25 FDA Approved Drugs That Eventually Got Banned
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- čas přidán 1. 06. 2024
- #FDAApprovedToBanned #pharmaceutical #didyouknow #facts #list25
Uncover the shocking truth behind 25 FDA-approved drugs that were later banned in this captivating video! Delve into a deep exploration of pharmaceutical history as we expose the controversial journey of these once-promising medications. From their initial approval to their eventual prohibition, discover the unforeseen consequences and significant lessons learned from these groundbreaking cases. Join us on this eye-opening journey and gain invaluable insights into the complex world of drug regulation. Stay informed, stay aware, and gain a new perspective on the pharmaceutical industry's past as we unravel the secrets of these banned drugs. Don't miss out on this thought-provoking video that will leave you questioning the reliability of the drug approval process!
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Author: Hestie Barnard
Video Editor: Ian Christopher Buyan
Music: Something is Going On - Godmode
Chapters:
0:00 - Intro
1:39 - 25
2:29 - 24
3:33 - 23
4:04 - 22
4:40 - 21
5:20 - 20
6:04 - 19
6:56 - 18
7:35 - 17
8:09 - 16
8:46 - 15
9:26 - 14
10:01 - 13
10:51 - 12
11:40 - 11
12:46 - 10
13:11 - 9
13:45 - 8
14:18 - 7
15:41 - 6
15:26 - 5
17:25 - 4
18:26 - 3
19:29 - 2
20:20 - 1
_________________________________________
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Kudos to Mike for being able to pronounce all those drug names! 🎉
This was not an easy list lol.
I agree that mike did a great job, especially for someone who doesn't work in health/pharmaceutical industries. Heck even with a biomedical science degree and extensive experience with pronoucing drug names (having previously worked in a pharmacy and having a mother who is a pharmacist), there were a few i would have struggled with on there.
I wonder how many takes it took to finally post this video.
Agreed lol. Pharmacy technician in training who’s been studying drug names for 8 months and I still struggle lol
That means a lot. I pride myself on pronouncing things correctly
I must say Mike, I give you a ton of credit for showing your psoriasis boo boos to the internet at large. It takes a lot of guts to do what you did, and I applaud you for it! ❤
I, too, battle psoriasis. Thank you for sharing your condition.
A close friend I had growing up had very severe Psoriasis almost from birth. I know how the condition ca be annoying, all the way to painful and debilitating. So I also applaud Mike's openly sharing this condition he's living with, and with a great sense of humor.
I have high hopes for a cure soon, or at least a treatment that puts it into 'remission' for a long time.
Best wishes for you and all who are enduring this Auto-Immune disease, Mike!
It looks really painful!!! I thought there is a treatment which is the use of I think is dark lights or UV saw it in an episode of My Deep Secret of a man with a severe case of it.
I have the worst case my doctor had ever seen, his words. I had given up and became a shut in.
Until I found an amazing doctor who prescribed ilumya and I literally got my life back. Zero breakouts for over 2 years now; I'll do anything to make sure I keep getting my dose every 3 months because it's a 100% difference. I have tears in my eyes writing this because of what I went through and what I thought about doing because of it.
Please ask your doctor about ilumya; I don't work for them or whatever but I almost quit this world and ilumya gave me another chance at happiness.
@@IrishMike22 oh my gosh! I am glad that you have been able to find a treatment that works for you! I live with chronic pain and have been on tons of different pain medications in the past 20+years, and I finally FINALLY found a medication that alleviates the pain enough that I can function (almost) normally. Take care, and best wishes 😊❤️
About 8 years ago, I walked into a hospital with extreme vomiting for over a month (was scared of costs of treatment. I know I was dumb) found out my gallbladder was full of sludge; had it removed, also have celiacs, AND gastroparesis (stomach muscle stop functioning and stopping anything from digesting).
I was given reglan through an IV. Within 30 minutes I suddenly started having involuntarily arm movements. Told the nurse but they said nothing. 6 hours later I got another dose of IV reglan. 30 minutes later while sitting still in a hospital bed watching TV, out of nowhere it felt like someone took a hot poker out of a fire and placed it on my lower spine. Over the next few hours I lost feeling from my bellybutton down. I couldn’t stand up. I looked up reglan since it was the only new thing that I was taking.
I found out that Reglan is on the FDA blacklist for causing peripheral neuropathy in a percentage of people! When I got to see the doctor again and told him about my new symptoms and what I read about reglan, the doctor told me “well you are being seen for your stomach issues and if you want to talk about your new symptoms you’ll have to go downstairs and try to get readmitted” then he left the room.
I had to learn how to walk again. I still use a walker. I’ve had a spinal cord stimulator implanted, multiple spinal cord injections over the years, still in physical therapy, and have chronic pain. I literally can’t lay flat and sleep in a hospital bed. It sucks
Some doctors can be real dicks!
Did you sue that doctor/hospital
@@cassiefarrow7785
We consulted with a few lawyers and basically was told that we had a valid case AND that we would win. BUT we’d basically go bankrupt before the case was settled due to the type of lawyers hospitals have. Hospital Lawyers (HL) would drag on the lawsuit on purpose to try to make it difficult for the average person to keep up with court fees, lawyer fees, court documents, etc to try to get us to drop the case before even getting to mediation. Due to not only the hospital doctors (HD) AND the hospital having separate lawyers, since I live in one county and the hospital being in a separate county, plus there’s a class action lawsuit pending against the pharmaceutical company as well.
It’s such a hot mess, I had two choices. Either fight for what I honestly deserve for compensation and bankrupt my family of five on one income or resign myself to my new normal.
Both choices honestly killed me. I’m still in pain each day, using a walker, in PT three times a week, sleeping in a hospital bed, and having the ripple effects (joint degeneration from “walking differently” using my walker, sex drive, nerve damage, sensitive to temperature changes, etc.)
I have gastroparesis. Luckily I knew about an enzyme deficiency I had prior to that diagnosis…so I’ve never taken Reglan, nor will I be starting. I got a GJ tube instead and took Phenergan.
@@ReineDeLaSeine14 I take phenergan as well. It doesn’t always help but it’s better than nothing.
I also call a mobile IV service to give me IV fluids and a vitamin mixture whenever I start feeling sick. If I don’t do this soon enough, I get horrifically sick and have to go to the hospital.
