Keratin Pearl (SCC) vs Horn Pseudocyst (SK) (aka "pseudohorn cyst")

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Easy tips for telling these two types of swirled keratin aggregates apart! You also might find these videos useful:
Seborrheic Keratosis: • Seborrheic Keratosis: ...
Squamous cell carcinoma & actinic keratosis: • Squamous Cell Carcinom...
You also might like my Dermatopathology survival guide textbook. Accessible for beginners yet filled with practical tips for practicing pathologists:
www.innovativesciencepress.co...
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
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[@JMGardnerMD]

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

[@hanamichisakuragi5482]

Thank you very much! You are my first Dermpath professor.

[@dennissondermann8868]

Every time you feel depressed and burned out just open Jerad and relax 🔆😀 thanks for giving us such alot of interesting stuff!

[@rashmijindal4164]

Thank you. You explain brilliantly.

[@chandansaloni]

Great video , really like your description/explanation of the subject ! :)

[@user-dc9kf9fq5z]

Thank you so much for your explanation! I really enjoy watching this video!

[@tamilarasirenganathan8243]

i 've had problem distinguishing these two for years. Your explanation was crystal clear. Please make more videos. Thank you very much!

[@thinker-nn9sn]

thank you very much Dr Gardner
😍

[@BruceFame]

Excellent clarity

[@senaysenay1975]

Thank you , thank you, thank you🙏💓

[@dipesh19__]

Thanks for the video 📸☺️

[@laxmishachandrashekar7187]

thank you for this interesting video

[@anakhad6345]

Thank you very much

[@doublejchill9157]

I will have exam today on afternoon thank you your video to clarify my confusing

[@kasunnj]

Thanku very much sir.. your videos are so interesting and informative.
Love from Sri Lanka❤

[@emilyarutyunova9037]

Thanks doc!

[@nwahm2006]

Thanks a lot sir!

[@aishvaryajandial9198]

Amazing 👍👍
Thanks 😇

[@hamidabslh1293]

Thanks!

[@manhcuongthieu669]

Thank you

[@elirsf4400]

Amazing👏🏻

[@Medicomnemonicstipsandtricks]

Sir your videos really helpful,. Thanku sir 😊

[@khadijaibrahim9153]

Supernice 👍
God bless you

[@SandhyaRamachandran]

great as always! tanx so much.
If in a thickened surface squamous epithelium, one sees squamous eddies and kertain pearls and a very mild dysplasia , does the presence of squamous eddies and kertain pearls make it a SCC-in-situ? or, can the squamous eddies and kertain pearls be seen in a squamous papillom aor Seb keratosis?Thank you.

[@SAIF-pm7bp]

You’re amazing

[@vinamratasoni3990]

Thankyou

[@huichunsu3584]

thanks

[@khadijaibrahim9153]

May u come one day to visit sudan..
We will be very happy to learn from you

[@JMGardnerMD]

I would love that!

[@annak628]

Any tips on how to recognize a squamous eddie from a keratin/horn pearl? (I believe parakeratosis in the center can be seen in both?)

[@JMGardnerMD]

Squamous eddies are swirls of keratinocytes within the epidermis. They have no orthokeratosis or parakeratosis inside of them. They are made completely of intact keratinocytes. This video may help czcams.com/video/0VDDZ_HyNeY/video.html

[@ankitapatil8679]

Thanku sir for this video! Can u please make a video on " true horn cyst vs pseudohorn cyst"?
How to differentiate them both?

[@JMGardnerMD]

Pseudohorn cyst (or Horn pseudocyst as I call them) are what you see in seborrheic keratosis. But I don't know what a true horn cyst is. It is not a term I ever use.

[@ankitapatil8679]

Thanku sir for the reply! I found that term in one of journal on seborrheic keratosis, will share u the link here. But I didn’t get the difference between them.
doi:10.4103/0973-029X.140926
(Seborrheic keratosis, by Rashmi GS Phulari)

[@misterB2231]

some SCC pearls have outer-in aspect,can you explain this ?

[@JMGardnerMD]

I don’t understand what you mean by “outer-in”

[@rimakattea2237]

❤❤

[@dr.chinmaypendharkar2227]

What is the significance of painting the 'base' of skin biopsy specimen?

[@JMGardnerMD]

The ink shows that it is the true surgical margin. Sometimes it can be hard to tell true margin vs artifact from tangential cut. However, I personally try to avoid giving margin status on shave biopsy specimens for BCC and SCC because you cannot reliably see all of the margin. This paper explains: pubmed.ncbi.nlm.nih.gov/27116089/

[@dr.chinmaypendharkar2227]

Thank you, Sir!

[@mohammad.shokrolahi]

:)
thx

[@vivaanpeyush8046]

Sir...is keratin pearls only seen in squamous cell carcinoma?

[@JMGardnerMD]

Well I guess we only use the term “keratin pearl” when referring to nodule of keratin in SCC. But I’ve seen similar appearance of keratin aggregates in other things both benign and malignant.

[@vivaanpeyush8046]

@@JMGardnerMD Thanku sir...u are a great teacher..a true inspiration

[@Chris-hp9be]

7:32 looks like Starry Night by Van Gogh😂

[@masoodmohebzadeh4153]

Dear Dr.
The color problem of your microscope is due to light path issue.It will be resolved with condesor,diaphragm and light focusing lens adjustments.

[@JMGardnerMD]

No in this case it was an issue with auto white balance setting on the camera. I have a new camera now so hopefully will not have this issue again.