similar method? You responded to one of my comments so I hope you understand if I go out on a limb and ask a question with hope of a response.
Also your videos are the vesicles that hold the neurotransmitters of entertainment that communicate electrical signals of invaluable knowledge to my consciousness. ...I've definitely had enough wine for tonight
@@shitbag. No one really does know what "brain zaps" are. Some think that they involve excessive excitatory activity--kind of like a mini localized seizure. We can't accurately measure membrane potential in a person. It's typically measured in cell cultures using a method called electrophysiology. Electrodes are placed into a cell and can be used to record electrical potential.
In the context of an action potential, hyperpolarization of that sort would significantly reduce the number of voltage-gated K+ channels that opened. Those channels are voltage-gated, so they're opening in response to depolarization.
The units would be milliseconds. The length of an action potential can vary but typically the change from negative to positive membrane potential only lasts about a millisecond. The whole time scale of the graph might be about 5 milliseconds.
If you're looking at the fundamental mechanisms underlying an action potential, then the outward potassium current follows the inward sodium current, and that potassium conductance starts to increase near the peak of the action potential. There are, however, potassium channels that open earlier. There is a channel, for example, called an A-type potassium channel that opens almost as quickly as the sodium channels. But when we're talking about what contributes most to the action potential, the focus is on what is known as a delayed rectifier potassium channel, and conductance across these begins near the peak of the action potential, right after sodium channels start to close.
This is great, but I worry it's too general, a lot of stuff isn't explained here that is key to understanding how the action potential is triggered, such as the temporal kinetics of the voltage gated potassium/sodium channels, or the probabilistic opening of them.
Hello I have a question that's it's so hard for me to find out it says action potential starts with deporalizaton or ends with hyperpolarization I think the correct is that it's starts with deporalizaton
It appears that this video is so nerdy and topic specific, it cannot be related to reality. I was hoping to find a video that relates action potential to its locations in the human body, and find out more than what was taught in psychology class. This video only serve people doing the specific topic and does not give any wider context. It explains it for people going through psych classes but it doesn’t relate it to other things. For example is the polarisation between the nerve ending and the muscle tissue or within the muscle tissue alone? What is polarised?
Hyperpolarization....hmm, must be what is happening when I suddenly can't recall the name of a famous person or something else I've known all my life, but then I suddenly can recall it, perhaps seconds, minutes or hours later (repolarization?).
This 2 minute explanation taught me more than my 1 hour lecture
Same 😂😂 I hate anatomy
@@zacharyflowers4529 Anatomy is pain
We went over this in psychology, and this video made it much easier to wrap my head around the concept.
Amazing video
truly
This man deserves an oscar for saving students honestly he is 100× better than teachers who just make these easy thing too complicated to understand
Learned more in two minutes than in a month of classes thank you
I am seriously crying right now because your videos have just helped me explain what I couldn't comprehend from rewatching my lectures the past 2 days. I was so stuck in this topic. Thank you so much for taking the time to create these videos!!
I think im in love with you. You may be the reason im passing my phys test next week
Your user name makes me smile
@@crushcollegechemistry I found this video extremely good for action potential
czcams.com/video/JMfjkrk6S_E/video.html
you’re covering neuron functioning in your physics class? :0
@@aidankarmali2888 The neurotransmitters follow the rules of physics
I guess
Why so few subscribers and views? This channel is extremely underrated. People need to find out about it.
6yrs later he’s got the recognition he deserves
I LOVE YOU! I was starting to panic because I had trouble understanding this concept through my psychology professor’s explanation. But you cleared all my doubts up! ❤️❤️❤️❤️
I love the concept behind these videos for when we dont have time for long videos but also have absolutely zero idea about the topic
2-minutes was all it took to fry my brain.
Gotta confuse the brain to get knowledge, right babe?
It is pretty simple once you break it down :D
@@Sly922 why u say babe
@@BobbyJohnson-if3tr: y not?
This series is the best. Why are there only 8K likes in the past 9 years? I agree with the comment below, each 2 minute episode is worth about 1 hr of lecture.
this was so simple and short and straight to the point! as a minor who knows nothing about neuroscience whatsoever, this was super easy to understand! tysm for this video!
