Microdosing: Just a Placebo?! 😱
Vložit
- čas přidán 3. 08. 2024
- Are the benefits of microdosing (psilocybin, acid, or DMT) down to the placebo effect? A recent study from Imperial College London would seem to indicate so. The study uses a self-blinding “citizen science” approach and has billed as the largest placebo-controlled study on psychedelics to date. Its findings have sent shockwaves across the media… but how much of this is truly warranted?
0:00 - Intro
2:25 - Overview of the Imperial study
4:59 - Acknowledged limitations (3)
7:39 - Unacknowledged limitations (2)
9:49 - THE JURY IS OUT, PEOPLE.
⭐️ Read the Study ⭐️
Self-blinding citizen science to explore psychedelic microdosing: elifesciences.org/articles/62878
Support This Channel:
►One-Time Donation: www.paypal.com/paypalme/julia...
►Recurring Donation: bit.ly/3vNgGij
(I will send you a personal "thank you" by the end of the month, as PayPal won't allow me to "thank you" via its interface. Needless to say, thank you!)
Connect w/ Me:
►Website: www.juliannekeu.com
►Instagram: /
►Twitter: / juliannekeu
►Facebook: /
Alternative title: Is microdosing psilocybin just a placebo? (A critique of the recent study from Imperial College London)
#microdosing#psychedelicresearch#critique#citizenscience#placeboeffect#psilocybin
Critiquing ONE study is *NOT* disrespecting the whole of psychedelic research. Science is meant to be respected, NOT fetishized. I don't believe I was being disrespectful towards the researchers in this video. I have the utmost respect for them. In time, this recent study will become a drop in the bucket in a sea of more substantive (better-funded) research. That is how science is supposed to work. I'm sure much of it will be conducted by the same trail-blazing team. Critique the study, but please don't bash the researchers. We need them.
P.S. Thanks for watching this video 🤗
Yes! This is just getting started!
Soon they’ll be legal I thank they are in a few states In the US.
In no such way did you disrespect anyone! We must critique and be skeptical towards everything mainstream! You're doing an amazing job spreading the word sharing your experiences and facts on the subject and I hope you continue because you got me more confident in my microdosing results and just to see others sharing the same experiences I mean the world and gives me a new sense of confidence that is currently reshaping my life into what I've hoped it would have become years ago!! God bless you and would love to ask you a few questions on the subject if you ever have the time for them.. ✌️&❤️
I do not believe that you are wrong at all about the study. It maybe the largest study but not conducted in a legitimate manner to prove anything.
My understanding of the study of the use of psychedelics to treat cluster headaches or any psychologic studies has to be approved by the powers that be. When "they" do grant permission the control group is very small. It is very difficult to prove something empirically with such small cohorts. I believe that is why ketamine has been studied for the treatment of depression and suicidal ideations bc it is legal to prescribe. The only reason I ever considered using LSD or mushrooms is trying to find relief for cluster headaches. Clusterbusters saved me. They have been advocating for a very long time for research studies as a means to treat one of the most painful conditions known to man. They are extremely organized and strong advocates. Also, known as suicide headaches bc many suffers commit suicide. As a substance abuse counselor I am definitely a statistic when it comes to comorbid mental health issues. Seventy to eighty percent of addicts have another mental health disorder and sadly have never been diagnosed. I was addict for 13 years with undiagnosed mental health issues and reoccurring trauma from childhood. I have been clean since 2007. I have also been diagnosed with several mental health disorders. No antidepressants have not helped. They left me unable to feel anything at all. No joy. No sadness. Just BLAH! That's not living either. After I was able to get hold of Vitamin M (mushrooms) for my cluster headaches (blessed - cured in 2 doses) I was so intrigued and wanted to learn as much as I possibly could. I started reading as much as I could. ADHD is another blessing I possess as you know either hyper focus or I get distracted by all the articles and end up saving more than I read. As you can see I often start out making a point and get lost before I ever make the point. 😉 Your thoughts on this study are not out of line at all. I believe you got it right. I'm still in awe that they were allowed to publish the study. Another question I have is who actually funded this study and what they hoped to find. It is pointless to bring so many people into a study that without a complete biopsychosocial evaluation that includes mental health issues. Personally, I feel that it's unethical and dangerous to ask somebody to do study without knowing or not what their mental Health situation status. It is well known that people who have are at risk for schizophrenia and they're late teens to early twenties that taking any sort of psychedelic I could set off a chain of events that could possibly and in suicide. It's known that these drugs can actually bring out the schizophrenia if it hasn't already shown itself. By the time people are in their 30s they are they're no longer in the risk zone for schizophrenia. Or rather the risk at that age pretty much diminishes the older they are. But a young person that may be at risk for schizophrenia but never had any symptoms might do one of these research studies without any control and all of a sudden go into a psychotic episode and have no idea what's going on with them. I know I've rambled for a long time and I hope I've made some sort of point with the rambling and I'm going to leave it at that or I'll never stop. But the main thing I wanted to say was you are correct about everything you said.
