Remdesivir & SARS-CoV-2 (COVID-19) | Mechanism of Action, Adverse Effects, Anti-Viral Properties
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- čas přidán 27. 04. 2020
- Remdesivir & SARS-CoV-2 (COVID-19) | Mechanism of Action, Adverse Effects and Overview of Anti-Viral Properties
In this lesson, I discuss the antiviral known as remdesivir, including how it is administered, adverse effects of its use, mechanism of action, and an overview of the antiviral effects remdesivir has on coronaviruses like SARS-CoV-2 (COVID-19).
1) Brief Introduction to Remdesivir, including what it is and what it was originally designed to treat
2) Overview of mechanism of Remdesivir’s anti-viral effects on coronaviruses like SARS-CoV-2
3) Summary of some Remdesivir data in in-vitro and in-vivo (mice and rhesus monkeys) studies used in treatment of other coronaviruses like SARS-CoV and MERS-CoV
***EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.***
DISCLAIMER All of these mechanisms have ONLY been shown in in-vitro studies (in a cell culture plate), so these mechanisms MAY NOT translate to actual clinical significance in treating humans. Until we have data from a randomized controlled trial in humans, WE DON’T KNOW whether these medications have anti-viral treatment properties (against SARS-CoV-2) in humans or not! This lesson is for information purposes ONLY. Please DO NOT take this medication without consulting a physician. This medication may have serious adverse effects.
**This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors of these articles instead of leaving accusatory and inflammatory comments in this comment section***
I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel - all of your support is greatly appreciated!
JJ
Subscribe for more free medical lessons / @jjmedicine
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
Given the peer reviews of Remdesivir, I think "Run, death is near" when I see/hear the word Remdesivir
Many know how things work but only few can see a solution. Clearly shows that innovate and creative minds are rare.
Does the 3-5 thing correct the error?
@@fernandohood5542 Yes the Exonuclease protein does correct the RNA error, however, the speed of viral RNA replication is reduced either way, which can reduce the overall speed of the disease.
@@KIDZXGETZXSCARED + But it kinda odd, people walk into the hospital, then induced into a coma, where fentanyl is given to put them on a ventilator. Then each day Remdesivir is given. Around 9th day, your patience is dead. Wonder why that was not looked into.
So basically this is experimental as far as humans go. My friend is in hospital being given this med for 5 days. He has no idea its only experimental. I was given bamalanam also experimental, when I covid 19. My doctor said I needed it so I never questioned it. Now I have stage 2 kidney failure, liver, heart, lung, and brain damage. No one can tell me if the damage was from the experimental treatment or the covid
Mary - I pray for you, hope you recover soon. And you said you were given "bamalanam", is it an antiviral medicine or may be I misunderstood?
100 percent sure its the meds,
Was from the meds. Millions had the virus with none of these side effects.
Did you have to sign a consent form for that and did you do it? I hope you are feeling better now.
What stops Remdesivir from interrupting native mRNA processes? This seems like it would be screwing up our own ribosomes and protein productions as well. I'll have to read the paper. Thanks for posting it.
Good Afternoon,I read that paper and It said there was actually two amino acid substitutions in the nsp12 polymerase(not the ExoN) causes allowed for resistance, im sure it doesn't matter because this video was excellent. I just dont want someone to give a presentation and say the wrong thing.
Again another great video lesson, well done
Can you do a video on NHC since that seems highly promising. It’s orally taken like Tamiflu, taken early and may be protective against future viruses too.
How Remdesivir works - 7:26
Please like :D
Pete Sapico 9:20
Very well explanation of Covid 19 and Remdesiver
excellent presentation
thank you
Nice presentation .....and good effective medicine
Fantastic explanation, thank you!!
Thanks a lot for explaining!.... Feeling great to learn this concept with such simple diagram as a high school student😊
Mechanism of Action, Adverse Effects, Anti-Viral Properties- knowledge providing explanation.
Спасибо, очень полезное видео !!!
Very informative. Thank you
Very informative. Thank you!
Thanks for the video! I just wonder where did you get all the information? from a study paper or any websites? Can I have the initial source if possible? thanxx
Kelly J MedCram has videos that explain this process with peer reviewed sources
Thank you JJ.
Thanks for such a valuable information sir
Good.tks...
More info. ace2 is little.
