Chronic Lymphocytic Leukemia (CLL) - Etiology, Risk Factors, Symptoms, Signs, Diagnosis, Treatment

Chronic Lymphocytic Leukemia (CLL) - Etiology Symptoms, Diagnosis, Treatment- Hematology & Oncology Series
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* Autoimmune hemolytic anemia (AIHA)
* Hypogammaglobulinemia -- decreased immunity
* Ritcher’s syndrome: aggressive large cell lymphoma (diffuse large B-cell lymphoma)
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Disclaimer 1: The medical information contained herein is intended for educational purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.
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[@MedicosisPerfectionalis]

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[@arlenegage9873]

Im a 75 yr old women with CLL 10 yrs. Im in otherwise excellent health and suffer only minor problems with my stage 3 cancer. Im one of the lucky ones says my Oncologist☺

[@MedicosisPerfectionalis]

I am happy to hear that you are in a good shape. 👍👍

[@kimp7977]

Thanks you give me hope!

[@MedicosisPerfectionalis]

50 hematology 💉 *cases* - written by me: www.medicosisperfectionalis.com/

[@itsjijai]

Whenever I need some previews of new topics, I always search for your versions bc I understand them much easier. Your drawings help a lot, too. Thank you!

[@MedicosisPerfectionalis]

I am so delighted 😃

[@rozash18]

Thank you for all of these amazing videos! You have a great way of making everything so clear and concise!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@wedeyforyou]

25k subs. Bro has almost a million now

[@MedicosisPerfectionalis]

Thank you! It’s all because I have wonderful people like you!

[@raneishaknight7188]

Over 1 million now🎉 it was interesting to watch this video and see that he was asking for 25k at one point. Goes to show that we all start somewhere 😊

[@scarletmigrino132]

I like how you say, "Can you solve it? Of course you can". I've been feeling down for missing out a few points on my Hematology practice quiz, and it's little things like those that count. Thank you so much.

[@christfollower5713]

Be encouraged , God bless u , all love

[@wedeyforyou]

@@christfollower5713naa mate. This guy probably had a 98 instead of 100

[@luisinha154]

you have literally saved my life with these videos! thank you so so much for making things easier to understand

[@MedicosisPerfectionalis]

Happy to help!

[@quyendisabino6877]

Thank you very much for being so generous in sharing your amazing knowledge!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@Mariah-ge5be]

Indeed you have made pathology easy for me 🤩👌
Can't thank you enough for your efforts!💙

[@MedicosisPerfectionalis]

Thank you so much...Please consider sharing my videos...Good luck with everything!

[@becky5950]

tip- I always remember 'Smudge CLL'

[@MedicosisPerfectionalis]

That’s cool 😎

[@nikhilhumane5540]

Thanks

[@adensphotosandnotes5414]

I love you. You make me feel like I can actually solve these questions!

[@abdulrahman_imad]

My hematology exam was yesterday, thank for God and for you, for your videos, your kindly explanation, God bless you my bro.

[@MedicosisPerfectionalis]

God bless you too!
How was your exam?

[@niharnayak6417]

Excellent explanation! Covered everything!! Thank you so much 😀😀😀

[@MedicosisPerfectionalis]

My pleasure 😇...Please consider sharing my videos with others! Thanks!

[@nouranhassan5352]

you literally saved my life, thank you so much!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@anvayajadhav9766]

Thank you so much! I wish our university teachers would have also taught us the way you taught !

[@MedicosisPerfectionalis]

Thanks a million!

[@madhukardeshpande563]

We must be very thankful for ur detailed information

[@MedicosisPerfectionalis]

Thanks a ton!

[@ayeshasaeed5443]

Ohhh ! Seriously thanku so very much ! At the end of my session ! I found such organized , lectures ! With short tym ! Nd full knowledge ❤️❤️✨ bundles of thanks 🥺

[@miahender7991]

I enjoy listening to your vids. Your low key sense of humor cracks me up every time! 🤣🤣🤣🤣

[@MedicosisPerfectionalis]

Haha 😂
Thank you ☺️

[@hi99999991]

Hello, I am a medical laboratory scientist student and your videos have been game changing! Totally helping me through school, thank you :)

[@MedicosisPerfectionalis]

You’re very welcome!

[@mcjabaresmael9558]

Thanks for the generous of sharing idea.

[@MusaMindset]

You should also mention how to diagnose CLL, which is by flow cytometry showing a clonality of mature B cells)

[@MedicosisPerfectionalis]

There is a video for that: Diagnosis& Treatment of Chronic Lymphocytic Leukemia (CLL) czcams.com/video/UPGi7V0vNQs/video.html

[@sameerasyed8572]

I love your videos... Its making concepts very clear .. the way you are explaining it .. Keep it up n make more such videos... Thank you

[@MedicosisPerfectionalis]

My pleasure...Thanks for your kind words!

