Grignard Reagent Formation - From the Lab to Industry (English)

In-situ production of Grignard reagents with continuous process control:
Since its discovery more than 100 years ago, the synthesis of Grignard reagents and their conversion with a variety of organic molecules such as ketones and aldehydes has been one of the most effective methods of C-C bond formation. In the synthesis of the top 50 active pharmaceutical ingredients, in about 10 percent of the synthetic pathways one Grignard reaction or more can be found.

[@LiborTinka]

What about cases where the Grignard reagent is not readily formed? For example, substitued halobenzenes may react slower than unsubstitued ones (e.g. bromobenzene vs 5-bromo-1,3-benzodioxole).

[@crabcrab2024]

I like it!

[@hkkhgffh3613]

Wicked!