What are incapacitating agents and how do they work?
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- čas přidán 7. 11. 2022
- This time, we're ranking incapacitating agents! The term incapacitating agent is defined by the United States Department of Defense as: "An agent that produces temporary physiological or mental effects, or both, which will render individuals incapable of concerted effort in the performance of their assigned duties." It describes an agent which renders a person unable to harm themselves or others, regardless of consciousness.
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References:
CS Gas Chempilation - • He Made Hydrogen Cyani...
WKUK PCP - • WKUK Gallon of PCP
Hamilton's Pharmacopeia PCP - www.vicetv.com/en_us/video/a-...
Scary book - Jared Ledgard, A Laboratory History of Chemical Warfare Agents - ISBN-13 number 978-0615136455
Nerve Agent Tierlist - • Which Nerve Agent is t...
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Molecules for this tierlist - Agent 15 (BZ), DMHP (EA-2233), Nonivamide, GHB, Phenacyl chloride (CN/Mace), Chloroform, Xylyl bromide, Capsaicin (OC), CS gas (EA-1779), MPK (EA-1778), Ethanol, Sneeze Mace, CR gas (EA-3547), LSD (EA-1729), Halothane, Adamsite (DM), Chloral hydrate, Carfentanil, Rohypnol (roofies), Sodium thiopental, PCP (EA-2148), Ketamine, Fentanyl, Nitrous oxide, Propafol, Chloroacetone, Diimine (DIM), Bromobenzyl cyanide (BBC), Chloropicrin (PS)
Tierlist Playlist - • Chemistry Tierlists
Yea Problems have a very low solurabilaty in EtOH I always use Hexanes
👀👀👀
Wat??
I use opioids....
DCM works best
@@DanielSmith-ze9lw Well yes, but Dichloromethane is relatively nasty stuff.
I'm sad that there isn't just a PNG of a brick somewhere on that list
Or like, the chemical structure of lignin labeled "baseball bat" or something
Fe, labelled "the other Mace"
Triknifeoxide is S tier.
@@chrstfer2452 polycellulose polylignin adduct trade name "Louisville Slugger"
I had to get sedated once and I took like triple the dose for my body weight and had no reaction so I think a brick would be the best bet
"The solubility of problems in ethanol is fairly low" incapacitated me more than any of the chemicals in this list. S+ tier
I’m glad to hear it :)
I was gonna say as a former active alcoholic, this is quite true. Ethanol works great in its initial concentration but as it gets lower, those problems come crashing right out of solution. ;)
Are ya winning son?
I almost spit out my beer!
I started drinking in order to drown my sorrows - the little fuckers learned how to swim!
You missed the most popular riot control chemical: H2O.
Gotta watch out for dihydrogen monoxide shit can kill u 😮
True, especially down here in RSA.
XD
Riots are actually mostly H2O. Little known fact
fun fact: H2O (better known as Dihydrogen Monoxide) can cause excess sweating, urination, and can even cause asphyxiation when applied to the lungs. It's the product of Hydroxic Acid and Hydronium Hydroxide.
"If someone was sneezing hard enough I guess they could be incapacitated."
My allergies have entered the chat...
Ok that is true
Absolutely, i can almost count on 2 hands how many times i almost hit something while driving and sneezing repeatedly
I would like to see Xenon on this list, precisely because it is completely impractical and ridiculously expensive.
it was on my extended list along with N2O, but I removed it cause it was getting a bit to anestheticy
Most wildly impractical molecules would make an interesting tier list, tho.
You also get a deep voice which is nice.
@@foxyfoxington2651 like octanitrocubane? azidoazide azide? nitrogen triiodide? silver fulminate?
@@virtualtools_3021 something, explosive, something, explosive. Sounds about right
Agent 15 / BZ is actually a lot more horrifying than was discussed in the video. You may have heard of what happens when you take too much benadryl - horrifying hallucinations of spiders, shadow people, demons, faces in the walls, etc. - BZ actually does the exact same thing, but with much greater potency. It essentially induces a state of temporary schizophrenia, which, especially in a conflict, would be absolutely terrifying. BZ was also the inspiration for the movie Jacob's Ladder.
Seeing anticholinergics interfere with muscle controle, they cause temporary paralyse, high enough doses would stop you breathing. So I have my doubts about the safe therapeutic index of BZ.
Sounds like scarecrows brew
Oh, and last around 3 days. Plus anticholinergic intoxication tends to cause paranoid/persecutory delusions and short term memory issues which can easily cause someone to forget they've been drugged even if it was initially obvious.