I’m sorry you’re going through gastroparesist but I’m extremely happy that you never got prescribed Reglan.
Thalidomide actually was never approved by the FDA, because the employee reviewing the case thought there was not enough evidence of its safety. She saved millions! A few doctors did give thalidomide out in the US during trials. But it was never widely available in the US like it was in other counties
They kept making it even after they knew all the dangers
@@cybersal7 oh absolutely!! It just wasn’t widely available in the USA
It screwed up a lot of people in the UK.
Frances Kersey was FDA commissioner at the time. She fought the approval of this drug.
@cybersal7 Thalidomide is still available in the US, it’s just contraindicated in pregnant women and used for some very specific things.
I took Cylert for about a month and it made my brain so loopy that I literally forgot my name one day at work! Thank God I refused to continue taking it, even though the doctor who prescribed it kept telling me that the "loopiness" side effects would pass. I was like, yeah, no! Anything that makes me forget my own name CANNOT be good for me!
I took it for probably a couple of years? But started hearing voices at work that people were scheming to get rid of me? I was working under a lot of stress at Goodwill and wasn’t liked because I was a stickler for accuracy but was extremely slow due to also suffering from severe OCD tendencies. Looking back I realize that I am probably on the autism spectrum and instead of putting me in an environment where I could concentrate. I was put in the warehouse sorting other people’s garbage. In a very chaotic environment.
Come on keep taking it, how else is the doctor going make money if he can't push big pharma on u, ur health should come 2nd or 3rd
That’s probably a feature, not a bug 😂
People often ask why I am so cautious about medical treatment. I've had 3 heart attacks so, obviously, I take a few medications. Watching this just confirms my suspicions about the medical "industry".
Yep. No one is perfect. Who knew?
My biggest complaint is that some doctors are idiots. If someone can't see an eye chart, don't just send them home.
Please, watch the channels of Pradip Jamnadas and Nadir Ali. They are both interventional cardiologists (Pradip in Orlando, Nadir in the Houston area.) they are not pill pushers, and give out very few prescriptions for statins opting to treat insulin resistance, metabolic imbalance T2D heart problems with diet.
They do things like pacemakers and stents with people who come to them in such a bad shape that they’re unable to wait for dietary to work. With your history, you may will still be prescribed a statin, but they’re not going to prescribe it as a matter of routine.
I was born in 1959, my mother took Thalidomide. It was prescribed by a British doctor for severe morning sickness. I was very lucky, my mother felt it really wasn’t helping that much and stopped taking it. When I was born in Germany, I was born with my right ear missing and no ear canal. The doctors freaked out (probably because they realized that their German drug had caused the birth defect)! It was rushed through most countries, including the U.S., without proper testing. So many people were born with severe birth defects! I believe it was the worst medication prescribed without proper testing in history (but I could be wrong about that)!
Anything that causes birth defects goes on the list of "the worst drugs"... automatically.
The problem is thalidomide has actual power for AIDs, cancer, and certain skin conditions, but definitely shouldn't be used in pregnancy due to its teratogenic properties.
@@suzukabladegotta love hastily approved drug pushing that continues to this day
There are many things that were prescribed. Uranium and mercury were some severe offenders. Its amazing how much we dont know how things affect the body in large doses. Severe mistakes can be made without proper testing. Thats why we generally recommend extensive testing for new drugs.
The drug was not approved in the United States in the 1960s, but as many as 20,000 Americans were given thalidomide in the 1950s and 1960s as part of two clinical trials operated by the American drug makers Richardson-Merrell and Smith, Kline & French. Outside of trial use, were doctors given this stuff as a drug to try for all sorts of ailments for men and women with severe consequences.
What's ironic about Zofran is they have proven that cannabis works better for chemo patients with very few side effects.
I think they should still keep zofran on the market though as it also helps people like me with GI issues. I definitely believe that it can sometimes be ineffective as I have still puked after taking it on multiple occasions
I was prescribed zophran less than 2 weeks ago
Wearing a Doctor Who t-shirt while giving us our latest dose of List 25 without any bad side effects is a brilliant choice of clothing.
Scary stuff! I could have been one of those death casualties. Years ago I lived in RI and contracted Lyme Disease... I saw no bite just got sick. After six months I had to see an orthopedist and I mentioned I thought I had got arthritis. He sent me to the lab for a blood draw and called me the next day saying get in here you have flaming Lyme Disease. I got the usual month of antibiotic but I never got better. For three years I saw many doctors because of the pain and fatigue. No help. I finally ended up at a rheumatologist and he diagnosed me with Fibromyalgia. He prescribed me Viox. After 2 days I was retaining a lot of fluid with my feet and legs blowing right up. When I called the nurse to report this she just said it's nothing to worry about. She said my body would adjust. Thankfully I did some reading and found out congestive heart failure was a complication. By then I was coughing a little and figured my lungs were starting to fill up. So I stopped on my own and never went back to that office.
I also live in RI and have a friend in CT who got late stage Lyme. I hope yours is under control now.
i have fibromyalgia too, doc says it's one of the worst cases he's seen (I have 3 other autoimmune things). My doc put me on Vioxx and it was doing the same to me, blowing up my limbs. I read up on it, dropped it immediately. I've gotten to where I will read up on EVERY drug I take before I put one in my mouth because it's just not safe to trust anyone. And don't even get me started on the Covid shot (Pfizer) that put my husband in a coma in ICU for four days with liver damage (stage 2 liver disease) and bleeding that took 5 pints of blood and two of plasma to fix. And it dropped me back out of remission on my MS from over 40 years ago. Nope, not taking one more vaccine. (we did 3).
When I was in collage many years ago, I had a nutrition professor who used to work for the FDA. He was on the FDA committee that approved aspartame and he said, "It is one of the biggest regrets of my life. If I knew then, what I know now, I would have never approved it." He felt like aspartame was a major reason for chronic migraines, other chronic health conditions, and even cancer.
He felt? Where's the science? Psychic medicine now?
@@653j521
Exactly.
There is a lot of "feelings" and not facts when it comes to things like aspartam. I want the facts.
