Less Chemotherapy for Breast Cancer: The TAILORx Results
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- čas přidán 3. 06. 2018
- We teach you about the TAILORx clinical trial results and how this information may save many women in the future from chemotherapy.
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Questions for your Breast Surgeon and Medical Oncologist:
*Do I qualify for an Oncotype DX genomic test?
*If so, will you order genomic testing for me?
*What if I have an "Intermediate" result?
*Do you follow the "TAILORx" trial recommendations?
*Would you order a genomic test before I see a medical oncologist?
What does the TAILORx Clinical Trial results mean to me?
On June 3rd, 2018 the results of the largest breast cancer trial reported results that help us better determine who MAY benefit or MAY NOT benefit from chemotherapy in early stage, favorable breast cancers. The results help patients and physicians better interpret the results from the genomic assay, Oncotype DX, which is commonly used in the United States. The trial concludes that most patients with an "Intermediate Recurrence Score" result may avoid chemotherapy. The results were also released for publication by the New England Journal of Medicine.
Journal Article Link:
www.nejm.org/doi/full/10.1056...
Video Outlining the TAILORx Clinical Trial:
• The video has been upd...
What is a genomic test?
These sophisticated tests are performed on a small sample of cancer tissue in appropriate patients with early stage breast cancer. Genomic tests are usually ordered after surgery when the pathology report is finalized. It measures unique aspects of the tumor to determine if a patient will benefit from chemotherapy in addition to hormonal therapy. Such “genomic assays” developed over the last decade are a dramatic advance in breast cancer care. The Oncotype DX assay by Genomic Health Inc. is the most utilized genomic assay of those available in the United States.
Who should consider a genomic test?
Patients who have small “Estrogen receptor positive” (ER+) and “HER2 receptor negative” (HER2-) tumors and no evidence of cancer in their lymph nodes may benefit from an Oncotype DX assay. The purpose of this test is to better identify people who do and do not benefit from chemotherapy. The decision to undergo chemotherapy is a complicated one. Your medical oncologist will examine multiple factors to help determine if you will benefit from chemotherapy. The NCCN Guidelines, listed in the website links below, outline in much greater detail recommendations for the use of genomic tests. An Oncotype DX test can be instrumental in this decision for many patients.
You may qualify for a Genomic Assay if…
You have early stage cancer (Stage I or II)
Your tumor is Estrogen receptor positive (ER+)
Your tumor is Her2 receptor negative (HER2-)
No cancer was found in your lymph nodes
You are willing to consider having chemotherapy
You are healthy enough to undergo chemotherapy
How is chemotherapy tailored to patients?
Genomic breast cancer tests are a leap forward in our ability to “look inside” breast cancer cells. Sophisticated breast cancer care is based upon the principle of providing maximal benefit from the least toxic therapy. Newly diagnosed breast cancer patients deserve the best information available to decide whether they need chemotherapy. Take our video lesson on “Will I Need Chemotherapy?“ (here) to understand the general concepts. Genomics is a promising and rapidly developing field.
Take Home Message:
Make sure to ask both your breast surgeon and medical oncologist if a genomic assay might play a role in your treatment decisions. For appropriate patients, these tests should be considered only one piece of the many “pieces of the puzzle” in deciding treatment decisions about chemotherapy and hormonal therapy.
Thank you so much for posting all these very informative videos. I’m better informed now and understand much better my condition. Can you please talks about types of lumpectomies and the need to remove lymph nodes
Take our Breast Cancer Surgery Course on our website. www.breastcancercourse.org/series/breast-cancer-surgery/ Scroll down to see the key decisions that need to be made with making surgical choices. I hope this is helpful.
Naseeba Alozaibi hi
As a new breast cancer patient, I was scared and started searching all the info I could get on the internet. Your videos are so informative and very well done. You have a very calming voice, I feel very educated after watching your videos. Many thanks!!!!!
I had hormone receptor positive nor I lymh nodes I had an oncologist. Dx test favor able results just took tamoxifen 4 10 years as I had a reocurring cancer
What great information!!
I’ve been recently diagnosed & I’m waiting on the results of this very test. I’m so happy I found this site.
I’ve been recently diagnosed & I’m waiting on the results of this very test. This is outstanding information. So happy I I found this site!
I am 40 years old...was diagnosed with infiltrating ductal carcinoma ..did not go to lymph nodes....my onco DX score was borderline...believe it was 30 or 31...because of age..had chemotherapy and radiation..only problem I had one chemo treatment and I developed MRSA in my port..so only had one chemo treatment..I'm one year cancer free...I have not had the other tests...I do worry since I only had one chemotherapy treatment..I do worry it wasn't enough...thinking about second opinion
I am so thrilled to have stumbled upon your videos as they are quite informative. I am sixty years young and was recently diagnosed with HR positive, node negative breast cancer. My Oncotype DX breast RS score is 29 and I just started chemotherapy which I have been ambivalent about due to this score. I can now better understand why my oncologist included it in my treatment plan. Thank you so much!
Thank you for your comments. Glad it was helpful information. Take a look at our more basic Genomic Testing video lesson (and text and links below the video) at the Breast Cancer School for Patients. Good luck! www.breastcancercourse.org/genomic-testing-2-2/
New remedies are favorabe
I have breast cancer stage 2 waiting for the result of laboratory
How can I treat a mass that is on the chest wall of the mastectomy site? Surgery or radiation?
Ask your doctor, not social media.
At the end of July I was diagnosed with breast cancer . I am 48 yo , had a lumpectomy on right brease, stage 1 , no cancer on lymph nodes and oncotype test result 20 . Do I need quemo? I am really scare about doing quemotherapy
Onco DX test clarified no chemo not in lymph nodes stage 2 hormone receptor positive no chemo tamoxifen 10 years reocurrience
I remember one of your other videos that you were saying er/pr positive, Her2 negative up to 3 lymph nodes positive, oncotype dx can be done. Am I wrong ?
Great question and you are really doing your homework! In a few unique situations. Very complicated topic and process to determine when it applies to someone. Engage your medical oncologist about the topic. Good Luck.
@@BreastCancerSchoolforPatients Thank you, I am working with two oncologist and they are disagree with what to do (i have 2 positive lymphnodes), oncotype 25 ( at the limit) and i just turned 50 (at the limit again(, i think i am a unicorn ! Totally in gray area (chemo is improving only 1% of my recurrance rate) and it seems like i need to decide.And i told them both i can not decide, Life is funny
Same as you ! My onco Dr she did not allow me to do the oncotype Dx test :( because where i live is very expensive arround 3000$
Lobular is different. They automatically say chemo has no effect. Why?
A very complicated topic and one we do not cover at the Breast Cancer School for Patients website. www.breastcancercourse.org This is an essential question to as a treating medical oncologist.