Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle
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- čas přidán 15. 06. 2024
- In this video, Dr. Tracey Marks provides an update on ketamine's use in treating depression, focusing on its mechanism as an NMDA receptor antagonist and role in neuroplasticity. She discusses the FDA approval of Spravato, a ketamine nasal spray, and compares its effectiveness with quetiapine. The video also explores the emerging role of ketamine injections and the continued success of intravenous ketamine, highlighting their potential in mental health treatment, especially for treatment-resistant depression.
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References
Reif A, Bitter I, Buyze J, et al. Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression. N Engl J Med. 2023;389(14):1298-1309. doi:10.1056/NEJMoa2304145
Loo C, Glozier N, Barton D, et al. Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial. The British Journal of Psychiatry. 2023;223(6):533-541. doi:10.1192/bjp.2023.79
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Quetiapine - you cant be depressed if you're asleep!! That was my experience on it...
Same
I have some hella inyense, sad dreams, freauently. So although sleep is my escape from reality it not great.
That was what Zoloft did to me.
Do you feel better when you wake up? Mornings are usually the roughest for depressed people
@@dibsdibs3495 I feel better now that I've started to deal with my traumas, medications were not helping they were helping doctors who didn't know how to help me feel better about their efforts...
I did 4 weeks of Ketamine IV (2xs a week). Those 4 weeks did more for my anxiety, depression, PTSD, than 10 years of the traditional approach of therapy and RX drugs.
Plus the sides were non-existent two hours after the session. No addiction, no fiending. I cant stop recommending Ketamine IV treatments for people that experience ongoing anxiety/depression.
@crushingit
Thank you for your encouraging assessment of ketamine treatment. It’s great to hear!
May I ask, do you still take any antidepressants?
@@b.j.7837Good question… I also look forward to the response
Does it help with anxiety?
@@b.j.7837 all I can say is try it first and see if you can reduce based on your experience.
I asked the Ketamine practitioner about this and he made me aware that patients can be on several meds during the day and take some more before going to bed.
Not to mention depression can be caused or run parallel to hundreds of reasons.
Long story short I'm going to keep my mouth shut as I only take about 10mg of Lexapro a day and it works for me
@@nanakrisdoggie7375 it INCREDIBLY helps with anxiety.
I had a session on a Friday where my work week had me shambles because of people quitting and other high end decisions. Five minutes into the session I figured out what to do next and laughed it off.
As I watched this video I became very emotional. I think of my friends Joe, Richie, Miranda, Hugh, Dean, Lydia and Gary. They did not make it through their depressions. They're spoken about in hushed tones because people still don't appreciate that Depression can be as terminal as heart disease and cancer. This video gives me such hope - followed a terrible sadness for those who didn't live to have the options we are now discovering. I hope in my heart that one day depression will be, if not totally eradicated, something that can have as little impact on life as the common cold.
God is the way, the truth, and the life. HE said “come to me all ye that labor and are heavy laden and I will give you rest unto your souls for my yoke is easy and my burden is light”
Truly amazing wonderful God who loves each of us with a love that He would come down in the flesh and suffer for us. Amen
@@chrisb5793 He also said that those who pray should pray in private.
@chrisb
I can’t enumerate on the number of times I prayed to God for relief from depression. It never worked!
I am still dealing with chronic depression and sometimes major depressive episodes or double depression.
Depression can be like your own, personal “demon”; it’s like hell on Earth sometimes.
If you’ve never experienced it, be ver thankful.
im so sorry they didn't make it I know the pain it puts on your heart. RIP to Joe, Richie, Miranda, Hugh, Dean, Lydia and Gary.
I’m so very sorry for your loss of 7 friends. That is just beyond awful. I’ve battled with depression too. I know the feeling of hopelessness in trying to get out from under the cold wet wool blanket (how I pictured depression). And yeah, it doesn’t matter how much you believe in God or how much scripture you read or how much scripture other people (well meaning yet self righteous & ignorant) shove at you, the depression just does NOT go away! But God has used my depression to show me how I must take steps to get help for myself, do the hard work of dealing with past trauma and accept His healing. It’s been a long process. After a couple decades it turns out I actually have ADHD, which is often misdiagnosed as depression,-especially in women! Now I’m taking Strattera and getting therapy. I still have times of feeling down but not like when I was younger. It’s a matter of getting the right chemicals to the right places in the brain. I wish you much healing. And don’t let people who just quote scripture without deep understanding turn you off to who God really is! ❤
As a Psychiatrist, I want to tell you what a wonderful public service you are doing. Keep up the fantastic work.
I took ketamine at a hospital for treatment resistant depression. It was a single dose in my belly, had instant effect on my depression, but it lasted only for a few days, but it was amazing to be completely depression-free after such a long time.