I was going to comment the same. Jacob's Ladder is one of the most terrifying movies imo due to it's realistic premise
Sorta like the chemical the Batman villain Scarecrow uses.
That line early on about getting pepper sprayed by a doctor before a surgery is just a hilariously absurd situation to think of. I couldn't stop laughing at that.
Oh u got no health insurance? Than I will use the cheap medication 😂
STOP MOVING WHILE I CUT YOU OPEN!!! *sprrrrrayyyy*
Surgeon: "ok, just relax and let the anesthetic do its work." *pepper sprays patient in the eyes*
Patient: *Intense Screeching*
I'm just waiting for the one person in the comments to show up with their story of the time their doctor used pepper spray on them for XYZ reason.
@@Tkmined "Whoops wrong one! Hold him one second and let me see... Ah yes here."
20 seconds later screaming stops. Patient wakes up four hours later with bright red irritsted eyes and skin. Asks the doctor what happened and why are your eyes so itchy if you just got a colonoscopy.
"Complications".
I was pepper sprayed by a doctor in the military! It was unpleasant, but we were doing "how to deal with noncompliant people" and the doctor said "and our guy here will demonstrate"
LUL
Did you comply?
@@mushyroom9569depending on the strength, you will become semi compliant. You will be in a panic/fear state and it simply turns you blind, often with the feeling of suffocating + a lot of pain. I would say pepper spray is twice as bad as CS gas.
I personally think the use of peper- spray on a non compliant person is not going to make them more compliant.
There’s this story told by my PI about a “prank” involving LSD. Apparently back in the early days of LSD, it was common for chemists to try and synthesize it for fun. You may know that working with DMSO can require extra attention, not because DMSO itself is really bad for you, but it is great in delivering what is dissolved in it right through your skin. There were stories about how some people would make LSD and dissolve it in DMSO, and proceed to cover doorknobs with it. One can imagine the outcome.
That’s hilariously dangerous
Hah, good goof
It's a song by the Dead Kennedys
Well lsd was always a good time
keske lisede kimya calissaydim ya harika olay
I love how the S tier is a combination of "effective and largely harmless" and "terrifying war crime" 😂💀
GHB is also used as a medication for narcolepsy because it consolidates sleep. I am on it, and it's changed my life for the better. :)
Glad to hear it!
“The solubility of problems in ethanol is quite low” 😂
Legendary quote
Lead would have been interesting to see. It either works over decades, replacing calcium in the bones while causing general metal and physical decline, or over a few milliseconds, depending on where it's aimed.
that was...unexpected.
Tetraethyl lead is acutely and chronically toxic enough and maintains a dense enough vapor that it could be used as a chemical weapon.
@@rachellilah3284 I mean it was inadvertently being used as that when it was a common fuel additive (it still is used in aircraft that use gasoline instead of other fuels)
Ah this again, the chemical vs physical reaction debate
I made bromobenzyl cyanide as a building block to make one of my molecules and did not realize it was such a powerful lachrymatory agent. After pipetting it to a vial in my fumehood, a drop or two came out of my pipette onto the floor next to me, and within seconds my colleague who is in the fumehood across from mine started complaining that his eyes were burning (mine were too, really badly) and he was halfway through a column which he had to pause so we could step out of the lab for an hour or two because it was so aggressive
That is so wild!
Ouch
i swear some of these chemistry terms just sound completely made up
and i love it
IUPAC: "No, we swear, it's all systematic!"
All terms are made up
Well, they were made up by someone
This is very useful information for uh reasons
This is very useful for when I do something illegal and unethical, that could get me arrested and sent to prison for several lifetimes in minecraft
😂😜🤔
I'd say that's a valid reason.
@@iscuit I believe in the USA they are supposed to give you the MSDS by request , by law after being exposed to some kind of chemical agent.
Very good luck trying that though....😜
I think the law might only apply to work, and enough criminals have gotten shut down for workman's comp getting injured trying to escape..
@@iscuit Wait, but there aren't any lifetimes in Minecraft.
Since the nerve agents tier list I have downloaded the scary book, and is WAY scarier than I initially thought
absolutely
@@That_Chemist I found a second lovely one :)
SCARY BOOK?
@@Yarkoonian I'd assume they mean Toxic: A History of Nerve Agents, From Nazi Germany to Putin's Russia"
Naah I'm seeing things, it was "A laboratory history of chemical warfare agents"
Sneeze mace would make for a nice covert alarm. The enemy didn't set off the alarm, the enemy IS the alarm.
That's actually pretty ingenious as a deterrent, especially since it can be used in almost every civilian setting without an intention to harm. Patent that shit.