The number is about 0.00001
So. If the Receptor is infuntionated?
very good information about drugs
Thank you for sharing this! Great explanation for common folk like me!!!
good information on Remdesivir
How do you feel about the glass particles in the serum?
How the analog of adenosine can differentiate between viral RNA and the mRNA(essential rna for protein formation)
It can block the protein formation in cell..
And can kill the cell..
That’s what I’m wondering to i was treated in sept my last dose was given sept 8. I’m having weird symptoms don’t know if it’s caused by the virus or Remdesivir.
There isn't much selectivity between the virus and cell replication; however the cell can always print out more mRNA copies when it needs to (since it uses DNA as the template) while the virus only relies on its own genome, which is why there is a difference
And hey, a lot of medications kill cells to a certain extent but most of the time the effects are either negligible or mediocre
Pr Raoult talks about kidney failure as side effectivement of rendemsivir
Good information thank you sir
THANK YOU FOR POSTING THAT.
Very informative video sir.. One doubt.. What if a healthy cell take up the drug remdesivir..will it get taken during dna replication?
I have this exact same question.. Have you found anything on this?
No nick..
No, it is used for HIV and does not affect other cells. I am taking three of the four drugs contained in Remdesivir, orally.
id say it's because it targets rdrp. in human cells this enzyme is not present as far as I know, as we produce our RNA straight from DNA instead of already existing RNA:)
Is it possible for the cells of the body to use this nucleotide analogue for the synstesis of its own genetic material & inhibit its own translation process during mitosis
I was hospitalised for 6 days with covid in December 2021. I was given shots of remdesiver and also given a steroid shot in my stomach at the same time. They said the steroid shot was to counteract the clotting that the remdesiver was known to cause. My menstrual cycle hasn’t been the same since. It’s very heavy with clotting. Has anyone else experienced this?
Is it the phosphates attached in ADP and ATP that render them ineffective compared to synthetic adenosines like Remdesivir?
i got this threw iv back in oct 2020 for 5 days.I felt fine but later i went back from a month due to swelling and been having liver and heart problems since! Im 37 and now applying for disability.I havent been right since so please be cautious,i didnt research this medicine and it was done because my doctor recommended it.......BAD MISTAKE
These hospitals should have figured this out by now. You cannot trust the so called medical studies Some of them were rigged. Does this dude in the know what he is talking about?
Well Remdasavir killed my husband caused his kidneys to fail. I believe they are using this to get the Covid death numbers up. I don’t trust Fauci and the NIH.
Did you have to sing a consent form to get this jeffery and how are you now ?
Yeah I'm still not well. Disability wasn't approved because they can't what's wrong I have no insurance and I can't get into to see a doctor and Disability just sent you to their doctors for questions and a few test like eye,coordination and blood pressure and whatnot.I still have I mean horrible chest pains and I can't walk down the street(I've gained about 100 lbs now so it don't help) but a week b4 this medicine I walked all day and welded for 12 hrs no problem.I walk an 1/8 mile without having to rest and my heart feels like it's going to blow up.I quit drinking alcohol and smoking cigarettes but that's the only good thing to happen.I don't think I can work and I can't seem to get help so praying for Something I mean from God to help me feel like I'm not worthless and to feel like a man again.l both financial and PYSHICAL! I think it's over I spend most days plotting suicide.I had to sign something and stay a week for testing yet I never heard of the drug and was still dealing from after effects of covid and was half loopy from the meds.I only took it because my doctor said i was a good participant for it and his recommendation
My was giving this last week without her consent or mine as her carer. The consent forms was on her chest not signed and I just got there in time. My mother was put into this clinical trail without her consent I am furious.
Great summary!
Very useful! 👍
Excellent
But how about the intricink RNA they will also incorporate that and thus none specific. How is our body differecient that?
What about the termination of other protein formation..
Interesting! Lysosomes are highly acidic (pH: 4) and contain proteolytic enzymes so how does this virus survive such high acidic environment?
Well assuming the water we drink already makes our inner environment acidic, it doesn't appear that acidity matters at those levels.
The lysosome disrupts the protein and lipid membrane of the endosome encapsulating the viral cell or cells, releasing the contents of the endosome (the viral capsules) into the surrounding cellular matter. Incidentally, Chloroquine and Hydroxychloroquine are alkaline, and can disrupt the functioning of the lysosome, keeping viral RNA captive within the viral capsule.
