What is Triple-Negative Breast Cancer, and How is it Treated?
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- čas přidán 5. 08. 2024
- What is triple-negative breast cancer? How common is it? What does treatment for triple-negative breast cancer look like, and how effective is it for different patients and circumstances? In this video, Dr. Jennifer Griggs explains everything you need to know about triple-negative breast cancer and its treatment.
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I love this doctor. She inspires me peace and hope. Thank you so much.
Glad to hear we can help! Would you be interested in participating in an interview to help us improve our products? It will consist of us showing you a sample Yerbba breast cancer report and you sharing your thoughts and opinions. Your input would be greatly appreciated!
Good day..i am from the Philippines.I am diagnoseas TNBC...i am so sad..learning that it is an aggressive cancer...but..praying to survive soon..
No don't worry they are all the same ❤️❤️ be optimistic
Thanks for writing. While we generally think of triple-negative breast cancer as "more aggressive," this cancer can be extremely responsive (treatable) with chemotherapy, and every oncologist has many many patients who are living years later with no evidence of recurrent cancer.
@@yerbbayessss
Diagnosed with Micropapillary breast cancer grade 2 with no node involvement and my IHU report came back as triple negative. I can't find much information on the internet. My doctor said it's a lazy type of cancer with good prognosis but have to do chemotherapy as it's triple negative.
Your doctor is right that chemotherapy is the best approach. If people have a BRCA mutation and a higher risk of recurrence, they should also get a year of olaparib, which is a pill taken twice a day. This does not apply to triple-negative breast cancer that is not associated with a BRCA mutation.
Hi! Very informative video!
My mom passed away from TPBC in 2018. She had genetic testing but it was all clear. Im 26, should I be more cautious in the future and begin mammograms sooner in life? Or I dont have a higher likeliness to get it than any women?
Thanks!!
Thanks for sharing your experience. Although it is tempting to want to start mammograms early, in general we want to avoid exposing young breast tissue to radiation even though the amount of radiation is low from mammograms. It would be worthwhile to discuss the best screening options with your medical team.
With Triple Negative Breast Cancer are you considered cured if you've passed the 5 year mark after recurrence?
Wonderful question. Triple-negative breast cancers do tend to recur earlier than other breast cancers. So if one makes it to the 5-year mark, the odds of the cancer coming back are quite low. Of course, everyone is different. It's also important to continue to have breast imaging because a new cancer can develop.
Can DCIS high nuclear grade 3 with micro invasion with negative ER and PR be triple negative breast cancer?
I don't know the HER2 status
Great question. Even with microinvasion, DCIS doesn't get classified as triple-negative or otherwise. We don't usually test DCIS for HER2 status because treatment doesn't depend on the HER2 status. I hope this is helpful.
Doctor? First of all, thank you for your effort in educating patients with breast cancer as well as their care givers. My mother was diagnosed as having stage 1 grade 2 TNBC in Jan 2024 and has completed 4 cycles of doxorubicin. We start paclitaxel next week for 12 weeks and then 15 cycles of radiation 2 weeks thereafter. Is the type and stage she was diagnosed with curable and not just treatable? I have been having sleepless nights overthinking about this. Her genetic testing reports have come back negative.
Your mother is fortunate to have you. In people with Stage I breast cancer that is triple-negative, the goal of treatment most certainly is cure. While no one can know for sure if she will be cured with this treatment, most people are indeed cured. Wishing you both the best.
Hi Doctor, i was diagnosed with DCIS high grade, negative lymph node...ER negative PR negative last week June 16 this year. My breast surgeon sending me to do MRI to see if its really DCIS or with IDC in it and wants me to do another biopsy which i dont like to do it again because i already did it before the diagnose. my breast became hard inside and still bruised..any advise for me if i will do again the biopsy.?? Thank you.
Thanks for writing with this question. If there are any concerns that this is invasive disease, additional tissue can help the surgeon know whether a lymph node assessment is warranted. It may therefore be helpful, yes.
