Lung Histology From Bronchi to Alveoli - For Beginners

Can't tell the difference between a tertiary bronchus and a bronchiole? That's covered. Stressing over Type I vs Type II pneumocytes? It's in there too. Can't sleep at night because you're filled with existential dread? At least you won't be worrying about lung histology.
This video gives a comprehensive walk-through of the histology of mammalian lungs from the bronchi right down to the alveolus with clear images and annotations.
You can even follow along with the digital slides on the website: downthescope.co.uk/slidedataba...
Got any questions about lung histology? Just leave a comment below and I'll get back to you.
Skip to the bit you really want to know about:
00:00 Introduction
0:49 Bronchus Structure
3:32 Bronchus vs Bronchiole
5:06 Terminal Bronchiole to Respiratory Bronchiole to Alveolar Duct
6:12 Alveolar structure - Type I vs Type II Pneumocytes
9:05 Alveolar macrophages

[@miasemloh5384]

I am low key obsessed with this channel.

[@DownTheScopeMicroscopy]

Thanks! Output's a bit sporadic, but I hope it's interesting.

[@user-qt7iz2iz8r]

Beautiful peace. Well-done!

[@DownTheScopeMicroscopy]

Thank you :)

[@martapradasperalta6175]

Thanks a lot. I was a beginner with so many difficulties to learn histology. But this video was helping me a lot! Nice work and thanks for your work ❤

[@DownTheScopeMicroscopy]

It's great the video was helpful! If you have a topic you find particularly difficult you can make a request, although I'm quite slow at making videos :)

[@ornulusoundeffects6423]

My brother! Love your voice, love your amazing way of explaining wverything in a flow and making it so easy for us to comprehend! You my brethren are the saviour of all medicine students like me. Thank you and love you from 🇵🇰

[@DownTheScopeMicroscopy]

Thanks, that's very kind! Hopefully going to make more videos this year :).

[@sevaljevicnatasa6449]

Thank you!

[@DownTheScopeMicroscopy]

You're welcome!

[@medicalscience1528]

Great lecture. Thank you !!

[@DownTheScopeMicroscopy]

Thanks for watching it :)

[@maxhughes2590]

As always, many thanks. Are all these sections post mortem? Would there be major differences if they were surgical biopsy specimens?

[@DownTheScopeMicroscopy]

All of them are post mortem samples. The only surgical samples I see of lung are whole lung lobes that have been removed due to a mass or infection. In this case, the tissue looks exactly the same. But that is only for veterinary medicine, perhaps in human medicine they take smaller biopsies or samples.

[@maxhughes2590]

@@DownTheScopeMicroscopy In human surgery, small biopsies are often obtained during bronchoscopy. However, I am not sure how these might differ from tissues obtained on relatively recently deceased patients.

[@maxhughes2590]

I also would like to request some embryological histology, if you have any suitable materials. Alternatively, how about some cytopathology? Thank you once again.

[@DownTheScopeMicroscopy]

I have a couple of slides of developing fetuses (downthescope.co.uk/histoslide/slide/002/ and downthescope.co.uk/histoslide/slide/009/). I will see what I can come up with! I'm not very good at cytology...

[@maxhughes2590]

@@DownTheScopeMicroscopy Thanks. That would be great.

[@fjaramillo887]

could you consider doing a video on COPD histology

[@DownTheScopeMicroscopy]

COPD of people? I'm afraid I wouldn't know where to start. I'm a veterinary pathologist so I only deal with samples from animals. As far as I know there is no equivalent condition in animals.

[@fjaramillo887]

@@DownTheScopeMicroscopy ohh yes sorry I meant in people like emphysema and chronic bronchitis. Btw your videos are very helpful for me in med school.

[@DownTheScopeMicroscopy]

Yes, in that case I wouldn't be able to help you on that! Chronic bronchitis and emphysema in people is quite different to the entity in animals. But I'm very glad the videos are helpful. If you have any requests for topics on normal histology, just let me know!

[@lorettamaikai3577]

Thank you!
How about other systems?

[@DownTheScopeMicroscopy]

Do you mean other organ systems? There are some more videos on the channel, new ones come out eventually but I'm quite slow at production! Or do you mean other respiratory systems?

[@lorettamaikai3577]

Yes,other organ systems.
Your videos are really clear!

[@merazulhasan402]

difficult to identify

[@ari-rh9wt]

is this for a level?

[@DownTheScopeMicroscopy]

I think this goes more in depth than what's on the A-level syllabus. The introduction about conductive vs respiratory anatomy and the general structure of an alveolus (and how it relates to gas exchange) is covered in A-level biology, but being able to identify different cell types goes beyond what you would need.
If you want more A-level oriented videos I would recommend the channel "Miss Estruch": czcams.com/video/Wyer9wvaxmM/video.html
Alternatively, I do some work for an interactive online learning tool called Brillder. I made a module for them on the respiratory system in mammals: app.brillder.com/play/brick/1502/cover/biology/the-respiratory-system-in-mammals
Hope that's helpful!

[@muhammadfikridzikrullah4373]

Is that sheep lung?

[@muhammadfikridzikrullah4373]

Or sheap?

[@DownTheScopeMicroscopy]

The first half of the video uses a slide of cat lung with a short clip from squirrel lung (the same with lots of blood in the capillaries). The second half from the respiratory bronchioles uses a slide of sheep lung. There are some anatomical differences - ruminants and pigs have much thicker interlobular septa - but the concepts are the same.

[@Asifkhan-jl9yy]

You made it so easy and clear 🫡

[@DownTheScopeMicroscopy]

Thanks, I'm really glad it was easy to understand :)