We need actual studies, with tens of thousands of patients. Isolated cases, and 'feelings' that a drug is dangerous can wind up with bad results, too. Cyclamates, a synthetic sweetener which tasted better than Sweet'n'low or aspertame, was taken off the market due to it causing cancer in mice, but no follow up to see if it was a problem for humans. The mice were being given hundreds of times the dose that wound up causing cancer. But the damage was done, and we still wound up with Saccharin, aka sweet'n'low, which itself, wound up being known to cause liver problems. So there are lots of drugs with problems, which are still on the market. But everyone wants to keep it quiet, because in America, profit is always the most important thing...... not lives.
@@653j521 I'm sorry if my exact wording wasn't proper enough for you. Do you want me to do the work for you to find all of the articles that are already published on the harmful effects of aspartame or are you just going to sit there and continue to pick on the wording instead of do a search for yourself?
@@NickanM You are going to have to do it yourself, if no one else can do it for you. If you are passionate enough about it, you could always put the effort into contributing to science, by becoming a researcher on the topic. That way you will get all the facts instead of just the "feelings."
I was prescribed zofran when I was pregnant. My insurance wouldn't cover it, because it was technically for cancer patients. They wanted me to pay over $2,000 for a 1 month supply. Needless to say, I never took it while I was pregnant. I couldn't afford it. I'm actually glad my insurance refused to pay for it. The one time a refusal was a good call!!!!
Something else that has been changed is the amount of nitrous oxide available to dental patients. It’s half what it was around 10 years ago. From 2011 to 2021 I actively fought an aggressive Stage 2 breast cancer. Part of it was Prolia injections, to strengthen the osteoporosis caused by chemo. A side effect of Prolia can be (paradoxically) jaw necrosis, or death of the jaw bone. My 8 new veneers all fell off 1st. Next every crown came off, just like in my nightmares. Every porcelain filling came out over a week’s time. I saw an oral surgeon, and for 7 or 8 years so far he’s been replacing all (ALL) of my teeth with implants. I only use nitrous oxide and Novocain for each step, and it’s most certainly NOT the gas I grew up with! My Dr. explained all the steps involved in cutting back the dose.
My Mom took Thalidomide but it didn’t hurt me. I took loads of Darvocet. I still take Zofran leftover from my cancer; it works spectacularly fast. Now my dh has a VERY aggressive Stage 4 prostate cancer plus separate thyroid cancer so I’m going to save all the rest for him.💊
my friend was given a freshly fda approved drug for panic disorder.
then a majority of their hair fell out. despite being the most orally hygienic person i knew..the medicine gave them non stop cavities and severe rapid tooth decay. had they’d been warned.. and properly treated instead of blamed after the fact i think things would have been different fs.
Do you know what med?
@@KysEcstacy pls pardon me, it was 7-8 yrs ago and due to my adhd and cptsd ridden ass i genuinely do not remember the name of the drug. i remember how my friend felt and some details from their experience the most. either way to my knowledge the drug was pulled off the market so no worries there 🫂
Zofran is still used today. However, our standard dose is 4mg instead 😬
YES i still use it
Is Zofran Ondansetron? I use it quite often to try to prevent me vomiting up my psych and pain meds. 4mg wafers or tablets that melt in your mouth. It’s an extremely useful drug.
So am I going to die?
Obviously I am but from my Ondansetron?
Zofran got me through the meds I had to take while undergoing radiation. Some of them made me intensely nauseous.
@@shegeek5559 Most of my stomach problems date from when I went through chemotherapy and radiotherapy, so I totally get it.
It’s such a useful medication!
Also realizing something shouldn't be used for one condition doesn't mean it can't be used for other things. That's happened several times, especially with ones that cause birth defects but don't do much to already born people.
Thalidomide is being used again for certain cancers including multiple myeloma. However, it isn't used in patients (male or female) who intend to conceive a child within a year of stopping treatment. I have smoldering multiple myeloma and have gone over all the treatment options with my oncologist. I was shocked when he mentioned thalidomide paired with dexamethasone as maintenance.
I wish you success. 🙏 A prayer just went up for you. Sending strength ur way! ⚡️🫶🏻
Thalidomide stops the development of blood vessels. Good treatment for cancers, obviously bad for pregnant women.
It's also used to treat Hansen's Disease, leprosy.
yeah, thalidomide is genuinely a really useful drug when used for things it's actually tested and indicated for. the problem was it being prescribed for morning sickness despite never having been tested for effects on foetal development - iirc before then it was genuinely believed that drugs couldn't affect a developing foetus for some reason. So yeah, terrible drug if you're a foetus, but can be pretty damn good otherwise
Insane and disturbing fact about Thalidomide is that doctors in Brazil are STILL prescribing this horrific medicine to pregnant mothers
😳 are you kidding?!
It's specifically not to be used in pregnancy unless it's treating a life threatening disease. It's got a black box warning.
@@katiekane5247black box warning in the US. Other countries don't follow our guidelines.
@@tianamarie989as an Australian pharmacist the one time I’ve seen it was for an elderly gentleman with cancer in 2015, the capsules literally had printed on them the no pregnancy symbol like no smoking 🚭 but swap the cigarette for 🤰. I’d seen the symbol on packaging before like on isotretinoin and most/all? Alcohol packaging but never on an actual capsule itself!
Cylert was the first ADHD med my son son took, back in 1992. It made a huge difference in his ability to function at school, but after a few months, routine bloodwork showed issues with his liver enzymes. He was switched to Ritalin for a few years. It was helpful, but he had a lot of side effects. When he was 10, he started taking the brand new Adderall, which worked much better for him. He's in his late 30s now and still takes it.
Things get approved after extensive testing but the rarer issues are statistically unlikely to become apparent until millions of doses have been given.
Wow damn man! Huge thanks for being someone that admits to having psoriasis. I have minor issues with it but it's still tough. You are my hero right now.
Why thank you!
I worked in an analytical laboratory that did drug development and discovery work. The scientists would tell me...."when this new drug comes on the market....DON'T EVER TAKE IT!"
The rule of thumb I was told was to wait 20 years after a new drug comes out to make sure it doesn’t, you know, kill a bunch of people… 😬
That's always been my preference! Or no pharmacy meds at all!
@@sackettfamily4685they can be just as bad.