I think I have hard to treat depression 😢
What did it feel like?
Well you may be a ketamine candidate! @@animalloveradvocate
It only lasted a couple of days? Are you kidding me? And it probably costs a fortune too.
I started doing drugs since my teenage. Got addicted to fentanyl for over 6 years. Fentanyl addiction actually destroyed my life. I suffered severe depression and mental disorder. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 2 years totally clean. Never thought I would be saying this about mushrooms.
Congrats on your recovery. Most persons never realizes psilocybin can be used as a miracle medication to save lives. Years back i wrote an entire essay about psychedelics. they saved you from death bud, lets be honest here.
I've been looking to try shrooms for depression, just very difficult to get a
reliable source here in Australia. Really need!
Yes Dr.medshrooms
Ive done shrooms last month in my house. It taught me how severely traumatized I was from alcohol. I healed from many mental traumas from my past and was able to forgive, let go. Shrooms to me is a remedy not a vice. I even felt more refreshed the morning after. So no hangovers. No depression mood for days. No anxiety.I now have a more calm mind
How do I reach out to him? Is he on insta
One of the many things I love about you Dr Tracey is how open minded you are about potential treatments for mental health conditions. Thank you for the work you do and for releasing consistently high-quality educational videos!
Spravato has changed my life. I’m hoping I benefit even more as time goes on. I no longer want to go to sleep and not wake up. I no longer want to disappear! I highly recommend it.
Me too! I source my own stuff however. It took me a handful of experiments, and over a year time to get the hang of it. This is why sourcing your own can be dangerous. Ketamine can help a ton, but it can also be another escape.
@Epicsiburg i regularly self IM Ketamine for depresssion and other mental disorders only problem have encountered is the finanical cost lol
So for all the people who jumped on Matthew Perry saying that "he wasn't sober" because he was using Ketamine should educate themselves before they all pile on a man who had fought so hard to conquer his addictions.
On top of battling his own addictions, he still managed to help so many other people with their own additions.
He was a damn warrior and should be commended for a hard fought battle that he ultimately won.
He was a hero to me. That's for darn sure.
People generally speak on/about people they don't know, and it doesn't matter. Nothing to take personal, the stupidity and ignorance of others my friend. This sentiment is super sweet. All the love.
@@themysticalgg thank you so much. And you’re 100% correct. I was just in an overly emotional mood when I wrote that. But I meant everything I said in regard to Matt Perry and the warrior he was.
I’m thinking he will indeed be remembered for the true fighter he was as well as his God-given talent for comedic acting.
Thanks again for your sweet comment. And much love to you, my friend!
😢
Ketamine infusions has been proven to help with my major depression disorder, anxiety and pain.
Quetiapine - This antipsychotic is regularly used for severe insomnia. I had to take it for several years due to insomnia.
Never helped with my depression at all. Just helped me sleep.
Without my seroquel I would not be able to sleep does not do anything for my depression 😢
Well, I have 100mg Seroquel....it's 2:54 am...again. Nothing works for my PSTD or 50yrs of chronic insomnia. The PSTD will never go away, that kind of trauma is there....some days are better than others, But with this severe insomnia my days run together anyway. Always wondering what day it is....up all night...and raising grandchildren all day, so I'm like the hamster on a wheel...just going in circles....just functioning...mostly on auto- piolet ...circling the runway....just wanting to land...and when I run out of gas....I crash. It sucks...it sucks bigtime. At least I can always say....Jesus take tha wheel!
@@jennifertx6419 I was on 300mg of Seroquel and it helped. IMO 100 mg is not effective for PTSD or depression. I believe the maximum dose for Seroquel is 400 mg @ night.
it gave me shocks and jolts as I going of to sleep terrible feeling.
I tried it for insomnia I woke up in two hours with night terror, we are all so different
i have been taken ketamine troches for almost a year now. total personality change and more mindful about everything i do in this world. I have a better understanding of my actions overall and can live more in the moment. my OCD has improved and my depression symptoms have subsided considerably. so far so good
Who do you work for, Big Pharma?
So glad for your improvements. So, would you recommend Ketamine treatments?
How many have you had and is it IV? Thanks
Sorry I seebyou take it by mouth. Can you tell me why that choice? I am DESPERATE
What does it feel like?
I get Ketamine Infusions weekly for chronic pain, treatment-resistant depression, and anxiety. It helps me enormously!
Don’t you have to pay hundreds if not thousands out of pocket each time?
@tonyh1345 I’m curious to know what they are paying too. I paid $400 per treatment over a year ago. But it worked wonders. Hoping they will take insurance soon
Weekly!!?? For how long?? That can't be good for your health.
@@tonyh1345 My insurance pays for most and my clinic doesn’t charge me for the balance. I’m now down to every two weeks.
