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Precision NanoSystems is now part of Cytiva
Registrace 7. 09. 2012
Don’t miss out on our new brand and our new home! Precision NanoSystems has completed our integration with Cytiva and can now offer so much more!
Our end-to-end workflow solutions are your helping hand to advance your therapeutics from concept to commercial delivery.
We are closing this CZcams account on 31 May 2024 - follow @Cytiva and find out what’s new!
#lipidnanoparticles
#nanomedicine
#NanoAssemblr
#Ignite
#lipidformulation
Our end-to-end workflow solutions are your helping hand to advance your therapeutics from concept to commercial delivery.
We are closing this CZcams account on 31 May 2024 - follow @Cytiva and find out what’s new!
#lipidnanoparticles
#nanomedicine
#NanoAssemblr
#Ignite
#lipidformulation
Turning Industry Challenges into Innovation: NanoAssemblr™ Commercial Formulation System
Over the last few years, the regulatory and commercial landscape of mRNA-encapsulated lipid nanoparticles (LNPs) has drastically changed. But what's driving this change, and how will it affect the next wave of therapies? Watch this video to hear directly from the engineers and LNP experts who developed the new NanoAssemblr commercial formulation system and what’s behind their motivation to continually innovate.
Learn more: www.precisionnanosystems.com/platform-technologies/product-comparison/nanoassemblr-commercial-formulation-system
Learn more: www.precisionnanosystems.com/platform-technologies/product-comparison/nanoassemblr-commercial-formulation-system
zhlédnutí: 495
Video
Scaled Up Production of mRNA-LNPs: Strategies & Parameters
zhlédnutí 605Před 9 měsíci
In this GEN webinar, Midhun Ben Thomas, Senior Scientist at the Centre for Process Innovation (CPI), discusses the strategies for scaling up mRNA-lipid nanoparticle (LNP) production in which the encapsulation approach, method of buffer exchange, and type of filtration all play a significant role.
Optimized and Scalable LNP Composition for RNA Vaccine Delivery
zhlédnutí 527Před 10 měsíci
Lipid nanoparticle encapsulated RNA (RNA-LNP) vaccines have played a pivotal role in the global response to the COVID-19 pandemic and are now at various stages of development against a wide-range of other infectious diseases. Limited access to potent ionizable lipids, a key component in LNPs, and expertise for formulation and scale-up, present real barriers to entry in this field. To overcome t...
Maximizing Yield and Purity in RNA-LNP Downstream Processing
zhlédnutí 648Před rokem
Downstream processing of RNA-LNPs can often be a bottleneck during scale-up to clinical production. Maximizing yield and purity is a key concern along with controlling critical process parameters. This panel discussion will examine tangential flow filtration (TFF), an essential step in post-formulation purification of RNA-LNPs, including: - The essential steps for designing and optimizing downs...
Standardizing Scale-up: Insights into Producing Clinical and Commercial RNA-LNP Drug Products
zhlédnutí 307Před rokem
Over the last few years, there was an unprecedented demand on biopharma manufacturers to produce an mRNA vaccine in an accelerated timeline. Given the considerable number of variables throughout the production workflow, new flexible and robust manufacturing solutions are required to accelerate scale-up and standardize GMP manufacturing processes. This presentation will share: - Insights into ne...
Clinical and Commercial Manufacturing of mRNA Therapeutics: Opportunities and Challenges
zhlédnutí 439Před rokem
The emergence of COVID-19 led to the rapid progression and commercial validation of mRNA vaccines and the lipid nanoparticle (LNP) technology underpinning this new drug modality. However, the industry still faces significant challenges navigating the evolving manufacturing and regulatory landscape. This interactive panel discussion will address: - Manufacturing strategies to expand LNP delivery...
RNA-LNP Therapeutics Panel Discussion
zhlédnutí 943Před rokem
Industry leaders come together to share insights into accelerating genomic medicine development. Listen to the conversation about current trends and best practices for RNA-based therapeutics, from screening lipid compositions to IND-enabling studies Learn more about ionizable lipids and lipid nanoparticles: www.precisionnanosystems.com/lipids
Ionizable Lipids to Optimize RNA-LNP Delivery
zhlédnutí 3,3KPřed rokem
Lipid nanoparticles (LNPs) mediate targeted, safe, and efficient intracellular drug delivery across applications and modalities including Vaccines, Cell Therapies, Protein Replacement, and Gene Editing. Ionizable lipids are the most important excipient as they play a significant role in protecting nucleic acids and facilitating their cytosolic transport. A well-characterized ionizable lipid por...