Sneezing makes me dizzy af. This would knock me out.
@@SteamCheese1 hard agree. Plus when I sneeze it is NEVER just once!
Imagine if you were at war in a dark multi-level building with enemies waiting around every corner. This sneezing s*** would be invaluable.
I'd put sneeze mace in D tier. Sneezing can be seriously incapacitating for activities that can't be safely interrupted. Also it's hilarious so that's +1.
The sneezing and vomiting agents were rarely by themselves, and instead mixed with vesicants and pulmonary agents like Lewisite and phospgene. The main reason this was done was to make it more difficult to don gas masks and force victims to remove gas masks as they filled up with mucous, saliva, and vomit. Once removed, the sneezing and vomiting would cause victims to take deep breaths, which would lead to worsened sneezing and vomiting, and more deep breathing, and more deep breaths of the main lethal agent. Basically a really horrible positive feedback loop.
Phosgene
That's an absolute nightmare holy crap
Whoever came up with that combination was just downright evil, no doubt a genius as well, but still really evil.
14:43 I am allergic to dust mites, this makes me sneeze uncontrollably sometimes. If someone made a sneeze bomb that would be super incapacitating. Can't see, breath, head hurts, can't catch your breath... It gives me shivers knowing something like this exist.
As one of the millions of soldiers, sailors, and marines who were gassed during basic training I can attest to the incapacitation power of CS.
From a historical perspective I would definitely put CN/Mace on the S list. It was very prominent in many wars from WW1 to vietnam because it was relatively low-harm and very coinvenient to spread in simple pyrotechnic (sub)munitions. Militatily it was one of the major war gases of the 20th century.
My first exposure to CS was egging on our CBRN NCO in Army basic training. Concentration was high enough to reduce visibility to about 2 feet and cause a burning sensation on the back of the neck. You can still function at about 80% if your pain tolerance is high enough. Managed to name the Army Chief of Staff (General Peter J. Schoomaker, at the time) and visual and demographic details about the guy next to me. "That's Private Smith, he's from Puerto Rico and his father was in the Navy." I always liked the yearly visit to the chamber: It was always when I had a cold or allergies. One run through the chamber and your chest, lungs, and sinuses are the cleanest they've ever been, mainly because you just snotted out about a gallon jug of it.
My first exposure to propofol was *also* in the Army. When they removed my (severely impacted) wisdom teeth. The story on that one was "Count backwards from ten" "Ten, ni..." [blink] [doctor suddenly covered in blood looking exhausted, bits of teeth, blood, gauze and bone everywhere] "The fu-?" [realize my mouth is suddenly full of gauze] "You tracking?" "Here's a bottle of oxycodone. Take one, twice a day. Here's extra gauze. No hard foods tomorrow. Replace the gauze after taking the oxy. Try not to smoke for the next week. I realize you're combat arms; Cut back and replace the gauze a little more often. Here's a bottle of rinse. Use this after smoking, or eating, just before you put new gauze in. Dry sockets suck. So really try to cut back on the cancer sticks. Here's your driver. If you need more, my number is on the bottle. Oh, and here's your profile: One week bed rest, after that, light duty for two more weeks. That was not an easy extraction."
The worst part of the Gas Chamber was that some wiseass range NCO planted a tree directly in front of the exit 30 years earlier, a tree that we each individually ran into as we exfil'd, all coughing and covered in snot and blind, flapping our arms, the Drill Sergeants all laughing their asses off.
@@wes11bravo the better one was the victim operated honesty checks: Drills had brought an open carton of open packs of cigarettes into the chamber for the entire [sqdn/bn/bty] training event. (Mind you, nonsmoking IET.) So, constant exposure to CS for a couple hours.
Then they stashed the cigarettes individually around the barracks and DFAC interiors, exteriors and bathrooms.
A drag off of one of those doesn't hit you immediately. But when it *does* hit, you feel like you're going to cough out your lungs. I did it to myself accidentally by putting a spare pack in that little pocket on the outside of my promask carrier before running through the chamber for a yearly. When I was hard up one exercise after that, I found that pack and promptly regretted it.
Sometimes it feels like this channel is a speed run for fastest visit from the fbi lol
What you haven't been checked out yet.. i have 🤣
Love the more comedic take on what most would call boring while still being highly educational. I also think the tier lists are very original. It would be really cool if you could do one including radioactive isotopes or something of the sort, maybe showing which ones are the most dangerous or something.
Radiactive elements are a bit more on the physics side imo, but would still be interesting.