@@SlimKeith11 I’m now going every two weeks. I’m now using less oral medications than I had been on.
Can’t wait for psilocybin! One of the main reasons why I’m becoming a psychiatrist. Dr. Marks, you’re an absolute inspiration to me 💖
To get access to psylos? 😂😂😂 or helping people?
@@LucienZeroOneyeah i guess im already a seasoned "psych" cause im never not going to facilitate recovery for people. The work is and has been done for ages and is sacred work
Ketamine saved my life.
I use Joyous but support any ketimine research.
I wanted to use them,but my Dr wasn't comfortable with it& bcuz had no giving a d psychiatrist,they denied me. I ended up with another company but that was 1x wk needed someone around etc & more expensive. Really liked the idea of the micro dose daily,the other helped but definitely could use the daily micro dose, I've tried everything else,was only thing that did anything,but can't afford it the way was doing & so hard to always have some one there
I had a friend do keta treatment like a year ago. It made a huge difference, altered a lot of their thinking, had a big and lasting impact.
Used k for depression 20 years ago. The 3 hour period afterward is when I was able to re- organize my world view and realize how distorted my thinking was beforehand. It saved my life several times. You have a multi dimensional perspective on everything and thus can metaprogram a reality which is more beneficial. It blows away the cobwebs...
great!
A friend of a friend couldn't get help from any mental health clinic, so thought to take things in his own hands and did intranasal Ketamine treatment (twice a week, later only once a week)
Results: improvement in symptoms in situations where his brain would fall into dread immediately. It felt like there's a "net" stopping his brain from falling into those dreadful thoughts/emotions.
DURING the self-administered (carefully measured) dosage, he said the floaty feeling was not his vibe at all. He is kinda surprised, how people use this recreationally.
That's just his two cents ✌🏻😁
@addysaw
Thank you for your “two cents.” It’s encouraging news.
How can you get the treatment?
Because you take 100-300mg and you will find your self in a clear empty space where everything is possible (like rly rly deep trancendent meditation) but i was an experienced user. One should start with maybe 50mg and meditate.
Hallo. Thank you for making an effort to write. After decades of servere depression and anxiety problems and NOTHING helping it- I've been recomended to take ketamine ( nasal use ) under the supervision of a psychiatrical institute. I'm also comming from EU . I'm very scared as I don't know much about IT, but since I can't stand my condition any more I'm prepared to try anything. Could you write a bit more about your experience, please? Much oblidged. Regards and many thanks. Jana
As someone who has depression and used MDMA (once used to treat depression) and ketamine recreationally, I have felt the difference in how it affects depression. The next day after using MDMA I felt so depressed but ketamine I felt slightly happier than the day before taking the drug. I live in the UK though so we’re leaps and bounds behind you when it comes to drugs and mental health
I get a Ketamine Infusion every 6 weeks for the past Year. I have to sign up for 1d inpatient and off-label use here (I´m not from USA). 2019 FDA approval of Nose Spray really was a game changer for depression Treatments in EU! I got my first infusions back then in 2019, but the dosis was pretty unkown. So we experamenting with a 3x lower dose than I´m getting today. It didn´t worked out for me the way it does today. I´m very happy that it´s possible now to get rid of the heavy depression symptoms! For me 1 infusion last for 4 weeks and then it slowly come back. But let´s say about 1 week of depression and then 3 days of recovery from infusion is totally worth the ~90% very good time I have! Before my docs and me tried Ketamine I was on 50+ different pills (of course not at the same time, but up to 8 different a day) and now I´m at 0 pills since a month.
I´m very excited for future, because Depression (and the medication) will be normal in the future!
Love you, Dr. Tracy. My extemporaneously exhausted long-term depressed brain can hardly hold any information these days, but youre always so informative without all the fluff. Thank you ❤
Sounds like you need ketamine! You won't believe how different you can feel in a couple of HOURS. I use the under-the-tongue lozenge (and remain on the same anti-depressants that I've been on for so many years). I can only heartily recommend it to you!
Ketamine helped me instantly a small line a cm long. 3 years treatment resistant Depression. Suicidal attempts. Fixed and gone in 2 hours. Been happy ever since. Did not expect that at a rave in a field. Never touched Ketamine or any drugs since.
I love it when I sit down with a licensed psychiatrist, tell them about all the literal 'self-medicating' I've done with particular substances and my genuine motives behind using them, it's always a paradoxical reaction of "While I can't come right out and explicitly endorse what you do, at least you're paying attention to the right stuff."
I am at least attempting to go legit and am currently paying a hefty out-of-pocket amount to a licensed anesthesiologist for ketamine infusions and it's easily the second-best horse-related medications I've ever had (just kidding, obviously).
But I'm glad there are people out there promoting this model of "take this substance because it'll make you feel good *after* you're no longer under the influence" instead of "take this substance that, if taken long enough, will ensure that you're a repeat-customer--or else."