If you or a loved one were hurt by the coof vaggs you may be entitled to compensation! xD
@@misspatvandriverlady7555 - Worst Pills, Best Pills recommend using new medicines after 7 years.
Should totally do a bit on acetaminophen. Took the FDA like 8 years to put a warning label on for potential liver damage and failure. Child's tylenol had higher concentrations than adult tylenol for years. Furthermore, don't drink when taking it, or other drugs like nyquil which readily put you into overdosing
Yes, you have to be careful with it. Take it as it says on the label and not with other products that have it in their ingredients.
I had a student whose parents were the primary scientific researchers into the whole acetaminophen / paracetamol liver damage / failure thing. They said in the US it causes more liver failure than even being an alcoholic. At least in the UK it is bundled with codeine so you don’t have to take as much to get good pain relief when you need it, but because of the codeine you can only use it for three days. It’s scary when people have to take acetaminophen every day for years. Especially in the US where all the foods have HFCS in them which also overtaxes the liver.
And think about this: damn near every drug recall was once approved by the FDA.........
This is why my policy is to take as little as possible! We cannot trust a system where profits are more important than people
@@annamossity8879Check what is approved in Western Europe since their healthcare systems are state run, if it is approved it’s probably alright it it’s not might be cause for concern.
Lyrica, before they knew that it can cause or exacerbate suicidal thoughts and tendencies, was prescribed to me for nerve pain. It did help the nerve pain but I also came extremely close to taking my own life during my divorce. The only reason I'm alive today is because my grandpa committed suicide when I was 13 and it was really rough for my mom who was very close with him. I just couldn't bear the guilt of putting the only person who loves me unconditionally through that again, especially a month before we had plans to attend a Women of Faith conference. When I found out about the side effects, handed an entire 90 day supply of lyrica to my doctor and said don't ever give me this again.
Ty. I was going to ask my doctor for that. I won't now
To clarify on the palladone recall, palladone was a specific extended release formulation of hydromorphone (think oxycontin, but with a different semi-synthetic opioid more potent than oxycodone). On top of the already existing increased risk for respiratory depression that occurs when opioids are consumed concurrently with alcohol, doing so with palladone would cause the pills binders to release early, allowing for the full dose of the pill to enter the system much mode rapidly than was intended
My mother was offered and thankfully refused Thalidomide while she was carrying me.
I was prescribed Vioxx and Darvon together for my osteoarthritis. I found that Naproxin worked just as well and asked my doctor to switch my prescription. I have definitely dodged a few bullets.
Hey dude!! Love you and as a fellow psoriasis sufferer I applaud your embrace. One thing I have found that works better than the steroids and the creams…. Sunlight on the skin not talking sunbathing, but just letting the sun hit you. NOT gonna lie the first three days were kinda awkward, but after I decided I didn’t care what people thought since they were worried it’s contagious. I made it through and if I could show you before and after pictures I would. I even cut my hair short. So I only have the red flaky patches from hell back!!!! I feel soooo much better that someone like you is proud of that. Thank you 🙏🏻 ❤❤❤❤❤ Kristina Smith Port Arthur Texas
P.S. I cut my hair because I had it SOOO bad no one would touch, but now I just got some patches on my back and behind my ears 😘😎🫠🤟
Accutane definitely caused me to have severe joint pain. I was only on it for 1 cycle when I was 15 (in 2001) but the joint pain lasted for several years afterwards. I had cystic acne that covered my entire back and shoulders...at least it cleared that up.
I kinda feel like Accutane can't do much that N-Acetylcysteine and liver can't do, the NAC to raise glutathione(or the body's master antioxidant which it makes itself, really great for immunity) which alone can be great for cystic acne and the liver for natural vitamin A in it's active form. Accutane kinda sorta is like a megadose of vitamin A, I think it's derived from synthetic vitamin A or something like that but not exactly sure how that works, but it's very bad. Accutane is horrible for the liver too where NAC is one of the best things for the liver, and of course so is eating literal liver lol.
Fuck big pharma, the FDA tried to ban NAC but thank God I can buy it locally, I even heard rumors of them wanting to ban magnesium, probably because it's a calcium channel blocker which helps protect against EMF where calcium does the opposite, especially when people are deficient in magnesium, vitamin D, and K2 which most people are. I don't think it's an accident a lot of stuff has calcium added and supplementing it has been kinda pushed over the years. Calcium oxalates in things like raw kale and spinach is bad too.
SAM-e comes to mind, the body makes it from methionine but supplementing it can have additional benefit. It's good for the liver too but also joints which you mentioned, kinda curious if it could potentially have benefits for things like acne too. But I love that stuff, it's so good for repairing dopamine and serotonin receptors and also for norepinephrine or adrenal fatigue, one of the best things for recovering from something like kratom or opioid addiction. From my experience going cold turkey off kratom, it could take 2 weeks just to start to notice an improvement mentally, with SAM-e it's a week or less which is around the time it takes to start working from the day you start taking it. So if you get a head start taking it before going off it might work even better or help reduce the addictiveness to begin with. It could maybe prevent tolerance buildup.
@@brians1793 that VERY interesting. How long did It take you to fully get off kratom? I assume you had problems sleeping at first? And everyone is DEFINITELY deficient in vitamin D especially....well, the ones that were the lowest are all dead now as COVID took them all out.
There is one whose effects really don't get mentioned much. Topamax (also known as topiramate) is an antiseizure and migraine medication. However, it has been linked to serious side effects in people who have a family history of movement disorders (think Parkinson's, essential tremors, etc...) I know this only because my mother and two of her sisters were given Topamax for migraines, and they now have severe movement issues due to it that's disabled them for life. My mom only discovered this because she wanted to know what was going on with her to deteriorate so quickly and read up on the medication. So yeah, if you start having any serious side effects that you believe are important, report them! It could have lasting effects for years.
I am so pleased Mike is back hosting this show. ❤🇨🇦
Me too! LoL
I'm glad to see Mike back too. We need Tristan back because they both made this channel more amusing with the fun banters they had.
At 6-minutes into this, there's still 20 to go on this list and it already sounds like a drug dystopia. How does anybody survive?
I was given Benedictin for morning sickness in 1983 and it was taken off the market a few weeks later. Never heard any more about it but my son was born with a congenital immune deficiency¡
I also took it for nausea. Luckily no issues.