Finally! I learned it within 2 minutes! Can't believe it was more effective than a course I'm taking.
Thank youuu
Words fail me - i can hardly find a word to describe how well you have done! Excellent work, mate. :O)
2 minutes to understand what i couldn't in almost 1h, thank you!
bruh this 2 minute video helped me more than my 2 hour class tysm
HOW IS IT THAT IT'S 2022 AND THIS HAS SO FEW VIEWS/SUBSCRIBERS? Action potentials are so difficult to wrap your brain around no matter when you start learning them and this is one of the videos that helps make it less scary!
講的真好，真清楚
Keep up the good work Man I mange to grasp the concept in 2 minutes thanks Much
Thanks, 🙏🏻 I better understand action potential after watching your video. I’m not going to lie that It should use as teaching material.
your videos are saving my life!
How did I not discover this channel any sooner.
This is very well explained in 2 minutes thank you a lot subbed!
you explained it so welll i finally got itt
You are a lifesaver by making these videos. Thank You!
OMG I FINALLY UNDERSTAND THIS THANK YOU SO MUCHHHH
you deserve billion likes and comments
W channel W video W explanation
Why is it called action 'potential' when there is clearly kinetic energy involved?
great. short and complete.
Tysm 🙏 this was very helpful
I wish you were my college teacher ❤ the college would be a great place then 🙂
Great video
Lowkey I feel like the 2 minute cap was a convenience thing (i.e. I'm not trying to watch a 10 minute video on APs), but I think you accomplish the same thing with 3 minutes. And that's a 50% increase in your current screen time fam. Consider it.
My physio psych exam OSS coming up and this shit SLAP
Thanks a lot extremely simple and helpful
Thanks a lot for this nice discussion.
Excellent!
Here in 2022...you my friend are a godsend
diyorm kii helal olsu karsim... iki dakikada 3 saatte anlatilamamis konuyu anlattin, eyw pasam
NO WORDS ONLY THANK U
test in 30 min. thank you
You helped me get a question right, thanks!
Want is the time frame of this process? Milliseconde, seconds ? Very helpfull video !
The length of an action potential can vary but typically the change from negative to positive membrane potential only lasts about a millisecond.
Physi midsem tmr and late min studying w this THANKS
Great way to revise ..thanks
thank you for the video!!
Very nice
school is so fucking stupid an incredibly expensive lecture and textbook both couldnt communicate this to me but this two minute video did.
Nice work. Thanks
What channel proteins are open and closed during resting potential and hyperpolarization?
Wow this is a classic lesson I need to teach it to my son whos going to be a future Pilot
Thank you! You’ve got a new subscriber ☺️
I love you
I love you too.
This is one second over
great
1:12
Why is it depolarization when the potential is in a positive charge?
Thank you.
Thank you so much!!!!!!!
0:37
I wonder if hyperpolerization is part of the reason people experience "brain/head zaps" from sudden SSRI discontinuation and amphetamine/phenethylamine WD.
?
P.s.
How accurately can we measure membrane potential? Like can we do it in semi real time with an EEG or similar method?
You responded to one of my comments so I hope you understand if I go out on a limb and ask a question with hope of a response.
Head zaps are awful and I have yet to meet a Dr. that really knows what they are.
Also your videos are the vesicles that hold the neurotransmitters of entertainment that communicate electrical signals of invaluable knowledge to my consciousness.
...I've definitely had enough wine for tonight
@@shitbag. No one really does know what "brain zaps" are. Some think that they involve excessive excitatory activity--kind of like a mini localized seizure.
We can't accurately measure membrane potential in a person. It's typically measured in cell cultures using a method called electrophysiology. Electrodes are placed into a cell and can be used to record electrical potential.
@@shitbag. :)
@@neurochallenged Rock the F on dude. THANKS!
Omg!!tqsm... 🤩✨️crystal clear🤟
Wait, what happens to all the sodium ions that enter the neurons? Shouldn't they leave too?
amazing videos! any chance you could do a video on myosin & actin muscle contraction?
Yes, it's something on my list that I definitely want to do at some point!