Yepp, self medicating is so broad but in a world where SSRIS antipsychotics and benzos are the best thing around it seems, self medication starts to sound like it could be better.
I was on Zoloft for a while and never could remember to take it (adhd as well) and it just seemed like a losing battle. Now I’m self medicating with psilocybin/shrooms and a single dose lasts up to a month, some benefits indefinitely.
But these revelations in my own self care are allllways met with quiet, under-the-table type reactions from medical or psych professionals.
Exactly. Take this and feel better. Not take this and be repeat customer ain’t that the truth. There’s no money in people being cured and healthy. Number one reason cannabis was such a fight.
@@aidenbloedowhow do you go about finding what you described? I apologize in advance for my ignorance. I am 67 and it seems like people like me at my age don’t need a psychiatrist anymore, as there are very little options once you hit 65. I have ADHD and basically suffered all
my life probably being misdiagnosed. I am on Zoloft and on a high dose and don’t feel it helps at all, but afraid to quit.
Wow. Great information. My mother suffered with drug resistant depression and chose to self medicate, leading to her death. I do hope there is further fda research leading approval and insurance approval. This may be life-saving. ❤❤❤
Aww, that’s sad. Sorry for your loss and may she be in everlasting love and peace. 🥺🙏🏽🪽
I am on the lozenge regimen and it doesn't really matter if the FDA approves this form of application. It is FDA approved for use with anesthesia .... The weekly lozenge is about $10! It comes through prescription a a compounding pharmacy.
Ugh. Back in I think 2017-2019 thereabouts I had an opportunity to be part of a ketamine study. Would have got a course of treatment for free. But I couldn't afford the public transport cost to the city. I really wish I'd taken it more seriously and found a way to get there. It probably would've changed my life.
Aww man, I so feel this. Would it be possible for you to try the spray?
Quetiapine made me put on so much weight. Now I have metabolic syndrome :-(
Im currently doing spravato once a week, and I am truly in disbelief in how well it works.
My self destructive ideation was completely dissolved after just the FIRST dose. Even crazier is that it continues to work and, knock on wood, I can even say I'm happy despite occasional poor circumstances. My emotions are actually aligned with whats going on.
I'm still a little worried my brain wil go, "lol just kidding" like it often does. Spravato has been more helpful than anything ive ever tried. And ive tried a lot of doctors and medications.
I do wish I could try infusions, but im just elated that government healthcare is paying for it 😭
Congrats, and I would say ditto!
I can't help wondering if people who are appear to be resistant to antidepressants are just people who have no idea they have ADHD, because i know several people who have no idea and refuse to even entertain the possibility, and yet they have anxiety and depression, that never goes away.
I personally think that everyone who has any signs of depression should always be assessed for ADHD aswell as standard procedure.
Because the amount of people who must be miss-diagnosed or completely overlooked with ADHD, could be huge, because of this problem.
That has been my experience. Adderal helps more than anything else. Every antidepressent makes me so much worse. My anxiety goes through the roof. I have more grief than depresson, and I am highly sensitive, but antidpressants feel like depressnts. who needs that. I don't know if a ketomine nasospray would work, but it would be nice to decrease anxiety. Nothing works for that.
I've been on Seroquel for 7yrs. I SO want to try Ketamine. Thank you for these videos! I alwaya talk with my psychiatrist about things I learn here.
DO IT! IT WORKS
25 years ago, my doctor had me on seroquel, I was so drugged out, I wouldn't have heard a fire alarm if it had gone off.
Dr. Marks I’m so glad I just saw that you’re highlighted on CZcams’s front page for BHM! 👏🏼 🙌🏼 🙌🏼 Thank you for all you do
After being for many years now on "old school" antidepressants, I believe it's time for a real discussion of their efficacy. So many studies published in major medical journals in the past few years showing that they're not better than placebo.
Zoloft was better than a placebo for me. But it would stop working after a year or two. The others didn't work as well.
@@Catlily5 that's true, and that's the first issue with antidepressants. They're working on 50% of the people, placebo being the same rate.
Second issue is that no psychiatrist would admit this, and instead of recommending people ketamine treatment, they're still pushing the antidepressant story.
@@OrangeMicMusic I don't take antidepressants anymore because I am bipolar. But I thought that all new meds had to be better than a placebo to go to market.
@@Catlily5 well, in 2024 still they aren't. The difference is 4-5% roughly, which in the whole picture is nothing.
Careful with “ no better than a placebo”. The placebo effect is very powerful.
Why does every drug cause weight gain? The drug companies consider the effects on the digestive system to be something that is lack of self care. That is wrong.
Wellbutrin and others that increase Norepinephrine = weight loss.