Ive been diagnosed with TNBC Stage4, with Metastasis to lymph nodes in armpit and chestwall. I also have an open wound under the breast...my doctors haven't given me much info after a month. Can you offer any hope?
This sounds really hard. There is hope to be had. The key is to learn more about the cancer to find out what treatment options may be available to you. If you're based in the U.S., consider visiting yerbba.com to get your personalized Yerbba Report. This comprehensive resource is designed to provide personalized treatment options and detailed insights into your specific diagnosis, helping you navigate your treatment decisions with confidence.
Hello doctor
My mother was diagnosed with non invasive ductural breast cancer some 15 days back. She has undergone mastectomy 9 days ago. Now her ER/PR report has came triple negative. Doctor is suggesting 8 chemotherapy. Please suggest something is this curable. Will she be fine??? Pls reply.
Chemotherapy is not recommended in anyone with noninvasive cancer. It is possible that there is invasive cancer in the biopsy. This would be a terrific question to take to her doctor.
Hello doctor,I hope you are fine .I m having T3N0M0 what it means and how much is the expectancy of life will this be curable and can I live fullest of my life I have axillary lymph nodes and mentioned termed
*Twice negative what it means please tell me about this mam and will I get lymphoedema in future I'm very much scared and rolling out tears each and everyday please tell about this clearly mam thank you so much
The goal of treatment for someone like you is cure. All treatment will be given in with the hope that you will be cured. While we cannot know for sure that you can be cured, there are many people with a tumor such as yours who are indeed cured. I have had many patients with this type of tumor survive for decades (I have been doing this a long time), and most oncologists I know agree. While it's normal to be sad and scared, we would like to encourage you to maintain hope.
Triple negative for a 66 years old. Stage 1A invasive ductal carcinoma with lobular features,, left breast mastectomy was done last Sept 17,2023. started 1st trial of chemo last November 17 2023 chemo meds are carboplatin and docetaxel chemo drugs..... how many chemo cycles do i need in your opinion please . Thank you
Thank you for watching. We encourage you to discuss any concerns or questions about your treatment plan directly with your medical team, as they can provide the most accurate and personalized information for your situation.
Mam my sister had triple nagative breast cancer and doctor said there are tumours of stage 2 . Please suggest me best treatment for my sister she is only 26
Help mam
Thank you for watching, if you are interested in a personalized breast cancer report to understand possible treatment options and are in the United States, you can visit www.yerbba.com. It is likely that chemotherapy will be part of your sister's treatment plan. Please also consider talking with your sister's oncologist about genetic testing.
Hello, is neoadjuvant therapy approved in TNBC and when?
Neoadjuvant therapy has been given before surgery for decades. The timing of treatment is not under the purview of the FDA. Rather, the drugs themselves are approved. The order in which systemic therapy is given relative to surgery is not associated with its toxicity or safety.
Hi Doctor…I was diagnosed last week with TNBC. Is chemo mandatory? Or should I do the lumpectomy and radiation, and then if it returns chemo?
In general, it is recommended to receive treatment with curative intent if such treatment is available. If people wait til the disease recurs in other parts of the body, treatment is not successful at curing people. Thank you for watching.
@@yerbba thanks for responding. I start chemo on 1/5/24.
Is T2N1 with grade 3 TNBC curable?
My mother age 40 ,T1NOMO with TNBC
She had mastectomy to left but pathological report showed with deep margin invovled by tumor , going with chemo (adreamycin,5FU, cyclophosphamide)
One oncologist suggested to do resurgery
Another oncologist said to go with chemo and radiation
Which one Is better mam
Can u help..mam
This must be hard. It's not possible to make a recommendation without knowing how much of the margin was involved and whether the involvement was diffuse or focal. It may be helpful to ask what the risks and benefits of both receiving radiation therapy versus having surgery again.
Thank you mam
Good day Dr, would it drastically inhibit chances of breast cancer if a young lady undergoes mastectomy based on family history of cancer and positive BRACA1 gene please? Like in the case for Angelina Jolie. I was reading that it drops chances of breast cancer from 87 to 8%
That's correct. Mastectomy is highly effective in reducing the risk of breast cancer.