Do you ever share when your going to be in a ceremony again. I would Like To Come
Just found this channel and the fact she never posted after this is concerning
I'm very curious about why you stopped making videos and what you're doing now. I'm about to start my treatment and have found your material particularly useful in my mental preparation. I'm also wondering about the microdosing course.
same. i hope its not bc of the studies in this video and the thumbnail.
how you getting on, I'm literally starting in 4 days... peace
@@derekbuttery4776 oh cool whats your plan?
@@derekbuttery4776how did it work for you?
Me, too. I tried Micro dosing psilocybin a couple months ago, but felt little. On the other hand, I was using ground up mushrooms of dubious potency. I’m going to run a proper micro dosing experiment on myself again soon, but in the meantime, I’d sure love to hear how she’s doing
Thank you, Thank you, Thank you. I was on prozac or lexapro in varying dosages for 15 years. Nothing has come close to being as effective as microdosing in treating my treatment-resistant diagnosis of Major Depressive Disorder. Nothing. Placebo? No. Not only am I in a much better place emotionally, but I'm also more focused and more productive than I've been in, well, 15 years.
This was my experience, but try adding several more to the list of medications tried. None worked and worse, they all had side effects!
The fact is, antidepressants do NOT work. But there is a HUGE interest in keeping these pharmaceutical failures as a first line treatment because these drugs are some of the most profitable drugs for these companies. There is not as much money in something natural, like mushrooms. Especially something that may have the ability to cause a long remission.
You must always look at who funds the studies. Often, the pharmaceutical companies will find studies that are poorly constructed to come to the conclusion that mushrooms don't work. This way, it can be reported in the media (who doesn't know how to read medical journals AND doesn't understand biases from those who fund the studies). Journalism has become a cess pool for propaganda- especially for big pharmaceutical companies.
Good job reporting on these bogus studies!
Eric, what was your dosage/ protocol? Were the effects immediate or progressive?
Its my theory that psilocybin is a power anti fungal . I have a very severe diseminated dymorphic fungal infection. In the human body it takes a yeast form . Its caused me many many health problems throughout the years, one being drug resistant depression.
When yeast is feeding , it puts off a discharge, phytochemicals, the yeast waist. Its piss and shit! Lol. It poisons you. Destroys you from the inside out. I feel this is why psilocybin works. Kills the yeast cells. No yeast...or less yeast , the less the chemical is poisoning you. When I fast, and drink a shit ton of water, i feel great. Thats flushing the system and expelling the yeast and by fasting, cuts off the fungus' food supply and it dies and/or doesnt put off waste product.
They've done live MRI of the brain then dosed them with psilocybin and watched neuropathways in the brain open , that had been blocked for years. This blockage , I speculate, is a build of yeast cells . The drug resistant depression i feel isnt depression, its a poisoning, hence the reason drugs dont work. I , a simple carpenter, had to research , study and diagnose my fungal infection on my own because the doctors know nothing about fungus. That or they're using it to keep us mildly sick and sell drugs that only alleviate symptoms so they can sell us more drugs in the future. ALLLL my health problems are caused by dymorphic fungus. From skin issues similar to acne, toe nail fungus, heart palpitations/ atrial fribulation, blood sugar problems , because fungus feeds on sugars and grains, it makes it seem like a blood sugar problem, when really its yeast eating your food. Acid reflux is active yeast cells feeding after you eat. Look into some antacids. Some have Azoles in them . Flucanazole is what i was on, theres protocanozole, clotrimazole, micanazole etc.
They know what's wrong with most of us , they're full of shit and misdiagnose so you keep coming back for their office visits and feeding big pharma. Its nothing but a racket, they know most people are infested with fungus, shit... pretty sure they shoot us up with it in our first vaccines. Babies get thrush... a lot of them. Thrush is fungal. Usually a sign of a severe fungal infection. Why do babies get thrush right after the first vax?
What in those chemtrails? How are fungal spores dispersed? The wind. Cancer is a fungus. I came to that conclusion after 5 years of studying dymorphic fungus, then googled IS CANCER A FUNGUS.....Its been a theory since the 1800s. 1870s if i remember right. Look up dymorphic fungal infections in your area. Look up the symptoms. Compare to any health problems you have. It can cause SOOOOOO MANY!
@@buckhead40z ive been doing it for a while and groe my own. I will say the species can make a difference . Some are better than others. As far as dosage, its very small, if I remember right like .5 to 1 milligram. I just bust a small piece off. Most do 3 or 4 days on and a few days off.
Look into lions mane mushroom also. Its know for enhancing brain activity also. Paul stammets , famous mushroom guy, does psilocybin, lions mane and vitamin b . He preps his own pills in gell caps.
Mescaline and LSD have the same effect . If you're suffering and can find some, i suggest any or all 3 for rebooting your brain. Be careful with LSD. Theres so.e fake china shit goin around out there.
Hey Eric, can I ask whether you microdosed while you were on antidepressants? I'm only 2 months in to escitalopram, but really eager to try psilocybin at the same time.
This is a very important video! I feel like people are quick to write microdosing off as placebo in order to avoid challenging their rigid beliefs about psychedelic compounds.
Big pharma would not want a natural substance to get FDA approval. They cannot obtain patents for nature so there will be more “studies” that will poopoo natural remedies like psilocybin.
@@kyootzee Yes they can. They are going to start doing it in the cannabis industry with GMOs. Same thing will happen with mushrooms if they are legalized.
