Biological Age & what it REALLY means | 9 - Longevity Science #3
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- čas přidán 8. 07. 2024
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Understanding Aging & Disease and How They're Related: • Understanding Aging & ...
Biological age-that is, how old your cells and tissues are based on physiological function-is a multifaceted and intricate concept that transcends numerical representation. Unlike chronological age, which refers simply to the number of years you have been alive, the concept of biological age delves into the dynamic interplay between physiological processes, genetic predispositions, and environmental influences that collectively shape an individual's health trajectory. Geroscientists are currently studying the biological mechanisms that might impact your biological aging rate and perhaps reverse some of the functional declines that accompany aging.
0:00 Trailer
0:53 Some important definitions
2:33 Biological age and automobiles
4:42 3 core concepts
5:26 Variation in biological aging rate determines the difference between chronological age and biological age
11:15 Why biological aging is an important concept to internalize
11:49 Biological aging rate can vary dramatically within and between species
15:55 Health and mortality risk are both strongly related to, but not equivalent to, biological age
17:40 Reversing aging
22:13 Takehome and recap of the 3 core concepts
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful! - Věda a technologie
Thank you for sharing very informative information 🙏🏻
what about David Sinclair his research seems really promising
When ppl talk about influencers making outrageous claims, we all know theyre talking about david sinclair. Don't know why they dont call him out by name.
Sinclair or better yet Bryan Johnson who has moved beyond theory...
The one scientist who has claimed to reverse aging in an animal (the rat) is Harold Katcher. He has apparently done this experiment multiple times and the active agent is young exosomes. He shows very impressive data showing age reversal in thirty biomarkers, plus the Horvath clock, plus strength and ability to navigate the maze. It would be great if you would interview him about his work. How about it?
This guy is here to blast you with big words from his living room.
You're among my favorite people in the longevity space
I don’t know you Matt but what I do know is that when you give the green light that biological aging has really been reversed I will surely believe you. You are trustworthy! Thanks for your expertise on this very exciting and important subject.
Excellent review and explanation of the subject. The hot topic is age reversal using Yamanka factors. But when you take a deeper dive, it’s worth pointing out that (in mouse) models, on average only 10% of cells reverse to a young state, demonstrating a very modest increase in life expectancy. Unfortunately due to exosome cross talk? between cells the re-programmed cells will eventually recalibrate to the age of the 90% of cells that resisted treatment.
We don’t have age reversal, but I can see some insight emerging that may make that possible.
What about Harold Katcher's rat Siima? I'm a doubter by nature and a skeptic by conviction, but I was very much surprised when I heard Steve Horvath talking about it. He was clearly convinced about the reversing of aging with the E5 elixer.
I guess a lot of scientist in the field will be trying to test the method. If this works, and Harold Katcher's explanation about how it works is right, it will open up a lot of new possibilities to reprogram organs.
I don't believe they have published the data on longevity. I've seen unpublished data, and the lifespan of Sima appears to be less than what has been previously accomplished from CR in mice and comparable to rapamycin. Of course Sima is a rat so not a perfect apples to apples comparison but we just don't have the comparable contemporary data set for other interventions in rats to compare against. Again, based on the unpublished graph that I've seen, Sima also appears to be a statistical outlier from a relatively small experiment. If that's the case, no serious scientist would hang their hat on this one animal. We really need to see the published data to draw any solid conclusions. I believe Steve is referring to epigenetic age, which is published for E5. In the absence of a comprehensive analysis of lifespan and healthspan metrics, epigenetic age doesn't mean much IMHO, but Steve is obviously a fan of this metric - MK
Thank you for a great podcast. I feel this one has greatly upped the game in term of being useful and informative in pulling multiple aspects of aging together. Keep up the great work!
Interesting insight on understanding aging thanks.
I remember hearing someone compare the lifespans of city rats and city squirrels in the same environment. If not eaten, rats die of cancer by age 5 (mice by 3), but the same size squirrel may not time-out till 25.