[@samilazhar8197]

god bless you and your channel ! so informative content thank you so much

[@celineait8131]

very very helpful you are saving my life

[@MedicosisPerfectionalis]

I am so happy right now...Best of luck!

[@dr.sananesar958]

U made it so simple...my concepts are much clear now, not just about CLL but other leukemia also..great 👍..

[@MedicosisPerfectionalis]

That’s excellent...You made my day 😊

[@dr.sananesar958]

Lots of love from India🧡🧡

[@dr.sananesar958]

So overwhelming☺☺... Plz upload videos on Thrombocytopenic perpura

[@MedicosisPerfectionalis]

❤️❤️

[@MedicosisPerfectionalis]

Sure! I will

[@mdrahamatullahmd4574]

Today i am 59 years old battling cll since one year. I am very much afraid and anxious about this disease. I am following the advices and suggestions of my oncologist. Would any one like to like experiences etc.

[@SHUBHAMRAJ-ff1pn]

You are a magician. You make us understand any topics in a very short span of time 😊😊 Thank you sir 🙏🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@Farheen78601]

Thanku sir for saving my life....i found hemat so tough but your videos r perfect like u...i love your way of teaching and your voice.😇😇😇

[@MedicosisPerfectionalis]

Thank you so much 😊

[@nilupulihennayake2390]

Thnks alot.very clearly Understood ❤

[@NuclearMedicine070]

This video made pathology interesting ..!!!!

[@catrina5808]

You help me a lot in my study , thx !

[@MedicosisPerfectionalis]

My pleasure 😇

[@meghaagrawal9723]

Stay safe , be happy and study hard .... Ty for these lines ♥️

[@MedicosisPerfectionalis]

My pleasure 😇
Good luck 🍀

[@Fr3doskin]

Congrats on the 1 million subs🙏🏾❤️

[@MedicosisPerfectionalis]

I appreciate you so much!

[@sahandsoltani6094]

In stage 3 and 4 of the Rai staging system we also need to have Lymphocytosis which is not mentioned in the video

[@rodeselgac]

Thanks so much prof! It was very clear

[@MedicosisPerfectionalis]

My pleasure 😇
I am not a prof 😊

[@esc5561]

I love it how you make associations like lemonade and lemon for betting understanding. Great way of teaching. I appreciate this very much. Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@sittienorhanietampi7267]

QUESTION. In stage 4 of CLL., Is smudged cells will still be present in the PBS?

[@008-rara9]

Can you describe about mechanism of action of Chronic lymphocytic leukemia?

[@rutvikrana512]

Teacher: "Who classified Leukaemia ?"
Me: "Who"
Teacher: "Yes that’s the question."
Me: "Who"
Teacher: "Ok! U don’t know. It’s WHO."
Me - 🥺🥺🥺

[@artyomgunard4491]

I'm pretty sure the owl make the classification of leukemia.

[@kikigonzaga1336]

Fantastic explanation!

[@MedicosisPerfectionalis]

Thanks, dear :)

[@wobbyyy]

Watching you ask for 25k subscribers when you have over 500k now! Growth!!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@upasanatayade4962]

Sir u are awesome.thank you ✨

[@abirkhan9940]

Thanks for the video

[@MedicosisPerfectionalis]

My pleasure! Thanks for watching and taking time to leave a comment! All the best!

[@linzyl7440]

Thank you ❤

[@rayan01]

You are a life saver!!😍

[@MedicosisPerfectionalis]

Thank you 🙏

[@danae7022]

Love this video..thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@gamergirlmars]

What about Central Nervous System Leukemia? I got diagnosed with MS and eerily enough I'm Albino with chronic anemia. I've been very, very sick my whole life, only to get worse here in recent years. Losing a ton of weight, just all the symptoms are there for some type of blood cancer. I'm not sure if I've been misdiagnosed or what. I can't hold on to iron so I get blood transfusions. This was in childhood until present. Haven't seen a hematologist in a very long time though. Blood work came back with some worrisome results at the neurologist. Currently waiting on the hematologist referral and so thus, my neurologists have decided to start Ofatumumab medicine in hopes that should my MS diagnosis be wrong, it could prove beneficial on all fronts. It's approved for leukemia's too. But It's been really hard trying to grapple with this potential diagnosis bc I honestly can't find much on it. Just that it really can mimic neurological and anemia conditions. Could you perhaps make a video on that? This video is so easy to understand and follow, hard to find!