@@racemaniak2000 After having watched this video I have my fingers crossed for a rocks/minerals tier list... Even tho it's probably about as far as you can get from "organic".
@@foxyfoxington2651 lol yeah
@@foxyfoxington2651 I'm a biochemist, and with the amount of times we've been dunked on by now, I don't think I'll get the Krebs cycle tierlist I wish for :c
I haven't been pepper sprayed by a doctor, but one did poison me with a drug from the same class as BZ!
Years ago I managed to get a small metal fragment in my eye while angle grinding (yes, I was wearing eye PPE, the fragment was caught in clothes which I took off later in the day).
My GP put some lignocaine in (a local anesthetic) and after failing to remove it, sent me to the local public hospital. Upon arriving I saw a sign on the wall in the ophthalmology unit, listing what each of the medications did - lignocaine: LA, tropicamide/atropine: mydriatic, etc. I assumed it was for med students, but I was still surprised they needed reminders of basic medication names. At the time I was a second year pharmacology student, and had a fair idea what most of them did.
After putting in some fluorescent dye and more local anesthetic, the doctor told me to stay *completely* still and proceeded to start digging around in my eye with a needle. It hurt like hell, and I couldn't help but flinch or blink. Each time this happened the doctor put in yet more local anesthetic and told me in an increasingly irritated tone to "STAY STILL". He eventually declared arrogantly that my flinching/blinking was "just psychological", and so put anesthetic in the other eye as well, which apparently helps reduce flinching sometimes. The vision in my injured eye was already blurry, I assumed from strain of trying to stay still, but now my other eye was slightly blurry too. Genuinely interested, I asked if topical anesthetics could cause blurred vision. He snappily replied that they didn't, continued his excavation and then sent me on my way.
After leaving I was feeling pretty dazed. I was anxious and my mouth was dry, which I put down to the ordeal I'd just been through. I decided to message a friend who lived within walking distance of the hospital to see if I could go there to recover for a bit. It was then that I realized my vision was so blurry I couldn't even read my phone screen. I called her and upon hearing the state I was in she offered to pick me up from the hospital. When she arrived, a look of shock crossed her face and she told me that both my pupils were absolutely HUGE...
It was then that the penny dropped. Dry mouth. Racing heart. Dilated pupils. Spaced out feeling..
The whole time the doctor was DIGGING AROUND IN MY EYE, he WAS NOT USING ACTUAL LOCAL ANAESTHETIC. I'd wound up with systemic toxicity from the huge amounts of anticholinergic eyedrops he'd put in my eyes instead. Even worse, the fact that the reminder sign was there probably means I wasn't the first...
That question about "blurry vision" should've snapped him right out of the mistake. Like, "why is he asking about that specifically?".
That's quite scary, hopefully you had no permanent damage. I was weeding a planter area in my yard and rubbed my eye at some point. Later on I got blurred vision and a slightly dilated pupil in one eye. Now I wear gardening gloves and do not touch my face while weeding. I'm lucky it wasn't something more poisonous.
@@davidg4288 Yeah, thankfully I was ok. I think the trauma was ultimately worse than the anticholinergic effects - I didn't have any delirium or anything like that. I'm glad my GP had already put some local anesthetic in an hour or two before I got the hospital. It must've still been working a bit, because I don't think I'd have been able to tolerate it otherwise.
Do you know what plant it was that you were weeding? I'm guessing it was probably something in the Solanaceae family like belladonna, henbane or white nightshade
@@rkirke1 I am not a botanist but I don't think belladonna grows around here (Northern Ohio). It could have been thornapple (or jimson weed), I would know what that looks like but an immature plant could have been hidden in the mess.
Normally the only plant to worry about here is poison ivy which is absolutely everywhere. Of course I wear gloves for thistle but for dandelions I can get a better grip and more of the root bare handed.
I just had Propofol the other day when getting a trial spinal cord stimulator "installed' (for lack of a better word) Being an outpatient procedure (despite attaching electrodes directly into my spinal cord) I didn't have to go under full anesthesia so only Propofol was given. Was such a weird experience as once I was waking back up, I felt as though I was never really out and vaguely remember talking my ass off like I normally do, but just with no clear recollection. I was extremely nervous leading up to the surgery because it's the first procedure I've ever had done outside of a few endoscopy's. They told me I'd have to be partially alert so that I could confirm that they were connecting to the correct nerves. Thankfully I don't recall any of that and actually felt really great very quickly after waking up.....until the small amount of Fentanyl they gave me began to wear off and the intense soreness and inability to bend, twist or move any part of my back easily.
They then made my anxiety climb even higher for the following week when I found out the procedure when I go back after 7 days for removing the temporary leads.......