They don’t want us to wake up! That’s what it is. They want us all unconscious and controlled by whoever, to think like everyone else. They don’t want us thinking from our soul/heart but with our minds.
If they think its a placebo, they should get some wavy caps and bust down like 5 grams then see how their brain works after. It's amazing. Like a brain reboot. Supercomputer status.
@@AthenaGate well I’ll grow my own before they start legalized them
I have struggled with mental illness and my mental health since I was a kid. Before I even knew what those terms were. After years of depression, anxiety, and even an attempt to take my life, I never thought I would be able to live without psych medications. I clung to them because it was the only thing that made my mind quiet, but it also made me a zombie. Microdosing has given me control of my mental health for the first time, and they essentially gave me my life back.
I’ve been researching on psychedelics and it’s benefits to individuals dealing with Anxiety, Depression, ADHD and from my findings, they really work and I’ve been eager to get some for a while but its been difficult to get my hands on them.
The Trips I've been having really helped me a lot. I’m now able to meditate and I finally feel in control of my emotions and my future and things that used to be mundane to me now seem incredible and full of nuance on top of that I'm way less driven by my ego and I have alot more empathy as well
I was having this constant, unbearable anxiety due to work stress. Not until I came across a very intelligent mycologist. He saved my life honestly
His name is *DR Adolf Petter*
@ohmakure4716
I feel the same way too. I put too much on my plate and it definitely affects my stress and anxiety levels. I am also glad to be a part of this community.
I miss your content and hope you return ❤
I've taken 4 microdoses and already I can see changes. I've done more in the last two weeks than I have in last year. I can't explain how much better I feel and I honesty didn't want to get out of bed in the morning and had struggled like that for over 20 years. I'm so glad that I have started I just wish I found it sooner
Everyone should be checked for fungal infections. Dymorphic fungal infections. Its a fungus in your body in yeast form, and when it puts off its waste, poops in you, it poisons your blood. Do you get tired after eating? Get bloated and tired after eating? Try fasting and drinking a lot of water, staying away from sugar and grains , as its fungus favorite food and see if you feel better. See if you perk up. If you do, you probably have a diseminated dymorphic fungal infection. Or possibly polymorphic. They can be in you for years and not know it. Around 30 for me before i almost died and had to self diagnose. Forced the doc to give me a certain med that worked failrly well.
@@scottpodgorski4102 Are you talking about candida, or something else?
@@ExplodingPsyche there are many dymorphic fungus. Im not sure if candida is dymorphic, polymorphic or always a yeast. I believe the one I have is blastomyces. Its known to be in my area. But theres many . Cryptococcus is another.
There are around 150 different candida fungus. Only like 5 can infect you. Candida auris has been making its way through hospitals and can be very drug resistant.
@@scottpodgorski4102 Thanks for the info.
How r u today friend ?
You have absolutely every right in the world to question science which includes these clinical trials.
I truly hope you’re doing well, Julianne. I really miss your content as psilocybin as saved me from myself
Yeah, what happened?
I was stuck in a pattern of self destructive behavior, sabotaging relationships and generally just not looking after myself like one should. Psilocybin gave me the kick in the a$$ that I needed. I actually prefer to macro dose once a month wearing a meditation/eye mask in silence
@@AudricMorrisonI’m so happy you made the choice that saved you from yourself, I am a mother and I see my son in you 💞
Ive been microdosing .5 - 1.0 gram for the past two months and im happy and proud to say for the first time in ten years, im not consumed by my depression 24/7, i havent had suicidal thoughts, in weeks. Which is also something ive struggled with for 10ish years due to being bullied for basically my whole school life.
I microdosed LSD 10 months ago once and literally stopped vaping and consuming nicotine(threw my vape away the same day) after smoking and vaping for 4.5 years daily and haven't touched it since. Pretty strong placebo😂
I love this. That’s how I quit cigarettes. I was puffing away while on some tabs and didn’t feel anything and decided it was useless.
Mfs should try microdosing lsd and then say it’s a placebo. Can’t say that powerful experience is a placebo! Keep spreading your love! Xx
Why have you stopped uploading? Just found you channel and it's really cool
Where have you been?? We miss you and your content. Really hope you’re doing okay!
There is so much about mushrooms that is dose dependent. Seems like each gradation of dose has a unique therapeutic effect. Because microdosing is sub-perceptual, it leaves open the subjectivity of the effects. I've since started mini-dosing (1 gram every Sunday morning while meditating). It seems to have a more profound impact on my week compared to microdosing. And the insights when combined with meditation never ceases to amaze me. I literally has been like going to Church and hearing a really good sermon while sitting in my hammock-chair under my apple tree with birds singing for my choir.
That sounds beautiful 🤗
Instead of 1 Gram Cubensis, try 1 Gram Cracker instead....
Huh?
Different effect?
What a surprise... These science guys need to catch up... ;-)
@@pheresy1367I think science guys really are in the know. Big pharma pays the bills and owns them.
What a great way of microdosing! I think I 'd like to tip so that too some day.
Is there any guided meditation that you can advise?
Thanks for sharing.