Your gut is very responsive to Serotonin, SSRIs often increase gut motility and are in fact a treatment for IBS.
MAOIs like EMSAM are very balanced, no side effects on weight. Probably reduce weight as you have more mental energy.
The pharmaceutical companies do that so you will end up getting diabetes. Psych drugs and diabetes drugs are big business for 'big pharma.' And now we are talking about ketamine, a drug that helps in surgery, being considered for use for depression? Another way to make money off of that? Hmmm. Sorry, but after being on all kinds of psych drugs for 26 years, I am slowly going off of all the ones I have been on over the years due to the fact that the side effects way outweigh the benefits. I like Dr Marks but I no longer believe in pills being the answer or any other pharmaceuticals. I now exercise, meditate, eat right and I feel so much better.😊
I lost a lot of weight on Prozac. But my brother gained weight on Prozac. Just depends on the person.
Bupropion doesn’t. It actually promotes weight LOSS (not a lot). But at least you won’t gain weight.
Dear Dr Tracey, thank you for making these videos 🙏😊. I have been watching them for about a year now, mostly ones from several years ago but i just subscribed and got this in my feed. Your work is so valuable ❤. And greetings from Australia 👋🇦🇺😃
Thank you for your consistency in publishing thorough well-researched mental health videos. In this post-COVID world, mental health is finally being discussed in a more "normal" fashion. The study comparison between ketamine and other effective drugs is positive in giving more options to consumers. Those with comorbidities such as having depression and diabetes (and HBP) definitely need to hear this! I encourage everyone hearing Dr. Tracey and reading this to focus on getting and MAINTAINING mental health care.
I began ketamine, once a week at the lowest dose, held under the tongue until absorbed. Mango flavor! I too have had a response to Ketamine that knocks the ball out of the park. I remain on my usual anti-anxiety and anti-depression medications, but ketamine is just incredible. Dr. Marks did not mention the lozenge dosing but I'm glad it exists. You are not supposed to drive after the treatment, and that would be a handicap for me. Lying on my couch when my husband is at home is just perfect, with no issue of driving. I have heard phrases come into my head during the treatment that are very uplifting and positive. And I am the author of those phrases, or my subconscious is. With this dosing, I have about 3-4 days of positivity with no anxiety or depression. This is the result of the least amount of dosage strength! I think it is a miracle.
Great to hear!. Since my series of infusions, I tell people it's like a spa day for the mind.
Thank you Dr. Tracy for the update on ketamine. I've been following your channel for a few years now and appreciate all the valuable knowledge you bring.
I am one of those labelled as "Treatment Resistant." Over the past 10-15 years of Major Despressive Disorder I've trialed 8 different SSRI's. The only one that 'remotely' gave me some results was Cymbalta -- however, it had one of the highest weight gain out of all of them and I had to stop the medication as I was reaching over 200 lbs (I am 5'9" and small build and could barely tie my own shoes).
I feel so defeated because I know there are new options for TRD but nobody wants to cover it. My depression got so bad I had to go on medical disability. Therefore, Medicare barely covers anything. I want there to be hope for me, but I don't think it will come in time for me to benefit from it.
Some doctors accept Medicare for Spravato
Have you tried bupropion? Everybody seems to resort to SSRIs as the first, second and third line therapies. I got damn lucky with bupropion. Perfect remission, zero side effects. If anything it has helped keep my weight in bounds rather than gaining.
@@kenofken9458bupropion is an excellent choice for many people. Often it promotes weight LOSS too (not a lot). But you won’t gain weight on it! It mainly works on dopamine instead of serotonin. I’m glad you’ve had success from it!
@@kenofken9458 ¿Sabes qué sucede con los psicofármacos?
Que cada persona pareciese tener su propio código genético. Con ello, la reacción a un medicamento y los beneficios/efectos secundarios, pueden ser muy variados y dispares de una persona a otra.
Siéntete afortunado por haber dado con el fármaco adecuado para ti, porque lo que sucede frecuentemente es que o no se obtenga una respuesta positiva, o se ha de probar distintos fármacos, con su correspondiente tiempo de espera que suele ser al menos de entre cuatro y seis semanas.
thank you for your research , you are thorough and unbiased , a true professional
Thank you, Dr. Marks. You are my favorite psychiatrist. I just wish I could have ever found a doctor like you. I have tried at least ten different antidepressants over 20 years. They cut the edge but I'm still depressed and I'm on the one the Genesight study said is best for me.
Thank you very much for this video , Dr. Tracey Marks.
I listen to your videos.
You are great.
Saying hello to you from Japan.
Thanks a lot.
Wow. Great explanation and always offering clear concise helpful perspective.
