I cannot thank you enough for how much your videos have helped me clearly understand biochem. My professors always leave out the details, leaving the students trying to fill in the blanks by themselves. You, however, cover everything! and your videos are the most helpful resource!!
My sister had diabetic ketoacidosis and it is a life-threatening condition.thank you ak lecture to teach such a important and complex topic so easily.....
I can actually smell ketosis on people. I've diagnoses Type II diabetes in several people just by sitting in close proximity to them. I told them they smelled ketotic and to have their blood sugar tested. Boom! All of them were (unknowingly) hyperglycemic. You can call me "Lassie." Woof! Woof!
but is liver is need insulin as mentioned????? It should be noted here that there are some tissues that do not require insulin for efficient uptake of glucose: important examples are brain and the liver.
Excelent lecture, but you did forgot to mention that advanced tipe 2 diabetics can also develop ketoacidosis, if almost all of their pancreas beta-cells are down. You are also not telling us how is it that muscle cells are not able to use ketone bodies quickly enough, what`s going on there?
You are right, Insulin stimulates the GLUT 4 transporters located in the heart muscle, skeletal muscle and adipose tissue. Glucose gets into the liver by the GLUT 2 transporter that has low affinity (high Km) to glucose thus it is active (aka transports glucose) when the concentration of glucose is high in the portal vein = after eating. Hope this helps :)
@@jehanzaibzafar9506 so if the liver takes up the glucose even in the absence of insulin, what is the actual reason for the production of ketone bodies then?
@@emaza3746 ketone bodies are produced in fasting state when glycogen reserves are depleted. Reasons for ketone production is that during fasting state there is breakdown of FAs which result in lots of production of Acetyl CoA. Now at the same time, Oxaloacetate of krebs cycle is depleted bcz it is being used in glucogeonesis, so the only pathway Acetyl CoA has is the production of Ketone Bodies.
Oxidation of fatty acids will produce acetyl coa… however OAA production could be stimulated by high leves of acetyl Coa due to the enzyme piruvate carboxylase when decent levels of acety coa are reached. Wouldn’t that restore the Krebs cycle and therefore keto bodies wouldn’t be form?
The pathogenesis of abdominal pain in DKA is unclear, though it's believed to be related to gastritis, pancreatitis, and liver engorgement. www.ncbi.nlm.nih.gov/pmc/articles/PMC2589676/pdf/yjbm00105-0009.pdf
I cannot thank you enough for how much your videos have helped me clearly understand biochem. My professors always leave out the details, leaving the students trying to fill in the blanks by themselves. You, however, cover everything! and your videos are the most helpful resource!!
Excellent - THE BEST explanation I've heard. Thank you so much.
My sister had diabetic ketoacidosis and it is a life-threatening condition.thank you ak lecture to teach such a important and complex topic so easily.....
Best video regarding diabetic ketoacidosis on youtube, thanks
Just letting you know you are AWESOME and helped soooo much with understanding biochemistry xoxox
Best lecture ever! Thanks a lot.
the legend has back
+ליאל אדרי :-)
You're an amazing teacher.
Thank you sooo. Much !!
Your videos are very helpful!!!!Thank you!!!!!
Really I am bad at Biochem but when i watch ur lectures it's just easy. i would love u to cover every point of Biochem.
I can actually smell ketosis on people. I've diagnoses Type II diabetes in several people just by sitting in close proximity to them. I told them they smelled ketotic and to have their blood sugar tested. Boom! All of them were (unknowingly) hyperglycemic. You can call me "Lassie." Woof! Woof!
Joe Kaye yeah, when we get ketoacidosis our breath smells “fruity” or like nail polish
Thank you so much your lectures very useful
Thankyou. your explaination is very clear
Awesome, the best ever.....really helped me with biochemistry nd still enjoying 😍
amazing explanation🌷keep on
Your videos help me a lot.😊
finally i got it..thank you!!
very nice sir
very analytical explanations
Great Lecture! Thank sincerely.
BEST KETOACIDOSIS VIDEO EVER
Thanks alootttt!!!!Sir your's lextures are really.... great👍👍👍👍👍👌👌👌👌👌
Thx
How do you know all this stuff? And you explain it so well..
thx for video. extra glucose in the blood also damages proteins by sticking to them irreversbly.
abi hayatta mısın nasıl gidiyor
I love you man
What is amazing
The lecture is very good but glucose molecules do not need insulin to enter hepatocytes they can diffuse passively by using GLUT
Pls explain then why ketoacidocis happens.
Didn't get that part of the lecture if glucose could enter through glut.
but is liver is need insulin as mentioned?????
It should be noted here that there are some tissues that do not require insulin for efficient uptake of glucose: important examples are brain and the liver.
Excelent lecture, but you did forgot to mention that advanced tipe 2 diabetics can also develop ketoacidosis, if almost all of their pancreas beta-cells are down. You are also not telling us how is it that muscle cells are not able to use ketone bodies quickly enough, what`s going on there?
El Vegano Cordobes &
Why does lack of glucose in cell lead to decreased oxaloacetate???
hi AK. When you say "Starvation", do you mean "FASTING"? I am a frequent faster from 1 day to 7 days... so? Thank you
Thanks! :)
0:50 I thought the liver had Insulin independant (GLUT-2) transporters. Is it not able to take up glucose even if the Insulin level is low?
I thought the same thing.
You are right, Insulin stimulates the GLUT 4 transporters located in the heart muscle, skeletal muscle and adipose tissue. Glucose gets into the liver by the GLUT 2 transporter that has low affinity (high Km) to glucose thus it is active (aka transports glucose) when the concentration of glucose is high in the portal vein = after eating. Hope this helps :)
yeah you are right. Liver is able to uptake glucose through GLUT 2 receptors which are insulin independent glucose uptakers
@@jehanzaibzafar9506 so if the liver takes up the glucose even in the absence of insulin, what is the actual reason for the production of ketone bodies then?
@@emaza3746 ketone bodies are produced in fasting state when glycogen reserves are depleted. Reasons for ketone production is that during fasting state there is breakdown of FAs which result in lots of production of Acetyl CoA. Now at the same time, Oxaloacetate of krebs cycle is depleted bcz it is being used in glucogeonesis, so the only pathway Acetyl CoA has is the production of Ketone Bodies.
can you explane to me how can DKA occur during pregnancy
Oxidation of fatty acids will produce acetyl coa… however OAA production could be stimulated by high leves of acetyl Coa due to the enzyme piruvate carboxylase when decent levels of acety coa are reached. Wouldn’t that restore the Krebs cycle and therefore keto bodies wouldn’t be form?
Привет. Почему уровень окзалоасетейт понижается в печени, когда в нее глюкоза не поступает?
Has any medicin for this
thank you Sir.
I'd like to ask you about the real cause of abdominal pain in people with DKA.
I've been searching a lot and didn't get any information
The pathogenesis of abdominal pain in DKA is unclear, though it's believed to be related to gastritis, pancreatitis, and liver engorgement.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2589676/pdf/yjbm00105-0009.pdf
why there is gastritis, pancreatitis...
what happens to them
I want to know the exact pathology of that
💚💚
You look buff here, i guess you used your medical knowledge to be so haha