Arousal as a universal embedding for spatiotemporal brain dynamics
Vložit
- čas přidán 21. 12. 2023
- Video abstract for “Arousal as a universal embedding for spatiotemporal brain dynamics”
by Ryan V. Raut, Zachary P. Rosenthal, Xiaodan Wang, Hanyang Miao, Zhanqi Zhang, Jin-Moo Lee, Marcus E. Raichle, Adam Q. Bauer, Steven L. Brunton, Bingni W. Brunton, and J. Nathan Kutz
www.biorxiv.org/content/10.11...
Neural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral and physiological measurements. We propose that this covariation reflects in part the dynamics of a unified, arousal-related process that regulates brain-wide physiology on the timescale of seconds. Taken together with theoretical foundations in dynamical systems, this interpretation leads us to a surprising prediction: that a single, scalar measurement of arousal (e.g., pupil diameter) should suffice to reconstruct the continuous evolution of multimodal, spatiotemporal measurements of large-scale brain physiology. To test this hypothesis, we perform multimodal, cortex-wide optical imaging and behavioral monitoring in awake mice. We demonstrate that spatiotemporal measurements of neuronal calcium, metabolism, and blood-oxygen can be accurately and parsimoniously modeled from a low-dimensional state-space reconstructed from the time history of pupil diameter. Extending this framework to behavioral and electrophysiological measurements from the Allen Brain Observatory, we demonstrate the ability to integrate diverse experimental data into a unified generative model via mappings from an intrinsic arousal manifold. Our results support the hypothesis that spontaneous, spatially structured fluctuations in brain-wide physiology-widely interpreted to reflect regionally-specific neural communication-are in large part reflections of an arousal-related process. This enriched view of arousal dynamics has broad implications for interpreting observations of brain, body, and behavior as measured across modalities, contexts, and scales. - Věda a technologie
Im an undergraduate who just recently took interest in the dynamical perspective of the brain (through Izhikevich's dynamical systems in neuroscience) and this video motivates me 100x more to keep exploring this field! Very cool stuff!
Really exciting talk! Thank you for sharing!
You bet!
I’m excited to see this field of mathematics used for neuroscience!
Part time dynamicist, part time biologist here. Really love this work. Can't wait to see it validated on more data but in the meantime I feel like you have just drawn back the curtains of ignorance in a profound way. Thank you for taking the time to share!
tbh it sounds like trying to predict what someone's doing on their computer based on how loud their fan is
Thanks!
Thanks for explaining.
Really cool work!
Fascinating...
some questions:
1. So.. is fluctuating arousal spontaneous instead of being triggered by a specific sensory input? What if the environment is made as "bland" as possible?
2. For time-delay embedding to work, is there a specific condition that needs to be met? for example... does the path of the dynamical system need to be periodic?
3. Is the "latent dynamics manifold" (shown in 15:36) the model that we're looking for?
I find this explains many important phenomenon
You should have more of summary at the start of the presentation about what arousal actually is.. so you don't have trouble later on bringing it up in a sciencetic context.. I think people would be excited to hear a summary about arousal and what it can do..
I wish I could believe this has a meaningful insight and not just random outputs..
A few years ago when I was being payed $17/hr at a lab, I used a U-net to map 128x128 US weather to weather in Africa, and surprisingly, it found some correlations and exhibited predictive skill, arguably due to season signals, phase delayed radiation, etc lol
looks like some kind of plasma! amazing!
Super cool! Do you think these methods are generalisable to fields like economics? And if so, do you think that this method can inform the way a metric might be constructed - say, as necessarily being a projection of the attractor into some basis, that might eliminate the possibility of some metrics (I'm thinking mostly about inflation indices here)? Thanks for the presentation!
14:19 I just tried the time delay phase plot with stock prices and it looks like a mess lol. I annotated different trajectories with different colors (i.e. delay 1, 2, ...11). As for inflation, I suspect the model might tease out the PE ratio as the principal component lol
Really exciting! But thinking of my brain as a dynamical system is scary
very interesting video!! i would love to learn how was the pupil tracking achieved !
The black t-shirt at the begining reminds me the dealer in buckshot roulette. XD
This is absurd! Thank you for your presentation. This concept of bodywise thinking has much to do with other "recent" conclusions of neuroscience.
Nice presentation, i have a question though, how do you determine if your observable is independent? Is it required that these observable be independent? What if there is a trade-off between your inputs? How neural networks can resolve possible trade-off or any relationship between your input datasets that sum into a brain function?
I feel kind of stupid for the way I came to this idea, but, after having watched an *amine recrustallize on glass, after being heated to a gas, and then seeing a microscope photo of fetus baby or child cortical iirc tissue, I thought "whoa, there is something similar in how those look." So, neuroplasticity, and ways of reconfiguring. I also remember reading or hearing, that the "visual cortex" has an observable role in spatial mapping, even in individuals without eyesight.
9:10 it looks like brain activity leads wisking and pupiling
Why not use spacetime as a universal embedding. Everything could be movement.
Hey Steve I have a working model of this, ot seems to explain the biolelectric origin of the first cell but I'm mostly using it for business where i apply biomimcry to give my business the capacity for self regulation. The arousal includes the kreb cycle, blood and air as well as money, I think of it resonant construction, operational scheduling of fluid dynamic flows where the stock becomes the container and the container can restructured through changing the proportions and frequency of certain fluid flows of which information is included. Please be careful with this one non zero dynamics and this research make for a pretty terrifying world
Careful guys I noticed a lot of dystopian dynamics in this one a few years ago. Our current political architecture is most likely going to use this to accelerate great power conflicts. Please push for biosphere dynamic system regulation instead of resource growth skill mastery exchange is a better basis for the economy once engineers make use of this in systems that affect the market. An extractionist philosophy will quickly erode the climate boundary.
By the way in my tribe it's called chi and in the east its called qi.
Kurt Vonnegut, author of, among many novels and a few memoirs, Cat's Cradle, about application of a seed molecule designed for military application (solidifying bodies of water to run Marines' tanks over them) gone horribly but not unforeseeably catastrophic, had a brother who did work on seeding clouds and modifying weather. There is also, a novel, How To Mutate and Take Over The World, by St. Jude and R.U. Sirius, with a plot element involving nahobots that manufacture key lime pie filling. Definitely some thematic overlap, maybe not exact analogies.