@@MrGsteele would it surprise yiu if i said there were no viruses?
@@davidbarrozo6621 No, because if you can't spell you, you might well say anything.
@@MrGsteele my only concern is spreading the truth. If the nature of the truth is anything different than what you percieve then fallacy is the resulting behaviour . You played right into it honestly, which shows your inner nature. You are not ready to evolve in consicousness. When you are ready come back, and we can discuss truth.
Could you please discuss Avigan Japanese drug. Chinese officials confirmed it is very effective and safe. They mentioned Avigan can have some side effects to babies in the wombs.
What happen if in natural cell or normal cell that the GS441524 will defect natural protein transcription? Or in natural DNA, will it effect natural DNA?
une Étude française de cas sur les cinq premiers patients traités par COVID-19 avec du remdesivir en France, a démontré que le traitement a dû
être interrompu pour des effets secondaires potentiels grave pour 4 patients sur 5, dont deux élévation de l'alanine aminotransférase (ALT)
et deux cas d'insuffisance rénale.
Please translate.
It’s a poison
So, if I understand correctly, this stuff is effective for Sars, Mers, Covid-19, etc...or like Tutti-fruti! The problem is the high price of this medecine and the benefits are very very small....
I heard the same thing. Plus my Aunt just passed away from covid & she was given this medicine. It seem to have attacked her organs.
I don't understand if this inhibits RNA reproduction for the Virus RNA+ then why does it not reduce it for normal cell RNA reproduction?
May be because of proofreading in our cells the analog is removed
@@irfana19nov I agree with you. It's 2 different types of proofreading so our cells might have a mutation to recognize remdesivir more easily. I would imagine scientists wouldn't have thought of this. This is what my next article search will be about...
@@hotdog16000 they gave me that I’m having weird symptoms idk if it’s caused by virus or the side effects of Remdesivir I’m having numb cold prickly sensation on my legs feet along with muscle or joint pain I’m concerned I feel sore or tired muscles just by doing light chores.
Nice video
Nice...
Thank you
Thanks very much. Excellently described and explained.
See what dr Bryan Ardis has to say??
im from the Philippines, i got my first iv of remdesivir i hope i get well soon . its my 5th day in hospital
How Re you doing now
My mom is on her 4th and is doing worser
@@ericagonzales9003 This is a common reaction. Kidney failure and pulmonary edema. This dude in the video is using a bunch of big words and terms
and don't know WTH he is talking about.
Did you survive?
@@Revelator2025 Yes! its effective
Can “Lactoferrin” or “Apolactoferrin” also work as an antiviral agent?
badass bobbyjohnson I take 300mg every night since the pandemic started until today. I don’t notice any adverse effects, it is marketed by a reputable “Supplement Company”, “Life Extension” to be exact. I did some research on Wikipedia and it seems to an effective anti-viral, anti-bacterial, and anti-fungal agent on most pathogenic organisms, but not all. The scientist say that it is effective against the current SARS covid-19 microbe. But like you said more testing has to be done. I live in New York City and I am a Licensed Funeral Director and I was in the thick of things during the peak of the pandemic, which was pretty much from Mid March all the way till the second week of May, I worked with no PPE just gloves maybe and I did not so much catch even a sniffle. But then again I also use “Black Seed Oil” and good “Liposomal Vitamin C” supplement and good Multivitamin and Multimineral supplement and a bunch of other supplements. I exercise and eat right and try to control my stress levels. Whereas my coworkers most but all caught the virus and recovered. I Thank God for helping me and family stay untouched by the virus both medically and economically. I appreciate the information that you provided to me. Thank You.
Great info! Hopefully it works for Covid-19
it will not! the side effects will outweigh the possible advantages. But it's very good for Gilead!
@@yogayantra what r the side effects
@@arko_0.0 Penis grows if you are a woman and vice versa.
@@nebojsa1976 you're not funny dumbass, people are dying cuz of this virus.
@@arko_0.0 People are dying because of the flu. People are dying because of the heart disease. People are dying because of the cancer. People are dying because of the suicide. People are dying because of the car accidents. People are dying because of the war. People are dying because of the violence. People are dying because of the HIV. People are dying because of the drinking bleach. People are dying because of the MS. People are dying because of the dementia. People are dying because they are old. People are dying because they are stupid.