I can literally feel the energy boost when microdose kicks in. I normally have ZERO energy, depression, anxiety, even before taking a microdose my anxiety is very high and after I take it I'm on edge bc I'm always worried about throwing up(happened before). I NEVER can focus and be present on the task at hand, and I know the microdose psilocybin is working when I literally go into the zone or flow state and realize holy crap I'm actually enjoying what I'm doing. It's no placebo.
Another incredible video. Thanks Julianne!
You are providing so much value to those struggling. Thank you!!
This is fantastic information Julianne, you are such an awesome person for explaining things. You can describe things better than if I did them myself.
Very clean and unbiased video. Good work 👌
Love your take on this J. Thanks
Great video, Julianne, thank you!
Great summary and salient points!
For those wondering where she went she was on a podcast a few months ago called hot pot here on CZcams and she explains why she stepped away from CZcams
you're amazing, bless you and your work, genuinely. grateful for what you do and post.
Thank you for doing thoughtful research and asking questions!!! Good point. Once you go through the experience you can put your mind into that state even when not taking mushrooms.
I imagine taking psychedelics is like a motivation starter for your mind. Much like how physical motivation is hard to get started the longer you sit around. As soon as you start moving around, you feel more motivation to keep going and is easier to get over that hump. It's a jump start for your mind/ mental health and as soon as you start thinking the positive thoughts, it's much easier to keep going with the positivity.
This video is sooooooo good for soooooo many reasons!
Nice work analyzing that study.
I'm one month into MD'ing for some seemingly unfixable health problems. I'm glad to have found your channel. I like your work.
Mine was delivered last week was an awesome trip. Checkout @mycoallen on Instagram he got any trips you want and he ships discreetly
Look into dymorphic fungal infections. Cross-reference symptoms. Its a serious problem that foes unaddressed due to lack of knowledge. Many seking psilocybin relief I believe have a fungus living in them.
This was a very clear and concise analysis of the study, I like the way your mind works. Thanks for taking the time to think about this, put it all together (the same can be said for your meditation app vid, your efforts are greatly appreciated and Waking Up was an excellent recommendation)
Im currently on day 13 of the waking up app. It's a good app.
Thank you for this! I was on the edge about microdosing after having read a few articles on the subject. You've convinced me that I should pick up microdosing once again for the benefit of my health. Thank you again, amazing content!
Bought mine from a online store
I've been thinking of you lately and hopin your okay and there was your video suddenly as I was scrolling. ☮️💚
How can that study even be acknowledged? I was just denied access to the Compass/Centre for addiction and mental health (Toronto) due to I’m not mushroom naive. Because I’ve been MDing for 8 months I was denied. After watching this video, I now know that they have good controls in place and the fact that the study is being done within their facilities gives me hope their results will be eye opening.
Sorry to hear you didn't get accepted... Hopefully more doors will open for you in other ways. I'm also optimistic about the research coming up in the field of microdosing.
@@JulianneKeu The door is there waiting to be unlocked, mushrooms are the key! 😉
Yep and most studies are the same, in one word - bogus!
Thank you for your channel, your respect, encouragement for critical thinking, thoroughness, and vulnerability. And also your resilience, you’re doing amazing work. The world needs you 🙏🏼 💜
What a wonderful comment!! Thank you:)
Second this! Great delivery 💝
Right, the world did not need her putting a bawling emoticon w/ the "placebo?" and the "should i delete my video?" and the no more news after that, instead of a SANE title along the lines of "mc study and its limitations"
I find it insulting as well! Thank you for this video
Brilliant video. I’ve recently joined Mind Medicine Australia and I believe this information will be valuable to the community.
This is your last video and it’s been over a year now. Will you be back anytime? Learned a lot from your content ❤️
I've been microdosing mushrooms for a little while now and it has been life changing! My anxiety has practically disappeared (of course I still have my days). I find I'm more productive, have more energy and overall just a happier person since starting microdosing. It's because of your channel I decided to start doing it. I've actually never even tripped on mushrooms before, I've only microdosed. So I don't believe it to be a placebo at all!
What protocol?
😮
Thats so awesome to hear stories like yours 😁
Better to have something grown naturally then anything from pharma
How r u today bro ?
Yes. With extensive daily use it just transforms my perspective, consciousness & its hard to tell days that I'm off. But that's the goal 😊
I love all your videos Fantastic explanation with great conference I am proud of you .
Hi. Why no more videos? I love your channel. Thanks for all this info. Keep up the good work
I would love an update on her it's been 2 years I hope she's fine ✨🔮🧙♂️
I think they could of chosen newbies just as well as experienced users. I believe the fact that the positive effects of psychedelics are so enduring that absolutely this could result in more placebo effect. Most ppl don't realize how profoundly a studys design has on its outcome.
love your videos!
WOOOOW The method of the study HAS SERIOUS LIMITATIONS!!! The fact that this was a self administered study is a MAJOR Red flag and the results should be taken with a grain of salt!!! These results are skewed no question!
Right??? I was like wait what? You recruited folks off reddit, and essentially got them to run the study themselves. WHAT? I really have no dog in this fight because I don't microdose. So I can't really speak to what effects they have or don't have. But this is so deeply unserious.