Thank you, Dr Tracey ❤
My Cocktail For My Bipolar 2 / CPTSD is LITHIUM LAMAGATRINE CYMBALTA I HAD TO COME OFF SEROQUEL / QUETAPINE BEING A DAMN ZOMBIE FOR YEARS - BUT THIS COMFO FOR MANY YEARS NOW HAS BEEN GREAT
This is fascinating. But it has to be used in a clinical setting to prevent addiction and misuse.
Galatians 6:7 - Be not deceived; God is not mocked: for whatsoever a man soweth, that shall he also reap.
@@chrisb5793 what on freaking earth does that have to do with the comment?
In my case, since I can't get a lift back home after I use the lozenge-style under-the-tongue version, my clinical setting is my couch with headphones and eye mask, with my husband staying about until I am back to being conscious. I will not become addicted to it and I will not misuse it! Why would I want to jeopardize my own mental health that I have strived for for so many years? Yes indeed this ketamine is FASCINATING.
Thank you so much for sharing this information.
Thx Dr. Marks. Good to know.
Nothing new. Anxiety just disappeared with K, it was like 10x therapy work. And yes, with K you are still working on your pain and mental illness, but without the emotional feeling that blocks you.
So informative. Thank you!
in
instagram
I used ketamin for resistant depression. I did several blood infusions and the boost in the mood is real. But while i received the infusions i had a lot of illusions and harsh feelings. It was like a nightmare every session (almost 4 hours each one). At the end of session i started to talk with a different accent for hours. And a lot of nausea makes me vomit a lot too. So i couldnt eat anything in the day of infusions and even tough i keep vomiting water or what was in my stomach. I tried use medications for this side effect but none worked. In my infusion, before i took bromoprida to help it secondary effects. But stills didnt work. And the effect of ketamin just take about 2 weeks. After that time i needed a new infusion. I had to stop because I was felling really bad and started a MAOI. I took the MAOI for one year and after the fear of drug interaction i tried to use a combination between fluoxetine, bupropion and quetiapine. It worked hopefully. I dont know if nasal ketamin has less side effects but to me was a very hard treatment...
Great information; please share any updates on effective OCD medication
How would we bring this up in a discussion with our mental health professional, without irritating them? Psychiatrists and other doctors seem put off when we patients make a suggestion if not, persistent with, wanting to switch to a particular med. In other words, not to offend or doubt their practise?
I just started Spravato and I'm cautiously optimistic. Hopefully it helps!
Does it help with anxiety because that is a bigger problem that predates depression.
Fantastic information 👌
Quietapine has been a miracle for treating my insomnia! I no longer have to wait until 2:30 am to go to sleep!
Can you talk about oral ketamine?
Ketamine is a miracle. I had it during a TKR. I came around feeling the best, emotionally and physically, than I had in decades. Sadly, it's not easily available in Australia. Like Kratom, its illegal. We are the boondocks in relation to health care.
Ketamine is accessible in Australia. Spravato is available also you just need a psychiatrist prescription for it.
What's the relation between Ketamine and Bipolar Depression (especially type 2)? Does it have similar effects in depressive episodes? Do we know what it does with respect to mania?
Same question but for bipolar 1.
Thanks for the video
Seroquel saved my life ❤
Interesting and Instructive
I second that, what an improvement!
I know many people who have used both the infusions and the spravato. For some of them it worked wonders, but for one person it caused severe dissociation and ptsd flashbacks. I think the treatment still helped him in the long run but it was a tough ride.
Very good thank you ❤
I've had therapists tell me I didn't want to get better because their anti-depressants made me worse.
@chinookvalley
I’m so sorry that happened to you. That was terribly unprofessional and negating. I’d bet that doc never experienced depression.
I know it’s difficult. I’ve been on many, many meds, myself, with most ending in “Prozac poop-out.”
Can this be used for prolonged depression (over 2 years ) in Bipolar Disorder? I take Quetiapine and am on my third antidepressant.. or would this cause mania/ a mixed episode?
I have been taking ketamine sublingually in my drs office. It’s dissociative effects last maybe 20-30 minutes and it is much less expensive than Spravato. Just curious how Spravato and sublingual ketamine differ in bioavailability.
Note: 73 canadian dollars for about three doses taken every couple weeks
I been watching a lot of your videos about depression and I noticed a lot of the older videos talk about depression not responding to treatment, about how the old antidepressants aren't working as well as we'd like... So I wanted to know, could you make a video about the latest treatments for depression?
Good to thought on with speed.