At 7:41: What is the metabolized form of Remdesivir?
You can look it up, it's just the nucleotide (remdesivir has some additional functional groups on the left phosphate)
Since adenine is part of cellular host DNA, too, how come this nucleoside doesn't affect our polymerase like the virus's?
I just want to know how the article about covid is printed in 2018
What!!! Remdisevir was discovered long ago ..that article is on it not on covid 19
Excellent!
Thanks... but why am I not allowed to put this on 2x speed?
Hey Sam Sung! Hope you liked it! I'm not sure why you couldn't watch it at higher speeds. It may still have been processing the high-definition version of the video, and that's why you couldn't watch at 2x, but I'm not sure!
@@jjmedicine what I like is learning. So you're saying the 2x version is a different video being streamed as such, instead of my client app accelerating the same. Interesting. Wasn't aware of this, now I am. It plays too. Thank you again!
You are able to do it 2x.. click the three dots top right and click playback speed then 2x
@@BigReox7 it wasn't working initially
Well the WHO said remdesivir is not effective enough.
Nicely explained!
Will remdesivir become activated in droplets on surfaces?
Nothing on surfaces to activate it. Viruses require a host for replication and the host also activates the drug.
@@gaorchidman are you saying viruses are not in host cells on surfaces and cannot find a host cell on a surface? That's not what I heard
There's no immuno response to a virus on a surface unless it's on the body beginning with a rash, so no Mrna. Is there a immune response to a virus on the body? Internally, opposite the location of the virus?
You didn't post this until today 5/2/2020
So if that machine will work against remdesivir to fix the RNA, this means the drug will not work !! I don't understand !!!
alhumaidy alenzi yes you do!
@badass bobbyjohnson where did you research this sketchy information sir?
My mom had this during her stay in the hospital due to severe pneumonia due to COVID19..
! How did it go?!?
@@derrikgriggs5 she's doing perfectly fine.. The doctors discussed the possible effects to us..
@@MmBee3 what effects?
and could you please tell me for how many days she was given this drug?
@@chocolatte7110 Remdesivir can have a negative effects on the patient's kidney (thankfully my mom didn't have a problem)... She was given 10 dosages of the med.. 1 dosage/day..
How does Remdesivir knows which cells are infected and which are not? We do not want to prevent non-infected cell from synthesizing protein.
Thats why there are side effects.
That's one of the whole difficulties of drug design and one of the main reasons why we haven't cured cancer yet
Nice, thanks
Thank you for the information
CZcams is to restricted and sensored to give you accurate information about (anything )
Wow
Many of the current HIV drugs effectively inhibit the virus at different places. I’m wondering why we can’t look at these drugs to try and mitigate this virus since coronavirus uses same mechanisms to replicate its RNA and make its proteins.
Remdesivir is an HIV med , it is four meds coformulated. Currently, I am taking three of those medicines, two protease inhibitors and an integrase inhibitor. I do not need the NRTI and my HIV viral load is undetectable. The integrase inhibitor (Tivacay) prevents the HIV from entering the nucleus of the lymphocyte, then making copies. I wonder if it could be used against the Chinese disease?
James Bond thank you. Stay well and I too wonder why more of these drugs couldn’t be used against this virus
@@westfield90 good thinking, did you come up with an answer ?
I got Covid in November 28 got the flu Dec 31 took a lot out off me. Jan 24 fever everyday loss off appetite. Kept going to doctors everyone said everything blood test ect came back normal . Kepted getting worse went somewhere else they did chest X-ray turns out I had small pneumonia and Covid again . Got hospitalized on day three off remdesevir breathing a lot better no more fevers got hunger back . Should go home Monday . I hope it’s not my original diagnosis of long covid . I can’t live like thatb
Remdesevir sounds a bit problematic because it prevents rna synthesis. On the flip side it's only for a few days, but I think it would also prevent the immune system from generating white blood cells during that time, or even the immune system working at all other than maybe a day's worth of cells ready to take on the virus. Does't sound like a great tradeoff at all
❤️🙌
A tous les chercheurs du monde entier, CONCENTREZ-VOUS sur les molécules 7.2 Kcal/mol. Notre vie est rattachée à la vôtre.
