Ligand Gated Ion Channel Receptor | Ionotropic Receptor | Receptor Pharmacology | Pharmacology

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Pharmacology- Pharmacology is made up of two main words- ‘Pharma’ + ‘Logy’ in some books there is Pharmakon in the place of Pharma, but to make you better understand we have made little changes. Pharma is related to drugs or medicine and logy means- to study. So if we merge these two words together, this will become- PHARMACOLOGY.
Receptor- Receptors are the macromolecule or binding site located on the surface or inside the effector cell that serves to recognize the signal molecule or drug and initiate the response to it, but they don’t have other functions.
The largest number of drug that does not bind directly to the effectors like- Enzyme, Channels, Transporter structural protein, template biomolecule but act through specific regulatory macromolecule or the site on them which bind and interact with the drugs are called “Receptor”
Ion Channel- Ion channels are the path or way through which any molecule move in or out in corresponding to the cell membrane. Protein which acts as ion-selective channels participate in transmembrane signalling and regulate intracellular ionic composition. These make them a common target of drug action. Drugs can affect ion channels, some of which actually are receptors because they are operated by specific signal molecule either directly and are called ligand-gated channels or through G protein and called G protein regulated ion channels.
Drugs can also act on voltage-operated and stretch sensitive channels by direct binding to the channel and affecting ion movement through it. Example- Local anaesthetic which blocks the voltage-sensitive ion channels.
Some drugs modulate the opening and closing of the channels.
Example- (1) Quinidine blocks myocardial Na+ channels
(2) Nicorandil opens ATP sensitive K+ channels.
(3) Nifedipine block L-Type of voltage-sensitive Ca2+ channel.
(4) Phenytoin modulates voltage-sensitive neuronal Na+ channel.
(5) Ethosuximide inhibits T type of Ca2+ channels in a thalamic neuron.
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