❤ excellent video
And I thought it was only used on Horses. Nice to know that there's at least a new option that could finally help. I've been on Seroquel for over 10 years at 100mg 3 times a day(I got off it full y back in 2017-ish) and that stuff made it all so much worse. Even with antidepressants.
current sprovato client. 2nd week stay tuned. thanks for ur videos, they & you are Amazing!
ps i previously used the ketamine torches. both of course have their pros & cons best, Lottie
I was really hoping that you would also mention the low-dose take-at-home troches or lozenges, that I've been seeing advertised
Ketamine infusion works wonders for specific types of depression and PTSD. General rule: if you're stuck in your head and can't break loose from repetitive thoughts, ketamine might be the ticket. I have cyclical depressive thoughts and hear music in my head constantly... it's a fear-memory feedback loop, very similar to how PTSD works. A single ketamine infusion shuts this down completely. It's also very effective in dealing with chronic pain, or at least the mental anguish one experiences when forced to exist in such a state. Hey, worst case it doesn't work and you get a nice clean trip! $200 is the going rate where I'm at, and it's worth every cent.
Where do you live? I'm in Arkansas and treatment is $500. 3k for 6 sessions!😮
PLEASE do an updated video on schizoaffective vs bipolar vs MDD with psych features
I'd love to try Spravato, but in Australia it is SO expensive to get it due to not many psychiatrists being trained in it yet, plus the initial cost of the psychiatrist session (being about $600). We don't have the same type of insurance here, particularly with mental health.
Seroquel was hideous for me. It made me so ANGRY and wired. No sleep. No sedation. Just horrible tension.
Has Ketamine been compared to any of the standard antidepressants like say Zoloft, Lexapro, Prozac, Effexor, Cymbalta, Nardil or Parnate?
Also, I've been depressed for a long time. It never changes. It's caused by 40 years of anxiety and OCD, and mostly manifests as anhedonia, not sadness or suicidality. Does Ketamine help anhedonia?
The costs of seeing specialists in Australia are ridiculous, and the wait times horrendus. My psychiatrist is only $250 in Sydney, but doesn't cover ADHD.
How does ketamine stack up against quetiapine for bipolar or schozoaffective disorder?
First, check if you need HRT before trying any of these strong drugs. That for ladies who entering their peri phase.
Any idea how far out the results on psilocybin are? Are we talking months or a few years or longer? As someone who's been dealing with depression since the 1960s, I'd like to know if I'm ever going to be able to get this kind of help.
That what I want to know also.
Just do your research. Lots of studies on magic mushrooms and MDMA will soon be fda approved
The problem is those compounds won't be approved. What will be approved is some synthetic derivative that can be patented and then sold for $2,500 per treatment which will only be administered in psychiatric settings.
I seem to remember hearing months at least. I can tell you a single ayahuasca session provided benefits still apparent 10 years after the fact.
These compounds challenge the idea that depression is all about simply inadequate levels of serotonin or NE in the synaptic space. It's thought that psilocybin and other entheogens may work by breaking the brain out of repetitive and unhelpful patterns of activity.
I can say with ayahuasca in particular that it wasn't as simple as "curing" a depression. What it did for me was to break me out of the thought patterns that I took for granted as "the way things are" and brought me face to face with a lot of traumas and negative baggage I had stuffed down for a lifetime. You face your personal shadows and horrors with aya, and it's hard to bear, but not more than you can bear. Kind of like lancing a boil so that healing can begin.
I describe it as a full death and rebirth experience. The thing you take for granted as "the real you" dies over the course of that night, but it's necessary for some of those things to die. What's left is reassembled and re-integrated piece by peace and born literally into the light of the new day and a lot of hope. It's like 10 years of therapy in one night. You still have to do the work afterward though. Aya can show you some truths but its up to you to recognize and implement them into your life.
@kenofken9458
Thank you for that information. Where can one experience ayahuasca, and how much would it set one back? In other words, can an average person ever hope for such a treatment?
My doctor gave me Seroquel as a mood stabilizer for my bipolar depression. This is my second go round I had to stop because I’m over weight again and my A1c is high. Would ketamine work for bipolar depression? I have to stop Seroquel.
actually had Quietiapine added to my anti-depressant (escitalopram) 2 years ago after a significant worsening and adding new symptoms (like complete inability to sleep, mainly because my brain just could not stop with forced thoughts and rumination) to my persistant depression. I'm still not doing well at all, but it that does not mean it did really help. That's why I can accept the side effects, because I don't want to ever fall back into the absolutely insufferable state I was in without it.
I am a therapist who has a client who previously underwent treatment with Ketamine. The effect it had on her was problematic. Her nervous system went into overdrive and she is triggered easily by sensory experiences. Has anyone else heard of this or know of any ways to help her move back to baseline? It has been two years since her Ketamine treatment ended, and she continues to suffer.
What about daily low dose oral ketamine? You can this form of Ketamine online fairly easily. It’s helping me.
Love you. I don't trust the FDA.
Hi, Dr. Thank you for doing this. I've been talking quetiapine for 14 years for severe insomnia, 100 mg alone with lorazepam 2 mg. The Dr gave quetiapine in order to reduce lorazepam, because I was taking 4 mg, the only way I could sleep. Besides, I am bipolar. My question is: can I take ketamine every night? If not, it won't be helpful in my case. Thanks!