We should start marching for this too; Why in the hell should we pay a dime for this medication when Trump dismantled the freakin program to avoid this disease; this was the governments fault, not ours; and they have the audacity to say if you don't have insurance you can't get it. This is outrageous. Keep posting that we should not be responsible for paying for this drug, this was not our fault.
I've never been the first
So basically since not enough people are drinking and killing their livers they come up with something like this to do the job faster... Lol
David Barrozo-Good Point, the side effect of liver damage is very important. I would never take this drug if i had coronavirus. I would ask to be given Hydroxchloroquine which is also used to trear coronavirus. It has side effects too but not as bad as liver damage. They should not put Remdesivir on the market.
@@curtisjones400 Hydrocloroquine kills probably about as much or i should say as effectively as remdesivir (the 2nd time around), and alcohol 😆
My father passed away because of taking Remdisivir... He is diabetic, liver chirosis and liver cancer.... I always have a question about why doctors taking this drug treating my father
After they find something out plse get brains for afrikas leaders
I play video games against people sometimes. I can notice when people are trying hard, but they still fall short of dominating the game. I see scientist talking like they know what they are talking about, but they are simply trying hard. God must be laughing his ass off. meanwhile, there are glass particles in "batches" of this drug. So we have try hards trying to be God . Enjoy the show
It Destroys your liver however is good for you 🤷🏻♂️🤦🏻♀️
Who needs a liver anyway 🤷🏻♀️
Remdesivir is as good as placebo
In 12:30, the article says june 2020...we are not in june yet!!!!!!!!!! Can someoje explain?!
Please like so that everyone sees this.
I *think* that is showing when the article will be published in whatever science magazine (I assume 'One Health'). But first the information and findings have to be peer reviewed, thus the future date. Whereas the information was first published on March 27th. I could be completely wrong, just my analysis.
CNN isn't going to like this😂
It won't matter, they report what they're told to report by their owners.
Long live the science.
Death drug! Turns out this drug is useless!
Blue cap
who else is looking for memes????
I defeated corona using this.
Are you still doing ok?
@@patricklopez884 yes, I am completely fine had some bubbles after the discharge on my hands but all got recovered. Any concerns you have for this? Would like to know
did u have severe covid-19?
and wdym by bubbles?
I've read somewhere remdesivir causes blood clots, is it true?
did ur doctor give u any blood thinners?
Yes It was severe, not any blood thinners I took, all the bubbles have gone now but having back pain since then and it's almost 8 months now. I too heard the different side effects of remdesivir.
@@hemantgarud1256 how many days it took for u to recover?
Would like to interview you on my video cast...could you please email me at lauralynnlive@gmail.com
failed ebola drug
1st
😆🤣🤡
if i have understood... this medicine is going to be quite expensive, whereas both the Chinese and French virologist Didier Raoult have offered a very cheap medication, hydoxychloroquinine associated to a classical antibiotic. Just that the Big Pharma doesn't seem to appreciate. Since the French ministers of Health all have conflicts of interests (understand Buzyn for instance was paid by the Big Pharma for 14 years, her husband Levi was the big boss of the INSERM, the new minister Veran is very much implicated in big pharma connections)... I would not trust anything like that.
Then you have not understood because hydroxychloroquinine is not a reliable treatment
@@jamesgalante7967 ah ah ah, Prof Didier Raoult has cured/healed over 3000 cases with hydrozychloroquinine. The side effects of Remdesivir far outweight its possible "healing" property, and the price is nothing compare! Do you understand French?
@@jamesgalante7967 czcams.com/video/27ajNP7nuls/video.html
@@jamesgalante7967 www.7sur7.be/monde/didier-raoult-publie-une-nouvelle-etude-sur-l-efficacite-de-la-chloroquine~a84281fb/
“Leur principal reproche: l'étude ne comprend pas de groupe-contrôle (ou groupe-témoin, c'est-à-dire des patients à qui on n'administre pas le traitement étudié) et il est donc impossible d'établir une comparaison pour déterminer si c'est bien le traitement qui est à l'origine de l'amélioration.”
Can't we just inject disinfectant?
you must have the stupidvirus!
ALFAru That is proven to be effective for advanced TDS.
please don't touch that medicine
🐑🐑🐑🐑🐑🐑🐑🐑🐑🐑🐑🐑
Very informative. Thank you
Excellent
Nice video