NanoAssemblr Commercial Formulation System Overview
zhlédnutí 4,3KPřed rokem
Learn how the NanoAssemblr® commercial formulation system enables efficient changeover and robust manufacturing processes for the clinical and commercial production of lipid nanoparticles under cGMP conditions. Learn more: www.precisionnanosystems.com/platform-technologies/product-comparison/nanoassemblr-system-commercial-formulation-system
Enabling and advancing mRNA-LNP medicines from concept to clinic
zhlédnutí 688Před rokem
This webinar will discuss key insights and experiences that leverage modular microfluidic platform technologies and analytics to enable rapid development, testing, and scale-up of mRNA-LNP vaccines and therapeutics. Learn more about BioPharma Services - www.precisionnanosystems.com/partnering/biopharma-services Follow us on LinkedIn: bit.ly/3F9uEiL Follow us on Twitter: bit.ly/3yBttpW
Accelerate development by outsourcing MRNA-LNP formulations to a CDMO
zhlédnutí 834Před rokem
RNA-lipid nanoparticle (LNP) vaccines have highlighted the impact of genetic medicines deployed at scale. RNA-LNP applications include gene editing, oncology, and rare diseases. A common need for these RNA-LNP therapies is a scalable manufacturing process, as development of RNA-LNPs can be time consuming, cost prohibitive and require deep expertise. In a field that is extremely dynamic and acce...
Novel Ionizable Lipid Portfolio for Enabling Non-Viral Delivery
zhlédnutí 766Před rokem
In this presentation, Dr. Ian Villamagna discusses how effective ionizable lipids are needed for various applications that demonstrate no measured toxicity in vitro, can effectively encapsulate nucleic acids, and can release the nucleic acids from the early endosomes of the target cell. Learn more about microfluidic technology: www.precisionnanosystems.com/platform-technologies/nxgen Follow us ...
Manufacture of LNPs for RNA delivery
zhlédnutí 2,2KPřed rokem
In this presentation, Professor Yvonne Perrie from the University of Strathclyde, discusses their considerations from payload to process in the manufacture of lipid nanoparticles for RNA delivery. Learn more about microfluidic technology: www.precisionnanosystems.com/platform-technologies/nxgen Follow us on LinkedIn: bit.ly/3F9uEiL Follow us on Twitter: bit.ly/3yBttpW
LNPs: Therapeutics for Acute Myeloid Leukaemia
zhlédnutí 326Před rokem
In this presentation for the Teatime Webinar Series, Dr. Hasan Issa presents about therapeutics using lipid nanoparticles for acute myeloid leukaemia.
Top 5 Things to know about our Lipid Nanoparticle Portfolio
zhlédnutí 394Před rokem
Precision NanoSystems lipids and compositions integrate years of trusted nanoparticle expertise into pre-optimized formulations enabling any scientist to easily validate drug delivery, fast-tracking the path to clinical development and commercialization. Learn more about the Lipid Nanoparticle Portfolio: www.precisionnanosystems.com/platform-technologies/genvoy-platform/Lipid-Nanoparticle-Portf...
New Approaches for LNP Design and Microfluidic Manufacturing for Vaccines and CAR T Cell Therapy
zhlédnutí 1,5KPřed rokem
New Approaches for LNP Design and Microfluidic Manufacturing for Vaccines and CAR T Cell Therapy
RNA-Lipid Nanoparticle Platform for the Multi-step engineering of gene edited CAR-T cells.
zhlédnutí 485Před rokem
RNA-Lipid Nanoparticle Platform for the Multi-step engineering of gene edited CAR-T cells.
