What is a PPI and how does it WORK? - Omeprazole, Prilosec, Losec, Antacids for GERD
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- čas přidán 23. 07. 2024
- Ever wondered how a PPI proton pump inhibitor works? Well, wonder no more. Here's the explainer with the what, how, why, side effects and history and pharmacology to boot (two advanced sections in the 2nd half). For reflux, dyspepsia, heartburn, GERD, GORD, curries and everything in between.
You might also know this drug by it's trade names: Prilosec, Losec, Prevacid, Protonix.
As always we go through things in simple terms and then for the hardcore enthusiasts we're into the complex stuff. Why? Because you should probably know how your drugs work!
You'll discover how a PPI stops your stomach producing acid, which in turn stops your heart burn!
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#reflux #medicine #GERD #ppic
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CHAPTERS:
00:00 - What is a PPI?
00:38 - Why take it?
02:05 - How does it work?
03:06 - Side effects
03:27 - How was it invented?
05:29 - Pharmacology
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Information on this video is up to date as of June 2023.
If you have any questions or clarifications please contact me through the Stealth Doctor channels in the About section.
So informative!🙂
Excellent . Thanks Dan. Judy
Excellent. Thanks. Judyxx
Thanks alot
Very helpful...Can you please do more of these videos (pharmacology). Many thanks.
I'll do my best
I feel attacked (and informed).
That's you stomach acid attacking you.
Thanks for that explanation. Have recently started on omeprazole before my midday and evening meals as I cough after eating, but no burning sensation in my throat, so didn't think it was reflux. Seems to be working but now I know why
Sounds like silent reflux. Glad you're feeling better!
Thank you for your video that was very useful, if it binds irreversibly but then those cells are then replaced that means their effects won’t last forever right? So why is it only usually given short term as in 4 weeks and not lifelong? Won’t those symptoms just come back if it’s stopped after 4 weeks or do their effects reduce the acid production forever?
It depends on the underlying reason for the need for PPIs. Often a period of protection allows the gut to recover sufficiently to mean that stopping them is okay. But some people have conditions or take medications which require long term use.
Thanks bro , true about the doctors not knowing all mechanisms of action , but I'm here to break that streak ;)
Thanks! Time to make more then :D
@@TheStealthDoctor yes ive subbed for more :3 good day bud
If they irreversibly binds to the proton pump, does it means that the proton pump they are bound to will be forever inactive?
Good question. Those cells - yes. But the cells of your gut lining are replaced at a very quick rate, so there'll be new cells to bind to soon enough.
@@TheStealthDoctor Okay, understood. Thank you for your response! You could do a next video on statins, you explain so well.
Thank you! Re statins: I've already done it Crystal, check out the other vids on the channel 😁
Yes, your stomach will be creating more and more such cells, changing its lining and that’s why you get horrible rebound. Long term PPI will scrw your kidneys, liver and… your stomach! Awesome drugs! See a naturopath to heal, or ask your AI. Fck these pillpushers.
Can i take Omeprazole twice a day before meals?
20mg morning and 20mg evening is okay but dont take more than 40mg a day.
You're a "doctor" and can't figure out that alkaline foods and the medications work the same way?
Correct. I've even looked at the evidence and everything 🤷
@@TheStealthDoctor so what does tums do? And what about sodium bicarb in the ICU? Why is that needed?
That was really a narrow and unscientific "explanation" against an alkalising diet. While the burger and french fries are burning under the stomach acid next to him.... It's just not credible to listen to as a health "expert". Wrong messages.
What a weird piece of criticism. That’s exactly what they were going for; you can tell by the script and video effects that they’re going for more of a casual and entertaining (as entertaining as you can make a video about the chemical processes of stomach acid) vibe.
If you want a “scientific” explanation, I’m sure there’s something else out there for you.