[@Roon864]

Thank you very much ❤️

[@MedicosisPerfectionalis]

You’re very welcome

[@33farahhafiz56]

excuse me . which textbooks do you refer sir

[@144.gali.tanmayi8]

Thank you for video medicosisperfectionalis.can you please reply Why there hepatosleenomegaly ??? In cll.

[@thedudeabides97]

Fantastic presentation!

[@MedicosisPerfectionalis]

Thank you 😊

[@haveaniceday7767]

My brother was diagnosed with ALL diagnosed at 42 and deceased at 44. He was told at his first appointment to get his affairs in order 2 years was his life expectancy. He dies 2 years and 2 moths later on October 6, 2016

[@MedicosisPerfectionalis]

I am so sorry to hear that.
My condolences!

[@haveaniceday7767]

@@MedicosisPerfectionalis TY.

[@hannahrosa5485]

Thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@emmanuelniyi3870]

Thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@abdurrhmanbinshmlan2670]

Can we see blast cell ( lymphoblastic ) in P•B or B•M ???

[@eliskavavreckova373]

Thank you very much 😊

[@MedicosisPerfectionalis]

My pleasure 😇

[@bradenharris4997]

Thank you!!

[@MedicosisPerfectionalis]

My pleasure!

[@allet3693]

I searched for a rubik's cube solving method called CLL, but I only got videos about a leukemia with the same acronym

[@MedicosisPerfectionalis]

Wow!

[@LOOP931]

At the beginning, u asked to reach 25000. Now 702 000 subscribers 🎉. CLOSE TO MILLION THANK U FOR EVERYTHING ❤

[@MedicosisPerfectionalis]

Thank you 😊 for your support!

[@raniaal-abdullah6629]

Thank you thank you
you make me love pathology ❤😊😊

[@MedicosisPerfectionalis]

I am so delighted to hear that!

[@aishwaryanagwanshi9303]

Sir spleenic sequestration mean?

[@Did6661]

2:18 I'm a female who's only 35 (dx last year) but have had CLL since my early 20s- I actually know a girl in my online CLL support group who was diagnosed at only 18. It's a lot more common in older people, that's true, but it can affect anyone, even teens

[@MedicosisPerfectionalis]

I agree...and I am so sorry you are going through this.

[@lucylu9792]

What support group did u join, i also joined an online support group

[@Did6661]

@@MedicosisPerfectionalis Thank you- I was diagnosed with High Risk CLL (there was a worry I had Richters Transformation for a while, but after tests & biopsies we were relieved to find it wasn't Richters). I've been doing well on an Ibrutinib & Venetoclax medical trial so, please God, I'll be around for a while 🙂

[@Did6661]

@@lucylu9792 Hi Lucy its called CLLSA 🙂

[@lucylu9792]

@@Did6661 i joined cllsa also my profile name is sushibruno

[@hishamsaadallah8902]

Now you reach 628k not only 25 k ..
Keep going and good luck 🤞

[@MedicosisPerfectionalis]

Thank you so much, Sir!

[@user-jh8iz9nk9i]

Hello ..if you please is there any video about types if CLL as unmutated IGHv and mutated؟ it is so confusing for me ...thank s

[@MedicosisPerfectionalis]

Thank you so much

[@IQ24908]

Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@mhtrang1]

Thankyou for all of your haematology morphology videos! Very useful n informative. Ur explanation is clear n it’s funny how u used the descriptive word for the cell: they suck! LOL 😂

[@MedicosisPerfectionalis]

I appreciate you so much!

[@nabeelabidhussain8577]

day before exams trying to save my medical year , Prayers needed

[@MedicosisPerfectionalis]

I wish you all the best!

[@user-xd2yw1zr7n]

Thanks

[@MedicosisPerfectionalis]

My pleasure!

[@gayathrijinesh3004]

In ALL, AML, anemia thrombocytopenia not high risk, since they begin with blasts replacing bonemarrow. But in CLL it is high risk, since it is not replacement, but is metastatic. Please correct me if I am wrong.

[@DentalClinician]

CLL is low risky, CML is most riskier... Only normal B cells increased in CLL...survival rate is 7-9 yrs. In other leukemia abnormality is present in cells depending on type of leukemia, but CLL has normal mature cells

[@gayathrijinesh3004]

@@DentalClinician Yes sir, what i meant was, anemia and thrombocytopenia shows later stages of CLL, than its first stages. Unlike ALL,AML where they are present at the start itself.. is that correct?

[@DentalClinician]

@@gayathrijinesh3004 yes, that's why I mentioned CLL as "Low risky"...
Risk = CML > AML > ALL > CLL.

