Frontline treatment of transplant eligible patients with myeloma: current approach & future changes

Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, discusses the therapeutic approach used for transplant-eligible patients with multiple myeloma (MM) in the frontline setting and outlines how this may change with data from ongoing clinical trials. Findings from the PERSEUS trial (NCT03710603) suggest that the addition of daratumumab to bortezomib, lenalidomide, and dexamethasone (VRd) induction and to lenalidomide maintenance results in improved rates of measurable residual disease (MRD)-negativity and subsequent progression-free survival (PFS). The ongoing RADAR trial (ISCRTN46841867) provides additional nuance to the treatment of this patient population through the use of genetic risk-adapted therapy and response-adapted therapy post-transplant using MRD. This interview took place at the 64th Annual Scientific Meeting of the British Society for Haematology (BSH) Congress in Liverpool, UK.
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