@@sheilaholmes996 I heard they are bringing it back, no signs of birth defects I guess.
Sorry to hear that. I hope he's doing well.
Thank to the YT algorithm for letting me know list 25 was back 9 months after it happened.
Mike!!! The best thing I used for psoriasis is Curel daily healing lotion I started clearing up in about 2 weeks. This stuff is magic
…I’m pregnant and I take Zofran for chronic nausea and vomiting (which began years before my pregnancy). My OB knows that I take it, and my pharmacy knows that I’m pregnant. Should I not be taking it?! I’m so concerned now. Definitely calling them first thing in the morning.
I can not believe that have just shown you psoriasis that simply. I have it and I'm covering myself up fully in tempreturs well above 37 celsius most of the year. Much respect.
Thanks Mike. Love your lists and your personality ❤
Thank you!
My uncle died of AIDS related PML in 97. He started getting headaches in May and was dead by October. At the end he couldn’t talk, feed himself or go to the bathroom by himself.
Marcia Angell, former editor of New England journal of medicine wrote a book called The truth about drug companies and how they decieve us.
Ah, there it is, Bextra. I was prescribed that in my 20s after a severe back injury. Had quite a cocktail prescribed to me, including Darvoset. Darvoset was "too much" for me. I took a partial dose and felt like I was in another world. I decided I would rather feel some pain and feel like myself than to be incapacitated from being ultra high. SO I never took it again, good thing. As for Bextra, I started to swell all over. I was getting edema in my legs, not something I had experienced before. Possibly not related, but I took myself off it figuring it was not worth the hassle. This was 2002/2003. I think Bextra was taken off market in 2005.
Great list. Disturbing too.
This is why I look at other countries ' ban lists.
What is the best resource for that?
5:50 when Mike mentioned accutane, it reminded me that it was an option for me. Back in like middle school/high school, I had REALLY bad acne, so my parents took me to the children's hospital dermatologist. They said that accutane was an option, and then they gave us an ENTIRE FUCKING PAMPHLET about the side effects and how you should NOT get pregnant while you are on it because of all the birth defects that could happen, and I might've been young, but I knew for a FACT that that was something I didn't want anywhere NEAR my body. So I never took it. And it turned out that I didn't need it because my acne cleared up like 3 years ago maybe? Lol anyway accutane scared me ngl
Same here but I was seated in a private room to watch a video on accutane, it scared me so bad I couldn’t finish it and left. I figured it couldn’t be good for me even if I didn’t get pregnant
A friend used it and we have reason to suspect he took higher doses than recommended. A few years into it, he had a schizophrenic episode and killed both of his parents.
@@ChrisW228wth????? Crazy
@@mibz1117 Very. He had the worst acne I’d ever seen. Still, and I’m 54 now, I’ve never seen anyone with it so bad. Then, it cleared up seemingly overnight and he had flawless skin ever since. He started doing more and more concerning things, to the point that other friends and I distanced ourselves. His parents had him held for 72 hours, but he is extremely intelligent and knew what to say, so they found him not to be a threat to himself or anyone else. A year later, I returned from work one evening to find my mother crying in front of the TV news…
Zofran is still available orally. I have a bottle of it sitting on my desk right now. After watching this, I'll need to talk to my doctor about it.
Zofran (ondansetron) is still used in my country quite commonly for nausea in pregnancy.
I was just prescribed it (in America) it's just not used for pregnancy anymore
Cancer patients get it but I found compazine to be much more effective, for me
I was on zofran for both my pregnancies (2018-19 and 2022-23) 😬
it's still commonly used for cancer patiënts because it is one of the few things that will help with nausea from chemotherapy
How about this: drug company executives must try their drugs before said drugs go to market. It could lessen the number of future drug recalls. Just a thought.
GREAT IDEA👏👏👏
The drug developers that push a drug to market without accurate data of testing shouldn't get a slap on the wrist if we want quality medical care some folks need to face negligent homicide charges for putting profits over lives.
No, they need to be poisoned. Eye for an eye.
Don't take any drug that hasn't been on the market for at least 15 years. Safety studies are done post-FDA approval in the general public. Physicians are supposed to report adverse events to the FDA but they rarely have the time so problems can go unrecognized for a long time.
This is a little scary...I was on Zofran for 2 of my 3 pregnancies (2nd one was only brief, 1st was longer as my morning sickness lasted well into my 2nd trimester). Fortunately, neither of these kids had any issues with their heart. As for Acutane, in about 2011, a dermatologist was trying to insist I use it (which I refused). So it was banned but they still push it (even now, to this day) for acne and other issues, like rosacea.
Fen-phen almost killed my aunt. Has had multiple heart surgeries as a result. She got a settlement but it didn’t even cover medical costs. Sometimes class actions aren’t the best route
My mom was given DES when she was pregnant with me and also my sister. I have a malformed cervix as a result and my sister was unable to conceive.
In my research on DES I found out it was used in US cattle feed until 1959. I was born in 1955.
Mine also.
My mom also. I was born in 1952 and us DES sons have problems in the reproductive area as well. Higher rates of testicular and prostate cancers and fertility problems than those with mothers that didn't take that drug while pregnant with them. No baseline study was done with this drug. It was not banned, but not prescribed to pregnant women since 1971. It was used in chicken feed to neuter the baby roosters as well for meat production. Me and my brother are still dealing with the aftermath of prostate cancer as there is no history of that with the males in my extended family.
Canned vegetables seem to make get small psoriasis flare ups. They go away when I stop eating canned veggies. Weird, I know.
I am in awe of your ability to wrap your tongue around all those long medical words. I'd be lost.
I used to take Zantac for heartburn years ago. It worked pretty well. A pharmacist told me to stagger it with other heartburn remedies to avoid building up a tolerance to the drug. So I rotated it with 2 other remedies. But Zantac was always the best and provided the quickest relief. I was quite upset when they removed it from shelves. I guess I should be thankful 😊
It's back on the market being reformulated. I won't trust it, though. Also, I got lots of side effects from it, too.
ANY need for a medication for the gastro intestinal tract is a message from your body to CORRECT your diet.
@@SusanMadge-vl9gx - What diet did you find that worked best?
