God dam! give this man an award... or money... or a cuddle or something. These videos are so easy to follow along. I wish I had a teacher like this back in the day. Thanks again for the great content
I've wrecked my whole brain for the past innumerable years.. To understand this pathway..... And here comes this God of a man to explain it in 4minutes!!!! Thank you so very much
Very nice Doc.. very simple..i wish i had a teacher like you to teach neurophysiology..i have seen a few other videos of the neuroscience... extremely helpful..
THIS IS WOW, MAN YOU HAVE DONE IN 4 MINUTES WHAT OTHERS WERE NOT ABLE TO DO IN HRS, THANK YOU SO MUCH FOR SUCH A NICE, BEAUTIFUL AND CRISPY EXPLAINATION.
Helpful content Hey I would love to discuss more concerning this disease, my grandpa has it If yes kindly send me a email or message me on hangout taylorracheal2@gmail.com ...🇺🇸will look out for your text or email by tomorrow bye
Preparing for my PhD prelim, going over some basics, and this was a very nice and concise description of these brain regions and their interconnectivity in PD. Thank you.
Really good, excellent way to show how the basal ganglia work; only, the projections between the basal ganglia and the thalamus aren't inhibitory neurons? so actually the direct pathway leads to an inhibition of those neurons, leading to increased thalamic activation; whilst the indirect pathway gives an excitatory feedback to the same projections, activating the inhibitory neurons and reducing thalamic neutrons activation and halting movement?
there are some misconceptions actually!! dr.mike when signals are sent from the Globus palidus internus (GPi) to the thalamus is to carry an inhibitory message to the thalamus and GPi is involved in the indirect pathway whereas the GPe is involved in the direct pathway by releasing GABA on subthalamic nucleus to inhibits it as the function of subthalamic nucleus is to activate the GPi which is involved in the indirect pathway!!
Excellent video to be sure. But I am so curious as to the actual methods, tests, scans, procedures that science uses to determine the fascinating and important information you present. How do scientists scan the living human body to find out how all these intricate chemical pathways work? Thanks so much!
Great question. The answer is that disease when a patient is living combined with a postmortem and dissection of the brain with examination under the microscope helps determine the cause of the disease. Everyone with Parkinson disease has pale substantia nigra on postmortem - tonnes of information then leads to our understanding via deduction
😭Gosh this feels very scary to me, as somebody with movement disorder.. I was given Maxolon aka reglan and it affected my basal ganglia.. TD parkinsonism stiffness cramps spasm and tics. It can happen from a dopamine suppressor. When I went to the neurologist, I asked if this could be the reason our two youngest children have tourettes. Taking anti-nausea dopamine suppressor during pregnancy. His answer was, most likely but more study needs to be done.. if this truly is the case, This kind of study is always worth more government grants. Please be careful of dopamine and serotonin suppressor medications during pregnancy. PubMed has hundreds of studies in this area. Also encouraging Professionals to join one or two support groups in the area they specialise in. Often very beneficial on both sides, to be a fly on the wall. I'm saying all of this because parkinsonism means drug-induced Parkinson's and we have to start paying attention to labels like environmental factors. We rely on you guys, Not to encourage medications that will make our movement disorder worse. If it says may or may not make it the condition worse, it really needs to be explained properly. I encourage everybody to listen to the pharmacists when they are explaining prescription medications If your prescriptions instructs you to wean off the medication and never go cold turkey. Please always pay attention to that.. This is such a huge subject on both sides full stop and three huge keywords in the upload title thank you
Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine that truly works that helped treat, cure and reversed all his symptoms. My Dad is well again…
This doctor is giving me motivation to ace my exams as well as joining the gym next month after exams
Yup
God dam! give this man an award... or money... or a cuddle or something. These videos are so easy to follow along. I wish I had a teacher like this back in the day. Thanks again for the great content
He's a ripped doctor. He's paid enough 😂
better than the teachers of a school i pay an absurd amount to go to
ouch
I don’t longer get herpes outbreak after using doctorojie1@yahoo.com natural herbs medication ..🌿🌿🌿❤️✅💊
hundred percent!