Step 1: Have me take a deep breath
Step 2: They Grab a hold of said leads
Step 3: They Yank
I am NOT looking forward to the uninstalling 😩
:(
How was it was it nice
19:53
I worked with chloral hydrate and it’s one of my most favourite chemicals ever. It has a very light and soft smell of watermelons and berry bubble gum from 90th.
Chloral hydrate is cheap, conveniently solid, and upon distillation with sulfuric acid converts into chloral, which is a transparent liquid with a strong and appealing, but irritating smell.
Sodium thiopental is also interesting because of its reputation as a truth serum. It turns out that this doesn't really work: people definitely have lower inhibitions and ability to make up lies when high AF, but it doesn't necessarily make them speak only truth either. Still, this didn't stop its reputation as "the stuff that you'll get before getting interrogated by the CIA" from spreading.
My favorite part of being a chemist is having *an immediate visceral reaction* to seeing highly reactive chemical structures.
Back in school I made an own indicator for acids and bases for a project. As I tested it in my kitchen at home, I had vinegar and drain cleaner (sodium hypochlorite) left over, as I tested the indicator with it. Guess what, would be a great idea to mix them up to neutralise it. So I basically made chlorine in my kitchen and it stank like hell and fumed, so I grabbed the glas and ran out through my living room with my parents in it screaming „Ich hab‘ Chlor gemacht, sorry, erklär’ ich später“. Great experience
I found WKUK thru childhood curiosity about a firing squad. Hearing you mention them for PCP made my day
RIP Trevor Moore
Love the video. Scopolamine is another really interesting incapacitating compound, especially how it's being used by criminals in Columbia
Yeah BZ is similar
Was about to comment this. I was exposed to it and it is brutal, though you get these moments when you suddenly transition to normal behavior without even noticing. Then back to "crazy real" dream again...
Scariest drug on earth
It is a goody way to get to the sex without having to wine or dine or make coversationl effort lool
@@DC3Refom fucking yikes dude
I definitely didn't put a spicy meme somewhere in the video
Idk if it is intentional but the agent 15 was said like the Burger King foot fungus meme
What happened to discord's fan favorite, the 'Salvinorin's?
it became too much of a tangent for the video
Spicy
While you were explaining EA-2233 you mentioned how long the agent lasts this happens precisely on 4:20.
This may be it but I may be pulling at straws here.
Studying pharmacy, it's always fun to see which of these compounds I already worked with not really minding their capabilities at all, because we used really small quantities. Thiopental and Flunitrazepam (Rohypnol) are among the ones I worked with in an analytics class last semester.
PS: Lawmakers aren't too thrilled about students handling benzodiazepines and opioids, but...
a) how else should we obtain experience in handling and identifying these compounds?
b) who in their right mind would be insane enough to study 8 semesters of pharmacy and do an extremely hard exam just to get like a milligram of morphine?
Lawmakers aren’t too thrilled (full stop)
Ahh the joys of Arzneistoffanalyse :D old memories...
@@eier5472 true
I can confirm that chloroform doesn't work like in the movies. I tried to extract something in chloroform in a big seperating funnel, but the NaHCO3 phase reacted far more than anticipated... TLDR, I got soaked from top to bottom and will never mix things in that funnel again, but a stirred beaker...
People around me complained for some odd reason about getting dizzy and that was after I changed my clothes (good thing that I was one of the few prepper, who have a second set of attire at work, LOL).
once seen somebody use it on a three legged cat in order to prepare DIY euthanization (when that was still legal around here). took several minutes with a rag and a plastic bag. might as well have not used chloroform, would have done the same job.
There are volunteers, and there are designated volunteers. The volunteers for those tests where almost all of the second flavour.
Lately, fentanyl have been in the news a LOT, and is associated with 100's of death by overdoses in Canada. It's to the point that first line respondents, paramedics and street workers always carry it's antidote. The antidote is also available in most pharmacies for free so that you may save a life.
According to a article called “the library of chemical warfare agents” diimine was once tested as a riot control agent but was too strong so they didn’t use it
30:25 brought me to tears, I cannot believe you incapacitated me so effectively with a virtual lachrymator
Ayo the video has been published 5 mins ago
Patreon fella ?
@@koukouzee2923 I don't regularly give early access to patrons - I only just finished editing the video before posting ;)
@@koukouzee2923 I am just drawn to BBC in any context
@@MetaChemist Understandable
It was interesting seeing you talk about Chloropicrin. There have been a few reports coming from the war in Ukraine that Russian units have used PS grenades due to their supply shortages. Absolutely wouldn’t want to be exposed to something that nasty.