Lipid Nanoparticle Portfolio for Enabling Non-Viral Delivery - Dr. Anitha Thomas
zhlédnutí 1,8KPřed rokem
Lipid Nanoparticle Portfolio for Enabling Non-Viral Delivery - Dr. Anitha Thomas
Biomimetic LNPs for Enhanced Targeting of Inflamed Tissue: What Are the Challenges?
zhlédnutí 400Před rokem
Biomimetic LNPs for Enhanced Targeting of Inflamed Tissue: What Are the Challenges?
CAR T Cell Therapy with a Scalable RNA Lipid Nanoparticle Platform
zhlédnutí 3,4KPřed rokem
CAR T Cell Therapy with a Scalable RNA Lipid Nanoparticle Platform
Robust low-volume production of lipid nanoparticles for nucleic acid drug discovery & screening
zhlédnutí 308Před rokem
Robust low-volume production of lipid nanoparticles for nucleic acid drug discovery & screening
Proteolipid vesicles: A novel delivery system for safe and effective delivery of nucleic acids
zhlédnutí 668Před rokem
Proteolipid vesicles: A novel delivery system for safe and effective delivery of nucleic acids
Building an LNP process for the Omega platform: a case study
zhlédnutí 463Před rokem
Building an LNP process for the Omega platform: a case study
CMC Considerations for Developing an Effective mRNA/LNP Therapeutic
zhlédnutí 1,4KPřed rokem
CMC Considerations for Developing an Effective mRNA/LNP Therapeutic
Developing a platform process for LNP manufacture
zhlédnutí 1KPřed rokem
Developing a platform process for LNP manufacture
Transient Expression of mRNA Lipid Nanoparticle-based Chimeric Antigen Receptors for Immunotherapy
zhlédnutí 1,3KPřed rokem
Transient Expression of mRNA Lipid Nanoparticle-based Chimeric Antigen Receptors for Immunotherapy
Process & Analytical Insights for GMP Manufacturing of mRNA-Lipid Nanoparticles
zhlédnutí 1,4KPřed rokem
Process & Analytical Insights for GMP Manufacturing of mRNA-Lipid Nanoparticles
Endosomal Escape of Lipid Nanoparticles: Novel Insights Using Reflectivity Techniques
zhlédnutí 2,3KPřed rokem
Endosomal Escape of Lipid Nanoparticles: Novel Insights Using Reflectivity Techniques
Manufacturing RNA lipid nanoparticles to deliver high quality transformative medicines
zhlédnutí 13KPřed rokem
Manufacturing RNA lipid nanoparticles to deliver high quality transformative medicines
Transient Expression of mRNA-LNP-based Chimeric Antigen Receptors for Safe Immunotherapy
zhlédnutí 707Před 2 lety
Transient Expression of mRNA-LNP-based Chimeric Antigen Receptors for Safe Immunotherapy
can we download the powerpoint from somewhere? the quality is not good enough to see the data points thanks
Hello, nice presentation. Can you perhaps tell how is the structure of the dye and in which way it binds to the RNA?
Nuremberg
Nice one Sir
www.precisionnanosystems.com/docs/default-source/pni-files/user-guides/genvoy-user-guide-2020-final-emailsize.pdf
Can you share the Excel here？ thankyou very much.🙆♀️
can I get the material in this video?
Hi where can I find the workbook for calculating encapsulation efficiency please?
Hello: Nice video. is it possible to do similar video on TFF?
Hello, What kinds of 96 well plate you used in this manipulation? Could you share me some reference of plate suitable for ribogreen assay? Thank you!
you can actually use all kinds of 96 well plates from clear, opaque white or black, depending upon the plate reader you're using that has background correction options available
This is amazing BUT can be weoponised
6 years ago when I was diagnosed of heart infection, to me life was no longer interesting, but am happy I came across Dr. Gbenga on youtube through a friend, but today using his herbal mixture for heart disease got me cured, life is back again
Que the lawsuits from stroke victims.
Don't push your high tech to every body eat all your AI we are Godly people and have strong faith in the Creator of he Universe
when you use this nano particles as a delivery system for mrna, how did you solve the problem of degrdation of the endoome and the ribonuclease ? what is the percentace of mrna that escape the endosome and arrive to ribosome to express the protein ?
Can't get enough of these videos . thanks to who provides them