I've wrecked my whole brain for the past innumerable years.. To understand this pathway..... And here comes this God of a man to explain it in 4minutes!!!!
Thank you so very much
I'm a speech therapy student learning about Parkinson's Disease. This video is so well explained!
Very nice Doc.. very simple..i wish i had a teacher like you to teach neurophysiology..i have seen a few other videos of the neuroscience... extremely helpful..
wrr, no stress etc nmw
THIS IS WOW, MAN YOU HAVE DONE IN 4 MINUTES WHAT OTHERS WERE NOT ABLE TO DO IN HRS, THANK YOU SO MUCH FOR SUCH A NICE, BEAUTIFUL AND CRISPY EXPLAINATION.
This has, by far, been the easiest video to follow through. THANK YOU SO MUCH!!!
Your videos are amazing, a 2 hour lecture all summed up in 4 minutes....thankyou so much 😊
this is the only video that I could find that does a good job of explaining how dopamine affects motor control
This video is a work of art, I was SO confused 😭 THANKYOU!!
your explanation is much better than my teacher!! you saved me, thank you!!
this is by far the best video on this topic that i have found on yt. thanks a lot. now i actually understand the clinical presentation :)
magnificent .THANKS ALLOT DOC
Helpful content
Hey I would love to discuss more concerning this disease, my grandpa has it
If yes kindly send me a email or message me on hangout taylorracheal2@gmail.com ...🇺🇸will look out for your text or email by tomorrow bye
So simple yet the best and most understandable
Thank youuu
SUCH AN AMAZING EXPLANATION! LOVE IT! GREAT TEACHER
I have given you the 800th thumbs up! My teacher didn't explain crap! Now I finally understand Parkinson pathophysiology.
I love you so much, been searching for this concept but couldn't find it. And then stumbled upon this video. You made it look so easy.
Preparing for my PhD prelim, going over some basics, and this was a very nice and concise description of these brain regions and their interconnectivity in PD. Thank you.
Amazing explanation! This makes so much sense, thank you so much for the work you do!! Much love
Love the way you explain complex topic. Thank you for posting your videos.
I’m speechless. This was very well explained thank you!!
Thank you..it was helpful🔥🔥
you are such my hero doc huhuhu. thank you for this one again
Sooo many of your videos have helped my pathophysilogy course over this last semester, thank you so much Doctor!!
I don’t longer get herpes outbreak after using doctorojie1@yahoo.com natural herbs medication ..🌿🌿🌿❤️✅💊
Such a great video to understand PD !!
Finally i understand why we get cogwheel rigidity!!!
I keep on coming back to this video to get that "aha! Clarity" every time i revise Parkinson
wow.... Your video is so helpful... it helped a lot seriously. Thank you. Your explanation is so clear
I have an exam tomorrow, ur saving my life ♡♡
Dr Mark & Dr Matt
God bless you people for me
Well understood sir
Really good, excellent way to show how the basal ganglia work; only, the projections between the basal ganglia and the thalamus aren't inhibitory neurons? so actually the direct pathway leads to an inhibition of those neurons, leading to increased thalamic activation; whilst the indirect pathway gives an excitatory feedback to the same projections, activating the inhibitory neurons and reducing thalamic neutrons activation and halting movement?
Thanks for making me understand the d2 receptors
this made me understand the topic so easily. thank you :)
excellent explanation ... just what i needed to clear my doubts.. thanks a lot Sir!!!
Just what I needed. Thank you sooo much!!!!
I love Dr Mike's lectures 🎉🎉🎉🎉
I totally get it now. Thank you...
Thanks for your teaching by this marvelous way
I’d like to ask how can I inhibit the dopamine inhibitors please mention some drugs
thanks for this easy explanation
Watching this video and finally understanding gave me dopamine
Thank you Doc
This was awesome. Thanks guys.
You saved few hours of my study time 😍😘
Great explanation. Thank you!
Thanks. Keep it up doc
Fantastic vid
Genius !!!!!!!!
This was so helpful. Thank you!