Chloropicrin definitely is far more a poison gas than a tear gas in ww1 people were gassed to death with it
Calling chloropicrin a tear gas is as much of a stretch as calling chlorine a tear gas. Both destroy all tissues.
If that is true, it would be a war crime.
@@jannikheidemann3805 it is, just like a Sarin attack or a chlorine tank in an IED.
One of the researchers working on MK-Ultra became convinced that he'd been dosed with LSD, and gradually became more and more paranoid about this until his colleagues actually dosed him with it.
I mostly get euphoria from LSD so it kinda does the opposite of incapacitate me.
I think Frank Olsen was worried about that Sydney Gotleib was doing that to him, Frank Olsen was also on the team that dropped acid on San Francisco from plane years before his death.
One thing you forgot to mention about BZ is that the main effects incapacitate for up to 60 hours. That shit is wild.
Wasn’t pepper sprayed by a doctor but a post doc I was eating lunch with nailed me in the eye with some fucked up hot sauce. It was pure agony.
I accept this as a valid answer
Propofol acts really fast intravenously, sudden fade to back just to wake up all cozy and warm in another room with this weird smile on your face and completely vulnerable. Nice list!
Totally agree!
it's like falling asleep within 5 seconds.
@@Hamstray Or even less... it's almost instantaneously
Did not get propofol but Versed (Midazolam) for a dental surgery. Smoothest experience ever as far as anesthesia goes. While still being half out of it, I managed to hold a completely coherent text message convo with a friend and we decided to meet for beers two days later. Didn’t remember any of this exchange and only saw it the next day, when they texted me about how the surgery had gone. And yes, we had beers the next day.
10/10, would recommend, sans the surgery bit.
Haha
Coming out of a propofol haze is pretty awful, it has been for me anyway. Imagine being startled awake and not knowing what is going on. Feels bad man.
I remember watching a film during chemical warfare training showing utterly gormless soldiers staggering about after being dosed with BZ.
30:21 “the wasabi receptor” is the perfect name for that as it immediately reminds you of wasabi/horseradish burning your sinuses. Cool!
Can you do an antipsychotic or antidepressants tierlist? Thanks!
all SSRIs in S tier, for their risk of inducing Suicide
@@virtualtools_3021 haven't they overall decreased the suicide rates in young people? Early in treatment, reduction of psychomotor inhibition occurs a while before the actual mood lifting qualities take effect, and so this can potentially lead to a less inhibited state where someone is more likely to commit suicide sometimes.
Very real risk, but overall more people commit suicide who were depressed and did NOT take SSRI's
There were reports from people claiming that they developed suicidal ideation after starting SSRI treatment that wasn't there before. Not all of the ssri did and I don't know if anyone statistical analysis on this. Basically I lost interest in the subject over a decade ago so haven't kept up with the literature. In the end I'm glad that talk therapy worked for me.
@@Dude8718 Links might be censored, but search for 'Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials' and you can find a paper on it.
Additionally 'Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies' shows that the risk is greatest in people aged under 25.
My favorite incapacitation agent is a 230gr projectile traveling at 1000fps, though most of my friends prefer a 124gr projectile traveling at 1200fps.
🙃
I have almost no clue what 80% of what you said means, nor could l ever begin to comprehend how the "diagrams" representing what these agents are composed of are supposed to be read, but your style still made it very enjoyable and entertaining. Good video !
Oh no I want to go in a rock store,you made my day.Great content very good explaining.
Glad you enjoyed it!
On the comment of the doctor and pepper spray, I have, twice in fact. served for a bit as a Specialist in the AFP's SFR-A 2nd Battalion. While I was working in an evacuated apartment complex a local doctor came back while I was in his room, somehow still in the building even though alarms were going off everywhere. I don't precisely *look* Asian so I got sprayed with commercial pepper spray. No biggie though, he apologized after realizing who we were lol.
The second time, I moved to the National Guard SF here in America while I was in college, and during training, I was told one run of UTM clearing drills would have a "surprise". So while I'm in the simulation, I begin securing someone, and another actor pops up and blasts me with pepper spray. Of course, after finishing the drill, I recognize the guy that sprayed me as the dad of a friend, a doctor themselves.
...I should consider doctor-repellant or something lol.
i suggest apples
I have absolutely no idea what you're talking about, but i watch every video for some reason, its soothing.