Cool topic and video
Im glad this got a lot of views of one of your best
I really loved the comparison of dying your hair with reversing aspects of biological aging.
has david sinclair been cancelled yet?
No, he's still the PR guru he has always been!
Not so much published research, though.
Too big to fail
By his peers, it sure seems like it
Sinclair has published way more than Kaberline and in the top journals . Sinclair Also has funding (mostly private investment and grants). Kaeberlein spends more time moaning about more sucessful peers than he does actually explaining his own research.
Envious much, matt? Yawn x
Finally we havea a clued up non salesmam dicussing aging and not jumping in one of the halllmarks . One of nine is layman's epigenetic 😢disregulation is onen of nine issues.
I feel like his argument is kinda dumb. "Make an old animal young again" is the most macro bar you can set, and until that time "it hasn't been proven". That's like saying aviation isn't possible until he sees jet airplanes. Engineering doesn't work like that. It's incremental and proceeds in small steps. Currently, several labs have reversed the age of various organs in lab animals. For example, Sinclair famously reset the age of the retina of blind mice to restore their vision. What does he call that?
I don't agree!
It's more like you aren’t flying if you are falling a little slower.
@@larsnystrom6698 Regrowing an axion from the retina to the brain is not "falling a little slower" though. That is clear rejuvenation and age reversal.
@Letsplay222
No, it's not rejuvenation. More like a stem cell therapy.
@@larsnystrom6698 In what way is it not rejuvenation? You take old cells, administer a therapy, the cells revert to their youthful state and regrow a connection to the brain that only happens during development. If that is not age reversal, I will still take it.
Ok, it’s pretty obvious that you can reverse the age of organs . It’s the whole animal/person etc that is too complex. However, we can retain a relatively young age by using epigenetic and other strategies, that’s the present state of the science….
I've reversed considerably age related issues thru diet, fasting, workouts, supplements. My aging trajectory has been reduced "age slowing". Btw I have a 99 4runner with over 400K, same with it even in a road salt region its rust free. Optimal focus gets optimal results.
Now that is a funny comparison lol.
chair looks comfy.
Final words: no one has yet reversed the age of an animal, in spite of some claims (and we know by who).
Brilliant information. It should inspire people to change the bad habits they have not matter what age they are. And yes we can’t reverse aging.
But they can make photoshopped resveratrol mouse pictures.
Epihidron + GDF11 + maybe yamanaka factors should pretty much reset cell status. At least, my protocol will include the first 2 :)
What are those? Do you have a video about these?
Interesting. After optimizing various aspects of aging, from diet and body composition to VO2 Max, I remain perplexed as to why the commercially available Horvath Clock places me in the fastest aging percentile of the population. Whatever their training dataset encompasses, surely the results should correlate with the improvements I have observed.
Interesting. Do you eat a lot of protein and are growing constantly? Are you fasting ever?
Well, David Sinclair does look very young and doesn't seem to have aged a bit since his late 30s
What do you think about Bryan Johnson … he actually does not claim to reverse aging .. he says that he is SEVERELY decreasing his rate of aging ..
What do y think of him ? - pls make a video . Thx
Quite a difference between reversing, or even stopping aging, and to slow it down.
Some claims down to 70% of the speed of cronological aging.
Timestamps would help your nice videos ❤
9:40 this change is at 40 of biological age, not chronological age. Otherwise great video, very informative
I like the thumbnail
You look as young as you are. How do you explain that some people look younger than their actual age? If you can't fight aging, does that mean that it's the same regardless of dietary lifestyle?
I know someone that's 60 that I look and think she's 30. Good eating exercise lots of sunshine and tanning bed in winter no sunscreen or lotions
Is the following correct?
If a lifespan practice reviews a broad, comprehensive blood analysis for a 60 year old man and proclaims that his biological age is 52 years, does that mean that his blood test scores are what would be expected for a 52 year old?
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Is it reasonable to assume that should such a discovery be made it will NEVER EVER propagate through social media?
I’ve reversed my age so much I was drafted into the First World War !