Helpful indeed.
Great explanation, thank you for keeping it simple!
Thanks for the great video, really helpful.
SO helpful. Thank you!
You saved me! Thank you
Thank you ❤
i love u, i legit understood in 2 seconds
I really like how you smile at us before every video c=
Very helpful thank you for the video
Thanks so much
crystal clear!
Thank you!!
there are some misconceptions actually!!
dr.mike when signals are sent from the Globus palidus internus (GPi) to the thalamus is to carry an inhibitory message to the thalamus and GPi is involved in the indirect pathway whereas the GPe is involved in the direct pathway by releasing GABA on subthalamic nucleus to inhibits it as the function of subthalamic nucleus is to activate the GPi which is involved in the indirect pathway!!
legend
and nice stache
Wow you are brilliant thanks a lot 🤯 👏👏👏❤❤❤❤
Dude, great video! Very distilled and understandable. Thanks!
Amazing explanation .thank u so much ❤from 2024
Ohh. Finally someone make this shit look easy.
Thank u
Excellent video to be sure. But I am so curious as to the actual methods, tests, scans, procedures that science uses to determine the fascinating and important information you present. How do scientists scan the living human body to find out how all these intricate chemical pathways work? Thanks so much!
Great question. The answer is that disease when a patient is living combined with a postmortem and dissection of the brain with examination under the microscope helps determine the cause of the disease. Everyone with Parkinson disease has pale substantia nigra on postmortem - tonnes of information then leads to our understanding via deduction
Nicely done . bravo
Thankyou so much!!!
You are amazing , thank you so much!
😭Gosh this feels very scary to me, as somebody with movement disorder..
I was given Maxolon aka reglan and it affected my basal ganglia.. TD parkinsonism stiffness cramps spasm and tics. It can happen from a dopamine suppressor. When I went to the neurologist, I asked if this could be the reason our two youngest children have tourettes. Taking anti-nausea dopamine suppressor during pregnancy. His answer was, most likely but more study needs to be done.. if this truly is the case,
This kind of study is always worth more government grants. Please be careful of dopamine and serotonin suppressor medications during pregnancy. PubMed has hundreds of studies in this area. Also encouraging Professionals to join one or two support groups in the area they specialise in. Often very beneficial on both sides, to be a fly on the wall. I'm saying all of this because parkinsonism means drug-induced Parkinson's and we have to start paying attention to labels like environmental factors. We rely on you guys, Not to encourage medications that will make our movement disorder worse. If it says may or may not make it the condition worse, it really needs to be explained properly.
I encourage everybody to listen to the pharmacists when they are explaining prescription medications
If your prescriptions instructs you to wean off the medication and never go cold turkey. Please always pay attention to that..
This is such a huge subject on both sides full stop and three huge keywords in the upload title thank you
You save my vivas🙌🔥
This was excellent
very helpful thank u❤
The best 👏👏thank uu
You guys are amazing
You explained this so simply it makes me want to DIE
great video!!!
Quick question. When you say start stop which processes are you referring to? The motor cortex signal and then the absence of dopamine?
Oh my God .. finally 😫
Thankyou sooo much sir
I don't get it. If pathway started with person deciding to move how comes that he has "resting" not "intentional tremor" ?
THE BEST
Thanks man
the bestest! thank you
Make it simple🙏
Really helpful, Thank you :)
Love it! Thank you Dr.!
Does Dopamine have any role in first path? normal situation? or it just plays a role in Parkinson situation?
Please, why this start/stop function in the first place?
omg.. so clear
Benzodiazepines damaged my brain/nervous system . I've been clean for 3 years but, It feels like I have parkinson's sometimes.
GOAT 🐐
My uncle is suffering from Parkinson disease. What drug can I buy for him?
wowwwww thanm u so much 😭💕
Sir,does Prefrontal cortex inhibit sexual motor response with the help of basal ganglia in human being?
So the shaking is comparable to flicking the lights on and off repeatedly? Huh.
Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine that truly works that helped treat, cure and reversed all his symptoms. My Dad is well again…
Do you do personal training doc 😆