You have not included the state when dietary carbohydrate is very low that means the case when persons are on LCHF or KETO diet. In case of situation when we are on Keto or LCHF diet, the fuel source is ketone bodies not glucose to produce ATP. You should say when our body fast or on LCHF or KETO diet ketone bodies are produced and they are used to produce ATP through cellular respiration. Please correct me if I am wrong. Ofcourse you probably didn't want to mention about diabetic keto acidosis. We are talking about dietary ketosis and ketolysis. We like to have videos with full modern day information not something which has been taught in medical school.
Ah I see now. After all glucose is gone from glucose reserves in muscle and liver, AND after new glucose is gone from gluconeogenesis, then fat is broken down (I have plenty right now LOL) and fatty acids go around your body in your blood stream. Most organs and muscles can use fatty acids to convert to fuel and not wait for ketones. But liver will convert some of those to ketones for your brain, heart, and kidneys, because those organs NEED ketones since the glucose is gone. But the rest of the body can live off of fatty acids and convert those directly to acetyl coa. Is that correct?
Animated way of learning is great for memorizing the concept for long time.. Thank you soo much for making these videos. I appriciate your hard work 👏👏 Keep going and keep making more videos 👏
KB are produced during starvation/DM, when gluconeogenic substrates are finished(oxaloacetates are depleted) and acetyl coA can't enter TCA cycle.... right?? Then while utilising KBs in fasting/starvation/DM, the acetyl coA is formed......How does this acetyl coA enters the TCA cycle now when there is no Oxaloacetate present???
ketone bodies are not utilized in hepatic tissues ,mostly they are utilized in extrahepatic tissues for example brain, In neurons gluconeogenic mechanisms are not prevalent so krebs cycle intermediates are not depleted.As a result, all the ketonebodies form acetyl coA which can be channeled into TCA
Many thanks for your detailed explanation and metaphor. You are an EDUCATOR in the truest sense of the word. Thanks Again. Question: Can muscles also use ketones? It must be yes. But you mention only brain, heart and kidney. Also is it healthy for body to use ketones as in low carb or keto diet?
Ketone bodies are oxidised as a fuel source during exercise, are markedly elevated during the post-exercise recovery period, and the ability to utilise ketone bodies is higher in exercise-trained skeletal muscle. In fact any cell with mitochondria can utilize ketone bodies.
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Hello Arpan sir...I m an iit jam aspirant this year ....I have many doubts about many topics...And ur lectures based on nmr are really awesome ...Sir I need more problem solving videos...Sir can u gave me ur email ...Plz..So that I can reach u ....I will be thankful if u do so sir....Respect from my side..And sir I m from west bengal ,Midnapore college
You have not included the state when dietary carbohydrate is very low that means the case when persons are on LCHF or KETO diet. In case of situation when we are on Keto or LCHF diet, the fuel source is ketone bodies not glucose to produce ATP. You should say when our body fast or on LCHF or KETO diet ketone bodies are produced and they are used to produce ATP through cellular respiration. Please correct me if I am wrong. Ofcourse you probably didn't want to mention about diabetic keto acidosis. We are talking about dietary ketosis and ketolysis. We like to have videos with full modern day information not something which has been taught in medical school.
Ah I see now.
After all glucose is gone from glucose reserves in muscle and liver,
AND after new glucose is gone from gluconeogenesis, then fat is broken down (I have plenty right now LOL) and fatty acids go around your body in your blood stream.
Most organs and muscles can use fatty acids to convert to fuel and not wait for ketones.
But liver will convert some of those to ketones for your brain, heart, and kidneys, because those organs NEED ketones since the glucose is gone.
But the rest of the body can live off of fatty acids and convert those directly to acetyl coa.
Is that correct?
You understood correctly 👏
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hi i have one doubt as If Liver can breaK ketones then how does it get energy ? also what about RBCs ??
Animated way of learning is great for memorizing the concept for long time..
Thank you soo much for making these videos.
I appriciate your hard work 👏👏
Keep going and keep making more videos 👏
Please share my channel link with your friends and help me to reach big audience
@@animatedbiologywitharpan Sure😇
Very informative video. Well explained.
Please share my channel link with your friends
KB are produced during starvation/DM, when gluconeogenic substrates are finished(oxaloacetates are depleted) and acetyl coA can't enter TCA cycle.... right??
Then while utilising KBs in fasting/starvation/DM, the acetyl coA is formed......How does this acetyl coA enters the TCA cycle now when there is no Oxaloacetate present???
ketone bodies are not utilized in hepatic tissues ,mostly they are utilized in extrahepatic tissues for example brain, In neurons gluconeogenic mechanisms are not prevalent so krebs cycle intermediates are not depleted.As a result, all the ketonebodies form acetyl coA which can be channeled into TCA
Many thanks for your detailed explanation and metaphor. You are an EDUCATOR in the truest sense of the word. Thanks Again.
Question: Can muscles also use ketones? It must be yes. But you mention only brain, heart and kidney. Also is it healthy for body to use ketones as in low carb or keto diet?
Ketone bodies are oxidised as a fuel source during exercise, are markedly elevated during the post-exercise recovery period, and the ability to utilise ketone bodies is higher in exercise-trained skeletal muscle. In fact any cell with mitochondria can utilize ketone bodies.
Please share my channel link with your friends and help me to reach big audience
Don't forget to check out my nutrition playlist czcams.com/play/PLKtiwIJ8Q7rpmGLeQ7uHnu3GMYY4gyfHm.html
Good explanation.
In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.
Hello Arpan sir...I m an iit jam aspirant this year ....I have many doubts about many topics...And ur lectures based on nmr are really awesome ...Sir I need more problem solving videos...Sir can u gave me ur email ...Plz..So that I can reach u ....I will be thankful if u do so sir....Respect from my side..And sir I m from west bengal ,Midnapore college