@@yerbba will its not 100 percent
I’ve have triple negative breast cancer. I’m on Keytruda and chemotherapy. Thank you for the information.
We're truly sorry to hear about your diagnosis, but I'm glad to hear that you found the information helpful. Remember, you're not alone in this journey, and your healthcare team is there to support you every step of the way. If you ever have questions or need support, don't hesitate to reach out. Wishing you strength, resilience, and the very best in your treatment. Take care.
Please let me know how you are doing, do you have node involvement?
Hello and thank you for posting this informative video. I was diagnosed with TNBC recently and my doctor informed me about a new study called S2212 Shorter Anthracycline-free Chemo Immunotherapy Adapted to Pathological Response in early Triple Negative Breast Cancer and wants me to try it. They need 2400 participants but so far only have 4 participants signed up. Have you heard of this study? If yes, do you have any insights on it? Do you recommend? I do want to help research and science but not if it’s going to be a big risk for me. Please let me know your thoughts on this.
This trial was designed by the SWOG (previously the Southwestern Oncology Group) and is open in hundreds of practices in the United States. The trial has extremely specific criteria for who is eligible and compares anthracycline-containing chemotherapy plus immunotherapy with non-anthracycline-containing chemotherapy plus immunotherapy. The study opened in mid-September of 2023. It is extremely likely that there are many people enrolled in the study across the country. In general, participating in a clinical trial is considered the best care. People on a clinical trial have a chance to receive something better than the best we already have. Only you can decide, however, if you want to take part in the study. We hope this is helpful.
@@yerbba Wow, thank you so much for responding back to me. It really means a lot. Yes I ended up signing up for the study the day after I posted this message. They needed an answer right away as to not delay my treatment. I did all the bloodwork necessary and was able to qualify for the study.
@@yerbba Thank You. Your response gave me more confidence that what I did was not only beneficial for future women but also for myself. I’m really thankful to you and your channel.
Mam how efficient are the Quinoline derivatives chemotherapy in triple negative breast cancer?
Science does not yet have information on these agents in people or even animals. They have been studied in computer models and in cell lines (cells taken from people but studied in test tubes).
My sister was diagnosed with triple negative breast cancer of stage 2 now her chemo cycles are over .she got 8 cycles of chemo..now the lump disappeared...and mammography and pet scan are normal..so i want to comfirm that if there is no lump n oll d reports are normal now surgery is required or not ...waiting of ur rply....please give me advice wat shud we do now
My mom has TNBC stage 4 as well . 🥺 she’ll have her first chemo this coming 22th this month . Im so so so sad when I heard about her condition .
@@connieroxanne368 dont worry dear give strength to ur mom...chemo is a bit painful procedure but there is no other way to treat such a challenging disease
@@anshugandhi9462 how’s your sister condition?
@@connieroxanne368 my sister is now absolutely fyn ...there is no lump now d problem is this now she shud go for surgery or not as there is no evidence of disease....and i suggest u dat go for chemo n ur mother will b absolutely fyn n hv faith in GOD d most powerful word ..
@@anshugandhi9462 Im so gald to hear that your sister is fine . Thank you for giving me strength and advice . I really appreciate it . I hope your sister and my mom gettin’s better and better each day . And may god always be with us in our journey fighting this disease together for both of them .
Hello Maam pls help me to understand my situation . Im tripple negative stage 3 n my chemo is done with 8 rounds and immunotherpy 8 rounds after that surgery n my tumor size is 22mm n 5 lymphynodes positive so they have remove my all axilurray lymphnodes n now 15 rounds of radiation completed n when surgery dine my tumor have cancer means no pcr n now they are giving again 9 Cycle of immunotherpy my point is if the same immunotherpy giving again to me then what is the use because it didnt reduce my cancer in my tumor size 22mm also when diagnos my tumor size is also 22mm so Will immunotherpy help to reduce my cancer reaccurance since no pcr Im worry abt reaccurance of cancer because of TNBC pls help me is my treatment is good Way going or i should check with my Doctor on any new medicine n also reaccurance how to reduce the risk ? Thank you maam
Great question. Even if there was little response to treatment, it does appear that there is benefit of continuing with the same treatment in terms of decreasing the risk of cancer coming back in the rest of the body. It is not uncommon to see this.