But as someone who is in research, I don't blame them so much as I blame the media. The folks were trying to work around a lot of obstacles. This was the best way they could do so. They most likely know their study cannot have any real impact or implications. But you know the media likes to take a story and run with it. Regardless of what the actual study is saying or any of the issues with said study. I take headlines with a mouthful of salt. Like media sites are all about clickbait bullshit.
I hadn't heard the term prior conditioning. But it also matches my experience, and I've actually been tapering off for that reason.
Surprisingly detailed and thoughtful video thanks.
great content! much love! keep up the great work! subbed...
Thank you so much for sharing your experiences in a clear and eloquent way! Ive learned so much.
I started micro-dosing about a month ago. I decided to nix the welbutrin which ive been on and off for 15 years this past January. (Was on other antidepressants off and on since my late 20’s am 59 now). Sure enough in 2 months time the horrible visuals of seeing my self dead, daily constant thoughts of hopelessness and my life being meaningless returned. I found myself (a very familiar place) couching it and drinking regularly). I still drank and tv couched on Wellbutrin but not every single day. By the time I got my hands on psilocybin capsules I was thinking “Oh No! What have I done?!” NOT AGAIN!!!! Ugh.
I decided to have faith and began (100mgs golden teacher). I realized by day three, TOOO much as I was really tired and felt brain foggy. So after more research I dropped to 1/2 a capsule and began Fadimans every 3rd day protocol.
Something positive is definitely starting to happen! Excited at the possibility that I am off the anti-depressants for good. Also very excited to hear you no longer are on a regimen, and that the effects are a lasting change! Thanks again for your insightful videos.
Great video! I have been micro dosing psilocybin for a while now to help with my generalized anxiety. I have experienced the immense effect it has on my own wellbeing. You raised some very important points about flaws of the study. I would like to see future studies where they use a clinical group of participants with no previous micro dosing experience, and where the psilocybin is administered by the researchers... Regardless, I know what I feel, and that is what's important to me.
Love 💗 you so much Julianne Keep The Truth Alive
Thanks for sharing this. :) I am planing on trying microdosing soon. With regards to the placebo of an experienced microdoser, I feel you are right when you said it is possible to create the effects of microdosing without actually taking anything (for those who are experienced microdosers. So, I quit drinking about 10 years ago, yet still, if I go out with friends and have a few alcohol free beers I begin to get the high I experienced when drinking alcohol (it's actually a little embarrassing if people ask how many drinks I have had - I simply explain that I am happy - which is true!). I work as a mind body practitioner and understand the placebo effect and also the conditioned response very well. What I am experiencing with alcohol and what you experienced with microdosing (when not actually microdosing) is the conditioned response, (you probably know all this! ;) ) where by there is a learnt unconscious response between a previously neutral stimulus and another stimulus which over time lights up a neural network familiar to the combined experience of both stimuli. The stimulus could be physical or emotional. In my case, the atmosphere of other drinkers around me and the taste, smell and flavour of the beer. Had I never been a drinker my brain would have never developed this conditioned response and hence I'd never experience a placebo high. Thanks again for the video, I am looking forward to receiving my shrooms.
Thank you for your channel!
@Raphaelfaco what?
Excellent points!
@aishahmohammed2623 Get lost, scammer!
Your awesome Julianne!
I have had Parkinson's Disease for more than 10 years. I take a 250 mg microdose of Penis Envy mushrooms and all of my pain goes down to pretty much zero for a good 2 hours (it also eases some of my other symptoms). A few days ago I took a 500 mg dose, expecting that it would make me feel quite good, but it had absolutely no effect. I then realized that I had purchased the 500 mg capsules over a year ago, so the psilocybin had been depleted. Trust me, it isn't a placebo effect.
Your microdosing videos got me interested in microdosing. Thank you ❤️
I think i’m in love lol jk. thank you for sharing this with us, I’ve learned a lot from you so far. I am fascinated by mycology, and I really want to microdose for my mental health, I have terrible anxiety, trauma, ocd, depression you name it. Tried tons of supplements, herbs, antidepressants, beta blockers, hydroxyzine etc, and it’s still pretty bad.
Hoping one day I can try microdosing and hoping that it will improve my life and spiritual journey like it has for you. I just have no idea how people get access to this stuff lol. You can definitely tell you have experienced an ego death, you seem very genuine, humble, and wise. Thank you for sharing the gift of nature with the world. ❤️
You are amazing. Thank you❤
Just checking in. I know there's more to your life than making videos for us. I'm just up and thought I check in. I hope all's well! Take good care, Julianne!
Hello! Thanks for checking in. I'm taking time off now to develop my course :). I don't have the bandwidth to make videos + develop my course at the same time. I've also been learning how to assist in plant medicine ceremonies! Lots of update to share when I get back. Hope you're doing well!
I hope you're making another video soon :) I like your stuff.
Text Jeremyco34 on Instagram he sells shrooms and psychedelics
Julianne I appreciate your authenticity! Keep shining a light on the haters! LEGALIZE NATURE
I hope she is ok. No videos in two years or any social posts. I have a feeling he has died. However her site is still active.... If she is alive I hope she is okay...
You are a gem girl! Thank u 😊
Your point on being in a state that you have learned or guided to is valid. Your brain becomes trained. I can enter the wonder state almost at will, but I would not have known that feeling if not guided there previously many years ago.
