Antibody Structure: The Immunoglobulin Fold and Antibody-Antigen Interactions

Dr. KP gives an overview of antibody structure, and takes a look at a human antibody bound to the SARS-CoV-2 spike protein.
PDB IDs
Available at rcsb.org: 1igt, 7k90
REFERENCES
• Akkaya, M., Kwak, K. & Pierce, S.K. B cell memory: building two walls of protection against pathogens. Nat Rev Immunol 20, 229-238 (2020). doi.org/10.1038/s41577-019-02...
• Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.
• Barnes, C.O., Jette, C.A., Abernathy, M.E. et al. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature 588, 682-687 (2020). doi.org/10.1038/s41586-020-28...
• Chiu ML, Goulet DR, Teplyakov A, Gilliland GL. Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies (Basel). 2019;8(4):55. Published 2019 Dec 3. doi:10.3390/antib8040055
• Lambert, J. M., & Berkenblit, A. (2018). Antibody-drug conjugates for cancer treatment. Annual review of medicine, 69, 191-207.
• Nose M, Wigzell H. Biological significance of carbohydrate chains on monoclonal antibodies. Proc Natl Acad Sci U S A. 1983;80(21):6632-6636. doi:10.1073/pnas.80.21.6632
• Pan S, Manabe N, Yamaguchi Y. 3D Structures of IgA, IgM, and Components. Int J Mol Sci. 2021;22(23):12776. Published 2021 Nov 26. doi:10.3390/ijms222312776
• Vollmers, H. Peter, and Stephanie Brändlein. Natural antibodies and cancer. New biotechnology 25.5 (2009): 294-298.

[@tstewpymol9475]

Great video! I'm one of the PyMOL developers and I would actually love to get in touch with you about how you went about making the images/animations for this video. My goal is to make it easier to view/visualize antibodies like these, while conveying meaningful information about their structure. Let me know if you have a business email or what is the best way to contact you!

[@ianfefchak6995]

Hey Im an undergraduate biochemistry student and I have found your videos to be incredibly useful! I especially like your videos going over enzyme catalysis and as I am currently struggling to understand how FAD+ and FADH2 function as cofactors in enzymes I would forever be in your debt if you could make a video going over how they function! Thanks so much for the amazing content, keep up the good work!

[@michaeladdis3323]

Underrated channel

[@didierbarradas1581]

Excellent video, I really like the way you use the transition and the color selections , keep the amazing work 😉

[@runshen7723]

Excellent!

[@kundanboral8409]

Thank you so much for the video! Really helpful!

[@evelynodeibeamanteaw6587]

perfect explanation

[@tiny7235]

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[@westfield90]

So fantastic

[@Jnely9]

Awesome.

[@biogfp9340]

Amazing 🤩