@@yerbba hello ma'am ,do you know the trails for residual cancer burden who has no PCR in Neo adjacent treatment now they are offering more chemo based anti drugs dato dxd for tnbc 3 stage patients is that good to hv that medicine ? I heard that is giving stage 4 cancer patients especially lung cancer n I'm stage 3 with RD waited
Hello thank you so much for the info , my mom 54 years old has TNBC stage 3b with lymh node involment , she had masectomy 8 weeks ago and is on chemotherapy now then radiation..
Is it bad when ki67 is 80% 😢...
Will she survive this im so afraid , that i may lose her
Breast cancer is scary indeed. Your mother is fortunate to have you. The goal of treatment in your mother's case is cure, and cure is certainly possible. Wishing her and you the best.
Please let me know how she’s doing, sending prayers
@@Alexanderthegreatjones thank you for asking, she is receiving chemotherapy and I can say that the side effects of the treatment are very strong and painful.
@@entelaqorri7474 have a family member doing through the same thing rn, the treatment is for 6 months then surgery, I truly hope everything works out for your mom and treatment works. Is there a noticeable reduction in size?
@@Alexanderthegreatjones no becuause she had surgery first
Does metformin help to prevent triple negative breast cancer ?
Does it increase /decrease occurrence of TNBC ?
Research shows mixed results.
You are correct that there are mixed results in several different clinical trials. Metformin has not been adopted widely because the findings are inconsistent.
My mother is stage 4 TNBC WITH LUNG Metastasis. She is done 4kind of chemotherapy drugs but no good response.. does she live long? She have open wound in her armpit big wounds..😢😢
It sounds like your mother has done everything right. We are sorry to hear of her struggles. Talking with her team about what to expect going forward, asking these hard questions, is the next best step. Sometimes cancer does not behave the way we want it to despite our best efforts.
@@yerbba thank you .. but my mother already gone last April 27. 😭😭😭 I didn't expect. It's hard but what to do is to accept.. 😭
@@pautvbengson5108😔💕🙏
@@pautvbengson5108so sorry for you loss, sending love your way
@@pautvbengson5108my mom also passed away 26 Feb 2024 recurrence after 13 year TNBC metastasis .spread lungs and spinal cord ..Doctor is not God, he can't save those who deserve to be saved.😢😢😡😡 Life is a bouquet of sorrows..without mom life is zero I miss you mom
My mother got a triple negative breast cancer, before 5 months back I consulted the doctor, she got stage 3 breast cancer, now she got spread hand also, 3 days back, doctor said that it is triple negative varient, it is aggressive, in hand stage 4, so again started chemotherapy (Eribulin medicine) , this is better or, which hospital is best to my mom, could you please suggest, madam suggest me please ... She have a two daughters, without marriage, so she is crying, please suggest me
Your mother is fortunate to have you. I can tell this is a really difficult time for you both. It sounds like there may be cancer in the bones of the hands, but I cannot quite tell. If your mother has had other chemotherapy, eribulin is a good treatment choice. There are many other medications that can be used. If there is involvement of cancer in the bones, a bone-modifying agent (zolendronic acid by vein) may also be part of her treatment plan. If the cancer is positive for ER and PR, endocine (hormonal) treatment is an option. Without her being my patient, it is difficult to know the best treatment course. All the best to you and your mother, and thank you for writing.
Sending prayers to you and your family. Everything should be fine, your mom shouldn’t be crying and making the situation worse. It’s probably a difficult time for your family. Trust in God and all will be okay.
How is she now?
Thank You so much but I see you told a young lady chemotherapy is not recommend for anyone with noninvasive. Please help me under stand Neg, Neg, Her 2Neg 1+ . For ductal carcinoma & Tumor necrosis.