It's been a long time since you posted anything. I hope you are okay. ❤
I know right? What happened to her?
You're great!! thank you!
Notes:
- positive effects were recorded, both from placebo and microdose groups;
- not having statistically different effect between the placebo group and microdose group does not mean that microdose was not effective: it only means that the placebo effect is also powerful on its own, i.e. that the mind is able to cure itself when thought and emotions are aligned;
- the sampled population was taken from forums inhabited by experienced users of psychedelics: for them, the marginal effect of microdosing is reasonable to be null (e.g. imagine after just a couple of regular dosed psychedelic sessions that caused already breakthroughs).
- psylocibin is a substance that enters the body and has neuroplastic effects, thus its effect cannot be null; but, for it to be beneficial, SET and SETTING are crucial;
- also most antidepressant researches show that they do, in average, no better than placebos, but still they are used and monetized!
Overall: imagine the effect it can have to microdose while also intentionally create a healing placebo effect on yourself.
A group of academics doing some research does not create TRUTH, science is not a religion, just a measurement which always contains errors (of the instrument and by the measurer).
Thank you!:)
Just started. Have had dissociation and derealization for over 25 years attached to cptsd and treatment resistant depression. . After first day it was reduced 80%. Nothing ever did that...and I have done EVERYTHING to treat my illnesses. Microdosing does not hurt one so why not try? Thanks you for your channel.
I was going through depression too. Mine was delivered last week was an awesome trip. Checkout @mycoallen on Instagram he got any trips you want and he ships discreetly
Something else to note is that the microdosing group DID show statistically greater improvements. "Acute (emotional state, drug intensity, mood, energy, and creativity) and post-acute (anxiety) scales showed small, but significant microdose vs. placebo differences; however, these results can be explained by participants breaking blind." The study notes that a whopping 72% of the participants broke the blind - ie were able to tell if they were microdosing or taking the placebo.
Figure 5 in the article is particularly interesting, it shows the outcomes for (1) people who got the placebo and correctly guessed they got the placebo, (2) people who microdosed but thought they got the placebo, (3) people who got the placebo and thought they microdosed and (4) people who microdosed and correctly guessed they microdosed. The charts show that whether the people thought they had microdosed or not was a lot more important than whether they actually had microdosed or gotten the placebo. However, although apparently not statistically significant, basically all the charts (both in figure 4 and figure 5) show that, even after correcting for the placebo effect, the average score for the people who microdosed was higher than for people who had the placebo, suggesting that there may be something in the drug itself above and beyond the placebo effect.
Bottom line, though, is that if you microdose and know you are microdosing, you should see improvements. Most of it may be due to the placebo effect, but does that matter?
As Michael Pollan has said about macro-dosing:
"There is some evidence that it is a strong placebo effect. I mean, these drugs, more than any other drug, I think, we've studied have expectancy effects. That is, what you expect to happen often happens. Because we know the experience is really variable and it's not the product of the drug exactly. It's really the product of your subconscious, the product of your intention, the product of your setting, your mind set, all these things go into it, so we shouldn't discount the role of placebo in this. But the fact is, you know, placebo works. And in this case, as one researcher described it to me, he said, 'These are placebos on rocket boosters."
There is a difference between the placebo effect and a drug that *enhances* the placebo effect. The latter is what I believe psychedelic microdosing does. -Also, I love Michael Pollan but let's not quote him here. His book How to Change Your Mind is geared towards a general audience and sections of it don't stand up to scientific scrutiny.- I've come back and edited my response b/c I felt I was unjustifiably combative the first time around. Apologies. Thanks for taking the time to highlight in the study what you've highlighted.
@@JulianneKeu After doing a bunch more reading and thinking about this, I think it is a mistake for studies to try to control for "breaking the blind" in the way that they do, and it is trying to do so that results in drugs appearing to be no better than placebos. In this study, and apparently most studies regarding antidepressants, over 70% of the participants are able to accurately determine whether they have received the drug or the placebo. In order to try to make the study a "double-blind" study, the researchers feel forced to control for those correct guesses, which ends up washing out almost all the non-placebo effects. This seems like a misleading way to analyze the data, because if someone correctly guessed that they are taking the drug, that means that they are feeling some effects from the drug and means that it is probably going to work for them. If you have 70%+ of participants breaking the blind, don't wash out those results; just acknowledge that you don't, and can't, do a true double-blind study because the effects of the drugs themselves cause most people to break the blind.
I note that guessing you are taking a drug because you feel its effects is different from a pure placebo effect, which is based on being told or thinking you are taking a drug before you take it or before you feel any effects.
Let's take a look at the 4 groups in Figure 5 of the study:
PL/PL - These are people who got the placebo and correctly guessed that they got the placebo, no doubt because they didn't feel any effect. Not surprisingly, this group had the worst results.
MD/PL - These people microdosed but thought they got the placebo, no doubt because they didn't feel any effect. The probably either weren't taking enough, were among the minority of people who don't respond to the drug, or were influenced by the fact that the new they might be taking a placebo to not expect a result and therefore had a nocebo effect (eg, if you believe something won't help you, it probably won't). This group's results were almost as bad as the PL/PL group.