@@SusanMadge-vl9gx Says random person on YT who knows the specific medical and genetic needs and conditions of everyone in the world..
What an interesting list. Been a huge fan for so long since 2016. This is the most interesting list. Sheds light that even the FDA is run by people and people make mistakes.
I was on ranitidine for a long time (years) until recently (due to changing doctors, not a recall). This is actually the first I'm hearing about the recall, and I will be finding out more. Thanks Mike and I'm glad to see and hear you listing things again. Much love from Canada
I took Zantac for years, Zantac was a great drug it was the contaminant in it that was a possible carcinogen. Losartin and Metformin also have this contaminant in them from time to time. Most of these generic drugs come from China.
A lot of my mental health clients were on Ranitidine 😮 And that was only five years ago!
@@coyoteinthepool That stands to reason since Zantac was the number 1 H2 blocker in the US, probably the world. I bet most of your mental patients also drank alcohol, milk, water, etc.
I use PPIs (like Prilosec) because of my history with ulcers. However, i used ranitidine, too for years. I never put two and two together - the headaches, the vomiting, the upset stomach, the nausea, etc. I know I took it for at least 10 years off and on. Right before it was recalled, I said F- it, one of my medicines are causing these side effects. I stopped taking each one for about 3 to 7 days. When I got to ranitidine (Zantac) it all made sense. I stopped having all my symptoms. You don't know how many days I called off from work, either! It all made sense why I was "always" sick in the morning. I swear people were thinking I was faking and it was all in my head. However, vomiting and feeling sick definitely wasn't. Supposedly it has been reformulated. I WILL NEVER take it again for all the times I got sick from it! If you need to be on that type of medicine, there are products like Gaviscon, Pepto Bismol, Pepcid, Pepcid Complete and Tagamet that are worthy to take and do your own research on them, too.
I took Zantac a few times because I was burping up stomach acid... luckily I stopped before I got much more than a stomach ache
I took Accutane and it was the worst thing ever. The prescribing doctor was dismissive and insulting, refusing to answer my questions or discuss, and eventually snapped "Do you want a prescription or not?"
It destroyed my skin and I have scars to this day. He immediately left and the covering doctor wouldn't raise the dose to a therapeutic dose, because she was afraid to make any prescription changes for the doctor she replaced.
Meanwhile, I was following through with a surgery consult that I very much needed, and was told Accutane ruled out my surgery and I would need to be off Accutane for a year. The prescribing doctor has refused to answer my questions about side effects, so I didn't know that it would derail my surgery. I was a teen! I asked questions and didn't know to stand up and push when I was disrespected and dismissed!
I stopped Accutane that day, and the horrific rash cleared up, and a year later I got my surgery.
If you don't mind answering, what surgery were you getting that the med derailed? Or was it surgery in general due to possibility of excessive bleeding.
@tianamarie989 It would have been any surgery because of the healing and bleeding issues caused by the meds. Luckily my surgery wasn't needed for survival, so it all worked out, but I was crushed.
I have taken *one* pill of Zofran. I think it was somewhat overkill for migraine but it did work.
Fun fact: thalidomide is now a cancer drug. What made it bad for fetuses is what makes it good against certain tumors.
I take zofran for migraines and nausea it works fine for me
I've taken it a bunch of times, didn't know about this
Well...
All of them were once considered "safe and effective". Trust the science!
I really appreciate this video. I take Tagamet for ulcers. But only the over the counter dose, the prescription of Tagamet I used back in the day, actually made me nauseated to a point that I would try to throw up myself. I also have what you have on my arms, I use Curel, it does help with breakouts. I am appalled at all of those drug commercials on media of all sorts. They make it seem like all people with diseases are so happy now that they are taking medication, then they lay out if list of side affects. Damn, I'd rather take my chances. Great one, Mike. So nice to have something interesting and intellectual on CZcams ✌️
Damn Mike, havent been listening long but I've already heard many a bad thing that you've gone through. How about a list of 25 good or exciting things that have happened to Mike Estrin?
I was born in 1980, and going into this list I thought of 5 that I knew of (either from friends or family previously using them, or the news itself). Of those 5, all of them were listed, and I figured Thalidomide was going to be #1…we actually discussed Thalidomide in my Organic Chem class and the reason why it was originally made.
Like Mike, I made the list too (twice!), so…yay? (Note: Pretty sure I’m ok…well, at least regarding the issues from those medications)
Similar. Years ago I was prescribed meloxicam for osteoarthritis. I also have some traits associated with Marfan Syndrome and like the doctors who put me on the prescription was unaware of the issue concerning allergic reactions to certain pharmaceuticals in some genetic conditions, a known issue with NSAID's (Non-Steroidal Anti-Inflammatory Drugs). The end result was sudden mood swings combined with intestinal bleeding and being forced to find safer alternatives. Thank you once again for another awesome video.
I have EDS and took it for a year…and seriously have never heard this before. I recently mentioned seeing if I can go back on it! Oops.
I just got a script for meloxicam (cancer patient) and I took one tablet, lost 3 days. All I did was sleep and when I did wake up I was “woohooing” all around the house 😂
I’m on a lot of pain meds and perhaps the combination wasn’t good. I’ll be having that discussion with my oncologist next month. Needless to say I didn’t like it and don’t plan on continuing it.
@@annamossity8879that’s interesting that Meloxidan affected you that much mentally. My dog was on that medication when he was near the end of his life and he did seem a bit sleepier than usual
So that’s why I never got Darvaswt after any other surgeries I’ve had. Sad, I get it but damn that stuff worked.
Accutane ended years of horrendous cystic acne, but I went through a terrible bout of depression during that time which was unexplainable.
Awesome video 😊
Cisapride (Prepulsid /Propulsid) was left out. Far more damaging than some on this list
Oh yea. My mom took that
Yay, I finally made a List25 list...figures it would have to be this one. But, yeah, I was prescribed seldane/erythromycin for an ear infection back in 1992. After the 1st dose, I began to feel pain in my chest and left arm. I called the dr's office and they asked if I showed any signs of rash. No, no rash. Was told to keep taking the medications as prescribed, which was 3x's per day. Took the next dose at 8:00pm and wow, the pain and tightness got really bad. At bed time, I decided if I didn't feel better in the morning, I would call the doctor back. However, it got to where I couldn't move my left arm, so I went to the ER. When I told then about waiting until morning, I was told point blank that I didn't have until morning. I was well on my way to having my heart stopped. Then the emergency measures they took to get the paralysis and heart problem corrected caused internal bleeding for a few days.