For non-invasive cancer, chemotherapy is not recommended regardless of the ER, PR, and HER2. There is no clear prognostic significance of HER2 in non-invasive breast cancer. In fact, early studies suggested the prognosis was better for people with HER2-positive DCIS. Thanks for watching.
Hi doc,
I was diagnosed with breast cancer grade 3, er low positive, pr negative, her2 negative.
Done 8cycle of chemo, lumpectomy and radiation therapy. My specimen result is YpT0N0. Do i need hormonal therapy?
Hormonal therapy is likely to be offered (depending on how low the ER was on your tumor). But the benefit is not as big as with a tumor that has higher levels of ER (and/or PR), so if you're not tolerating it well, stopping is not as big a deal as in someone whose tumor has a higher level of hormone receptors.
My mother age 44.tnbc...T2n0m0 ...please help me
Your mother is fortunate to have you looking after her and searching out information. Triple-negative breast cancer is generally treated with chemotherapy. We often give the chemotherapy before surgery, but chemotherapy after surgery is also common. Her oncology team will be in charge of deciding her exact treatment and in getting it started. Your mother is really young, and the hope is that she will live a long life. All the best to you and to her.
My mom has TNBC stage 4 . How long she’ll survive ? Pls do reply my comment . Inreally want to know . 🥺
Dear Connie, I wish your mother and your whole family were not dealing with this. The survival in people with advanced triple-negative breast cancer varies a great deal. If she responds to her first treatment (what we call "first-line" therapy), her chances of surviving a couple of years is good. We tend not to see people live many years with triple-negative cancer. If there is no response (benefit) with the first-line treatment, we generally try a second-line therapy and a third-line therapy before we change from cancer-directed therapy to maximal supportive care. Please write back if you have more questions, and I wish I could support all of you further.
Mam is T3 N1a M0 tnbc cureable
Yes, the goal of treatment in this type of cancer is cure. Stay hopeful.
My mother age 69, T2N0M0, how long will she live. TNBC
With that stage, the goal of treatment is to cure your mother. If she has no evidence of the cancer coming back in the next few years, she is likely to enjoy her full life expectancy.
I too have same stage and presently doing my chemo ma'am...i pray God i live my life to the full expentancy
I would like to know why doctors are not allowed to deviate from the protocols, even in the face of studies that show they are outdated, and not very effective that the patient's request.
What can we do about that stonewalling to complementary therapies like hyperbaric oxygen and reduced dose chemotherapy ?(we know that the existing protocol of maximum tolerated dose is based on liquid cancer, not solid cancer. It is extremely out of date and furthermore, the literal outcomes are dismal like 2% improvement in survivability.) we are not talking relative statistics that say there is a twofold improvement in survivability..
Great questions. We are allowed to deviate from protocols when it's in the patient's best interest. Our protocols are updated yearly. In general, we do not recommend treatments that have not been shown in a randomized controlled trial to be better than placebo or best available therapy. Dose intensity does matter for solid tumors, including breast and lung cancers. Unwarranted dose reductions compromise survival especially in people with triple-negative breast cancer and in people who are heavy.
I have er positive breast cancer and Dr is counting me as triple negative. I don't know the reason. Can you please explain it
This sounds confusing, and it's not possible to explain from what you have shared. If the estrogen receptor level is very very low, some doctors may call this triple-negative. It would be worth asking your doctor about this.
Tnbc....er negative pr positive (11 20%)her2 neu negative...stages..2a...1st
pT2N0...T2nomo
Thanks for watching our videos. Wishing you all the best going forward.
Any suggest mam.....please...India
What will happen if they do surgery first and then chemo with stage 2b triple negative? Because mostly I saw that chemo first then surgery🥹
Chemotherapy first followed by surgery would be a very reasonable option. Similarly, surgery before chemotherapy is also an option. There is no difference in survival between the two options. There are advantages of giving chemotherapy first. You may find our video on primary systemic (neoadjuvant) chemotherapy helpful.