PL/MD - These people got the placebo but thought they had microdosed, no doubt because they felt some positive effect. This is the only true placebo-affected group. These people are similar to the soldiers who were injected with saline solution but told they were getting morphine and in fact had a reduction in pain. The thought that they might be getting a microdose was enough to make them expect a result and they got one. Placebo studies show that actual changes in brain chemistry arise in this situation, just like if people got the actual drug. Unfortunately, this probably only works so long as people at least think they may be getting a real drug.
MD/MD - These people microdosed and correctly guessed that they did, no doubt because they felt a positive effect. This group got the best results and represents normal micro-dosers. Should their results be ignored because they broke the blind? Obviously not. The fact that they felt an effect was a result of the drug, not somehow cheating the test.
Ignoring the BS they used to try to control for breaking the blind, the study indicates that microdosing has statistically significant beneficial results on mental health - even for the relatively healthy group of prior microdosers who participated in the study.
The main thing not taken into account, is that both groups were still microdosing. The 1 week microdosing could have lingering effects for 2 months for all we know, this means any data from the placebo weeks is irrelivant.
Darling you are awesome and sane people will stay with you.
Remember, we are moving into a world where Breast feeding is being called “chest feeding” and “mothers” are being referred to as “birthing people”. The world is becoming crazier by the day.
You seem like one of the loveliest people on the planet. God bless 😂🌹🤙☮️
Since our entire perception of reality is belief-based, so every experience really is, one could strongly argue that EVERYTHING in some form is a placebo effect. It becomes a question of degree of collective "agreement" after which we don't call it placebo anymore, and I'm 100% convinced that shrooms and other psychedelics absolutely clearly have realty-experience-altering effects, and clearly there's also a measurable biological reaction these substances cause, from serotonin to other receptors, and if a high amount causes strong altering sensations, it needs not be argued that a smaller amount will elicit more subtle reactions which is exactly desired. The effects are clear and present, and gradual in relation to dosage. So, to me, the whole discussion is moot and basically just semantics. That's my opinion.
Great take. I agree with you. It sounds kind of silly to say "threshold dosing works" but "sub-threshold dosing doesn't"..? I mean, come on. There are also plenty of companies in R&D right now looking to create some sort of psychedelic-like pharmaceutical but without the hallucinatory effects (no matter how minute). It seems that they are looking to extract the therapeutic value of microdosing from its "psychoactive" properties (no matter how sub-perceptual). So that in itself says something, IMO.
I hope you come back one day. I found your account today and this is empowering if that makes sense.
Any study, even with limitations due to ethical or monetary reasons is great and we should commend the researchers on their efforts and refrain from negativity. One good thing to come from this is that the results seem to indicate that microdosing is not inherently harmful. That in itself is very good starting point as there is less fear attached regarding potential future studies if participating in the studies can be deemed safe enough for the general public. More studies will definitely come.👍
I understand your perspective and I agree to an extent. However, I felt that I needed to make this video because of the confusion [the headlines around] this study has garnered. Science itself is a self-correcting mechanism. It is meant to be critiqued and I don’t believe I disrespected the researchers in doing so. I have huge respect for them and have linked to the same research team in multiple other videos.
@Julianne Keu
Thanks for replying! Your videos are always on point, balanced and respectful, which I like. I agree with your stance on science. It's not perfect but it's the best mechanism we have for investigating things.
I wrote my comment more for the community, seeing some of the comments here.. Just wanted to remind people here that yes, there is something positive about this as well, although it might not seem like it right now.🙄🙂
Interesting. I hadn't really heard of anyone claiming placebo before this. Then again I'm more into psychedelics than earlier. :)
Please make more videos. It's been two years since the last. I hope you are well.
What happened to Julianne?
I think you made some good observations....so-called "science" studies often have lots of confounding variables that obscure the true cause and effect determination. I took an experimental design course 34 years ago in a psych grad school program and it was shocking to see how many studies have faulty / weak designs. Real science requires thick skin and a parking of egos at the door. Thanks for the video!
*I got my stuffs from this mycologist whose been my guide, he got Shroooms,lsd,dmt,edibles etc. Ships local and international discretely*
*Dude is on telegram **
*@nubrowntrip*
Interesting hearing about nutbrowntrip I have benefited from his products and I'll recommend you try out
I have just been learning about you and your channel for the past week or so. Listening to your critique of the study convinces me even more of your wisdom and intelligence. When someone pursues a Doctorate or PhD., a huge emphasis is placed on learning to understand and judge the validity of studies. I suspect that you have followed such a path as your analysis is spot on and shows the skill of someone versed in this science.
Your most important observation was on the lack of participants with existing mental health issues. The potential for benefit from microdosing was so small given the high baseline of participants that of course there was no noted improvement over a placebo. A peer review panel should have rejected the study for this reason alone.
When good research is scarce because of challenges such as legality and access to controlled subjects and the quality of the medication, the temptation is to publish what ever research comes in. Your analysis shows why it is far better to publish nothing rather than such defective and misleading work.