[@HafizahHoshni]

Thank you so much! 28/7/2019

[@MedicosisPerfectionalis]

My pleasure 😇.
It has been a long time since you commented.
How is everything?

[@HafizahHoshni]

Medicosis Perfectionalis everything is good ! I’m in my final year now my final examination is about one month time ! Hehe

[@zeglammohamed]

thank you

[@MedicosisPerfectionalis]

You're welcome 😇

[@jafarsaif182]

Thanks alot. ..great. .

[@MedicosisPerfectionalis]

Most welcome!

[@hassanabdigedi4502]

thanks dr

[@MedicosisPerfectionalis]

My pleasure 😇

[@Priyanka-rawat.154]

My grandmother wbc count is 90,000 nd her blood test mentioned smudge cells....does it mean CLL?

[@MusicalK93]

2:40 What about patients aged 14-40? Thanks.

[@muhammadasadrazajatoi959]

U r life saver man...Love from pakistan💙

[@MedicosisPerfectionalis]

Thank you :)

[@michaelkino3637]

Best video ever made

[@MedicosisPerfectionalis]

Thank you, sir!

[@michaelkino3637]

You are mostly welcome. Keep making more videos

[@MedicosisPerfectionalis]

I sure will....Thanks again!

[@ItsMe-jr6kd]

You are the best like usual ❤😍❤

[@MedicosisPerfectionalis]

Thank you 🙏

[@ayannagoring2796]

Can someone answer my question please? A patient with CLL that has hepatomegaly and splenomegaly, what stage is she at?

[@MedicosisPerfectionalis]

What else does the patient have?

[@zahraamohsen8352]

Amazing

[@MedicosisPerfectionalis]

Thanks 🙏

[@Faisal-ek5nv]

You are the best❤

[@MedicosisPerfectionalis]

Thank you 😊

[@AsimAli-vk6oz]

CLL only effect the lymphocyte then how anemia and thrombocypenia occur in CLL ?

[@MedicosisPerfectionalis]

The abnormal WBCs will "crowd out” other cell lines as discussed in the introduction videos.

[@rathodnehal2869]

wow great 😊👍👍👌 i enjoyed 😊 your lacture

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@noorhamed4690]

Thanks for this video...I have question...how can differentiate between CLL and lymphoma ow non hodgkin's lymphoma???? I want the answer becuses I have exam

[@MedicosisPerfectionalis]

What does “ow” mean?

[@DentalClinician]

CLL : normal B cells but increased in PBS...Lymphoma : RS cell I.e, abnormal giant B cell (RS cell ) seen in Lymphnode biopsy

[@ekeomodigabrielle9195]

I love you Medicosis 😊❤❤❤❤❤❤

[@masoomesadraei6695]

thank u sooooo much

[@MedicosisPerfectionalis]

My pleasure 😇

[@alexanderbeck5786]

really really good! im a German and understand everything :D

[@MedicosisPerfectionalis]

Thank you 🙏

[@isrameh9014]

thank u 😍

[@MedicosisPerfectionalis]

My pleasure!

[@gayathrijinesh3004]

Immunophenotype?

[@nazmircool]

You came a long way from trying to achieve 25k subs to having 246k subs

[@MedicosisPerfectionalis]

Thank you so much 😊

[@kii9579]

Nice explain 😊

[@MedicosisPerfectionalis]

Thanks a lot 😊

[@justlovehz]

Please can u make cardiology playlist?! 🙆‍♀️🙆‍♀️🙆‍♀️

[@stephiix3]

Watch & wait for what? For it to get worse or go away in its own?

[@MedicosisPerfectionalis]

Aggressive intervention may do more harm than good when the cancer is not aggressive.

[@SajidaMoizQamari]

Thank you so much for your videos. They are a great help and also fun to watch. May God bless you. Love from Pakistan

[@MedicosisPerfectionalis]

Thank you so much 😊
God bless you too!

[@Sommatix]

Can CLL occur in patients at a slightly younger age? My father passed away from CLL at 50 years old and I was just curious to know.

[@MedicosisPerfectionalis]

It’s possible

[@bcham7373]

I was diagnosed age 33 and 48 now. I’ve been fairly stable and have not needed any treatments so far for it.

[@dr.areenmansour6677]

U r great❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@aminrudwan231]

amazing❤️✨️

[@MedicosisPerfectionalis]

Thank you 🙏

[@cametientaucoeur]

Informative . However, please clarify; I the last example, you have symbol for man not woman & usually found in males. Also last example stage 0 not 1? Jeanne

[@ulfatgul868]

thanks a trillion

[@MedicosisPerfectionalis]

You’re always welcome!