Any chance there will be a RCT between Spravato and infusions? Or between ketamine and TMS? Sign me up!
Seroquel with Zoloft worked well for me, until I got prolonged QTc and had to change my whole regime for bipolar and anxiety. So see your psychiatrist if you get really dizzy standing up with an unsteady heartbeat/rate.
May I ask what QTc is, please? I've been on Zoloft since early November '23 & boy has it been a ride. 🥴 I get dizzy/light headed, 'jelly' muscles, change in breathing & fast heart when standing up after sitting/laying/bending down. It passes after a short minute or so though, thankfully. I've got to hold onto or lean against something during that time. 😅
@MizzNixx86 In short it is a heart rhythm issue. I wouldn't take advice from strangers on the internet, but I would go to a doctor or the hospital to get that checked out.
Thank you for your reply. 😊 I am already seeing my GP, Neurologist, Respiratory etc.. I also see a Psychologist & am on a waitlist to see a Psychiatrist. I had raised concerns to my GP about my heart since before being diagnosed with Epilepsy in 2020, but only ever had an ECG done to check back then.
I'm on my second try of Spravato with a different Doctor's office. The first time the rules set forth by Janssen were not stuck to and I had a very sub-par experience and still feel like my money had been wasted.
Now I'm at another Doctor's office and they are strictly sticking to the rules set out, food and drink consumption before, transportation requirements, a Nurse sitting with me, etc. This experience has been a complete 180 from the first as far as efficacy goes. Almost all of the two hours is spent feeling numb (sleeping, fuzzy, extremity) from head to toe, the rest of the experience is like having an eye dilation for an exam while being very drunk. I haven't had any dissociation or sedation, which seem to be the main concerns.
I've completed 3 months of weekly appointments and am sad to say that the positive physiological effects are starting to be less impactful than they were in March and April. I am moving into a maintenance phase at the moment so perhaps less frequent appointments will help rejuvenate the effects since Spravato will not be so familiar to my body moving forward. I feel like I need more/better direction from the Doctor on what to do while medicated.
If you are able to use insurance and can find an in-network Provider, try to leverage the assistance program offered when filling out your paperwork with Janssen you can get Spravato for a pretty reasonable price. Excluding my transportation costs (über), my out of pocket cost for the medicine and office visit is $35.
I wonder if a POTS patients would be contraindicated? Or maybe it would be helpful since it raises blood pressure?
Exactly. I was on it for insomnia.
My older sister had this treatment. It didn't work for her. She's tried many solutions but again they didn't work. I trust her judgement in trying new things because I have the same issues. I prefer the holistic approach. I've done quite well with it.
Quetiapine makes me Seriously depressed. It helps me not to argue with people.
Ketamine also works for my dramatic Bipolar I depressions! If you're considering trying it, this is a sign to talk to your doctor 💜
Has it ever triggered a manic episode? That would be my concern in using it for bipolar.
@@kenofken9458 I wouldn't think so, but sometimes the dissociation effects last longer than expected and I don't interact too well with the environment. For example I feel like when I go for a walk, I'm in a movie. But it's a minor temporary side effect of course.
I've recently been diagnosed as Bipolar. I did 6 sessions of ketamine intravenously and now I'm on Seroquel. For me seroquel has been much more effective -- for bipolar -- but damn it makes me tired.
Shrooms work better, and unlike Ketamine, it’s not addictive
Has there been any research on Spravato as a treatment for ADHD/executive dysfunction?
Ketamine also modulates kapa-opioid receptors to make natural opiates more potent in the body for several days after use (and can make some opiate drug doses toxic because of this)
My GP would not give me this ketamine , he said it was dangerous and can cause suicidal thoughts . It was only meant to be for all the patient to in extreme pain that caused their depression. Does that make sense?
Thank you for this! Do you know about the FDA approving it for bipolar? I have bipolar 2 and BPD and was trying to get into a TMS program, but none in my area will take me because it is still off label for bipolar. I'm wondering if I'll run into the same thing with ketamine.
I have BPD. medication for me is a short term thing. I've had better results with long term psychotherapy. Dialectical behavioural therapy and Mentalisation Based Therapy.
@@marleyhill34 I am also in therapy and use DBT, but I also have bipolar which in my case needs medication. Medication for me has helped stabilize me enough that I'm able to implement my skills; without it I barely function much less use skills.
Dr. Marks, Sapravato is not available for people with depression and have ever had an episode of psychosis. Could you please share your thoughts and any research done on ketamine or Sapravato for Depression with Psychotic features?
I have cognitive problems since my depression started but it is mild depression will ketamine help my depression
Worthy of medical CE credits. Thx!