I am 71 now, eat organically, take supplements, don't drink, never smoked, but have terrible osteoarthritis from various accidents. It is painful and not reversible. Otherwise I am healthy. I am concerned about developing osteoporosis. Young people need to be more concerned at an early age about taking care of their bones with adequate vitamin D and other supplements.
I appreciate your effort, you got some things right, but you got some things wrong. “I think” with no data does not equate to fact. Hair color and makeup is not a good analogy to anything biological, ever. That is a little conflation there in the logic about how something looks and how it is. The shina Yamanaka factors - you can only use 3 of the 4, OSK, not M. Reportedly if you use the M, that is what causes tumors. I’m skipping the rest of this, but if you aren’t tracking it, learn more about bioelectricity as well. It is all interconnected - the body is a system of systems.
“Make an old animal young again”… very big hand wave there, that’s the measure I was waiting for after explaining that everyone in the field trying to measure biological age is wrong/dishonest.
Obviously we are making cells biologically younger given iPSCs are a thing. Published papers are showing animals with fairly dramatic extensions in mean remaining lifespan.
Of course nothing is actually ready for prime time yet and there are plenty of grifters, but I’d say just being a contrarian naysayer isn’t actually that helpful at this point.
You're such a buzz kill. The Grim Reaper of science
All science is incomplete or wrong. Tribal CZcams belief systems are not science.
No, he's the grim reaper of misplaced hypes and hopes.
I see maintaining organ functionality slow atrophy while correcting nutritional Hormonal deficiencies with a focus on the Microbiome and mitochondrial function and will all that remember we are all biochemically unique
So, you better start eating GMO and enjoying your beer
wrong. see david sinclair in videos by the years . me too
You need to stop our bodies from drying out from the inside. All the different fluids, oils etc.
Seems most are in decent shape until their Thymus function deteriorates.
How is biological age measurable" Is there a standard measurement for biological age? Is the biological age a linear function? What are the variables of biological aging? If these questions can not be answered, biological aging is meaningless.
So what about maximum species (or breed, race)? Also, organs age at different rates according to Horvath's clocks? Changing biological aging rate is not the solution, rejuvenation, reversing the biological aging "clock" is the answer. Our longest lived treated rat, "Sima" (boundary in Hindi) lived the human equivalent of 160 years. In our experiments,. You are wrong, we've published reversal aging by 30+ phenotypes, including cognition, grip strength, liver and kidney enzyems, blood lipids, anti-oxidant concentration, and we have made old animals young again. You are wrong and we have proven it! We are not lying, and have several published results showing it.
Infrared sauna vitamins organic food food good water intermittent exercise. Weight training stay away from. Palliative medicine
The
Hopefully Aubrey de greys mouse project will provide proof that animal ageing can be reversed
I hope so - MK
He's still a thing? Haven't heard from him in years.
you are missing he central point of the concept biological age. It lingers always around the corner, but you miss it. You constantly take it as if it was an objective measure. Yet it is not, for many reasons. The definition, which is usually underlying its usage, would be like: bio age refers to the average condition and adaptability of the physiology of a body as compared to a population average. From that, the rate of bio aging is derived.
That means that a rate of bioage today of let me say 0.8, may be equal, ceteris paribus, to a value of 1.1 in 50 years. The use of the whole concept is generally still not applied properly. The correlation between different methods of determining the bio age is usually less than 0.5 !! A long list of theoretical fallacies are still built in.
Main issue: it is impossible to measure, yet. Because there is no theory. Because it is not possible to derive a simple categorization. Yes, you can measure SOMETHiNG, but nobody knows what it s measuring, and the claim that it has a good correlation with chronoage is circular.
one other major mistake in your presentation is at @18:53, when you talk about age reversal. Implicitly you apply a theory of aging, which mot likely is utterly wrong.
Overall, your talk is not to be taken serious.
Idiotsplaining: Random internet troll says nonsensical words and tells a world expert on a topic how they got it wrong 😆
@@jds02153 join him. Then you are already 2.
@@jds02153 world expert doesn't mean he's infallible, now does it??
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