Type 3 Hypersensitivity Made Easy - Immunology

Type III hypersensitivity occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes. Such reactions may progress to immune complex diseases.
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These immune complexes insert themselves into small blood vessels, joints, and glomeruli, causing symptoms. Unlike the free variant, a small immune complex bound to sites of deposition (like blood vessel walls) are far more capable of interacting with complement; these medium-sized complexes, formed in the slight excess of antigen, are viewed as being highly pathogenic
Such depositions in tissues often induce an inflammatory response, and can cause damage wherever they precipitate. The cause of damage is as a result of the action of cleaved complement anaphylotoxins C3a and C5a, which, respectively, mediate the induction of granule release from mast cells (from which histamine can cause urticaria), and recruitment of inflammatory cells into the tissue (mainly those with lysosomal action, leading to tissue damage through frustrated phagocytosis by PMNs and macrophages)
The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunological memory of the precipitating antigen. Typically, clinical features emerge a week following initial antigen challenge, when the deposited immune complexes can precipitate an inflammatory response. Because of the nature of the antibody aggregation, tissues that are associated with blood filtration at considerable osmotic and hydrostatic gradient (e.g. sites of urinary and synovial fluid formation, kidney glomeruli and joint tissues respectively) bear the brunt of the damage. Hence, vasculitis, glomerulonephritis and arthritis are commonly associated conditions as a result of type III hypersensitivity responses.

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[@ankitasinhamahapatra4677]

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[@user-li9eo9gd6s]

Hypersensitivity reaction

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[@teenaalatti5032]

The acute glomerulonephritis explanation is wrong in this video other than that a very great video

[@beautyhacksandshopping5262]

Thanx excellent.
What heppend s to the antitoxin- antibody complex when infusing animal serum into human body?
(Is it anti body or whole complex)

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[@deepsaha6324]

Can you please explain why poststreptococcal glomerulonephritis is type 3 hypersensitivy and not type 2, as you said antigen which are bound to cell surface are mediated by type 2 hypersensitivity. Here the same situation in poststreptococcal glomerulonephritis but why type 3 mediated???.....Kindly please explain🙏🙏🙏🙏🙏🙏🙏

[@marouadje8460]

I have thé some question
Poststrepto in thé RAA id type 2 because thé is thé some ag in thé bactérie bd thé cells if thé body
But why glomérulonéphrite id type 3?

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👍

[@gaurabshakya485]

what type of hypersensitivity does Cipro cause? I got rashes from it?

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Where is type 2 ???

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