Interesting note on Adamsite, while not considered a lethal agent, when developing chemical weapon doctrines Adamsite was to be used in conjunction with other more lethal agents such as phosgene. The idea being that although the gas attack would be detected and defending troops would don their masks, the exposure to Adamsite would induce vomiting so that soldiers in the effected area would remove their masks and thus expose themselves to more lethal agents. That was the theory, in practice it was considered difficult to produce the needed concentration of Adamsite in battlefield conditions to have this effect, especially when you could just saturate an area with lethal agents and expose defending troops to lethal concentrations before countermeasures such as donning masks would keep them safe.
Sidenote: S-tier description of Ethanol, bravo.
Wouldn’t the mask protect them from it though?
@@KanyeTheGayFish69 Ideally yes, but the idea was that Adamsite would be used in the initial part of the attack, thus exposing soldiers to the agent before they first donned their gasmasks. This initial exposure was thought to be enough so that troops who were now masked up would be forced to remove those masks after several minutes during the ongoing gas attack. Though as stated it would have been too difficult to deploy effectively on the battlefield.
Please do a video on Edgewood Arsenal!! Not a ton of easily accessible information i can find on it, and i feel like what I’ve read would be sorta relevant with what topics you have covered!
I watched the nerve agent video last week and I'm still here baby! Good job man. You hooked me for 30min, and that's not easy.
I was fully conscious but immobilized and relaxed during a procedure where they used propofol. Let’s just say people over the age of 50 get this procedure done. The staff who administered it didn’t believe me until I told her the entire conversation about baseball they had during the procedure. She was like ohhhh. Sorry!
5 years later I had to repeat the procedure and in the notes it basically said “give him more than his weight dose says” because not only do I have zero memory but for the rest of the day I was totally relaxed and kinda off mentally.
These are genius. Pls never stop. If you ran out of chemicals just invent more.
There are so many chemicals - we will never run out
@@That_Chemist I hope. I wish someone taught stuff like this at uni.
@@That_Chemist literally endless possibilities I love it
I'd say nerve agents are more effective than anything on this list. It's hard to carry on what you were doing when you are dead.
I find it odd that the Department of Defense don't include "non-lethal" or "not permanent" in their description of incapacitating agent.
I love your content! I enjoy your discussion of pharmacology when you talk about psychoactive compounds! I know it's not your main focus but I would love for you to make more videos discussing receptors and all of that fun stuff.
Maybe even making some videos on protiens? Like what if you made a tier list of a bunch of proteins either from the human body or from plants or bacteria etc. I would love this!
Fascinating video thanks mate
Your description of propofol makes my wisdom teeth procedure make way more sense. They initially tried a sleeping gas and I reacted bad to it, so they gave me propofol I guess!
I’ve just found your videos and love them it’s like a fun mix of chemistry and history
Welcome to the channel :)
Chemhistory 😂
@@emilyrln the best kind of history 😂
Love these videos, thank you very much, good luck my friend I will keep watching!
Thank you for your kind words :)
My memory of the milk of amnesia was very similar too yours. The next 24/32 hour was a bit blurry but with horrible flashbacks.
Imagine someone deploying the "Sneeze Mace" during the height of Covid.....Pretty sure that would have counted as some form of terrorism
Like, the hallucinations from BZ are terrifying, nightmarish, and are like if Sauron himself took control of your mind
Dont tell the people at r/dph or they might start abusing BZ gas instead of benadryl
@@virtualtools_3021 those folks have no soul at this point
Sneeze mace really ought to be up there next to mace. It's only two hydroxyl groups away.
Researchers have tried making TRPV1 antagonists either as an antidote to pepper spray or as a new class of non-addictive painkillers. While those effects do occur, the problem is that blocking the nervous system from detecting heat leads to severe hyperthermia. Nature likes to reuse the same building blocks.
Fart, halitosis and body odor- classic incapacitating agents, especially in enclosed spaces.
Loose cheeks sink ships?
There’s been times when I would have taken bear spray over halitosis .
@@Kwikii1 loose cheeks stink ships
I would bump ethanol up one tier, both due to popularity/availibility but also because the vapors are quite irritating to the eyes and nose, though without lasting duration. (Try putting some on a rag and wiping it over your face)
I will remember these tips on my first date. thanks mate!
"One of the things people try to dissolve in Ethanol is their problems! However the solubility of problems in ethanol is fairly low" best thing Ive heard today
I'm loving this tierlists! Very fun to watch when you're insomniac 🙃
Also, I love the thumbnail, hilarious!
I'm not sure how many people would be interested in learning about biochem, but a tierlist of neurotransmitters could be interesting imo.
Of course, it's up to TC to decide... I'm not sure if it is even on his field of work
It's probably a stranger idea but don't judge my tired brain can't do much right now
Sorry T.T
Glad you enjoy it!
