Endosomal Escape of Lipid Nanoparticles: Novel Insights Using Reflectivity Techniques

In this presentation, Dr. Alice Spadea, Research Associate in Drug Delivery at The University of Manchester and NoWCADD, presents on how surface pressure (π) and ellipsometry (Δint) data have been used to obtain, for the first time, novel insight into the interaction between LNPs and model endosomal monolayers, highlighting the different types of processes occurring at the air/water interface, such as insertion of lipids, binding of whole LNPs and ionizable lipid-nucleic acid complexes delivery.
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