I gotta say I like the new and improved list 25. I just hope you don't get canceled.
I took vioxx, darvon, and Zantac. Didn't have any side-effects. You should add the original formulation of Seroquel. It caused a lot of problems
I remember darvon...... it worked so much better than oxycodone and even morphine for my severe chronic pain (at the time only CRPS formerly known as RSD but I now have CRPS from C4 down, central pain syndrome along with hyperalgesia and allodynia and my now current since 2020 pain management provider has me on hydromorphone with an absolute max per 24hrs of 24mg= 6 4mg tablets in a day).
Same here. I took those things and they worked. Well Vioxx really didnt help me but Darvocet and Zantac did. No harmful effects from any of them though. Not as if I was taking much of them anyway.
I used to take Seroquel for sleep issues and I was smart enough to spit them out once my mum walked away after giving me my meds
@@EdnaK728 I'm female. I was on Risperdal and then Seroquel. For Risperdal it is like 1 in 200,000 or something for a female to produce BREASTMILK(!!!!) without having a child. For Seroquel it is something like 1 in 1 million for the same effect.
Guess what I was producing on each of these fucking meds? And keep in mind that I started having this side effect at about age 14 ½ on Risperdal and was 15 y.o.a. when I was taken off of Seroquel and placed on fricking birth control in order to dry out but I ended up having 4 cases of mastitis during this process and the only way to clear this sort of infection is to use a breast pump to get the solidified milk and the pus that was behind it out while being pumped full of various IV antibiotics to prevent the mastitis from turning into a sepsis case. Imagine poor me (15y.o.a.) having to have consultations with a lactation consultant without a pre-existing child as a fricking child having to be cared for by the ICU team on a post-partum unit with no child for nearly 5 months (🤦♀️).
Like dear God I still HATE crying babies and fricking vacuum cleaners from the time of about 1 month after starting Risperdal at about 14 ½ yo to when they were finally able to fully dry me out and clear the infection at nearly 15 ½ yo. Just that one year was ROUGH AF.
Used darvacet several times for dental pain and severe monthly pain with period cramps where I would take it the first 2 to 3 days of my period. Never had issues with it . I never mixed it with any other drugs as it was a narcotic
My dad passed in 2005 to colorectal cancer. He took Zantac almost religiously for years before his cancer diagnosis. How would I go about joining the lawsuit for Zantac?
I would Google "Zantac Class Action Suit". You should find the answer that way. I'm so sorry for your loss.
Just tell them your dad died from cancer that you have reason to believe was caused by Zantac, also I'd have his death certificate ready as proof just in case they don't believe you
That would be impossible to prove
@@hojo70 then I don't know how to help, I'm sorry I can't do more for you
if these drugs were OKed by the FDA, instead of the just maker being liable, shouldn't the FDA also be held liable
I was part of a US drug study in 2008 testing agomelatin, which later was marketed as Valodox. It was the first SMRI, acting on melatonin in the brain, alleviating insomnia in depression patients. I did very well on it, but could not get more after the study ended. Because of liver damage in 1 in 10000 patients, it was never okayed by FDA for prescription use in the US. It is however available by prescription in Canada, Europe and parts of Asia.
So the US fda deemed it not beneficial/woking? And Europe deemed it beneficial/works? Isn't it usually the other way around?
Ranitidine, Vioxx, and Darvocet. Knock on wood! Did lose a friend's mom to fen phen related complications with her heart. It was devastating. :(
Thank you for sharing this information
I was working in the industry dispensing a lot of these when they were removed from the shelves. So I do know a lot of them.
As a Pharmacy tech. I can confirm that at least 3 of these drugs still exist and are still being prescribed today. The first one Zofran (or generic of) is a very popular item, surprised to see it on here, but the strength on it is much less then mentioned in this video. The other being Isotretinoin. We were educated on its effects and are usually dispensed in a box and not taken out of the box by the pharmacy staff. It I not prescribed very often. The last one is phentermine, which is a controlled substance and is still prescribed for weight loss purposes.
I can confirm that zofran is still on the market. It works great for nausea. I was really surprised to see that on the list.
I heard that thalidomide is now being used for some things but very rarely.
I can also confirm that isotretonian and zofran are on the market as I have taken the two within the past 2 years. Most dermatologists only prescribe accutane for cases that are severe or if you won’t respond to any other med. It is very regulated tho and I had to take pregnancy tests and blood work done while on it. Both accutane and zofran are drugs that have drastically improved my life.
He said IV 32mg zofran. I have never given that much to a patient. 8 mg IV max. Bc long QT syndrome. And yes, accutane is still available.
My husband used to take Seldane. I remember hearing that taking Seldane with grapefruit juice could cause a fatal interaction.
Grapefruit juice can interfere with the breakdown of many drugs which can cause a higher blood level of the parent compound. Ketoconazole is an anti-fungal that can interact with many drugs.
My dad took seldane and would get a sharp pain going up his neck when he took it with grapefruit. He stopped taking it before the recall because has really bad hypertension
The definition of insanity is the FDA
Zofran is still prescribed in the U.S. as a sublingual tablet for infection related nausea (or at least its was last time I was made aware of it in 2018)
I've questioned a lot of medications for years. Have you heard some of the side effects lately, they have more side effects than the problem it's supposed to cure. So they have to give you another medicine for the side effects. 🤦🏾 It's not about health anymore, it's about how much money the company makes annually.
Like the Dr Who shirt.
Devils advocate here, pharmacy Technician, yes there are many side effects, and the more severe ones are usually tracked. One thing to remember as a guideline is the higher up on the list, the more common the side effect is. The one thing doctors decide is 'does the risk outweigh the benefit to the pt.' I have taken 2 of the drugs on this list with great outcomes, no more arthritis pain. As a matter of fact, Bextra was fantastic! Also, it takes so long to get drugs approved it's insane, and it is extremely expensive to do so, and I still don't like that it's so expensive when they come to market! My so was on Xarelto, which we paid our $35 copay for a 3 month supply, we have a high deductible and without the insurance it's $1400/month! That just sucks, it's a blood thinner and he can't go without.