Apparently, there's a deeper story about the gall in the thumbnail that *absolutely no one had ever knew about.*
Used to be a Corrections officer and I can confirm Capsaicin (OC) works wonders on breaking up fights and gaining compliance when needed.
Ethanol, in my understanding, is clear - but paradoxically has cloudy properties - it clouds the mind and fogs memory.
Another classic. Waiting for that anesthetic tierlist ;)
As a doctor who has prescribed capsacin cream for peripheral neuropathy pains, I am worried that some people have rubbed their eyes without washing them properly. There is a chance I have indirectly pepper srayed someone
Fun Fact: 2016 SYD Hospital tested 86 so called cases of "drink spiking"" none of the patients tested positive for the typical's, they were all just too pissed, being all girls. I can hear them from here. "" I only had 6 shots 4 brezzers and 10 tinnies"
You would have to have access to benzo powder which is not impossible but yea no one is ever going to be able to crush a benzo or dump enough ketamine in a drink without you noticing it tastes like shit
Pretty awful living in a society where women have to assume the worst when simply out drinking. Men generally don't have this worry, they can get as pissed as they want and not fear being predated upon by some creep or 'nice guy' vying for sex with a semi-conscious, often emotionally manipulated woman, who's fearful of how he'll react if she tells him to fuck off. But I'm glad you found their fear amusing, it's a perfect representation of how we treat women and how the culture of sexual assaults and harassment continues (blaming victims, belittling concerns, propagating the false belief that women often lie about SA). Indeed, a man is more likely to be a victim of rape himself (230 x times more likely) than to ever be falsely accused of rape.
that doesn't surprise me; I've had numerous friends become convinced someone drugged them despite there not having been any opportunity for someone to spike their many drinks, nobody trying to take advantage of their inebriation, and them being there with a 6 foot tall, 265lb man lmao
I accidentally snorted PCP one time. I was using opioids at the time, and I was given PCP instead. They both look like white powders, so I naively did a bump and waited for the high.
The high was very strange. A few effects that’s stood out: my sense of time became so distorted. I remember sitting in my car in a parking lot before walking into a restaurant to get my take out. It felt like I was sitting in my car for hours, whilst in reality it was no more than 10 minutes.
Another effect: I remember hallucinating faces in inanimate objects. It wasn’t scary, but was unnerving.
One bump lasted maybe 4-8 hours. Hard to tell. I would not do it again. I threw the rest out. It wasn’t as euphoric/pleasurable/fun as opioids.
I was just thinking about these after your nerve agent vid
Oh my god I was hoping you’d mention WKUK when talking about PCP because that’s also the first thing I think about. Rip Trevor 😢
RIP
Hey, I had the same flashback experience as 27:25 a few days ago after an upper endoscopy/colonoscopy. Very unpleasant. I was sedated with fentanyl and midazolam and had to be given extra because it wasn't fully putting me under. I was super fucked up for the next 12 hours.
Straight and to the point, I like it. 👍🏻
Your videos are fantastic bro keep it up
thank you :)!
Honestly, after being exposed to tear gas and OC, I don’t find them to be extremely incapacitating. After my exposure with OC, I still had different tasks to complete and did. Tear gas I found a lot harder to do anything, but I could find myself still completing tasks if it was necessary. Maybe I’m thinking of incapacitation differently, but thought I’d put my 2 cents in there.
I will use this guide for warcrimes in minecraft
Amazing video and I died laughing at the thumbnail, cheers!
I appreciate the information.
I like how the EA tags basically is like "okay what cursed shit is this possibly involved with."
Now you just need to go over blood, pulmanory and blister agents
I definitely plan to ;)
mustard plant vs mustard condiment vs mustard gas 🙃
@@That_Chemistmaybe expand blood agents to also include "general toxins" so you can also add stuff like flouroethyl flouroacetate.
"The rock store" was the best part
Damn that cough medicine looked AMAZING! We need to get that back on the shelves ASAP!!!!
BZ and tiserzin would be my choice. Reziniferotoxin is also quite incapsaicating. ))
Resiniferatoxin is about 1000x stronger than capsaicin iirc, right?
@@Kwikii1 It varies from source to source, but it is definitely somewhere between 1000 and 10000. 😁
How to make casual CZcams edutainment viewers result in getting put on a list. Thanks ThatChemist!
You're welcome!
Had Propofol, Chloral Hydrate, Fentanyl patches, and Ketamine. Good stuff.
Yeaaa I'm definitely on some kind of watchlist now