Bought mine from a online store
cHeck Trip_mycologist
just found you're chanel .you give me hope ! me and my ex breakup 4 months ago and im a guy who have a lot of depress moment , i just took my first microdose this morning i HOPE to see good results
Does it take couple of weeks to see some changes or only after couple of dose you see mood change ?
sorry for my bad english im french canadian
Your critique of this study is brilliant. Another flaw is that they included DMT as one of the substances that could be microdosed, but DMT is not orally active unless it's combined with a MAO Inhibitor such as the ayahuasca vine, so the idea of microdosing DMT by itself is ridiculous. This would seem to indicate that the researchers were not that informed.
Are you OK? Haven't seen any updates for a while.
I noticed this too. And her social media has gone
Another thing, about the number two, on 8:53. It was exactly the first thought i had on the question. I was in a group working with ayahuasca for 3 years. At least, i just needed a half of a half of an usual dose, or less, to enter the "borracheira", that is a word for the higher effects of it. So, it's true that you can, after some time of use, reach the point by conditioning.
thanks a lot... a Lot! God bless you
There's a 2006 study (hopefully I'm relaying this accurately) of sub hallucinogenic doses of lsd and psilocybin used in the successful treatment of cluster headaches. I would think that something unbearable as a cluster headache probably would only have the most minimal response to placebo. I emailed the other to request a pdf of the study. As soon I hear from them I'll share it with you. (I've dug around and so far I was only able to find abstracts).
Edit: Still waiting to see if the author will send a freebee of the article! 5/21.
Hey Julianne, if you had to choose one to heal past trauma, would rather micro dose every few days or do a full dose every once in a while?
Brilliant & beautiful
"The jury is out" means "a decision has not yet been reached on a controversial subject". But I'm pretty sure you mean that a conclusion has been reached. Yes?
In any event. Good video. Thanks.
In love with your presentation, editing , and all other skills 🥰. I think I should just microdose and stop being a chicken 😬.
My shrooms and microdosing caps, chocolate bars was delivered last week was an awesome trip. Checkout @mycoallen on Instagram he got any trips you want and he ships discreetly
I've been MDing (self-diirected) on and off since January, with mushrooms alone at first, and in conjunction with LSD more recently.
While I have used both a couple times before, micro has been an entirely different experience. I was also failed by pharmaceuticals (they made me actively suicidal), and had been concerned that I might never be "ok".
MDing has been life-changing for me, and I'd love to try Ketamine as well, as CPTSD has severely impacted the depression and anxiety I've struggled with since childhood. I think a macro of mushrooms and/or K could set me on a better path, without the negative side effects of pharmaceuticals, which include numbness, lack of sex drive, and suicidal thoughts, as I experienced on Paxil about 20 years ago.
Fascinating. Did you ever experiment with psilocybin while on Paxil? (I'm currently tappering off of paxil and am considering MDing psilocybin at some point)
Madeliene...could I reach out to you in DM please ?
The selection bias point is a HUGE one it kind of goes without saying if 90% of people thought they should be getting good effects then placebo group would be imagining that things are better etc
Excellent analysis. Study was completely bogus. Thank you.
food for thought, SSRI medications are widely believed to be placebo effect. Turns out intention has a lot more to do with individual outcomes. I wonder if there is some truth to the autonomy involved in microdosing as compared to the percieved control in a clinical setting.
Also there an impossibility of comparing the qualia experience across the board, well-being is a hard measure to nail down across the board, I would argue that if my day to day experience of qualia sensations are regulated that there would be no way of comparing that to another body. that in essence the study attempts to quantify an unfalsifiable claim, they aren't measuring what they claim to be measuring.
I took part in the Imperial College self-blinding study, and I have some doubts about the accuracy. On certain days when I could feel physical somatic effects that felt 100% like my 5 ug of LSD, which turned out later to be placebo days, and other days when nothing seemed to happen and it turned out to be microdosing days (they unblinded afterward). I followed the instructions to the letter, but it's possible that something got screwed up somewhere. How could anyone ever find out whether the math was done correctly on the QR codes and the shuffling of envelopes? No one can ever verify it (not even me, since I was self-blinding). In hindsight, I wish I had kept track of all the codes independently so I could verify that the unblinding information that they shared with me was actually correct. Also, out of a 6-week study, there were only 4 actual microdoses and all the rest placebos, which is a fairly small n.
You said in the video that you get manifestation as tho you microdosed sometimes. I'm not using the same mushrooms as you so my experience is different, but I can sleep better thinking about mushrooms and poppies even tho I took nothing. Your study shows that the placebo can do us some good, which I agree with. It doesn't prove these medicines don't work.. :)
Please come back! Only just found you. Learning so much.
Fair limitations mentioned here, although, those limitations don’t necessitate the findings being incorrect though, they just need more studies.
The study is nonsense -- purely based on the fact that they studied mainly healthy people. I don't understand why they wasted resources on it *and* then published it.
Yeah :/ what hurts most is the coverage this study seems to be getting. People making gross generalizations based on ONE study without acknowledging the full context.
Absolutely, the media has already sensationalised this study which is a massive bummer for possible future clinical studies that may try to get grants etc. and using healthy people who already microcode seems pointless, they possibly have already reached a plateau of the effects. A study of people who have never microdosed would be much more important, though as mentioned in the video, the legality is a huge issue.
You don't know how it was designed. The subjects weren't selected based on mental health, it was self subjective reports. Do you think the college would accept a 'nonsense' study to be conducted at their institution?