@@smb611
🤣🤣🤣 Seriously, you can say whatever you want I've seen how some doctors pad their pockets risking the health of others. My mother who will be 100yrs old this fall with luck. At one time the doctor she had in the early 2000s had her on 13 pills a day. I knew she wasn't in that bad of health.
Found her a new doctor about 21yrs ago, a good doctor. He went through her meds and found 8 of the 13 she didn't even need. Her original doctor was over medicating her. Most were meds to help her deal with the side effects of the other medications she didn't need in the first place. (Explained it to me thoroughly) He changed that one med and eliminated the others. Since then she only takes 4 pills daily plus a pain pill occasionally.
She went from almost $900 a month in meds to $120 a month. I know cause I paid out of pocket for her meds she wasn't able to pay the deductible. She's in good health for her age and doing fine. So you tell me why would the first doctor do that? If not to get kick backs and line his pockets from the pharmaceutical company? You tell me.
@@deathscythehell7937decreasing the amount of meds given seniors used to be part of a care plan. Now it's just accepted 😢
I went through the same with my Mother. I do my homework and find many issues can be dealt with by proper nutrition, something not many Drs will acknowledge or even have familiarity with. We live in a society that wants a pill for everything and the medical “practice” is all too happy to oblige
@katiekane5247 it is though. From what they wrote this was 21 years ago. Those programs weren't as used as they are today. Pharmacies that supply nursing homes have a pharmacist team that go over patient meds after admittance and every so many months. I think this issue is mainly in states that don't have these regulations. I think there needs to be more regulations in the Healthcare field than in any other field.
Bro.... you look slim, trim, and healthy. The old videos will always have a special place in my heart, but you look great
Thank you so much
I used Zantac maybe a couple of times in years past when I couldn’t find Cimetidine(which works better for my body).. or when someone else went to the store for me.I am thankful for this every day! I remember many of these, and some also advertised on t.v…
I took it a few times when I couldn't find an alternative, but it made me burp up stomach acid so I try to avoid it whenever I can
@@EdnaK728I’mjust pretty glad it didn’t agree with us! Some folks weren’t so fortunate. And also being born in 1960 ( and having had terrible 1st trimester morning sickness myself) I’m pretty sure my mother did as well. I thank her every day for not taking thalidomide. I have a dear friend who has lower arms that come from her shoulders, and she was teased mercilessly in school by being called “T- Rex “and horrible names… but we became friends in our 30’s.
List 25 is FDA approved
A little off topic, but... I love your shirt, Mike!!
We still have Zantac /ranitidine here in Canada. Super weird lol
It was recalled and they reformulated it. So it's back on the market. In my personal opinion I don't trust it and won't take that particular product ever again.
I took ranitidine for excess acid production when I was expecting one of my babies. Fortunately we both were ok.
Re Thalidomide in the USA, I heard the story that a female scientist working at the FDA kept refusing to authorize its use for morning sickness in the US. Apparently she initially found the paperwork to be little more than an advert for it, iirc. She sent it back a number of times, refusing it each time. The drug company tried to get her sacked (female scientist, 1950s... I don't need to say anything else). By the time they finally sent the required studies, etc, word had started to spread about the birth defects it caused. Obviously it wasn't granted a licence.
Having said that, apparently it's incredibly effective for leprosy. So it shouldn't be thrown away, just kept away from pregnant women.
I feel like so many drugs including OTC can not be taken by pregnant women which is yet another reason I have 100% respect for moms!
Glad I read down the comments before posting mine, I was going to use both your points (never approved by FDA and Hansen's disease.)
You really need to be cautios of what you ingest when youre pregnant. It can be particularly tough for women with chronic conditions that will see their preffered medication off limits to them while pregnant and breastfeeding. Even things like vaccines can be off limits to pregnant women.
Even if it was a man they would've tried to get him fired. What a sexist statement
@@psyclotronxx3083if it was a man they wouldn't have to try to fire him...(there would of been no push back.)
It is worth noting that the FDA has approved Thalidomide use for some forms of leprosy complications and multiple myeloma.
You have a great sense of humor and you are a wealth of information. I have subscribed to you and I look forward to your CZcams.
Fasting can do a great deal to keep you off medicines. Great for blood pressure, autoimmune conditions, and much more.
You go Mike I love you. Your so honest and love this show so proud you showed your psoriasis #nobodyshaming that takes takes strength and guts!! Thank you for that for everyone!! Your the best host of all the shows I watch I love this channel thank you everyone
Thank you so much for putting this important information together for us all
I know my sister took phen phen back when it was popular - unfortunately she is still with us
Oh my
Mike, how long did you have to practice to pronounce some of those drug names. You spit some of those difficult ones out like you used them in everyday conversations. I was amazed that a few that I have taken over the years was on the list. What really makes me mad is one that I was forced to take by my health insurance company, Zantac, because the insurance company wouldn’t pay for the drug that actually worked for me.
For future reference, use the med they prescribe and insurance will pay for, go back to the doctor and say as such and ask for a pre Auth and make sure your doctor writes on the pre Auth that "patient took _____ med without significant change in symptoms or too many side effects. Would like to try _____ med(the one you want)." They usually accept this and then pay for it. (I fill these out at a pediatric office daily) we're mostly successful when going this route.
@@tianamarie989 - That's a good tip. However, Zantac is back in a new formation. Not sure if I would trust it in my opinion. There are other medicines in the similar category - Pepcid, Pepcid Complete and Tagamet.
Amazing work. Great vid. Subbed:) Thank u
I don't know when I last saw a video from you but I am now subscribed and hope to catch up! ❤
Zofran is still being used in hospital…….my son has the same shirt, TRUST ME IM THE DOCTOR LOL; I also suffer the pain of psoriasis Humira helped but had to stop because the prices of these drugs are insane!!!
my mother improved on a gluten free diet
I'm really impressed with Mike's amazing pronunciations. Those were not easy words and he did beautifully. Keep up the great work. I'm currently binging all your lists😊
Thanks for being so open about psoriasis. What a positive spokesman. I liked and subscribed
Thank you so much!
You still look really good even with your psoriasis. 😘😉