Very helpful my exam is today
what happens if the action potential voltage gated an channels are blocked by poison? what happens to the action potential?
Thank you!
Hang On! I'll be right back in 2 mins... Right after I watch the video on Membrane Potential 🤓
Hey how much is the time in which the neuron cannot receive any stimulation, in other words i want to know the x (time)
If the cell membrane were hyperpolarized to a resting potential of -110 mV, what would be the effect on the potential opening of K+ channel?
In the context of an action potential, hyperpolarization of that sort would significantly reduce the number of voltage-gated K+ channels that opened. Those channels are voltage-gated, so they're opening in response to depolarization.
Thank you, it makes more sense now.
lol of course I'm already subscribed
thannk you
Very very thankful yaar
What App or software do you use to create your videos? I like them.
I draw the images myself using a program called Sketchbook, then create the whiteboard animation using a program called Videoscribe.
@@neurochallenged wow thanks for your answer. Was not expecting one that soon. God bless the work of your hands 🙏🙏🙏
Do you have any references I could borrow?
An action potential at the axon hillock causes signal propagation down the axon (re-initiation process), correct?
Yes, that's correct.
You are awesome!
What are the units and scale of the time period in your graph?
The units would be milliseconds. The length of an action potential can vary but typically the change from negative to positive membrane potential only lasts about a millisecond. The whole time scale of the graph might be about 5 milliseconds.
❤
good keep it up
Make all cranial nerves please🙌
czcams.com/play/PLNZqyJnsvdMp5fxWG_JF0C3yoL6oA1t9R.html
Depok?
In your video, you show that the potassium channel open at the peak, but I thought the potassium channels open earlier than that.
If you're looking at the fundamental mechanisms underlying an action potential, then the outward potassium current follows the inward sodium current, and that potassium conductance starts to increase near the peak of the action potential. There are, however, potassium channels that open earlier. There is a channel, for example, called an A-type potassium channel that opens almost as quickly as the sodium channels. But when we're talking about what contributes most to the action potential, the focus is on what is known as a delayed rectifier potassium channel, and conductance across these begins near the peak of the action potential, right after sodium channels start to close.
There is always an open potassium channel! The leak Potassium channel. That may be what you are thinking of.
wait, during depolarisation, do sodium ions rush IN or OUT through the membrane????
IN
Love you thank you
i love you
I love you too.
Stupid question but is this happening within the soma?
no it happens in the axon's cell membrane.
how long does this take?
The entire firing process happens in a matter of less than a second I believe. That’s pretty remarkable.
A question for everyone who watches this video:
Why do cells go through action potential?
Hi there - im wandering the approximate time period of this process please
A couple of milliseconds.
Thanks! :)
This is great, but I worry it's too general, a lot of stuff isn't explained here that is key to understanding how the action potential is triggered, such as the temporal kinetics of the voltage gated potassium/sodium channels, or the probabilistic opening of them.
bless
Not me binging these for AP Psych
If you watch it at 2x speed, you get neuroscience in 1 minute.
Big brain
Hello I have a question that's it's so hard for me to find out it says action potential starts with deporalizaton or ends with hyperpolarization I think the correct is that it's starts with deporalizaton
Yes, it starts with depolarization and ends with hyperpolarization.
zuko is that you?
It appears that this video is so nerdy and topic specific, it cannot be related to reality. I was hoping to find a video that relates action potential to its locations in the human body, and find out more than what was taught in psychology class. This video only serve people doing the specific topic and does not give any wider context. It explains it for people going through psych classes but it doesn’t relate it to other things. For example is the polarisation between the nerve ending and the muscle tissue or within the muscle tissue alone? What is polarised?
um excuse me what?
Hyperpolarization....hmm, must be what is happening when I suddenly can't recall the name of a famous person or something else I've known all my life, but then I suddenly can recall it, perhaps seconds, minutes or hours later (repolarization?).
he is a liar. The video is 2:01 even though it said "2 minutes" which should be exactly 2:00. LIAR.
Too fast!
SOMEONE EXPLAIN THIS TO ME LIKE I'M A 5 YEAR OLD.